Amino acid dipepetide frequency for Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.433AlaAla: 7.433 ± 4.36
0.572AlaCys: 0.572 ± 0.351
2.287AlaAsp: 2.287 ± 1.539
1.715AlaGlu: 1.715 ± 0.656
2.287AlaPhe: 2.287 ± 0.838
6.861AlaGly: 6.861 ± 2.569
0.0AlaHis: 0.0 ± 0.0
4.002AlaIle: 4.002 ± 0.969
0.0AlaLys: 0.0 ± 0.0
5.718AlaLeu: 5.718 ± 1.921
0.572AlaMet: 0.572 ± 0.64
0.0AlaAsn: 0.0 ± 0.0
6.289AlaPro: 6.289 ± 2.314
3.431AlaGln: 3.431 ± 0.826
8.576AlaArg: 8.576 ± 2.318
1.715AlaSer: 1.715 ± 1.198
5.146AlaThr: 5.146 ± 1.173
4.002AlaVal: 4.002 ± 1.859
2.859AlaTrp: 2.859 ± 1.056
2.859AlaTyr: 2.859 ± 1.754
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.144CysAsp: 1.144 ± 0.702
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
3.431CysGly: 3.431 ± 1.07
0.0CysHis: 0.0 ± 0.0
2.287CysIle: 2.287 ± 1.539
0.572CysLys: 0.572 ± 0.596
0.572CysLeu: 0.572 ± 0.59
0.572CysMet: 0.572 ± 0.351
1.715CysAsn: 1.715 ± 0.66
1.144CysPro: 1.144 ± 0.503
0.572CysGln: 0.572 ± 0.351
0.0CysArg: 0.0 ± 0.0
2.287CysSer: 2.287 ± 0.838
0.0CysThr: 0.0 ± 0.0
1.144CysVal: 1.144 ± 0.702
0.0CysTrp: 0.0 ± 0.0
0.572CysTyr: 0.572 ± 0.351
0.0CysXaa: 0.0 ± 0.0
Asp
5.718AspAla: 5.718 ± 1.262
1.715AspCys: 1.715 ± 1.078
0.572AspAsp: 0.572 ± 0.351
4.574AspGlu: 4.574 ± 0.717
1.715AspPhe: 1.715 ± 0.816
3.431AspGly: 3.431 ± 2.155
0.0AspHis: 0.0 ± 0.0
1.144AspIle: 1.144 ± 0.503
1.715AspLys: 1.715 ± 1.053
5.146AspLeu: 5.146 ± 1.448
0.572AspMet: 0.572 ± 0.351
0.572AspAsn: 0.572 ± 0.351
3.431AspPro: 3.431 ± 1.068
2.287AspGln: 2.287 ± 1.539
0.572AspArg: 0.572 ± 0.59
4.574AspSer: 4.574 ± 1.646
3.431AspThr: 3.431 ± 0.433
0.572AspVal: 0.572 ± 0.351
1.144AspTrp: 1.144 ± 0.702
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
4.002GluAla: 4.002 ± 1.411
1.144GluCys: 1.144 ± 1.18
2.859GluAsp: 2.859 ± 1.485
4.002GluGlu: 4.002 ± 1.821
0.572GluPhe: 0.572 ± 0.351
1.715GluGly: 1.715 ± 0.606
0.0GluHis: 0.0 ± 0.0
2.859GluIle: 2.859 ± 1.353
4.002GluLys: 4.002 ± 1.859
2.859GluLeu: 2.859 ± 0.699
0.572GluMet: 0.572 ± 0.519
1.144GluAsn: 1.144 ± 0.702
0.572GluPro: 0.572 ± 0.351
1.144GluGln: 1.144 ± 0.672
2.287GluArg: 2.287 ± 1.539
5.718GluSer: 5.718 ± 1.589
4.002GluThr: 4.002 ± 0.443
1.715GluVal: 1.715 ± 0.816
0.0GluTrp: 0.0 ± 0.0
1.715GluTyr: 1.715 ± 0.631
0.0GluXaa: 0.0 ± 0.0
Phe
0.572PheAla: 0.572 ± 0.351
2.287PheCys: 2.287 ± 0.838
1.715PheAsp: 1.715 ± 1.053
2.859PheGlu: 2.859 ± 0.699
1.144PhePhe: 1.144 ± 0.702
2.859PheGly: 2.859 ± 1.353
1.144PheHis: 1.144 ± 0.503
0.572PheIle: 0.572 ± 0.351
0.572PheLys: 0.572 ± 0.596
1.144PheLeu: 1.144 ± 0.482
0.572PheMet: 0.572 ± 0.596
0.572PheAsn: 0.572 ± 0.596
0.572PhePro: 0.572 ± 0.596
1.715PheGln: 1.715 ± 1.053
2.287PheArg: 2.287 ± 0.597
2.287PheSer: 2.287 ± 0.671
1.144PheThr: 1.144 ± 0.702
0.572PheVal: 0.572 ± 0.351
0.572PheTrp: 0.572 ± 0.351
1.715PheTyr: 1.715 ± 0.631
0.0PheXaa: 0.0 ± 0.0
Gly
3.431GlyAla: 3.431 ± 1.116
0.0GlyCys: 0.0 ± 0.0
8.005GlyAsp: 8.005 ± 4.462
4.002GlyGlu: 4.002 ± 1.898
0.572GlyPhe: 0.572 ± 0.596
13.15GlyGly: 13.15 ± 4.378
2.859GlyHis: 2.859 ± 0.83
3.431GlyIle: 3.431 ± 1.668
1.144GlyLys: 1.144 ± 0.702
4.574GlyLeu: 4.574 ± 0.879
1.144GlyMet: 1.144 ± 0.702
2.859GlyAsn: 2.859 ± 1.353
5.146GlyPro: 5.146 ± 1.227
3.431GlyGln: 3.431 ± 1.167
3.431GlyArg: 3.431 ± 0.722
4.002GlySer: 4.002 ± 0.975
6.861GlyThr: 6.861 ± 3.468
0.0GlyVal: 0.0 ± 0.0
1.715GlyTrp: 1.715 ± 0.912
2.287GlyTyr: 2.287 ± 0.888
0.0GlyXaa: 0.0 ± 0.0
His
3.431HisAla: 3.431 ± 0.566
1.144HisCys: 1.144 ± 0.503
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.572HisPhe: 0.572 ± 0.59
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
2.287HisIle: 2.287 ± 0.838
1.144HisLys: 1.144 ± 0.727
4.574HisLeu: 4.574 ± 1.675
0.572HisMet: 0.572 ± 0.524
1.715HisAsn: 1.715 ± 1.053
5.718HisPro: 5.718 ± 0.829
0.572HisGln: 0.572 ± 0.351
3.431HisArg: 3.431 ± 1.582
5.146HisSer: 5.146 ± 1.968
0.572HisThr: 0.572 ± 0.351
0.0HisVal: 0.0 ± 0.0
1.715HisTrp: 1.715 ± 1.078
1.715HisTyr: 1.715 ± 1.053
0.0HisXaa: 0.0 ± 0.0
Ile
4.002IleAla: 4.002 ± 0.444
1.144IleCys: 1.144 ± 0.702
0.572IleAsp: 0.572 ± 0.351
0.572IleGlu: 0.572 ± 0.59
2.287IlePhe: 2.287 ± 0.888
2.859IleGly: 2.859 ± 0.699
2.287IleHis: 2.287 ± 1.061
2.859IleIle: 2.859 ± 1.754
2.859IleLys: 2.859 ± 1.353
2.287IleLeu: 2.287 ± 1.403
0.0IleMet: 0.0 ± 0.0
0.572IleAsn: 0.572 ± 0.596
2.859IlePro: 2.859 ± 0.769
1.144IleGln: 1.144 ± 0.727
4.002IleArg: 4.002 ± 0.444
0.572IleSer: 0.572 ± 0.351
2.287IleThr: 2.287 ± 0.888
2.287IleVal: 2.287 ± 1.061
0.0IleTrp: 0.0 ± 0.0
1.715IleTyr: 1.715 ± 1.053
0.0IleXaa: 0.0 ± 0.0
Lys
2.287LysAla: 2.287 ± 1.007
0.572LysCys: 0.572 ± 0.351
2.287LysAsp: 2.287 ± 1.344
1.144LysGlu: 1.144 ± 0.672
1.715LysPhe: 1.715 ± 1.053
1.144LysGly: 1.144 ± 0.702
1.144LysHis: 1.144 ± 0.702
2.859LysIle: 2.859 ± 1.353
9.148LysLys: 9.148 ± 2.983
1.715LysLeu: 1.715 ± 0.631
0.572LysMet: 0.572 ± 0.351
2.859LysAsn: 2.859 ± 1.099
2.859LysPro: 2.859 ± 1.184
4.002LysGln: 4.002 ± 1.557
7.433LysArg: 7.433 ± 1.836
4.002LysSer: 4.002 ± 1.214
5.718LysThr: 5.718 ± 0.869
1.144LysVal: 1.144 ± 0.503
1.715LysTrp: 1.715 ± 1.053
1.715LysTyr: 1.715 ± 0.816
0.0LysXaa: 0.0 ± 0.0
Leu
7.433LeuAla: 7.433 ± 3.551
0.572LeuCys: 0.572 ± 0.351
2.859LeuAsp: 2.859 ± 1.297
3.431LeuGlu: 3.431 ± 0.566
2.859LeuPhe: 2.859 ± 1.353
4.574LeuGly: 4.574 ± 1.052
1.715LeuHis: 1.715 ± 0.66
2.287LeuIle: 2.287 ± 1.403
2.859LeuLys: 2.859 ± 1.353
6.861LeuLeu: 6.861 ± 1.374
0.0LeuMet: 0.0 ± 0.0
1.144LeuAsn: 1.144 ± 0.702
6.861LeuPro: 6.861 ± 2.413
8.005LeuGln: 8.005 ± 1.829
4.002LeuArg: 4.002 ± 0.912
4.574LeuSer: 4.574 ± 2.121
2.859LeuThr: 2.859 ± 0.794
2.287LeuVal: 2.287 ± 1.061
0.572LeuTrp: 0.572 ± 0.351
1.715LeuTyr: 1.715 ± 0.6
0.0LeuXaa: 0.0 ± 0.0
Met
1.715MetAla: 1.715 ± 0.912
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.572MetGlu: 0.572 ± 0.351
1.144MetPhe: 1.144 ± 0.503
0.0MetGly: 0.0 ± 0.0
1.144MetHis: 1.144 ± 0.727
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
1.715MetLeu: 1.715 ± 0.602
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.715MetPro: 1.715 ± 0.631
1.144MetGln: 1.144 ± 0.672
0.572MetArg: 0.572 ± 0.351
0.0MetSer: 0.0 ± 0.0
0.572MetThr: 0.572 ± 0.351
0.0MetVal: 0.0 ± 0.0
1.715MetTrp: 1.715 ± 1.078
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.287AsnAla: 2.287 ± 0.671
0.0AsnCys: 0.0 ± 0.0
0.572AsnAsp: 0.572 ± 0.351
0.0AsnGlu: 0.0 ± 0.0
3.431AsnPhe: 3.431 ± 1.154
2.859AsnGly: 2.859 ± 0.83
1.144AsnHis: 1.144 ± 0.702
0.572AsnIle: 0.572 ± 0.351
2.287AsnLys: 2.287 ± 1.176
2.287AsnLeu: 2.287 ± 0.838
0.0AsnMet: 0.0 ± 0.0
2.859AsnAsn: 2.859 ± 0.873
2.859AsnPro: 2.859 ± 1.194
2.287AsnGln: 2.287 ± 0.599
3.431AsnArg: 3.431 ± 1.207
4.002AsnSer: 4.002 ± 1.706
2.287AsnThr: 2.287 ± 0.86
0.572AsnVal: 0.572 ± 0.351
0.0AsnTrp: 0.0 ± 0.0
0.572AsnTyr: 0.572 ± 0.351
0.0AsnXaa: 0.0 ± 0.0
Pro
9.72ProAla: 9.72 ± 4.888
