Amino acid dipepetide frequency for Asaccharospora irregularis DSM 2635

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.17AlaAla: 3.17 ± 0.091	0.727AlaCys: 0.727 ± 0.033	2.499AlaAsp: 2.499 ± 0.056	2.971AlaGlu: 2.971 ± 0.076	2.208AlaPhe: 2.208 ± 0.051	3.478AlaGly: 3.478 ± 0.086	0.783AlaHis: 0.783 ± 0.034	5.702AlaIle: 5.702 ± 0.083	4.805AlaLys: 4.805 ± 0.09	5.227AlaLeu: 5.227 ± 0.096	1.594AlaMet: 1.594 ± 0.049	2.733AlaAsn: 2.733 ± 0.067	1.298AlaPro: 1.298 ± 0.052	1.442AlaGln: 1.442 ± 0.052	1.952AlaArg: 1.952 ± 0.052	3.348AlaSer: 3.348 ± 0.076	2.832AlaThr: 2.832 ± 0.07	3.617AlaVal: 3.617 ± 0.078	0.297AlaTrp: 0.297 ± 0.022	1.947AlaTyr: 1.947 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.603CysAla: 0.603 ± 0.03	0.225CysCys: 0.225 ± 0.023	0.729CysAsp: 0.729 ± 0.035	0.833CysGlu: 0.833 ± 0.036	0.46CysPhe: 0.46 ± 0.027	1.074CysGly: 1.074 ± 0.047	0.184CysHis: 0.184 ± 0.016	1.163CysIle: 1.163 ± 0.044	0.994CysLys: 0.994 ± 0.038	0.853CysLeu: 0.853 ± 0.033	0.344CysMet: 0.344 ± 0.02	0.639CysAsn: 0.639 ± 0.034	0.527CysPro: 0.527 ± 0.032	0.262CysGln: 0.262 ± 0.018	0.4CysArg: 0.4 ± 0.024	0.936CysSer: 0.936 ± 0.04	0.569CysThr: 0.569 ± 0.028	0.701CysVal: 0.701 ± 0.034	0.054CysTrp: 0.054 ± 0.009	0.378CysTyr: 0.378 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.715AspAla: 2.715 ± 0.072	0.682AspCys: 0.682 ± 0.031	3.251AspAsp: 3.251 ± 0.073	5.182AspGlu: 5.182 ± 0.095	2.655AspPhe: 2.655 ± 0.065	3.4AspGly: 3.4 ± 0.074	0.545AspHis: 0.545 ± 0.024	7.24AspIle: 7.24 ± 0.107	5.877AspLys: 5.877 ± 0.096	5.388AspLeu: 5.388 ± 0.095	1.662AspMet: 1.662 ± 0.045	3.395AspAsn: 3.395 ± 0.075	1.35AspPro: 1.35 ± 0.045	0.977AspGln: 0.977 ± 0.037	2.164AspArg: 2.164 ± 0.047	3.315AspSer: 3.315 ± 0.075	2.741AspThr: 2.741 ± 0.055	3.718AspVal: 3.718 ± 0.072	0.346AspTrp: 0.346 ± 0.024	2.753AspTyr: 2.753 ± 0.07	0.0AspXaa: 0.0 ± 0.0
Glu	3.793GluAla: 3.793 ± 0.085	0.749GluCys: 0.749 ± 0.033	4.781GluAsp: 4.781 ± 0.091	7.178GluGlu: 7.178 ± 0.134	3.158GluPhe: 3.158 ± 0.062	4.174GluGly: 4.174 ± 0.08	0.97GluHis: 0.97 ± 0.035	7.448GluIle: 7.448 ± 0.116	7.66GluLys: 7.66 ± 0.129	6.904GluLeu: 6.904 ± 0.112	1.952GluMet: 1.952 ± 0.053	5.374GluAsn: 5.374 ± 0.088	1.351GluPro: 1.351 ± 0.048	1.803GluGln: 1.803 ± 0.05	2.504GluArg: 2.504 ± 0.06	4.037GluSer: 4.037 ± 0.08	2.862GluThr: 2.862 ± 0.063	5.445GluVal: 5.445 ± 0.104	0.361GluTrp: 0.361 ± 0.024	3.323GluTyr: 3.323 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	2.217PheAla: 2.217 ± 0.069	0.474PheCys: 0.474 ± 0.025	2.59PheAsp: 2.59 ± 0.057	2.831PheGlu: 2.831 ± 0.061	1.769PhePhe: 1.769 ± 0.062	2.636PheGly: 2.636 ± 0.067	0.436PheHis: 0.436 ± 0.023	4.47PheIle: 4.47 ± 0.102	3.648PheLys: 3.648 ± 0.069	3.723PheLeu: 3.723 ± 0.092	1.157PheMet: 1.157 ± 0.042	2.583PheAsn: 2.583 ± 0.054	0.99PhePro: 0.99 ± 0.035	0.768PheGln: 0.768 ± 0.031	1.36PheArg: 1.36 ± 0.043	2.912PheSer: 2.912 ± 0.067	2.114PheThr: 2.114 ± 0.055	2.678PheVal: 2.678 ± 0.068	0.26PheTrp: 0.26 ± 0.017	1.651PheTyr: 1.651 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	3.808GlyAla: 3.808 ± 0.082	1.043GlyCys: 1.043 ± 0.044	3.264GlyAsp: 3.264 ± 0.074	4.325GlyGlu: 4.325 ± 0.087	2.949GlyPhe: 2.949 ± 0.073	4.142GlyGly: 4.142 ± 0.101	1.047GlyHis: 1.047 ± 0.04	6.642GlyIle: 6.642 ± 0.103	5.445GlyLys: 5.445 ± 0.082	5.393GlyLeu: 5.393 ± 0.096	1.823GlyMet: 1.823 ± 0.049	3.12GlyAsn: 3.12 ± 0.069	1.267GlyPro: 1.267 ± 0.054	1.496GlyGln: 1.496 ± 0.047	2.242GlyArg: 2.242 ± 0.061	3.897GlySer: 3.897 ± 0.087	3.14GlyThr: 3.14 ± 0.067	4.812GlyVal: 4.812 ± 0.088	0.448GlyTrp: 0.448 ± 0.026	2.992GlyTyr: 2.992 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	0.658HisAla: 0.658 ± 0.032	0.188HisCys: 0.188 ± 0.016	0.655HisAsp: 0.655 ± 0.029	0.907HisGlu: 0.907 ± 0.035	0.583HisPhe: 0.583 ± 0.027	0.941HisGly: 0.941 ± 0.04	0.287HisHis: 0.287 ± 0.023	1.409HisIle: 1.409 ± 0.042	1.074HisLys: 1.074 ± 0.041	1.154HisLeu: 1.154 ± 0.046	0.362HisMet: 0.362 ± 0.023	0.771HisAsn: 0.771 ± 0.032	0.579HisPro: 0.579 ± 0.032	0.327HisGln: 0.327 ± 0.022	0.514HisArg: 0.514 ± 0.028	0.845HisSer: 0.845 ± 0.038	0.682HisThr: 0.682 ± 0.031	0.708HisVal: 0.708 ± 0.031	0.079HisTrp: 0.079 ± 0.01	0.502HisTyr: 0.502 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.575IleAla: 5.575 ± 0.107	1.25IleCys: 1.25 ± 0.044	6.895IleAsp: 6.895 ± 0.113	7.746IleGlu: 7.746 ± 0.125	3.854IlePhe: 3.854 ± 0.096	6.421IleGly: 6.421 ± 0.097	1.218IleHis: 1.218 ± 0.038	9.142IleIle: 9.142 ± 0.132	9.245IleLys: 9.245 ± 0.123	9.208IleLeu: 9.208 ± 0.138	2.274IleMet: 2.274 ± 0.059	6.164IleAsn: 6.164 ± 0.112	3.233IlePro: 3.233 ± 0.066	2.196IleGln: 2.196 ± 0.05	3.245IleArg: 3.245 ± 0.071	7.343IleSer: 7.343 ± 0.116	4.676IleThr: 4.676 ± 0.073	6.593IleVal: 6.593 ± 0.103	0.451IleTrp: 0.451 ± 0.025	3.601IleTyr: 3.601 ± 0.09	0.0IleXaa: 0.0 ± 0.0
Lys	4.327LysAla: 4.327 ± 0.083	0.861LysCys: 0.861 ± 0.038	6.028LysAsp: 6.028 ± 0.105	8.683LysGlu: 8.683 ± 0.133	3.256LysPhe: 3.256 ± 0.064	5.066LysGly: 5.066 ± 0.074	1.191LysHis: 1.191 ± 0.05	8.342LysIle: 8.342 ± 0.115	8.575LysLys: 8.575 ± 0.121	7.815LysLeu: 7.815 ± 0.116	2.624LysMet: 2.624 ± 0.056	6.759LysAsn: 6.759 ± 0.119	2.009LysPro: 2.009 ± 0.048	2.348LysGln: 2.348 ± 0.061	3.21LysArg: 3.21 ± 0.066	5.965LysSer: 5.965 ± 0.09	4.179LysThr: 4.179 ± 0.078	5.981LysVal: 5.981 ± 0.099	0.503LysTrp: 0.503 ± 0.027	4.251LysTyr: 4.251 ± 0.084	0.0LysXaa: 0.0 ± 0.0
Leu	4.992LeuAla: 4.992 ± 0.079	0.977LeuCys: 0.977 ± 0.036	6.04LeuAsp: 6.04 ± 0.091	6.775LeuGlu: 6.775 ± 0.134	3.598LeuPhe: 3.598 ± 0.079	6.313LeuGly: 6.313 ± 0.106	0.981LeuHis: 0.981 ± 0.036	7.972LeuIle: 7.972 ± 0.126	8.313LeuLys: 8.313 ± 0.117	7.648LeuLeu: 7.648 ± 0.123	2.164LeuMet: 2.164 ± 0.052	5.74LeuAsn: 5.74 ± 0.092	2.563LeuPro: 2.563 ± 0.064	1.897LeuGln: 1.897 ± 0.053	3.275LeuArg: 3.275 ± 0.07	6.664LeuSer: 6.664 ± 0.094	4.326LeuThr: 4.326 ± 0.086	6.056LeuVal: 6.056 ± 0.106	0.476LeuTrp: 0.476 ± 0.026	3.139LeuTyr: 3.139 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.714MetAla: 1.714 ± 0.056	0.293MetCys: 0.293 ± 0.017	1.589MetAsp: 1.589 ± 0.052	1.858MetGlu: 1.858 ± 0.051	1.02MetPhe: 1.02 ± 0.035	1.814MetGly: 1.814 ± 0.052	0.331MetHis: 0.331 ± 0.021	2.309MetIle: 2.309 ± 0.054	2.5MetLys: 2.5 ± 0.058	2.308MetLeu: 2.308 ± 0.055	0.797MetMet: 0.797 ± 0.039	1.691MetAsn: 1.691 ± 0.046	0.92MetPro: 0.92 ± 0.042	0.704MetGln: 0.704 ± 0.03	0.912MetArg: 0.912 ± 0.035	1.861MetSer: 1.861 ± 0.055	1.231MetThr: 1.231 ± 0.043	1.627MetVal: 1.627 ± 0.052	0.143MetTrp: 0.143 ± 0.015	0.914MetTyr: 0.914 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	2.656AsnAla: 2.656 ± 0.056	0.693AsnCys: 0.693 ± 0.034	2.931AsnAsp: 2.931 ± 0.061	4.097AsnGlu: 4.097 ± 0.071	2.429AsnPhe: 2.429 ± 0.052	3.244AsnGly: 3.244 ± 0.067	0.807AsnHis: 0.807 ± 0.034	7.356AsnIle: 7.356 ± 0.119	6.273AsnLys: 6.273 ± 0.117	5.822AsnLeu: 5.822 ± 0.08	1.695AsnMet: 1.695 ± 0.047	4.189AsnAsn: 4.189 ± 0.082	2.213AsnPro: 2.213 ± 0.056	1.601AsnGln: 1.601 ± 0.045	2.185AsnArg: 2.185 ± 0.052	3.735AsnSer: 3.735 ± 0.078	3.064AsnThr: 3.064 ± 0.069	3.36AsnVal: 3.36 ± 0.07	0.367AsnTrp: 0.367 ± 0.021	2.719AsnTyr: 2.719 ± 0.068	0.0AsnXaa: 0.0 ± 0.0
Pro	1.355ProAla: 1.355 ± 0.051	0.318ProCys: 0.318 ± 0.02	1.468ProAsp: 1.468 ± 0.05	2.084ProGlu: 2.084 ± 0.06	1.257ProPhe: 1.257 ± 0.038	1.695ProGly: 1.695 ± 0.056	0.457ProHis: 0.457 ± 0.026	2.764ProIle: 2.764 ± 0.062	2.341ProLys: 2.341 ± 0.063	2.188ProLeu: 2.188 ± 0.057	0.693ProMet: 0.693 ± 0.032	1.559ProAsn: 1.559 ± 0.049	0.545ProPro: 0.545 ± 0.03	0.794ProGln: 0.794 ± 0.032	0.875ProArg: 0.875 ± 0.037	1.79ProSer: 1.79 ± 0.057	1.569ProThr: 1.569 ± 0.041	1.877ProVal: 1.877 ± 0.055	0.182ProTrp: 0.182 ± 0.017	1.212ProTyr: 1.212 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.37GlnAla: 1.37 ± 0.045	0.24GlnCys: 0.24 ± 0.021	1.261GlnAsp: 1.261 ± 0.037	1.854GlnGlu: 1.854 ± 0.051	0.822GlnPhe: 0.822 ± 0.032	1.603GlnGly: 1.603 ± 0.042	0.314GlnHis: 0.314 ± 0.019	2.324GlnIle: 2.324 ± 0.059	2.152GlnLys: 2.152 ± 0.055	2.091GlnLeu: 2.091 ± 0.065	0.713GlnMet: 0.713 ± 0.034	1.468GlnAsn: 1.468 ± 0.047	0.611GlnPro: 0.611 ± 0.032	0.678GlnGln: 0.678 ± 0.034	0.998GlnArg: 0.998 ± 0.038	1.414GlnSer: 1.414 ± 0.043	1.068GlnThr: 1.068 ± 0.038	1.616GlnVal: 1.616 ± 0.044	0.135GlnTrp: 0.135 ± 0.014	0.977GlnTyr: 0.977 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.831ArgAla: 1.831 ± 0.057	0.392ArgCys: 0.392 ± 0.021	2.088ArgAsp: 2.088 ± 0.059	3.073ArgGlu: 3.073 ± 0.073	1.484ArgPhe: 1.484 ± 0.047	2.185ArgGly: 2.185 ± 0.049	0.506ArgHis: 0.506 ± 0.026	3.056ArgIle: 3.056 ± 0.059	3.14ArgLys: 3.14 ± 0.057	3.093ArgLeu: 3.093 ± 0.069	0.91ArgMet: 0.91 ± 0.033	1.982ArgAsn: 1.982 ± 0.051	0.955ArgPro: 0.955 ± 0.036	1.024ArgGln: 1.024 ± 0.041	1.496ArgArg: 1.496 ± 0.046	1.795ArgSer: 1.795 ± 0.049	1.569ArgThr: 1.569 ± 0.051	2.666ArgVal: 2.666 ± 0.057	0.242ArgTrp: 0.242 ± 0.019	1.559ArgTyr: 1.559 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.138SerAla: 3.138 ± 0.074	0.724SerCys: 0.724 ± 0.036	3.372SerAsp: 3.372 ± 0.075	4.22SerGlu: 4.22 ± 0.084	2.859SerPhe: 2.859 ± 0.078	4.226SerGly: 4.226 ± 0.082	0.888SerHis: 0.888 ± 0.036	7.177SerIle: 7.177 ± 0.124	6.35SerLys: 6.35 ± 0.102	6.001SerLeu: 6.001 ± 0.09	1.745SerMet: 1.745 ± 0.053	3.918SerAsn: 3.918 ± 0.081	1.636SerPro: 1.636 ± 0.053	1.799SerGln: 1.799 ± 0.044	2.294SerArg: 2.294 ± 0.056	4.493SerSer: 4.493 ± 0.096	3.288SerThr: 3.288 ± 0.07	4.151SerVal: 4.151 ± 0.073	0.397SerTrp: 0.397 ± 0.024	2.625SerTyr: 2.625 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	2.641ThrAla: 2.641 ± 0.072	0.509ThrCys: 0.509 ± 0.026	2.57ThrAsp: 2.57 ± 0.063	2.913ThrGlu: 2.913 ± 0.064	1.907ThrPhe: 1.907 ± 0.055	3.512ThrGly: 3.512 ± 0.069	0.797ThrHis: 0.797 ± 0.032	4.654ThrIle: 4.654 ± 0.08	3.949ThrLys: 3.949 ± 0.08	4.603ThrLeu: 4.603 ± 0.08	1.188ThrMet: 1.188 ± 0.04	2.707ThrAsn: 2.707 ± 0.068	1.747ThrPro: 1.747 ± 0.051	1.198ThrGln: 1.198 ± 0.043	1.572ThrArg: 1.572 ± 0.042	3.196ThrSer: 3.196 ± 0.075	2.581ThrThr: 2.581 ± 0.066	3.392ThrVal: 3.392 ± 0.072	0.296ThrTrp: 0.296 ± 0.02	1.932ThrTyr: 1.932 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	3.913ValAla: 3.913 ± 0.087	0.976ValCys: 0.976 ± 0.041	4.454ValAsp: 4.454 ± 0.079	4.927ValGlu: 4.927 ± 0.088	3.009ValPhe: 3.009 ± 0.061	4.591ValGly: 4.591 ± 0.083	0.84ValHis: 0.84 ± 0.035	6.215ValIle: 6.215 ± 0.101	5.316ValLys: 5.316 ± 0.09	6.34ValLeu: 6.34 ± 0.093	1.584ValMet: 1.584 ± 0.05	3.559ValAsn: 3.559 ± 0.079	1.854ValPro: 1.854 ± 0.043	1.376ValGln: 1.376 ± 0.048	2.185ValArg: 2.185 ± 0.061	4.583ValSer: 4.583 ± 0.085	3.002ValThr: 3.002 ± 0.066	5.039ValVal: 5.039 ± 0.093	0.402ValTrp: 0.402 ± 0.024	2.503ValTyr: 2.503 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.353TrpAla: 0.353 ± 0.027	0.091TrpCys: 0.091 ± 0.011	0.396TrpAsp: 0.396 ± 0.024	0.386TrpGlu: 0.386 ± 0.023	0.238TrpPhe: 0.238 ± 0.019	0.418TrpGly: 0.418 ± 0.025	0.093TrpHis: 0.093 ± 0.01	0.571TrpIle: 0.571 ± 0.034	0.394TrpLys: 0.394 ± 0.026	0.488TrpLeu: 0.488 ± 0.028	0.17TrpMet: 0.17 ± 0.017	0.354TrpAsn: 0.354 ± 0.021	0.118TrpPro: 0.118 ± 0.012	0.137TrpGln: 0.137 ± 0.012	0.221TrpArg: 0.221 ± 0.018	0.335TrpSer: 0.335 ± 0.022	0.269TrpThr: 0.269 ± 0.02	0.392TrpVal: 0.392 ± 0.026	0.073TrpTrp: 0.073 ± 0.01	0.25TrpTyr: 0.25 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.803TyrAla: 1.803 ± 0.048	0.519TyrCys: 0.519 ± 0.028	2.495TyrAsp: 2.495 ± 0.062	2.984TyrGlu: 2.984 ± 0.074	1.753TyrPhe: 1.753 ± 0.055	2.363TyrGly: 2.363 ± 0.056	0.55TyrHis: 0.55 ± 0.028	4.373TyrIle: 4.373 ± 0.097	3.922TyrLys: 3.922 ± 0.083	3.663TyrLeu: 3.663 ± 0.076	1.083TyrMet: 1.083 ± 0.039	2.731TyrAsn: 2.731 ± 0.057	1.254TyrPro: 1.254 ± 0.044	0.879TyrGln: 0.879 ± 0.033	1.442TyrArg: 1.442 ± 0.052	2.839TyrSer: 2.839 ± 0.07	2.099TyrThr: 2.099 ± 0.051	2.24TyrVal: 2.24 ± 0.053	0.235TyrTrp: 0.235 ± 0.017	1.703TyrTyr: 1.703 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2538 proteins (743199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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