Amino acid dipepetide frequency for Bifidobacterium phage BadAztec4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.153AlaAla: 5.153 ± 1.123
1.288AlaCys: 1.288 ± 0.449
7.729AlaAsp: 7.729 ± 1.107
3.06AlaGlu: 3.06 ± 0.718
2.576AlaPhe: 2.576 ± 0.582
4.992AlaGly: 4.992 ± 0.808
1.61AlaHis: 1.61 ± 0.481
3.06AlaIle: 3.06 ± 0.864
4.831AlaLys: 4.831 ± 0.98
4.67AlaLeu: 4.67 ± 1.025
2.415AlaMet: 2.415 ± 0.875
4.992AlaAsn: 4.992 ± 1.214
2.415AlaPro: 2.415 ± 0.68
4.187AlaGln: 4.187 ± 1.096
4.831AlaArg: 4.831 ± 1.055
5.153AlaSer: 5.153 ± 0.97
5.636AlaThr: 5.636 ± 1.029
2.899AlaVal: 2.899 ± 0.498
1.771AlaTrp: 1.771 ± 0.418
3.865AlaTyr: 3.865 ± 0.798
0.0AlaXaa: 0.0 ± 0.0
Cys
0.322CysAla: 0.322 ± 0.183
0.0CysCys: 0.0 ± 0.0
1.288CysAsp: 1.288 ± 0.42
0.161CysGlu: 0.161 ± 0.164
0.0CysPhe: 0.0 ± 0.0
1.288CysGly: 1.288 ± 0.683
0.0CysHis: 0.0 ± 0.0
0.805CysIle: 0.805 ± 0.415
0.644CysLys: 0.644 ± 0.294
0.805CysLeu: 0.805 ± 0.349
0.161CysMet: 0.161 ± 0.153
0.805CysAsn: 0.805 ± 0.306
0.161CysPro: 0.161 ± 0.139
0.161CysGln: 0.161 ± 0.172
0.644CysArg: 0.644 ± 0.4
1.449CysSer: 1.449 ± 0.502
0.322CysThr: 0.322 ± 0.191
0.483CysVal: 0.483 ± 0.24
0.0CysTrp: 0.0 ± 0.0
0.644CysTyr: 0.644 ± 0.286
0.0CysXaa: 0.0 ± 0.0
Asp
3.865AspAla: 3.865 ± 0.818
0.966AspCys: 0.966 ± 0.374
7.89AspAsp: 7.89 ± 1.992
3.221AspGlu: 3.221 ± 0.541
2.738AspPhe: 2.738 ± 0.603
4.831AspGly: 4.831 ± 1.052
1.127AspHis: 1.127 ± 0.409
6.602AspIle: 6.602 ± 1.015
5.797AspLys: 5.797 ± 0.789
4.509AspLeu: 4.509 ± 0.667
3.382AspMet: 3.382 ± 0.873
4.348AspAsn: 4.348 ± 0.896
2.254AspPro: 2.254 ± 0.746
2.576AspGln: 2.576 ± 0.562
3.704AspArg: 3.704 ± 0.675
6.119AspSer: 6.119 ± 1.356
4.992AspThr: 4.992 ± 0.951
4.026AspVal: 4.026 ± 1.029
0.322AspTrp: 0.322 ± 0.211
3.221AspTyr: 3.221 ± 0.631
0.0AspXaa: 0.0 ± 0.0
Glu
3.221GluAla: 3.221 ± 0.779
0.483GluCys: 0.483 ± 0.284
3.06GluAsp: 3.06 ± 0.68
2.093GluGlu: 2.093 ± 0.665
2.576GluPhe: 2.576 ± 0.675
1.61GluGly: 1.61 ± 0.645
1.288GluHis: 1.288 ± 0.508
4.509GluIle: 4.509 ± 0.686
2.415GluLys: 2.415 ± 0.55
3.382GluLeu: 3.382 ± 0.675
1.932GluMet: 1.932 ± 0.572
2.899GluAsn: 2.899 ± 0.643
2.093GluPro: 2.093 ± 0.522
2.415GluGln: 2.415 ± 0.645
2.899GluArg: 2.899 ± 0.819
1.61GluSer: 1.61 ± 0.442
3.865GluThr: 3.865 ± 0.789
2.576GluVal: 2.576 ± 0.501
1.288GluTrp: 1.288 ± 0.318
2.576GluTyr: 2.576 ± 0.753
0.0GluXaa: 0.0 ± 0.0
Phe
3.543PheAla: 3.543 ± 0.556
0.322PheCys: 0.322 ± 0.227
3.543PheAsp: 3.543 ± 0.768
2.093PheGlu: 2.093 ± 0.648
1.771PhePhe: 1.771 ± 0.471
4.187PheGly: 4.187 ± 0.72
0.483PheHis: 0.483 ± 0.262
2.415PheIle: 2.415 ± 0.748
0.966PheLys: 0.966 ± 0.288
2.415PheLeu: 2.415 ± 0.668
1.288PheMet: 1.288 ± 0.32
2.093PheAsn: 2.093 ± 0.609
1.932PhePro: 1.932 ± 0.626
2.254PheGln: 2.254 ± 0.709
3.221PheArg: 3.221 ± 1.067
2.415PheSer: 2.415 ± 0.665
1.288PheThr: 1.288 ± 0.428
1.932PheVal: 1.932 ± 0.399
0.644PheTrp: 0.644 ± 0.343
0.966PheTyr: 0.966 ± 0.338
0.0PheXaa: 0.0 ± 0.0
Gly
3.704GlyAla: 3.704 ± 0.691
1.127GlyCys: 1.127 ± 0.651
3.865GlyAsp: 3.865 ± 0.959
3.382GlyGlu: 3.382 ± 0.775
2.093GlyPhe: 2.093 ± 0.44
4.67GlyGly: 4.67 ± 1.198
0.805GlyHis: 0.805 ± 0.268
5.958GlyIle: 5.958 ± 1.065
4.187GlyLys: 4.187 ± 1.033
4.348GlyLeu: 4.348 ± 0.675
1.932GlyMet: 1.932 ± 0.522
6.763GlyAsn: 6.763 ± 0.794
1.127GlyPro: 1.127 ± 0.37
2.415GlyGln: 2.415 ± 0.766
4.026GlyArg: 4.026 ± 0.684
4.026GlySer: 4.026 ± 0.963
4.348GlyThr: 4.348 ± 0.807
3.704GlyVal: 3.704 ± 0.759
0.483GlyTrp: 0.483 ± 0.229
3.704GlyTyr: 3.704 ± 0.703
0.0GlyXaa: 0.0 ± 0.0
His
0.805HisAla: 0.805 ± 0.302
0.161HisCys: 0.161 ± 0.156
1.449HisAsp: 1.449 ± 0.487
0.966HisGlu: 0.966 ± 0.405
0.644HisPhe: 0.644 ± 0.289
1.771HisGly: 1.771 ± 0.574
0.322HisHis: 0.322 ± 0.196
0.805HisIle: 0.805 ± 0.291
0.644HisLys: 0.644 ± 0.357
1.449HisLeu: 1.449 ± 0.384
0.322HisMet: 0.322 ± 0.217
0.644HisAsn: 0.644 ± 0.285
0.644HisPro: 0.644 ± 0.357
0.483HisGln: 0.483 ± 0.304
0.966HisArg: 0.966 ± 0.437
1.449HisSer: 1.449 ± 0.462
0.483HisThr: 0.483 ± 0.289
1.127HisVal: 1.127 ± 0.49
0.644HisTrp: 0.644 ± 0.421
1.127HisTyr: 1.127 ± 0.315
0.0HisXaa: 0.0 ± 0.0
Ile
4.992IleAla: 4.992 ± 0.817
0.805IleCys: 0.805 ± 0.384
4.348IleAsp: 4.348 ± 0.917
3.06IleGlu: 3.06 ± 0.738
3.221IlePhe: 3.221 ± 0.785
5.153IleGly: 5.153 ± 0.875
0.966IleHis: 0.966 ± 0.383
3.221IleIle: 3.221 ± 0.99
2.254IleLys: 2.254 ± 0.567
4.026IleLeu: 4.026 ± 0.822
2.254IleMet: 2.254 ± 0.396
3.382IleAsn: 3.382 ± 0.682
2.576IlePro: 2.576 ± 0.61
2.254IleGln: 2.254 ± 0.581
2.576IleArg: 2.576 ± 0.639
3.382IleSer: 3.382 ± 0.613
4.026IleThr: 4.026 ± 0.592
5.475IleVal: 5.475 ± 0.614
0.805IleTrp: 0.805 ± 0.259
2.093IleTyr: 2.093 ± 0.551
0.0IleXaa: 0.0 ± 0.0
Lys
3.382LysAla: 3.382 ± 0.805
0.322LysCys: 0.322 ± 0.218
3.543LysAsp: 3.543 ± 0.613
2.738LysGlu: 2.738 ± 0.594
2.576LysPhe: 2.576 ± 0.675
4.67LysGly: 4.67 ± 0.702
0.161LysHis: 0.161 ± 0.156
3.221LysIle: 3.221 ± 0.699
2.415LysLys: 2.415 ± 0.552
6.119LysLeu: 6.119 ± 0.965
1.288LysMet: 1.288 ± 0.393
3.221LysAsn: 3.221 ± 0.8
1.61LysPro: 1.61 ± 0.628
1.449LysGln: 1.449 ± 0.511
3.543LysArg: 3.543 ± 1.431
3.704LysSer: 3.704 ± 0.558
4.026LysThr: 4.026 ± 0.864
3.06LysVal: 3.06 ± 0.671
0.644LysTrp: 0.644 ± 0.356
1.61LysTyr: 1.61 ± 0.502
0.0LysXaa: 0.0 ± 0.0
Leu
4.831LeuAla: 4.831 ± 0.469
0.966LeuCys: 0.966 ± 0.378
4.348LeuAsp: 4.348 ± 0.805
4.187LeuGlu: 4.187 ± 0.994
2.738LeuPhe: 2.738 ± 0.479
4.67LeuGly: 4.67 ± 1.057
1.288LeuHis: 1.288 ± 0.484
4.67LeuIle: 4.67 ± 0.704
3.543LeuLys: 3.543 ± 0.831
5.475LeuLeu: 5.475 ± 1.231
2.093LeuMet: 2.093 ± 0.612
4.509LeuAsn: 4.509 ± 0.785
2.738LeuPro: 2.738 ± 0.754
3.221LeuGln: 3.221 ± 0.855
5.797LeuArg: 5.797 ± 1.26
4.831LeuSer: 4.831 ± 1.06
3.382LeuThr: 3.382 ± 0.545
3.704LeuVal: 3.704 ± 0.756
0.805LeuTrp: 0.805 ± 0.391
2.093LeuTyr: 2.093 ± 0.52
0.0LeuXaa: 0.0 ± 0.0
Met
3.704MetAla: 3.704 ± 0.619
0.161MetCys: 0.161 ± 0.172
1.932MetAsp: 1.932 ± 0.44
1.288MetGlu: 1.288 ± 0.307
1.61MetPhe: 1.61 ± 0.335
1.932MetGly: 1.932 ± 0.608
0.644MetHis: 0.644 ± 0.268
1.61MetIle: 1.61 ± 0.447
1.449MetLys: 1.449 ± 0.503
1.771MetLeu: 1.771 ± 0.603
0.805MetMet: 0.805 ± 0.428
1.449MetAsn: 1.449 ± 0.421
1.771MetPro: 1.771 ± 0.604
0.322MetGln: 0.322 ± 0.181
1.288MetArg: 1.288 ± 0.483
2.415MetSer: 2.415 ± 0.488
1.771MetThr: 1.771 ± 0.534
1.288MetVal: 1.288 ± 0.472
0.644MetTrp: 0.644 ± 0.358
1.449MetTyr: 1.449 ± 0.472
0.0MetXaa: 0.0 ± 0.0
Asn
6.602AsnAla: 6.602 ± 1.223
0.483AsnCys: 0.483 ± 0.336
4.187AsnAsp: 4.187 ± 0.907
2.415AsnGlu: 2.415 ± 0.581
2.738AsnPhe: 2.738 ± 0.576
3.221AsnGly: 3.221 ± 0.632
1.449AsnHis: 1.449 ± 0.447
3.865AsnIle: 3.865 ± 0.814
4.187AsnLys: 4.187 ± 0.849
5.797AsnLeu: 5.797 ± 0.665
2.415AsnMet: 2.415 ± 0.627
5.475AsnAsn: 5.475 ± 1.163
2.899AsnPro: 2.899 ± 0.666
1.932AsnGln: 1.932 ± 0.605
2.415AsnArg: 2.415 ± 0.419
4.187AsnSer: 4.187 ± 0.899
4.187AsnThr: 4.187 ± 0.799
3.221AsnVal: 3.221 ± 0.544
0.483AsnTrp: 0.483 ± 0.283
1.932AsnTyr: 1.932 ± 0.627
0.161AsnXaa: 0.161 ± 0.179
Pro
1.771ProAla: 1.771 ± 0.613
0.161ProCys: 0.161 ± 0.138
4.026ProAsp: 4.026 ± 0.678
2.415ProGlu: 2.415 ± 0.608
1.127ProPhe: 1.127 ± 0.484
1.932ProGly: 1.932 ± 0.652
0.322ProHis: 0.322 ± 0.299
0.966ProIle: 0.966 ± 0.33
2.093ProLys: 2.093 ± 0.412
1.449ProLeu: 1.449 ± 0.403
0.644ProMet: 0.644 ± 0.272
2.093ProAsn: 2.093 ± 0.617
2.093ProPro: 2.093 ± 0.468
2.415ProGln: 2.415 ± 0.583
2.093ProArg: 2.093 ± 0.556
2.576ProSer: 2.576 ± 0.62
3.221ProThr: 3.221 ± 0.545
2.576ProVal: 2.576 ± 0.684
1.288ProTrp: 1.288 ± 0.335
2.576ProTyr: 2.576 ± 0.646
0.0ProXaa: 0.0 ± 0.0
Gln
5.636GlnAla: 5.636 ± 0.935
0.161GlnCys: 0.161 ± 0.155
2.738GlnAsp: 2.738 ± 0.639
0.966GlnGlu: 0.966 ± 0.274
0.966GlnPhe: 0.966 ± 0.411
2.415GlnGly: 2.415 ± 0.65
0.322GlnHis: 0.322 ± 0.22
2.415GlnIle: 2.415 ± 0.566
2.254GlnLys: 2.254 ± 0.573
2.254GlnLeu: 2.254 ± 0.498
1.449GlnMet: 1.449 ± 0.453
2.738GlnAsn: 2.738 ± 0.81
1.771GlnPro: 1.771 ± 0.542
3.543GlnGln: 3.543 ± 0.89
1.449GlnArg: 1.449 ± 0.509
3.221GlnSer: 3.221 ± 0.838
2.576GlnThr: 2.576 ± 0.621
2.738GlnVal: 2.738 ± 0.696
0.966GlnTrp: 0.966 ± 0.42
1.61GlnTyr: 1.61 ± 0.455
0.0GlnXaa: 0.0 ± 0.0
Arg
3.221ArgAla: 3.221 ± 0.695
0.805ArgCys: 0.805 ± 0.332
3.865ArgAsp: 3.865 ± 0.768
3.382ArgGlu: 3.382 ± 0.695
3.06ArgPhe: 3.06 ± 0.702
2.254ArgGly: 2.254 ± 0.402
1.932ArgHis: 1.932 ± 0.973
4.348ArgIle: 4.348 ± 0.78
4.026ArgLys: 4.026 ± 1.431
5.153ArgLeu: 5.153 ± 1.277
1.127ArgMet: 1.127 ± 0.515
2.738ArgAsn: 2.738 ± 0.92
1.61ArgPro: 1.61 ± 0.599
2.254ArgGln: 2.254 ± 0.515
2.899ArgArg: 2.899 ± 0.562
2.899ArgSer: 2.899 ± 1.101
1.771ArgThr: 1.771 ± 0.524
3.06ArgVal: 3.06 ± 0.657
0.644ArgTrp: 0.644 ± 0.342
3.865ArgTyr: 3.865 ± 0.459
0.0ArgXaa: 0.0 ± 0.0
Ser
6.924SerAla: 6.924 ± 0.73
0.322SerCys: 0.322 ± 0.226
5.958SerAsp: 5.958 ± 1.325
3.865SerGlu: 3.865 ± 0.638
2.415SerPhe: 2.415 ± 0.592
5.153SerGly: 5.153 ± 1.115
0.805SerHis: 0.805 ± 0.34
3.704SerIle: 3.704 ± 0.77
4.348SerLys: 4.348 ± 1.004
4.348SerLeu: 4.348 ± 0.756
1.288SerMet: 1.288 ± 0.369
4.992SerAsn: 4.992 ± 0.938
1.449SerPro: 1.449 ± 0.346
3.543SerGln: 3.543 ± 0.664
2.738SerArg: 2.738 ± 0.773
4.67SerSer: 4.67 ± 1.309
4.026SerThr: 4.026 ± 0.551
5.475SerVal: 5.475 ± 0.65
1.127SerTrp: 1.127 ± 0.489
2.576SerTyr: 2.576 ± 0.601
0.0SerXaa: 0.0 ± 0.0
Thr
4.992ThrAla: 4.992 ± 1.107
0.322ThrCys: 0.322 ± 0.181
5.314ThrAsp: 5.314 ± 1.077
3.221ThrGlu: 3.221 ± 0.714
3.865ThrPhe: 3.865 ± 0.687
4.992ThrGly: 4.992 ± 1.181
0.644ThrHis: 0.644 ± 0.313
3.382ThrIle: 3.382 ± 0.62
2.254ThrLys: 2.254 ± 0.639
3.543ThrLeu: 3.543 ± 0.691
2.093ThrMet: 2.093 ± 0.545
2.738ThrAsn: 2.738 ± 0.815
3.221ThrPro: 3.221 ± 0.601
2.576ThrGln: 2.576 ± 0.481
3.382ThrArg: 3.382 ± 0.601
4.67ThrSer: 4.67 ± 0.806
4.509ThrThr: 4.509 ± 0.765
3.221ThrVal: 3.221 ± 0.614
1.449ThrTrp: 1.449 ± 0.561
2.576ThrTyr: 2.576 ± 0.513
0.0ThrXaa: 0.0 ± 0.0
Val
4.67ValAla: 4.67 ± 0.741
1.127ValCys: 1.127 ± 0.392
2.415ValAsp: 2.415 ± 0.641
3.704ValGlu: 3.704 ± 0.618
1.127ValPhe: 1.127 ± 0.452
3.543ValGly: 3.543 ± 0.942
1.288ValHis: 1.288 ± 0.655
2.576ValIle: 2.576 ± 0.616
2.415ValLys: 2.415 ± 0.47
4.67ValLeu: 4.67 ± 1.181
1.127ValMet: 1.127 ± 0.364
3.382ValAsn: 3.382 ± 0.91
2.415ValPro: 2.415 ± 0.592
2.093ValGln: 2.093 ± 0.638
2.576ValArg: 2.576 ± 0.665
5.475ValSer: 5.475 ± 1.069
5.475ValThr: 5.475 ± 0.892
4.348ValVal: 4.348 ± 1.593
1.288ValTrp: 1.288 ± 0.408
2.738ValTyr: 2.738 ± 0.59
0.0ValXaa: 0.0 ± 0.0
Trp
2.415TrpAla: 2.415 ± 0.545
0.0TrpCys: 0.0 ± 0.0
1.61TrpAsp: 1.61 ± 0.504
0.483TrpGlu: 0.483 ± 0.265
0.644TrpPhe: 0.644 ± 0.374
0.322TrpGly: 0.322 ± 0.213
0.161TrpHis: 0.161 ± 0.149
0.966TrpIle: 0.966 ± 0.342
0.966TrpLys: 0.966 ± 0.249
0.483TrpLeu: 0.483 ± 0.265
0.322TrpMet: 0.322 ± 0.2
2.254TrpAsn: 2.254 ± 0.725
0.805TrpPro: 0.805 ± 0.278
0.966TrpGln: 0.966 ± 0.377
0.483TrpArg: 0.483 ± 0.251
1.449TrpSer: 1.449 ± 0.412
0.805TrpThr: 0.805 ± 0.328
0.483TrpVal: 0.483 ± 0.33
0.0TrpTrp: 0.0 ± 0.0
0.644TrpTyr: 0.644 ± 0.248
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.382TyrAla: 3.382 ± 0.648
0.161TyrCys: 0.161 ± 0.15
3.382TyrAsp: 3.382 ± 0.774
2.093TyrGlu: 2.093 ± 0.472
1.288TyrPhe: 1.288 ± 0.567
3.06TyrGly: 3.06 ± 0.753
1.288TyrHis: 1.288 ± 0.359
1.771TyrIle: 1.771 ± 0.488
1.61TyrLys: 1.61 ± 0.414
3.221TyrLeu: 3.221 ± 0.546
0.805TyrMet: 0.805 ± 0.458
2.738TyrAsn: 2.738 ± 0.683
2.254TyrPro: 2.254 ± 0.411
1.127TyrGln: 1.127 ± 0.294
3.221TyrArg: 3.221 ± 0.575
4.026TyrSer: 4.026 ± 0.914
2.254TyrThr: 2.254 ± 0.404
3.06TyrVal: 3.06 ± 0.922
0.966TyrTrp: 0.966 ± 0.302
2.093TyrTyr: 2.093 ± 0.444
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.161XaaArg: 0.161 ± 0.179
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.161XaaXaa: 0.161 ± 0.179
Statistics based on 24 proteins (6211 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski