Amino acid dipepetide frequency for Streptococcus phage Javan272

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.144AlaAla: 4.144 ± 0.789
0.545AlaCys: 0.545 ± 0.23
4.144AlaAsp: 4.144 ± 0.849
5.562AlaGlu: 5.562 ± 0.828
2.618AlaPhe: 2.618 ± 0.512
3.599AlaGly: 3.599 ± 0.582
0.545AlaHis: 0.545 ± 0.249
5.126AlaIle: 5.126 ± 0.659
4.69AlaLys: 4.69 ± 0.722
5.671AlaLeu: 5.671 ± 1.263
2.072AlaMet: 2.072 ± 0.501
3.163AlaAsn: 3.163 ± 0.754
1.418AlaPro: 1.418 ± 0.445
2.399AlaGln: 2.399 ± 0.507
2.836AlaArg: 2.836 ± 0.534
4.363AlaSer: 4.363 ± 0.685
4.472AlaThr: 4.472 ± 0.792
4.581AlaVal: 4.581 ± 0.971
0.436AlaTrp: 0.436 ± 0.204
2.945AlaTyr: 2.945 ± 0.628
0.0AlaXaa: 0.0 ± 0.0
Cys
0.109CysAla: 0.109 ± 0.115
0.0CysCys: 0.0 ± 0.0
0.109CysAsp: 0.109 ± 0.095
0.327CysGlu: 0.327 ± 0.187
0.218CysPhe: 0.218 ± 0.14
0.327CysGly: 0.327 ± 0.201
0.0CysHis: 0.0 ± 0.0
0.873CysIle: 0.873 ± 0.4
0.436CysLys: 0.436 ± 0.203
0.327CysLeu: 0.327 ± 0.201
0.0CysMet: 0.0 ± 0.0
0.218CysAsn: 0.218 ± 0.148
0.0CysPro: 0.0 ± 0.0
0.436CysGln: 0.436 ± 0.23
0.436CysArg: 0.436 ± 0.205
0.436CysSer: 0.436 ± 0.191
0.109CysThr: 0.109 ± 0.113
0.327CysVal: 0.327 ± 0.19
0.0CysTrp: 0.0 ± 0.0
0.654CysTyr: 0.654 ± 0.259
0.0CysXaa: 0.0 ± 0.0
Asp
3.708AspAla: 3.708 ± 0.621
0.218AspCys: 0.218 ± 0.127
4.908AspAsp: 4.908 ± 0.714
4.799AspGlu: 4.799 ± 0.843
3.708AspPhe: 3.708 ± 0.719
4.581AspGly: 4.581 ± 0.754
0.654AspHis: 0.654 ± 0.264
5.78AspIle: 5.78 ± 0.888
5.017AspLys: 5.017 ± 0.759
5.344AspLeu: 5.344 ± 0.63
1.636AspMet: 1.636 ± 0.359
4.363AspAsn: 4.363 ± 0.813
1.418AspPro: 1.418 ± 0.411
1.2AspGln: 1.2 ± 0.321
1.636AspArg: 1.636 ± 0.378
3.817AspSer: 3.817 ± 0.728
2.072AspThr: 2.072 ± 0.433
3.49AspVal: 3.49 ± 0.534
1.636AspTrp: 1.636 ± 0.448
3.163AspTyr: 3.163 ± 0.555
0.0AspXaa: 0.0 ± 0.0
Glu
5.126GluAla: 5.126 ± 0.734
0.218GluCys: 0.218 ± 0.144
2.945GluAsp: 2.945 ± 0.633
6.98GluGlu: 6.98 ± 1.34
3.054GluPhe: 3.054 ± 0.862
3.599GluGly: 3.599 ± 0.532
0.873GluHis: 0.873 ± 0.413
5.998GluIle: 5.998 ± 0.691
6.108GluLys: 6.108 ± 0.926
9.488GluLeu: 9.488 ± 0.953
2.836GluMet: 2.836 ± 0.616
4.253GluAsn: 4.253 ± 0.661
0.982GluPro: 0.982 ± 0.368
2.945GluGln: 2.945 ± 0.597
3.49GluArg: 3.49 ± 0.556
4.253GluSer: 4.253 ± 0.511
4.144GluThr: 4.144 ± 0.745
5.453GluVal: 5.453 ± 0.905
1.309GluTrp: 1.309 ± 0.329
