Amino acid dipepetide frequency for Xylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990 / XIL07)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.688AlaAla: 23.688 ± 0.225	0.804AlaCys: 0.804 ± 0.03	9.115AlaAsp: 9.115 ± 0.118	8.086AlaGlu: 8.086 ± 0.119	3.629AlaPhe: 3.629 ± 0.053	13.537AlaGly: 13.537 ± 0.137	2.84AlaHis: 2.84 ± 0.055	4.494AlaIle: 4.494 ± 0.085	2.251AlaLys: 2.251 ± 0.055	14.797AlaLeu: 14.797 ± 0.147	2.626AlaMet: 2.626 ± 0.056	2.009AlaAsn: 2.009 ± 0.046	7.611AlaPro: 7.611 ± 0.107	4.265AlaGln: 4.265 ± 0.069	11.005AlaArg: 11.005 ± 0.143	6.574AlaSer: 6.574 ± 0.071	8.621AlaThr: 8.621 ± 0.094	13.643AlaVal: 13.643 ± 0.156	2.297AlaTrp: 2.297 ± 0.05	2.306AlaTyr: 2.306 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.683CysAla: 0.683 ± 0.026	0.06CysCys: 0.06 ± 0.008	0.344CysAsp: 0.344 ± 0.017	0.281CysGlu: 0.281 ± 0.017	0.143CysPhe: 0.143 ± 0.011	0.636CysGly: 0.636 ± 0.023	0.124CysHis: 0.124 ± 0.011	0.136CysIle: 0.136 ± 0.011	0.066CysLys: 0.066 ± 0.007	0.47CysLeu: 0.47 ± 0.021	0.063CysMet: 0.063 ± 0.007	0.112CysAsn: 0.112 ± 0.011	0.374CysPro: 0.374 ± 0.022	0.132CysGln: 0.132 ± 0.01	0.365CysArg: 0.365 ± 0.019	0.348CysSer: 0.348 ± 0.019	0.375CysThr: 0.375 ± 0.02	0.472CysVal: 0.472 ± 0.019	0.08CysTrp: 0.08 ± 0.009	0.106CysTyr: 0.106 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	9.698AspAla: 9.698 ± 0.124	0.276AspCys: 0.276 ± 0.018	5.504AspAsp: 5.504 ± 0.101	3.884AspGlu: 3.884 ± 0.06	1.351AspPhe: 1.351 ± 0.036	7.328AspGly: 7.328 ± 0.096	1.298AspHis: 1.298 ± 0.039	1.57AspIle: 1.57 ± 0.037	0.875AspLys: 0.875 ± 0.033	6.56AspLeu: 6.56 ± 0.084	0.658AspMet: 0.658 ± 0.023	0.825AspAsn: 0.825 ± 0.026	4.64AspPro: 4.64 ± 0.075	1.481AspGln: 1.481 ± 0.038	4.461AspArg: 4.461 ± 0.083	2.012AspSer: 2.012 ± 0.038	2.833AspThr: 2.833 ± 0.052	7.173AspVal: 7.173 ± 0.089	0.912AspTrp: 0.912 ± 0.032	1.073AspTyr: 1.073 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.323GluAla: 7.323 ± 0.111	0.256GluCys: 0.256 ± 0.014	2.596GluAsp: 2.596 ± 0.048	2.544GluGlu: 2.544 ± 0.064	1.311GluPhe: 1.311 ± 0.037	3.769GluGly: 3.769 ± 0.063	1.6GluHis: 1.6 ± 0.04	2.272GluIle: 2.272 ± 0.047	1.036GluLys: 1.036 ± 0.035	6.176GluLeu: 6.176 ± 0.078	0.75GluMet: 0.75 ± 0.031	0.965GluAsn: 0.965 ± 0.033	3.548GluPro: 3.548 ± 0.066	2.037GluGln: 2.037 ± 0.044	5.037GluArg: 5.037 ± 0.078	2.354GluSer: 2.354 ± 0.053	2.862GluThr: 2.862 ± 0.052	4.794GluVal: 4.794 ± 0.077	0.726GluTrp: 0.726 ± 0.026	0.981GluTyr: 0.981 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.765PheAla: 3.765 ± 0.062	0.172PheCys: 0.172 ± 0.013	2.002PheAsp: 2.002 ± 0.047	1.511PheGlu: 1.511 ± 0.039	0.831PhePhe: 0.831 ± 0.032	2.86PheGly: 2.86 ± 0.056	0.521PheHis: 0.521 ± 0.023	0.699PheIle: 0.699 ± 0.03	0.376PheLys: 0.376 ± 0.022	2.482PheLeu: 2.482 ± 0.05	0.37PheMet: 0.37 ± 0.02	0.513PheAsn: 0.513 ± 0.023	1.296PhePro: 1.296 ± 0.034	0.667PheGln: 0.667 ± 0.027	1.709PheArg: 1.709 ± 0.038	1.298PheSer: 1.298 ± 0.038	1.862PheThr: 1.862 ± 0.054	2.603PheVal: 2.603 ± 0.054	0.485PheTrp: 0.485 ± 0.023	0.516PheTyr: 0.516 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	11.898GlyAla: 11.898 ± 0.133	0.564GlyCys: 0.564 ± 0.024	5.263GlyAsp: 5.263 ± 0.082	4.858GlyGlu: 4.858 ± 0.069	2.845GlyPhe: 2.845 ± 0.049	8.343GlyGly: 8.343 ± 0.112	1.992GlyHis: 1.992 ± 0.046	3.621GlyIle: 3.621 ± 0.067	1.965GlyLys: 1.965 ± 0.047	9.442GlyLeu: 9.442 ± 0.107	1.828GlyMet: 1.828 ± 0.045	1.649GlyAsn: 1.649 ± 0.048	4.666GlyPro: 4.666 ± 0.076	2.564GlyGln: 2.564 ± 0.049	6.906GlyArg: 6.906 ± 0.084	5.131GlySer: 5.131 ± 0.069	6.493GlyThr: 6.493 ± 0.097	8.705GlyVal: 8.705 ± 0.082	1.773GlyTrp: 1.773 ± 0.048	2.005GlyTyr: 2.005 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.875HisAla: 2.875 ± 0.05	0.105HisCys: 0.105 ± 0.01	1.548HisAsp: 1.548 ± 0.038	1.165HisGlu: 1.165 ± 0.03	0.481HisPhe: 0.481 ± 0.022	2.209HisGly: 2.209 ± 0.043	0.627HisHis: 0.627 ± 0.023	0.493HisIle: 0.493 ± 0.02	0.274HisLys: 0.274 ± 0.016	2.383HisLeu: 2.383 ± 0.054	0.251HisMet: 0.251 ± 0.013	0.327HisAsn: 0.327 ± 0.017	1.524HisPro: 1.524 ± 0.043	0.554HisGln: 0.554 ± 0.023	1.864HisArg: 1.864 ± 0.039	0.765HisSer: 0.765 ± 0.028	1.118HisThr: 1.118 ± 0.034	2.009HisVal: 2.009 ± 0.047	0.311HisTrp: 0.311 ± 0.017	0.379HisTyr: 0.379 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.087IleAla: 5.087 ± 0.083	0.175IleCys: 0.175 ± 0.013	2.623IleAsp: 2.623 ± 0.048	2.005IleGlu: 2.005 ± 0.047	0.755IlePhe: 0.755 ± 0.032	3.319IleGly: 3.319 ± 0.067	0.538IleHis: 0.538 ± 0.023	1.045IleIle: 1.045 ± 0.041	0.61IleLys: 0.61 ± 0.024	2.687IleLeu: 2.687 ± 0.064	0.45IleMet: 0.45 ± 0.022	0.626IleAsn: 0.626 ± 0.023	1.781IlePro: 1.781 ± 0.047	0.712IleGln: 0.712 ± 0.027	1.862IleArg: 1.862 ± 0.041	1.521IleSer: 1.521 ± 0.042	2.44IleThr: 2.44 ± 0.056	3.313IleVal: 3.313 ± 0.062	0.382IleTrp: 0.382 ± 0.018	0.532IleTyr: 0.532 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.21LysAla: 2.21 ± 0.056	0.06LysCys: 0.06 ± 0.006	1.0LysAsp: 1.0 ± 0.034	0.831LysGlu: 0.831 ± 0.032	0.38LysPhe: 0.38 ± 0.021	1.324LysGly: 1.324 ± 0.041	0.408LysHis: 0.408 ± 0.017	0.66LysIle: 0.66 ± 0.028	0.547LysLys: 0.547 ± 0.028	1.389LysLeu: 1.389 ± 0.041	0.234LysMet: 0.234 ± 0.015	0.405LysAsn: 0.405 ± 0.02	0.987LysPro: 0.987 ± 0.035	0.52LysGln: 0.52 ± 0.021	1.171LysArg: 1.171 ± 0.038	0.877LysSer: 0.877 ± 0.034	1.047LysThr: 1.047 ± 0.035	1.54LysVal: 1.54 ± 0.043	0.162LysTrp: 0.162 ± 0.013	0.376LysTyr: 0.376 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	16.185LeuAla: 16.185 ± 0.143	0.549LeuCys: 0.549 ± 0.023	7.306LeuAsp: 7.306 ± 0.095	4.842LeuGlu: 4.842 ± 0.075	2.388LeuPhe: 2.388 ± 0.056	9.514LeuGly: 9.514 ± 0.109	2.091LeuHis: 2.091 ± 0.043	2.778LeuIle: 2.778 ± 0.057	1.349LeuLys: 1.349 ± 0.037	10.345LeuLeu: 10.345 ± 0.13	1.486LeuMet: 1.486 ± 0.038	1.463LeuAsn: 1.463 ± 0.038	5.977LeuPro: 5.977 ± 0.08	2.278LeuGln: 2.278 ± 0.048	8.181LeuArg: 8.181 ± 0.103	4.466LeuSer: 4.466 ± 0.068	6.894LeuThr: 6.894 ± 0.088	10.214LeuVal: 10.214 ± 0.118	1.34LeuTrp: 1.34 ± 0.034	1.491LeuTyr: 1.491 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.015MetAla: 2.015 ± 0.046	0.099MetCys: 0.099 ± 0.011	0.758MetAsp: 0.758 ± 0.028	0.571MetGlu: 0.571 ± 0.024	0.465MetPhe: 0.465 ± 0.024	1.111MetGly: 1.111 ± 0.033	0.326MetHis: 0.326 ± 0.019	0.633MetIle: 0.633 ± 0.024	0.302MetLys: 0.302 ± 0.016	1.684MetLeu: 1.684 ± 0.041	0.212MetMet: 0.212 ± 0.015	0.399MetAsn: 0.399 ± 0.019	1.067MetPro: 1.067 ± 0.03	0.4MetGln: 0.4 ± 0.017	1.247MetArg: 1.247 ± 0.03	1.295MetSer: 1.295 ± 0.033	1.728MetThr: 1.728 ± 0.041	1.317MetVal: 1.317 ± 0.033	0.21MetTrp: 0.21 ± 0.015	0.247MetTyr: 0.247 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.107AsnAla: 2.107 ± 0.053	0.094AsnCys: 0.094 ± 0.008	0.955AsnAsp: 0.955 ± 0.032	0.761AsnGlu: 0.761 ± 0.027	0.472AsnPhe: 0.472 ± 0.022	1.573AsnGly: 1.573 ± 0.048	0.388AsnHis: 0.388 ± 0.018	0.567AsnIle: 0.567 ± 0.024	0.273AsnLys: 0.273 ± 0.017	1.747AsnLeu: 1.747 ± 0.042	0.24AsnMet: 0.24 ± 0.015	0.35AsnAsn: 0.35 ± 0.018	1.425AsnPro: 1.425 ± 0.042	0.494AsnGln: 0.494 ± 0.024	1.081AsnArg: 1.081 ± 0.034	0.667AsnSer: 0.667 ± 0.025	0.987AsnThr: 0.987 ± 0.036	1.568AsnVal: 1.568 ± 0.035	0.255AsnTrp: 0.255 ± 0.016	0.386AsnTyr: 0.386 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	9.045ProAla: 9.045 ± 0.121	0.221ProCys: 0.221 ± 0.016	4.577ProAsp: 4.577 ± 0.072	3.717ProGlu: 3.717 ± 0.058	1.593ProPhe: 1.593 ± 0.038	6.066ProGly: 6.066 ± 0.085	1.261ProHis: 1.261 ± 0.033	1.474ProIle: 1.474 ± 0.04	0.792ProLys: 0.792 ± 0.03	4.988ProLeu: 4.988 ± 0.074	0.893ProMet: 0.893 ± 0.029	0.835ProAsn: 0.835 ± 0.027	3.201ProPro: 3.201 ± 0.07	1.627ProGln: 1.627 ± 0.041	3.853ProArg: 3.853 ± 0.063	3.263ProSer: 3.263 ± 0.068	4.192ProThr: 4.192 ± 0.088	5.924ProVal: 5.924 ± 0.081	0.987ProTrp: 0.987 ± 0.031	1.041ProTyr: 1.041 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.897GlnAla: 3.897 ± 0.054	0.126GlnCys: 0.126 ± 0.01	1.33GlnAsp: 1.33 ± 0.033	1.271GlnGlu: 1.271 ± 0.033	0.738GlnPhe: 0.738 ± 0.027	2.162GlnGly: 2.162 ± 0.05	0.656GlnHis: 0.656 ± 0.023	1.098GlnIle: 1.098 ± 0.038	0.443GlnLys: 0.443 ± 0.021	2.602GlnLeu: 2.602 ± 0.05	0.465GlnMet: 0.465 ± 0.02	0.515GlnAsn: 0.515 ± 0.025	1.614GlnPro: 1.614 ± 0.045	1.089GlnGln: 1.089 ± 0.038	2.415GlnArg: 2.415 ± 0.046	1.201GlnSer: 1.201 ± 0.036	1.48GlnThr: 1.48 ± 0.031	3.031GlnVal: 3.031 ± 0.051	0.482GlnTrp: 0.482 ± 0.022	0.57GlnTyr: 0.57 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	10.075ArgAla: 10.075 ± 0.132	0.384ArgCys: 0.384 ± 0.022	4.366ArgAsp: 4.366 ± 0.078	4.177ArgGlu: 4.177 ± 0.069	2.216ArgPhe: 2.216 ± 0.05	5.77ArgGly: 5.77 ± 0.088	1.696ArgHis: 1.696 ± 0.042	2.73ArgIle: 2.73 ± 0.053	1.312ArgLys: 1.312 ± 0.04	8.033ArgLeu: 8.033 ± 0.104	1.558ArgMet: 1.558 ± 0.039	1.196ArgAsn: 1.196 ± 0.034	4.433ArgPro: 4.433 ± 0.075	2.074ArgGln: 2.074 ± 0.049	7.257ArgArg: 7.257 ± 0.105	4.06ArgSer: 4.06 ± 0.068	5.254ArgThr: 5.254 ± 0.072	6.58ArgVal: 6.58 ± 0.08	1.495ArgTrp: 1.495 ± 0.042	1.64ArgTyr: 1.64 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.477SerAla: 6.477 ± 0.075	0.295SerCys: 0.295 ± 0.016	2.784SerAsp: 2.784 ± 0.055	2.059SerGlu: 2.059 ± 0.041	1.507SerPhe: 1.507 ± 0.04	5.373SerGly: 5.373 ± 0.071	0.894SerHis: 0.894 ± 0.03	1.715SerIle: 1.715 ± 0.04	0.776SerLys: 0.776 ± 0.028	4.662SerLeu: 4.662 ± 0.063	0.985SerMet: 0.985 ± 0.033	0.847SerAsn: 0.847 ± 0.03	2.875SerPro: 2.875 ± 0.05	1.246SerGln: 1.246 ± 0.031	3.414SerArg: 3.414 ± 0.053	2.81SerSer: 2.81 ± 0.055	3.584SerThr: 3.584 ± 0.053	4.342SerVal: 4.342 ± 0.067	0.897SerTrp: 0.897 ± 0.032	0.891SerTyr: 0.891 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.895ThrAla: 8.895 ± 0.112	0.355ThrCys: 0.355 ± 0.018	3.75ThrAsp: 3.75 ± 0.067	2.913ThrGlu: 2.913 ± 0.053	1.96ThrPhe: 1.96 ± 0.046	6.455ThrGly: 6.455 ± 0.087	1.332ThrHis: 1.332 ± 0.035	2.386ThrIle: 2.386 ± 0.05	0.929ThrLys: 0.929 ± 0.032	6.359ThrLeu: 6.359 ± 0.078	1.018ThrMet: 1.018 ± 0.031	1.083ThrAsn: 1.083 ± 0.032	4.894ThrPro: 4.894 ± 0.095	1.625ThrGln: 1.625 ± 0.042	4.28ThrArg: 4.28 ± 0.062	3.546ThrSer: 3.546 ± 0.054	5.148ThrThr: 5.148 ± 0.08	6.556ThrVal: 6.556 ± 0.098	1.112ThrTrp: 1.112 ± 0.033	1.33ThrTyr: 1.33 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	13.995ValAla: 13.995 ± 0.145	0.553ValCys: 0.553 ± 0.022	6.352ValAsp: 6.352 ± 0.073	5.736ValGlu: 5.736 ± 0.087	2.395ValPhe: 2.395 ± 0.051	8.275ValGly: 8.275 ± 0.108	1.965ValHis: 1.965 ± 0.043	3.111ValIle: 3.111 ± 0.06	1.388ValLys: 1.388 ± 0.038	10.6ValLeu: 10.6 ± 0.131	1.49ValMet: 1.49 ± 0.042	1.551ValAsn: 1.551 ± 0.037	5.869ValPro: 5.869 ± 0.081	2.291ValGln: 2.291 ± 0.051	7.347ValArg: 7.347 ± 0.109	4.478ValSer: 4.478 ± 0.065	6.787ValThr: 6.787 ± 0.086	12.35ValVal: 12.35 ± 0.161	1.271ValTrp: 1.271 ± 0.036	1.456ValTyr: 1.456 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.87TrpAla: 1.87 ± 0.046	0.123TrpCys: 0.123 ± 0.012	0.982TrpAsp: 0.982 ± 0.035	0.722TrpGlu: 0.722 ± 0.028	0.556TrpPhe: 0.556 ± 0.021	1.104TrpGly: 1.104 ± 0.034	0.402TrpHis: 0.402 ± 0.02	0.563TrpIle: 0.563 ± 0.024	0.267TrpLys: 0.267 ± 0.017	1.78TrpLeu: 1.78 ± 0.044	0.297TrpMet: 0.297 ± 0.017	0.406TrpAsn: 0.406 ± 0.021	0.77TrpPro: 0.77 ± 0.027	0.588TrpGln: 0.588 ± 0.018	1.301TrpArg: 1.301 ± 0.036	0.948TrpSer: 0.948 ± 0.032	1.144TrpThr: 1.144 ± 0.035	1.384TrpVal: 1.384 ± 0.036	0.407TrpTrp: 0.407 ± 0.02	0.295TrpTyr: 0.295 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.411TyrAla: 2.411 ± 0.045	0.102TyrCys: 0.102 ± 0.01	1.256TyrAsp: 1.256 ± 0.035	1.002TyrGlu: 1.002 ± 0.03	0.522TyrPhe: 0.522 ± 0.023	1.782TyrGly: 1.782 ± 0.042	0.303TyrHis: 0.303 ± 0.015	0.418TyrIle: 0.418 ± 0.018	0.297TyrLys: 0.297 ± 0.016	1.95TyrLeu: 1.95 ± 0.043	0.211TyrMet: 0.211 ± 0.015	0.314TyrAsn: 0.314 ± 0.016	1.0TyrPro: 1.0 ± 0.03	0.54TyrGln: 0.54 ± 0.022	1.552TyrArg: 1.552 ± 0.04	0.819TyrSer: 0.819 ± 0.032	1.074TyrThr: 1.074 ± 0.041	1.742TyrVal: 1.742 ± 0.042	0.323TyrTrp: 0.323 ± 0.018	0.383TyrTyr: 0.383 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3441 proteins (1156556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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