1.715ProCys: 1.715 ± 0.606
0.0ProAsp: 0.0 ± 0.0
3.431ProGlu: 3.431 ± 1.631
2.287ProPhe: 2.287 ± 1.403
6.861ProGly: 6.861 ± 1.901
1.715ProHis: 1.715 ± 1.078
1.144ProIle: 1.144 ± 0.702
6.861ProLys: 6.861 ± 1.73
4.574ProLeu: 4.574 ± 0.621
1.144ProMet: 1.144 ± 0.727
2.287ProAsn: 2.287 ± 0.662
12.579ProPro: 12.579 ± 7.731
6.289ProGln: 6.289 ± 2.772
8.576ProArg: 8.576 ± 1.954
4.002ProSer: 4.002 ± 0.894
5.146ProThr: 5.146 ± 2.06
3.431ProVal: 3.431 ± 1.315
1.144ProTrp: 1.144 ± 0.672
2.859ProTyr: 2.859 ± 0.873
0.0ProXaa: 0.0 ± 0.0
Gln
2.859GlnAla: 2.859 ± 1.194
0.0GlnCys: 0.0 ± 0.0
2.859GlnAsp: 2.859 ± 1.194
5.718GlnGlu: 5.718 ± 2.265
0.572GlnPhe: 0.572 ± 0.596
1.715GlnGly: 1.715 ± 0.6
4.002GlnHis: 4.002 ± 1.898
2.859GlnIle: 2.859 ± 0.873
1.715GlnLys: 1.715 ± 0.919
9.72GlnLeu: 9.72 ± 2.672
0.572GlnMet: 0.572 ± 0.59
2.287GlnAsn: 2.287 ± 1.539
6.861GlnPro: 6.861 ± 1.441
6.289GlnGln: 6.289 ± 2.596
2.287GlnArg: 2.287 ± 0.597
4.574GlnSer: 4.574 ± 1.061
3.431GlnThr: 3.431 ± 0.876
2.287GlnVal: 2.287 ± 0.64
0.572GlnTrp: 0.572 ± 0.351
1.144GlnTyr: 1.144 ± 0.482
0.0GlnXaa: 0.0 ± 0.0
Arg
5.146ArgAla: 5.146 ± 2.039
0.572ArgCys: 0.572 ± 0.351
3.431ArgAsp: 3.431 ± 1.207
1.715ArgGlu: 1.715 ± 1.198
0.572ArgPhe: 0.572 ± 0.596
12.007ArgGly: 12.007 ± 1.577
7.433ArgHis: 7.433 ± 0.864
1.715ArgIle: 1.715 ± 0.606
1.715ArgLys: 1.715 ± 1.046
3.431ArgLeu: 3.431 ± 1.167
1.715ArgMet: 1.715 ± 0.816
2.859ArgAsn: 2.859 ± 1.896
6.861ArgPro: 6.861 ± 1.368
0.572ArgGln: 0.572 ± 0.59
41.166ArgArg: 41.166 ± 16.226
5.718ArgSer: 5.718 ± 1.987
0.572ArgThr: 0.572 ± 0.596
5.146ArgVal: 5.146 ± 1.331
3.431ArgTrp: 3.431 ± 1.434
3.431ArgTyr: 3.431 ± 1.2
0.0ArgXaa: 0.0 ± 0.0
Ser
1.144SerAla: 1.144 ± 0.672
2.287SerCys: 2.287 ± 1.516
5.718SerAsp: 5.718 ± 1.403
4.574SerGlu: 4.574 ± 1.49
1.144SerPhe: 1.144 ± 1.192
2.859SerGly: 2.859 ± 0.775
4.574SerHis: 4.574 ± 0.7
2.287SerIle: 2.287 ± 1.061
5.146SerLys: 5.146 ± 1.509
3.431SerLeu: 3.431 ± 1.221
0.0SerMet: 0.0 ± 0.0
4.002SerAsn: 4.002 ± 1.706
6.861SerPro: 6.861 ± 1.811
2.859SerGln: 2.859 ± 1.353
2.859SerArg: 2.859 ± 1.297
19.44SerSer: 19.44 ± 8.183
4.574SerThr: 4.574 ± 1.87
2.859SerVal: 2.859 ± 0.83
2.859SerTrp: 2.859 ± 0.83
1.144SerTyr: 1.144 ± 0.702
0.0SerXaa: 0.0 ± 0.0
Thr
3.431ThrAla: 3.431 ± 1.154
0.572ThrCys: 0.572 ± 0.596
4.574ThrAsp: 4.574 ± 0.889
2.859ThrGlu: 2.859 ± 1.754
0.572ThrPhe: 0.572 ± 0.351
4.002ThrGly: 4.002 ± 1.646
1.144ThrHis: 1.144 ± 0.702
1.144ThrIle: 1.144 ± 0.503
3.431ThrLys: 3.431 ± 0.877
2.287ThrLeu: 2.287 ± 1.061
0.0ThrMet: 0.0 ± 0.0
2.287ThrAsn: 2.287 ± 0.838
8.005ThrPro: 8.005 ± 2.203
7.433ThrGln: 7.433 ± 2.586
2.287ThrArg: 2.287 ± 1.161
3.431ThrSer: 3.431 ± 0.85
5.146ThrThr: 5.146 ± 2.537
1.144ThrVal: 1.144 ± 0.702
1.715ThrTrp: 1.715 ± 0.631
1.144ThrTyr: 1.144 ± 0.503
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
1.715ValCys: 1.715 ± 1.053
2.287ValAsp: 2.287 ± 1.061
0.0ValGlu: 0.0 ± 0.0
1.144ValPhe: 1.144 ± 0.503
0.572ValGly: 0.572 ± 0.351
1.715ValHis: 1.715 ± 0.606
0.572ValIle: 0.572 ± 0.351
4.002ValLys: 4.002 ± 1.088
2.287ValLeu: 2.287 ± 0.64
1.715ValMet: 1.715 ± 0.591
1.144ValAsn: 1.144 ± 0.702
1.715ValPro: 1.715 ± 0.816
5.146ValGln: 5.146 ± 2.776
2.859ValArg: 2.859 ± 1.353
2.287ValSer: 2.287 ± 0.597
0.572ValThr: 0.572 ± 0.351
0.572ValVal: 0.572 ± 0.351
3.431ValTrp: 3.431 ± 0.566
0.572ValTyr: 0.572 ± 0.351
0.0ValXaa: 0.0 ± 0.0
Trp
0.572TrpAla: 0.572 ± 0.351
0.0TrpCys: 0.0 ± 0.0
1.144TrpAsp: 1.144 ± 0.672
0.0TrpGlu: 0.0 ± 0.0
1.715TrpPhe: 1.715 ± 1.078
0.572TrpGly: 0.572 ± 0.351
1.144TrpHis: 1.144 ± 0.672
1.715TrpIle: 1.715 ± 0.816
2.859TrpLys: 2.859 ± 1.184
0.572TrpLeu: 0.572 ± 0.351
0.572TrpMet: 0.572 ± 0.596
0.572TrpAsn: 0.572 ± 0.596
1.715TrpPro: 1.715 ± 1.078
2.287TrpGln: 2.287 ± 0.838
6.861TrpArg: 6.861 ± 1.097
0.572TrpSer: 0.572 ± 0.351
0.572TrpThr: 0.572 ± 0.351
0.0TrpVal: 0.0 ± 0.0
3.431TrpTrp: 3.431 ± 1.825
3.431TrpTyr: 3.431 ± 1.434
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.715TyrAla: 1.715 ± 1.053
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
1.715TyrGlu: 1.715 ± 1.046
0.572TyrPhe: 0.572 ± 0.351
0.572TyrGly: 0.572 ± 0.351
1.144TyrHis: 1.144 ± 0.702
0.572TyrIle: 0.572 ± 0.351
4.002TyrLys: 4.002 ± 1.133
1.715TyrLeu: 1.715 ± 0.6
0.572TyrMet: 0.572 ± 0.351
2.859TyrAsn: 2.859 ± 1.754
1.144TyrPro: 1.144 ± 0.702
1.715TyrGln: 1.715 ± 1.053
2.287TyrArg: 2.287 ± 0.662
1.715TyrSer: 1.715 ± 1.053
1.715TyrThr: 1.715 ± 1.046
4.574TyrVal: 4.574 ± 1.358
1.715TyrTrp: 1.715 ± 0.912
2.287TyrTyr: 2.287 ± 0.662
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski