Amino acid dipepetide frequency for Candidatus Jidaibacter acanthamoeba

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.17AlaAla: 5.17 ± 0.121	0.72AlaCys: 0.72 ± 0.034	2.938AlaAsp: 2.938 ± 0.077	4.572AlaGlu: 4.572 ± 0.097	2.917AlaPhe: 2.917 ± 0.082	3.86AlaGly: 3.86 ± 0.095	1.083AlaHis: 1.083 ± 0.041	5.864AlaIle: 5.864 ± 0.087	5.18AlaLys: 5.18 ± 0.101	7.606AlaLeu: 7.606 ± 0.135	1.491AlaMet: 1.491 ± 0.053	3.29AlaAsn: 3.29 ± 0.067	1.78AlaPro: 1.78 ± 0.055	2.057AlaGln: 2.057 ± 0.054	2.594AlaArg: 2.594 ± 0.074	4.097AlaSer: 4.097 ± 0.082	2.807AlaThr: 2.807 ± 0.073	3.884AlaVal: 3.884 ± 0.091	0.548AlaTrp: 0.548 ± 0.03	2.434AlaTyr: 2.434 ± 0.062	0.001AlaXaa: 0.001 ± 0.001
Cys	0.585CysAla: 0.585 ± 0.031	0.18CysCys: 0.18 ± 0.016	0.408CysAsp: 0.408 ± 0.025	0.57CysGlu: 0.57 ± 0.032	0.582CysPhe: 0.582 ± 0.032	0.65CysGly: 0.65 ± 0.032	0.194CysHis: 0.194 ± 0.017	0.894CysIle: 0.894 ± 0.035	0.853CysLys: 0.853 ± 0.033	1.157CysLeu: 1.157 ± 0.043	0.228CysMet: 0.228 ± 0.02	0.598CysAsn: 0.598 ± 0.032	0.331CysPro: 0.331 ± 0.024	0.246CysGln: 0.246 ± 0.02	0.387CysArg: 0.387 ± 0.027	0.725CysSer: 0.725 ± 0.035	0.466CysThr: 0.466 ± 0.024	0.514CysVal: 0.514 ± 0.03	0.088CysTrp: 0.088 ± 0.012	0.502CysTyr: 0.502 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	2.633AspAla: 2.633 ± 0.06	0.502AspCys: 0.502 ± 0.027	2.095AspAsp: 2.095 ± 0.063	3.449AspGlu: 3.449 ± 0.079	2.264AspPhe: 2.264 ± 0.066	2.382AspGly: 2.382 ± 0.058	0.86AspHis: 0.86 ± 0.038	5.397AspIle: 5.397 ± 0.1	4.754AspLys: 4.754 ± 0.096	4.84AspLeu: 4.84 ± 0.096	0.902AspMet: 0.902 ± 0.04	3.24AspAsn: 3.24 ± 0.083	1.566AspPro: 1.566 ± 0.049	1.432AspGln: 1.432 ± 0.048	1.899AspArg: 1.899 ± 0.059	3.013AspSer: 3.013 ± 0.081	2.225AspThr: 2.225 ± 0.068	2.322AspVal: 2.322 ± 0.068	0.452AspTrp: 0.452 ± 0.031	2.167AspTyr: 2.167 ± 0.059	0.001AspXaa: 0.001 ± 0.001
Glu	4.944GluAla: 4.944 ± 0.099	0.631GluCys: 0.631 ± 0.034	3.306GluAsp: 3.306 ± 0.078	6.577GluGlu: 6.577 ± 0.186	2.91GluPhe: 2.91 ± 0.067	4.025GluGly: 4.025 ± 0.104	1.429GluHis: 1.429 ± 0.066	6.746GluIle: 6.746 ± 0.117	6.653GluLys: 6.653 ± 0.124	7.243GluLeu: 7.243 ± 0.116	1.528GluMet: 1.528 ± 0.047	4.539GluAsn: 4.539 ± 0.098	1.61GluPro: 1.61 ± 0.051	3.032GluGln: 3.032 ± 0.075	3.053GluArg: 3.053 ± 0.078	3.866GluSer: 3.866 ± 0.077	2.787GluThr: 2.787 ± 0.064	4.857GluVal: 4.857 ± 0.099	0.617GluTrp: 0.617 ± 0.03	2.911GluTyr: 2.911 ± 0.083	0.006GluXaa: 0.006 ± 0.004
Phe	2.789PheAla: 2.789 ± 0.079	0.603PheCys: 0.603 ± 0.032	2.22PheAsp: 2.22 ± 0.053	2.762PheGlu: 2.762 ± 0.057	2.074PhePhe: 2.074 ± 0.065	2.587PheGly: 2.587 ± 0.08	0.667PheHis: 0.667 ± 0.033	4.681PheIle: 4.681 ± 0.099	3.853PheLys: 3.853 ± 0.077	4.473PheLeu: 4.473 ± 0.103	0.971PheMet: 0.971 ± 0.039	2.832PheAsn: 2.832 ± 0.079	1.32PhePro: 1.32 ± 0.048	1.186PheGln: 1.186 ± 0.045	1.36PheArg: 1.36 ± 0.048	3.455PheSer: 3.455 ± 0.083	2.317PheThr: 2.317 ± 0.062	1.958PheVal: 1.958 ± 0.054	0.423PheTrp: 0.423 ± 0.025	1.895PheTyr: 1.895 ± 0.056	0.003PheXaa: 0.003 ± 0.002
Gly	4.262GlyAla: 4.262 ± 0.126	0.592GlyCys: 0.592 ± 0.031	2.774GlyAsp: 2.774 ± 0.081	3.854GlyGlu: 3.854 ± 0.087	2.898GlyPhe: 2.898 ± 0.079	3.691GlyGly: 3.691 ± 0.101	1.204GlyHis: 1.204 ± 0.05	5.413GlyIle: 5.413 ± 0.111	4.987GlyLys: 4.987 ± 0.111	5.164GlyLeu: 5.164 ± 0.09	1.488GlyMet: 1.488 ± 0.053	3.21GlyAsn: 3.21 ± 0.08	0.628GlyPro: 0.628 ± 0.04	1.398GlyGln: 1.398 ± 0.049	2.415GlyArg: 2.415 ± 0.067	3.975GlySer: 3.975 ± 0.09	2.502GlyThr: 2.502 ± 0.068	3.64GlyVal: 3.64 ± 0.083	0.542GlyTrp: 0.542 ± 0.03	2.535GlyTyr: 2.535 ± 0.056	0.004GlyXaa: 0.004 ± 0.002
His	1.058HisAla: 1.058 ± 0.043	0.186HisCys: 0.186 ± 0.019	0.825HisAsp: 0.825 ± 0.03	1.149HisGlu: 1.149 ± 0.046	0.838HisPhe: 0.838 ± 0.039	1.103HisGly: 1.103 ± 0.044	0.433HisHis: 0.433 ± 0.026	1.762HisIle: 1.762 ± 0.05	1.597HisLys: 1.597 ± 0.046	1.976HisLeu: 1.976 ± 0.059	0.399HisMet: 0.399 ± 0.023	1.186HisAsn: 1.186 ± 0.047	0.878HisPro: 0.878 ± 0.05	0.56HisGln: 0.56 ± 0.03	0.676HisArg: 0.676 ± 0.034	1.242HisSer: 1.242 ± 0.044	0.93HisThr: 0.93 ± 0.044	0.865HisVal: 0.865 ± 0.037	0.156HisTrp: 0.156 ± 0.013	0.874HisTyr: 0.874 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.456IleAla: 6.456 ± 0.107	0.975IleCys: 0.975 ± 0.04	4.794IleAsp: 4.794 ± 0.098	6.82IleGlu: 6.82 ± 0.121	3.951IlePhe: 3.951 ± 0.089	5.286IleGly: 5.286 ± 0.112	1.485IleHis: 1.485 ± 0.057	8.479IleIle: 8.479 ± 0.142	8.132IleLys: 8.132 ± 0.137	8.157IleLeu: 8.157 ± 0.138	1.746IleMet: 1.746 ± 0.062	6.602IleAsn: 6.602 ± 0.143	3.132IlePro: 3.132 ± 0.065	2.267IleGln: 2.267 ± 0.061	3.297IleArg: 3.297 ± 0.073	7.088IleSer: 7.088 ± 0.106	4.994IleThr: 4.994 ± 0.089	4.476IleVal: 4.476 ± 0.093	0.613IleTrp: 0.613 ± 0.031	3.237IleTyr: 3.237 ± 0.079	0.003IleXaa: 0.003 ± 0.002
Lys	5.587LysAla: 5.587 ± 0.098	0.676LysCys: 0.676 ± 0.031	4.75LysAsp: 4.75 ± 0.107	7.752LysGlu: 7.752 ± 0.139	3.492LysPhe: 3.492 ± 0.084	4.415LysGly: 4.415 ± 0.082	1.741LysHis: 1.741 ± 0.051	7.419LysIle: 7.419 ± 0.109	6.627LysLys: 6.627 ± 0.108	8.53LysLeu: 8.53 ± 0.136	1.889LysMet: 1.889 ± 0.049	5.382LysAsn: 5.382 ± 0.093	2.441LysPro: 2.441 ± 0.068	3.378LysGln: 3.378 ± 0.088	3.179LysArg: 3.179 ± 0.085	5.115LysSer: 5.115 ± 0.083	3.91LysThr: 3.91 ± 0.079	5.221LysVal: 5.221 ± 0.099	0.687LysTrp: 0.687 ± 0.034	3.732LysTyr: 3.732 ± 0.083	0.0LysXaa: 0.0 ± 0.0
Leu	6.294LeuAla: 6.294 ± 0.104	1.027LeuCys: 1.027 ± 0.043	4.806LeuAsp: 4.806 ± 0.105	7.459LeuGlu: 7.459 ± 0.138	4.212LeuPhe: 4.212 ± 0.1	5.816LeuGly: 5.816 ± 0.114	1.921LeuHis: 1.921 ± 0.069	8.682LeuIle: 8.682 ± 0.131	9.289LeuLys: 9.289 ± 0.132	9.805LeuLeu: 9.805 ± 0.168	2.157LeuMet: 2.157 ± 0.067	6.862LeuAsn: 6.862 ± 0.123	3.608LeuPro: 3.608 ± 0.079	2.988LeuGln: 2.988 ± 0.063	3.822LeuArg: 3.822 ± 0.083	8.02LeuSer: 8.02 ± 0.12	4.826LeuThr: 4.826 ± 0.094	5.168LeuVal: 5.168 ± 0.101	0.656LeuTrp: 0.656 ± 0.037	3.657LeuTyr: 3.657 ± 0.095	0.003LeuXaa: 0.003 ± 0.003
Met	1.338MetAla: 1.338 ± 0.052	0.197MetCys: 0.197 ± 0.019	0.835MetAsp: 0.835 ± 0.037	1.257MetGlu: 1.257 ± 0.041	0.854MetPhe: 0.854 ± 0.04	1.24MetGly: 1.24 ± 0.047	0.533MetHis: 0.533 ± 0.024	1.731MetIle: 1.731 ± 0.05	1.794MetLys: 1.794 ± 0.059	2.515MetLeu: 2.515 ± 0.071	0.725MetMet: 0.725 ± 0.039	1.031MetAsn: 1.031 ± 0.04	0.819MetPro: 0.819 ± 0.03	0.952MetGln: 0.952 ± 0.037	1.08MetArg: 1.08 ± 0.036	1.363MetSer: 1.363 ± 0.048	0.902MetThr: 0.902 ± 0.036	1.322MetVal: 1.322 ± 0.044	0.152MetTrp: 0.152 ± 0.015	0.611MetTyr: 0.611 ± 0.03	0.003MetXaa: 0.003 ± 0.002
Asn	3.527AsnAla: 3.527 ± 0.094	0.601AsnCys: 0.601 ± 0.032	2.902AsnAsp: 2.902 ± 0.082	3.932AsnGlu: 3.932 ± 0.081	3.016AsnPhe: 3.016 ± 0.07	3.008AsnGly: 3.008 ± 0.1	1.223AsnHis: 1.223 ± 0.047	6.708AsnIle: 6.708 ± 0.118	5.762AsnLys: 5.762 ± 0.1	6.484AsnLeu: 6.484 ± 0.123	1.199AsnMet: 1.199 ± 0.041	4.953AsnAsn: 4.953 ± 0.127	2.247AsnPro: 2.247 ± 0.06	2.3AsnGln: 2.3 ± 0.079	2.142AsnArg: 2.142 ± 0.056	4.144AsnSer: 4.144 ± 0.091	3.257AsnThr: 3.257 ± 0.08	2.541AsnVal: 2.541 ± 0.067	0.538AsnTrp: 0.538 ± 0.03	2.829AsnTyr: 2.829 ± 0.076	0.003AsnXaa: 0.003 ± 0.003
Pro	1.796ProAla: 1.796 ± 0.059	0.276ProCys: 0.276 ± 0.022	1.688ProAsp: 1.688 ± 0.051	2.528ProGlu: 2.528 ± 0.071	1.485ProPhe: 1.485 ± 0.058	1.578ProGly: 1.578 ± 0.059	0.613ProHis: 0.613 ± 0.034	2.587ProIle: 2.587 ± 0.066	2.406ProLys: 2.406 ± 0.067	3.377ProLeu: 3.377 ± 0.071	0.495ProMet: 0.495 ± 0.026	1.908ProAsn: 1.908 ± 0.056	0.949ProPro: 0.949 ± 0.044	1.108ProGln: 1.108 ± 0.048	1.011ProArg: 1.011 ± 0.047	2.186ProSer: 2.186 ± 0.064	1.503ProThr: 1.503 ± 0.054	1.743ProVal: 1.743 ± 0.056	0.302ProTrp: 0.302 ± 0.021	1.326ProTyr: 1.326 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.397GlnAla: 2.397 ± 0.06	0.231GlnCys: 0.231 ± 0.018	1.762GlnAsp: 1.762 ± 0.053	2.689GlnGlu: 2.689 ± 0.086	1.218GlnPhe: 1.218 ± 0.044	2.085GlnGly: 2.085 ± 0.065	0.639GlnHis: 0.639 ± 0.033	2.683GlnIle: 2.683 ± 0.063	2.6GlnLys: 2.6 ± 0.063	3.011GlnLeu: 3.011 ± 0.07	0.639GlnMet: 0.639 ± 0.03	2.099GlnAsn: 2.099 ± 0.066	1.0GlnPro: 1.0 ± 0.039	1.283GlnGln: 1.283 ± 0.047	1.263GlnArg: 1.263 ± 0.045	2.039GlnSer: 2.039 ± 0.065	1.375GlnThr: 1.375 ± 0.043	1.908GlnVal: 1.908 ± 0.055	0.199GlnTrp: 0.199 ± 0.018	1.257GlnTyr: 1.257 ± 0.046	0.001GlnXaa: 0.001 ± 0.002
Arg	2.322ArgAla: 2.322 ± 0.062	0.38ArgCys: 0.38 ± 0.028	1.89ArgAsp: 1.89 ± 0.055	3.405ArgGlu: 3.405 ± 0.093	1.594ArgPhe: 1.594 ± 0.049	2.382ArgGly: 2.382 ± 0.068	0.684ArgHis: 0.684 ± 0.029	3.219ArgIle: 3.219 ± 0.07	3.135ArgLys: 3.135 ± 0.078	3.593ArgLeu: 3.593 ± 0.08	0.832ArgMet: 0.832 ± 0.036	2.226ArgAsn: 2.226 ± 0.061	1.033ArgPro: 1.033 ± 0.044	1.192ArgGln: 1.192 ± 0.044	1.747ArgArg: 1.747 ± 0.058	2.326ArgSer: 2.326 ± 0.059	1.699ArgThr: 1.699 ± 0.056	2.245ArgVal: 2.245 ± 0.057	0.359ArgTrp: 0.359 ± 0.022	1.553ArgTyr: 1.553 ± 0.052	0.004ArgXaa: 0.004 ± 0.003
Ser	4.01SerAla: 4.01 ± 0.087	0.701SerCys: 0.701 ± 0.031	3.206SerAsp: 3.206 ± 0.066	4.455SerGlu: 4.455 ± 0.081	3.291SerPhe: 3.291 ± 0.069	4.165SerGly: 4.165 ± 0.088	1.195SerHis: 1.195 ± 0.044	6.322SerIle: 6.322 ± 0.101	5.78SerLys: 5.78 ± 0.096	7.499SerLeu: 7.499 ± 0.117	1.497SerMet: 1.497 ± 0.049	4.163SerAsn: 4.163 ± 0.095	2.219SerPro: 2.219 ± 0.06	2.102SerGln: 2.102 ± 0.071	2.497SerArg: 2.497 ± 0.054	5.472SerSer: 5.472 ± 0.127	3.443SerThr: 3.443 ± 0.082	3.244SerVal: 3.244 ± 0.079	0.62SerTrp: 0.62 ± 0.031	2.829SerTyr: 2.829 ± 0.071	0.003SerXaa: 0.003 ± 0.002
Thr	3.324ThrAla: 3.324 ± 0.083	0.464ThrCys: 0.464 ± 0.027	2.142ThrAsp: 2.142 ± 0.063	2.96ThrGlu: 2.96 ± 0.069	2.02ThrPhe: 2.02 ± 0.063	2.868ThrGly: 2.868 ± 0.078	0.882ThrHis: 0.882 ± 0.038	4.121ThrIle: 4.121 ± 0.082	3.688ThrLys: 3.688 ± 0.074	5.204ThrLeu: 5.204 ± 0.112	0.844ThrMet: 0.844 ± 0.032	2.661ThrAsn: 2.661 ± 0.07	2.313ThrPro: 2.313 ± 0.068	1.721ThrGln: 1.721 ± 0.057	1.657ThrArg: 1.657 ± 0.049	3.337ThrSer: 3.337 ± 0.081	2.658ThrThr: 2.658 ± 0.073	2.453ThrVal: 2.453 ± 0.065	0.329ThrTrp: 0.329 ± 0.021	1.731ThrTyr: 1.731 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	3.615ValAla: 3.615 ± 0.083	0.61ValCys: 0.61 ± 0.033	2.702ValAsp: 2.702 ± 0.061	4.138ValGlu: 4.138 ± 0.093	2.373ValPhe: 2.373 ± 0.06	3.169ValGly: 3.169 ± 0.081	0.819ValHis: 0.819 ± 0.04	5.162ValIle: 5.162 ± 0.098	4.656ValLys: 4.656 ± 0.091	5.242ValLeu: 5.242 ± 0.097	1.252ValMet: 1.252 ± 0.051	3.198ValAsn: 3.198 ± 0.078	1.584ValPro: 1.584 ± 0.056	1.426ValGln: 1.426 ± 0.045	2.01ValArg: 2.01 ± 0.058	3.751ValSer: 3.751 ± 0.08	2.618ValThr: 2.618 ± 0.076	3.399ValVal: 3.399 ± 0.09	0.411ValTrp: 0.411 ± 0.029	1.784ValTyr: 1.784 ± 0.052	0.003ValXaa: 0.003 ± 0.002
Trp	0.502TrpAla: 0.502 ± 0.042	0.128TrpCys: 0.128 ± 0.014	0.464TrpAsp: 0.464 ± 0.028	0.494TrpGlu: 0.494 ± 0.027	0.362TrpPhe: 0.362 ± 0.023	0.511TrpGly: 0.511 ± 0.029	0.218TrpHis: 0.218 ± 0.018	0.564TrpIle: 0.564 ± 0.027	0.579TrpLys: 0.579 ± 0.028	0.964TrpLeu: 0.964 ± 0.048	0.159TrpMet: 0.159 ± 0.017	0.482TrpAsn: 0.482 ± 0.028	0.218TrpPro: 0.218 ± 0.018	0.393TrpGln: 0.393 ± 0.024	0.355TrpArg: 0.355 ± 0.024	0.545TrpSer: 0.545 ± 0.028	0.218TrpThr: 0.218 ± 0.02	0.532TrpVal: 0.532 ± 0.03	0.116TrpTrp: 0.116 ± 0.013	0.357TrpTyr: 0.357 ± 0.025	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.282TyrAla: 2.282 ± 0.071	0.479TyrCys: 0.479 ± 0.027	1.886TyrAsp: 1.886 ± 0.057	2.449TyrGlu: 2.449 ± 0.066	2.071TyrPhe: 2.071 ± 0.059	2.351TyrGly: 2.351 ± 0.071	0.865TyrHis: 0.865 ± 0.041	3.552TyrIle: 3.552 ± 0.073	3.598TyrLys: 3.598 ± 0.082	4.233TyrLeu: 4.233 ± 0.08	0.81TyrMet: 0.81 ± 0.03	2.854TyrAsn: 2.854 ± 0.077	1.187TyrPro: 1.187 ± 0.049	1.357TyrGln: 1.357 ± 0.057	1.372TyrArg: 1.372 ± 0.048	2.951TyrSer: 2.951 ± 0.072	1.936TyrThr: 1.936 ± 0.058	1.632TyrVal: 1.632 ± 0.054	0.354TyrTrp: 0.354 ± 0.024	1.917TyrTyr: 1.917 ± 0.066	0.001TyrXaa: 0.001 ± 0.002
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.003XaaPhe: 0.003 ± 0.002	0.001XaaGly: 0.001 ± 0.001	0.003XaaHis: 0.003 ± 0.003	0.006XaaIle: 0.006 ± 0.004	0.001XaaLys: 0.001 ± 0.001	0.007XaaLeu: 0.007 ± 0.003	0.001XaaMet: 0.001 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.002	0.006XaaArg: 0.006 ± 0.003	0.003XaaSer: 0.003 ± 0.002	0.004XaaThr: 0.004 ± 0.003	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 2204 proteins (678764 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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