3.163GluTyr: 3.163 ± 0.745
0.0GluXaa: 0.0 ± 0.0
Phe
2.508PheAla: 2.508 ± 0.502
0.109PheCys: 0.109 ± 0.115
3.163PheAsp: 3.163 ± 0.535
4.253PheGlu: 4.253 ± 0.92
1.636PhePhe: 1.636 ± 0.546
3.926PheGly: 3.926 ± 0.584
0.654PheHis: 0.654 ± 0.273
3.599PheIle: 3.599 ± 0.59
4.472PheLys: 4.472 ± 0.668
3.163PheLeu: 3.163 ± 0.601
1.963PheMet: 1.963 ± 0.606
3.49PheAsn: 3.49 ± 0.503
0.982PhePro: 0.982 ± 0.347
1.2PheGln: 1.2 ± 0.405
1.418PheArg: 1.418 ± 0.423
1.418PheSer: 1.418 ± 0.405
1.636PheThr: 1.636 ± 0.39
1.527PheVal: 1.527 ± 0.382
0.218PheTrp: 0.218 ± 0.171
2.181PheTyr: 2.181 ± 0.516
0.0PheXaa: 0.0 ± 0.0
Gly
3.599GlyAla: 3.599 ± 0.683
0.109GlyCys: 0.109 ± 0.113
3.381GlyAsp: 3.381 ± 0.63
3.054GlyGlu: 3.054 ± 0.484
3.272GlyPhe: 3.272 ± 0.521
3.708GlyGly: 3.708 ± 0.806
0.982GlyHis: 0.982 ± 0.357
3.49GlyIle: 3.49 ± 0.693
4.144GlyLys: 4.144 ± 0.558
5.017GlyLeu: 5.017 ± 0.768
1.636GlyMet: 1.636 ± 0.426
4.253GlyAsn: 4.253 ± 0.69
0.436GlyPro: 0.436 ± 0.204
3.272GlyGln: 3.272 ± 0.626
1.636GlyArg: 1.636 ± 0.456
3.926GlySer: 3.926 ± 0.682
3.926GlyThr: 3.926 ± 0.607
3.708GlyVal: 3.708 ± 0.572
0.763GlyTrp: 0.763 ± 0.299
3.272GlyTyr: 3.272 ± 0.792
0.0GlyXaa: 0.0 ± 0.0
His
0.545HisAla: 0.545 ± 0.318
0.218HisCys: 0.218 ± 0.137
1.091HisAsp: 1.091 ± 0.449
1.091HisGlu: 1.091 ± 0.422
0.763HisPhe: 0.763 ± 0.322
0.873HisGly: 0.873 ± 0.33
0.436HisHis: 0.436 ± 0.228
2.181HisIle: 2.181 ± 0.575
0.763HisLys: 0.763 ± 0.296
1.309HisLeu: 1.309 ± 0.386
0.545HisMet: 0.545 ± 0.299
0.763HisAsn: 0.763 ± 0.262
0.327HisPro: 0.327 ± 0.16
0.763HisGln: 0.763 ± 0.249
0.109HisArg: 0.109 ± 0.11
1.309HisSer: 1.309 ± 0.427
0.545HisThr: 0.545 ± 0.288
0.436HisVal: 0.436 ± 0.175
0.109HisTrp: 0.109 ± 0.124
1.091HisTyr: 1.091 ± 0.447
0.0HisXaa: 0.0 ± 0.0
Ile
4.908IleAla: 4.908 ± 0.942
0.982IleCys: 0.982 ± 0.319
6.217IleAsp: 6.217 ± 0.871
4.908IleGlu: 4.908 ± 0.705
1.854IlePhe: 1.854 ± 0.371
2.727IleGly: 2.727 ± 0.589
1.854IleHis: 1.854 ± 0.502
4.581IleIle: 4.581 ± 0.927
8.616IleLys: 8.616 ± 1.191
5.998IleLeu: 5.998 ± 0.741
2.399IleMet: 2.399 ± 0.457
3.708IleAsn: 3.708 ± 0.58
2.29IlePro: 2.29 ± 0.461
1.636IleGln: 1.636 ± 0.491
2.181IleArg: 2.181 ± 0.542
5.344IleSer: 5.344 ± 0.891
5.78IleThr: 5.78 ± 0.873
5.235IleVal: 5.235 ± 0.836
0.654IleTrp: 0.654 ± 0.238
2.399IleTyr: 2.399 ± 0.551
0.0IleXaa: 0.0 ± 0.0
Lys
5.78LysAla: 5.78 ± 0.85
0.327LysCys: 0.327 ± 0.196
4.472LysAsp: 4.472 ± 0.782
7.853LysGlu: 7.853 ± 0.966
3.599LysPhe: 3.599 ± 0.507
2.836LysGly: 2.836 ± 0.543
0.873LysHis: 0.873 ± 0.396
5.235LysIle: 5.235 ± 0.654
7.416LysLys: 7.416 ± 1.143
5.998LysLeu: 5.998 ± 0.667
2.29LysMet: 2.29 ± 0.533
5.235LysAsn: 5.235 ± 0.633
3.163LysPro: 3.163 ± 0.642
3.599LysGln: 3.599 ± 0.635
3.381LysArg: 3.381 ± 0.632
4.799LysSer: 4.799 ± 0.727
6.653LysThr: 6.653 ± 0.948
4.472LysVal: 4.472 ± 0.659
0.982LysTrp: 0.982 ± 0.401
2.399LysTyr: 2.399 ± 0.632
0.0LysXaa: 0.0 ± 0.0
Leu
7.307LeuAla: 7.307 ± 0.787
0.327LeuCys: 0.327 ± 0.194
5.78LeuAsp: 5.78 ± 0.626
6.871LeuGlu: 6.871 ± 0.875
3.599LeuPhe: 3.599 ± 0.747
5.126LeuGly: 5.126 ± 0.54
0.763LeuHis: 0.763 ± 0.276
5.889LeuIle: 5.889 ± 0.773
6.762LeuLys: 6.762 ± 0.775
5.671LeuLeu: 5.671 ± 0.801
1.2LeuMet: 1.2 ± 0.385
4.69LeuAsn: 4.69 ± 0.771
2.618LeuPro: 2.618 ± 0.651
3.054LeuGln: 3.054 ± 0.786
3.272LeuArg: 3.272 ± 0.74
6.326LeuSer: 6.326 ± 0.966
5.562LeuThr: 5.562 ± 0.663
4.908LeuVal: 4.908 ± 0.734
0.436LeuTrp: 0.436 ± 0.191
2.727LeuTyr: 2.727 ± 0.656
0.0LeuXaa: 0.0 ± 0.0
Met
1.527MetAla: 1.527 ± 0.345
0.0MetCys: 0.0 ± 0.0
1.527MetAsp: 1.527 ± 0.338
1.745MetGlu: 1.745 ± 0.497
1.636MetPhe: 1.636 ± 0.551
1.527MetGly: 1.527 ± 0.453
0.327MetHis: 0.327 ± 0.222
1.963MetIle: 1.963 ± 0.414
2.072MetLys: 2.072 ± 0.449
1.963MetLeu: 1.963 ± 0.474
0.218MetMet: 0.218 ± 0.209
2.181MetAsn: 2.181 ± 0.407
0.873MetPro: 0.873 ± 0.362
0.654MetGln: 0.654 ± 0.359
1.636MetArg: 1.636 ± 0.394
2.508MetSer: 2.508 ± 0.474
2.399MetThr: 2.399 ± 0.6
0.873MetVal: 0.873 ± 0.275
0.327MetTrp: 0.327 ± 0.208
0.654MetTyr: 0.654 ± 0.231
0.0MetXaa: 0.0 ± 0.0
Asn
3.381AsnAla: 3.381 ± 0.527
0.763AsnCys: 0.763 ± 0.392
3.599AsnAsp: 3.599 ± 0.597
3.708AsnGlu: 3.708 ± 0.689
2.29AsnPhe: 2.29 ± 0.55
4.581AsnGly: 4.581 ± 0.95
1.2AsnHis: 1.2 ± 0.401
3.163AsnIle: 3.163 ± 0.674
4.472AsnLys: 4.472 ± 0.746
4.581AsnLeu: 4.581 ± 0.808
1.745AsnMet: 1.745 ± 0.496
2.399AsnAsn: 2.399 ± 0.433
2.399AsnPro: 2.399 ± 0.572
2.508AsnGln: 2.508 ± 0.412
2.727AsnArg: 2.727 ± 0.493
4.363AsnSer: 4.363 ± 0.821
4.581AsnThr: 4.581 ± 0.791
4.908AsnVal: 4.908 ± 0.689
0.654AsnTrp: 0.654 ± 0.288
2.181AsnTyr: 2.181 ± 0.562
0.0AsnXaa: 0.0 ± 0.0
Pro
1.636ProAla: 1.636 ± 0.459
0.218ProCys: 0.218 ± 0.154
1.963ProAsp: 1.963 ± 0.725
1.854ProGlu: 1.854 ± 0.423
1.2ProPhe: 1.2 ± 0.299
0.654ProGly: 0.654 ± 0.235
0.327ProHis: 0.327 ± 0.195
2.508ProIle: 2.508 ± 0.578
1.854ProLys: 1.854 ± 0.425
2.29ProLeu: 2.29 ± 0.378
0.327ProMet: 0.327 ± 0.166
0.873ProAsn: 0.873 ± 0.374
0.436ProPro: 0.436 ± 0.275
1.636ProGln: 1.636 ± 0.378
1.2ProArg: 1.2 ± 0.347
2.508ProSer: 2.508 ± 0.497
1.418ProThr: 1.418 ± 0.389
2.399ProVal: 2.399 ± 0.551
0.327ProTrp: 0.327 ± 0.153
0.873ProTyr: 0.873 ± 0.266
0.0ProXaa: 0.0 ± 0.0
Gln
3.708GlnAla: 3.708 ± 0.719
0.109GlnCys: 0.109 ± 0.117
1.854GlnAsp: 1.854 ± 0.478
3.817GlnGlu: 3.817 ± 0.571
2.399GlnPhe: 2.399 ± 0.579
1.963GlnGly: 1.963 ± 0.399
0.545GlnHis: 0.545 ± 0.245
2.399GlnIle: 2.399 ± 0.555
2.727GlnLys: 2.727 ± 0.545
2.836GlnLeu: 2.836 ± 0.651
0.545GlnMet: 0.545 ± 0.206
1.963GlnAsn: 1.963 ± 0.529
1.418GlnPro: 1.418 ± 0.347
2.072GlnGln: 2.072 ± 0.512
2.399GlnArg: 2.399 ± 0.529
1.636GlnSer: 1.636 ± 0.359
1.963GlnThr: 1.963 ± 0.398
2.072GlnVal: 2.072 ± 0.571
0.327GlnTrp: 0.327 ± 0.178
1.309GlnTyr: 1.309 ± 0.402
0.0GlnXaa: 0.0 ± 0.0
Arg
2.29ArgAla: 2.29 ± 0.505
0.0ArgCys: 0.0 ± 0.0
2.181ArgAsp: 2.181 ± 0.585
2.399ArgGlu: 2.399 ± 0.635
1.527ArgPhe: 1.527 ± 0.567
1.854ArgGly: 1.854 ± 0.487
0.982ArgHis: 0.982 ± 0.322
2.618ArgIle: 2.618 ± 0.677
4.144ArgLys: 4.144 ± 0.938
3.163ArgLeu: 3.163 ± 0.556
1.309ArgMet: 1.309 ± 0.366
3.163ArgAsn: 3.163 ± 0.674
1.418ArgPro: 1.418 ± 0.37
2.399ArgGln: 2.399 ± 0.508
1.636ArgArg: 1.636 ± 0.459
2.181ArgSer: 2.181 ± 0.451
1.963ArgThr: 1.963 ± 0.505
2.399ArgVal: 2.399 ± 0.502
0.327ArgTrp: 0.327 ± 0.186
1.963ArgTyr: 1.963 ± 0.565
0.0ArgXaa: 0.0 ± 0.0
Ser
3.817SerAla: 3.817 ± 0.693
0.218SerCys: 0.218 ± 0.172
3.926SerAsp: 3.926 ± 0.629
4.908SerGlu: 4.908 ± 0.756
2.727SerPhe: 2.727 ± 0.718
4.035SerGly: 4.035 ± 0.848
1.2SerHis: 1.2 ± 0.389
4.908SerIle: 4.908 ± 0.715
4.363SerLys: 4.363 ± 0.77
5.017SerLeu: 5.017 ± 0.6
1.527SerMet: 1.527 ± 0.398
4.581SerAsn: 4.581 ± 0.548
2.181SerPro: 2.181 ± 0.572
2.508SerGln: 2.508 ± 0.529
2.508SerArg: 2.508 ± 0.584
4.363SerSer: 4.363 ± 0.847
3.817SerThr: 3.817 ± 0.682
4.363SerVal: 4.363 ± 0.811
0.654SerTrp: 0.654 ± 0.244
2.618SerTyr: 2.618 ± 0.571
0.0SerXaa: 0.0 ± 0.0
Thr
4.035ThrAla: 4.035 ± 0.753
0.109ThrCys: 0.109 ± 0.125
4.69ThrAsp: 4.69 ± 0.816
4.144ThrGlu: 4.144 ± 0.725
2.836ThrPhe: 2.836 ± 0.605
4.908ThrGly: 4.908 ± 0.846
0.873ThrHis: 0.873 ± 0.331
5.562ThrIle: 5.562 ± 1.275
4.581ThrLys: 4.581 ± 0.681
5.126ThrLeu: 5.126 ± 0.837
1.636ThrMet: 1.636 ± 0.45
2.836ThrAsn: 2.836 ± 0.574
0.982ThrPro: 0.982 ± 0.352
1.418ThrGln: 1.418 ± 0.398
2.399ThrArg: 2.399 ± 0.503
3.381ThrSer: 3.381 ± 0.67
3.49ThrThr: 3.49 ± 0.646
5.78ThrVal: 5.78 ± 0.793
1.091ThrTrp: 1.091 ± 0.437
2.836ThrTyr: 2.836 ± 0.57
0.0ThrXaa: 0.0 ± 0.0
Val
4.363ValAla: 4.363 ± 0.663
0.218ValCys: 0.218 ± 0.173
4.253ValAsp: 4.253 ± 0.613
5.017ValGlu: 5.017 ± 0.876
2.072ValPhe: 2.072 ± 0.457
3.054ValGly: 3.054 ± 0.486
1.091ValHis: 1.091 ± 0.33
5.344ValIle: 5.344 ± 0.907
4.908ValLys: 4.908 ± 0.767
4.472ValLeu: 4.472 ± 0.567
1.309ValMet: 1.309 ± 0.368
4.363ValAsn: 4.363 ± 0.629
1.745ValPro: 1.745 ± 0.438
1.527ValGln: 1.527 ± 0.275
2.072ValArg: 2.072 ± 0.584
4.363ValSer: 4.363 ± 0.616
6.108ValThr: 6.108 ± 0.706
3.163ValVal: 3.163 ± 0.513
0.763ValTrp: 0.763 ± 0.544
2.508ValTyr: 2.508 ± 0.564
0.0ValXaa: 0.0 ± 0.0
Trp
0.545TrpAla: 0.545 ± 0.208
0.0TrpCys: 0.0 ± 0.0
0.436TrpAsp: 0.436 ± 0.23
0.763TrpGlu: 0.763 ± 0.34
0.545TrpPhe: 0.545 ± 0.204
0.873TrpGly: 0.873 ± 0.31
0.109TrpHis: 0.109 ± 0.115
0.654TrpIle: 0.654 ± 0.271
0.654TrpLys: 0.654 ± 0.265
1.091TrpLeu: 1.091 ± 0.314
0.218TrpMet: 0.218 ± 0.155
1.418TrpAsn: 1.418 ± 0.485
0.109TrpPro: 0.109 ± 0.113
0.982TrpGln: 0.982 ± 0.299
0.873TrpArg: 0.873 ± 0.327
0.763TrpSer: 0.763 ± 0.285
0.327TrpThr: 0.327 ± 0.206
0.654TrpVal: 0.654 ± 0.238
0.109TrpTrp: 0.109 ± 0.09
0.545TrpTyr: 0.545 ± 0.237
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.29TyrAla: 2.29 ± 0.505
0.654TyrCys: 0.654 ± 0.276
2.508TyrAsp: 2.508 ± 0.542
3.163TyrGlu: 3.163 ± 0.758
1.963TyrPhe: 1.963 ± 0.523
2.836TyrGly: 2.836 ± 0.516
0.982TyrHis: 0.982 ± 0.388
2.399TyrIle: 2.399 ± 0.487
3.163TyrLys: 3.163 ± 0.697
4.363TyrLeu: 4.363 ± 0.769
1.091TyrMet: 1.091 ± 0.31
2.29TyrAsn: 2.29 ± 0.59
1.309TyrPro: 1.309 ± 0.483
1.854TyrGln: 1.854 ± 0.491
2.072TyrArg: 2.072 ± 0.394
2.181TyrSer: 2.181 ± 0.475
1.854TyrThr: 1.854 ± 0.464
1.963TyrVal: 1.963 ± 0.431
0.545TyrTrp: 0.545 ± 0.275
1.963TyrTyr: 1.963 ± 0.549
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (9170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski