Amino acid dipepetide frequency for Rheinheimera salexigens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.355AlaAla: 10.355 ± 0.136	0.993AlaCys: 0.993 ± 0.034	6.075AlaAsp: 6.075 ± 0.077	6.716AlaGlu: 6.716 ± 0.093	3.482AlaPhe: 3.482 ± 0.062	6.435AlaGly: 6.435 ± 0.091	1.597AlaHis: 1.597 ± 0.043	6.657AlaIle: 6.657 ± 0.089	5.461AlaLys: 5.461 ± 0.089	11.056AlaLeu: 11.056 ± 0.115	2.653AlaMet: 2.653 ± 0.056	4.267AlaAsn: 4.267 ± 0.072	2.996AlaPro: 2.996 ± 0.053	4.601AlaGln: 4.601 ± 0.079	3.788AlaArg: 3.788 ± 0.064	5.767AlaSer: 5.767 ± 0.078	5.128AlaThr: 5.128 ± 0.082	6.672AlaVal: 6.672 ± 0.078	1.026AlaTrp: 1.026 ± 0.036	2.531AlaTyr: 2.531 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.824CysAla: 0.824 ± 0.03	0.163CysCys: 0.163 ± 0.013	0.523CysAsp: 0.523 ± 0.024	0.422CysGlu: 0.422 ± 0.021	0.449CysPhe: 0.449 ± 0.021	0.728CysGly: 0.728 ± 0.03	0.286CysHis: 0.286 ± 0.017	0.59CysIle: 0.59 ± 0.024	0.379CysLys: 0.379 ± 0.022	0.935CysLeu: 0.935 ± 0.034	0.182CysMet: 0.182 ± 0.013	0.324CysAsn: 0.324 ± 0.018	0.429CysPro: 0.429 ± 0.025	0.64CysGln: 0.64 ± 0.026	0.456CysArg: 0.456 ± 0.025	0.689CysSer: 0.689 ± 0.029	0.443CysThr: 0.443 ± 0.023	0.496CysVal: 0.496 ± 0.023	0.139CysTrp: 0.139 ± 0.01	0.334CysTyr: 0.334 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.783AspAla: 4.783 ± 0.067	0.466AspCys: 0.466 ± 0.023	2.849AspAsp: 2.849 ± 0.073	2.876AspGlu: 2.876 ± 0.06	2.341AspPhe: 2.341 ± 0.055	3.428AspGly: 3.428 ± 0.073	0.997AspHis: 0.997 ± 0.032	4.291AspIle: 4.291 ± 0.067	3.126AspLys: 3.126 ± 0.066	5.069AspLeu: 5.069 ± 0.078	1.354AspMet: 1.354 ± 0.033	2.649AspAsn: 2.649 ± 0.055	1.884AspPro: 1.884 ± 0.042	2.009AspGln: 2.009 ± 0.052	1.983AspArg: 1.983 ± 0.052	3.303AspSer: 3.303 ± 0.069	2.728AspThr: 2.728 ± 0.049	3.588AspVal: 3.588 ± 0.066	0.821AspTrp: 0.821 ± 0.027	2.027AspTyr: 2.027 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.422GluAla: 4.422 ± 0.07	0.355GluCys: 0.355 ± 0.019	2.109GluAsp: 2.109 ± 0.056	2.261GluGlu: 2.261 ± 0.057	2.214GluPhe: 2.214 ± 0.04	2.596GluGly: 2.596 ± 0.059	1.509GluHis: 1.509 ± 0.042	3.122GluIle: 3.122 ± 0.062	2.657GluLys: 2.657 ± 0.058	6.677GluLeu: 6.677 ± 0.092	1.332GluMet: 1.332 ± 0.039	2.045GluAsn: 2.045 ± 0.05	1.957GluPro: 1.957 ± 0.047	5.249GluGln: 5.249 ± 0.076	2.765GluArg: 2.765 ± 0.056	2.561GluSer: 2.561 ± 0.052	2.544GluThr: 2.544 ± 0.048	3.55GluVal: 3.55 ± 0.065	0.549GluTrp: 0.549 ± 0.024	1.53GluTyr: 1.53 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	4.125PheAla: 4.125 ± 0.071	0.485PheCys: 0.485 ± 0.023	2.433PheAsp: 2.433 ± 0.055	1.906PheGlu: 1.906 ± 0.052	1.585PhePhe: 1.585 ± 0.05	3.031PheGly: 3.031 ± 0.054	0.703PheHis: 0.703 ± 0.027	2.966PheIle: 2.966 ± 0.056	1.863PheLys: 1.863 ± 0.045	3.196PheLeu: 3.196 ± 0.063	1.02PheMet: 1.02 ± 0.033	2.225PheAsn: 2.225 ± 0.051	1.276PhePro: 1.276 ± 0.039	1.278PheGln: 1.278 ± 0.035	1.456PheArg: 1.456 ± 0.042	3.631PheSer: 3.631 ± 0.071	2.438PheThr: 2.438 ± 0.053	2.535PheVal: 2.535 ± 0.056	0.585PheTrp: 0.585 ± 0.027	1.479PheTyr: 1.479 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.216GlyAla: 5.216 ± 0.081	0.779GlyCys: 0.779 ± 0.031	3.213GlyAsp: 3.213 ± 0.068	3.431GlyGlu: 3.431 ± 0.066	3.194GlyPhe: 3.194 ± 0.068	4.405GlyGly: 4.405 ± 0.097	1.477GlyHis: 1.477 ± 0.04	4.47GlyIle: 4.47 ± 0.074	3.501GlyLys: 3.501 ± 0.065	6.935GlyLeu: 6.935 ± 0.085	1.768GlyMet: 1.768 ± 0.043	2.477GlyAsn: 2.477 ± 0.059	1.643GlyPro: 1.643 ± 0.041	2.964GlyGln: 2.964 ± 0.063	2.885GlyArg: 2.885 ± 0.064	4.069GlySer: 4.069 ± 0.072	3.153GlyThr: 3.153 ± 0.074	4.622GlyVal: 4.622 ± 0.073	0.927GlyTrp: 0.927 ± 0.029	2.522GlyTyr: 2.522 ± 0.048	0.001GlyXaa: 0.001 ± 0.001
His	1.814HisAla: 1.814 ± 0.043	0.328HisCys: 0.328 ± 0.017	1.008HisAsp: 1.008 ± 0.037	0.851HisGlu: 0.851 ± 0.028	1.07HisPhe: 1.07 ± 0.034	1.543HisGly: 1.543 ± 0.044	0.578HisHis: 0.578 ± 0.026	1.465HisIle: 1.465 ± 0.039	1.094HisLys: 1.094 ± 0.034	2.206HisLeu: 2.206 ± 0.049	0.423HisMet: 0.423 ± 0.02	0.988HisAsn: 0.988 ± 0.033	1.056HisPro: 1.056 ± 0.035	1.272HisGln: 1.272 ± 0.034	0.98HisArg: 0.98 ± 0.031	1.549HisSer: 1.549 ± 0.043	1.083HisThr: 1.083 ± 0.034	1.156HisVal: 1.156 ± 0.033	0.421HisTrp: 0.421 ± 0.021	0.966HisTyr: 0.966 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	7.189IleAla: 7.189 ± 0.081	0.637IleCys: 0.637 ± 0.028	4.08IleAsp: 4.08 ± 0.073	3.857IleGlu: 3.857 ± 0.064	2.132IlePhe: 2.132 ± 0.048	4.362IleGly: 4.362 ± 0.078	1.047IleHis: 1.047 ± 0.033	3.952IleIle: 3.952 ± 0.08	3.527IleLys: 3.527 ± 0.061	5.46IleLeu: 5.46 ± 0.082	1.316IleMet: 1.316 ± 0.034	3.387IleAsn: 3.387 ± 0.061	2.477IlePro: 2.477 ± 0.048	2.453IleGln: 2.453 ± 0.052	2.762IleArg: 2.762 ± 0.057	4.776IleSer: 4.776 ± 0.072	3.874IleThr: 3.874 ± 0.074	4.042IleVal: 4.042 ± 0.075	0.652IleTrp: 0.652 ± 0.029	1.678IleTyr: 1.678 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.852LysAla: 4.852 ± 0.085	0.263LysCys: 0.263 ± 0.015	2.263LysAsp: 2.263 ± 0.049	2.07LysGlu: 2.07 ± 0.056	1.485LysPhe: 1.485 ± 0.043	2.606LysGly: 2.606 ± 0.057	1.253LysHis: 1.253 ± 0.041	2.8LysIle: 2.8 ± 0.054	2.381LysLys: 2.381 ± 0.059	5.779LysLeu: 5.779 ± 0.091	1.223LysMet: 1.223 ± 0.04	1.888LysAsn: 1.888 ± 0.045	2.48LysPro: 2.48 ± 0.055	3.868LysGln: 3.868 ± 0.074	2.488LysArg: 2.488 ± 0.056	2.715LysSer: 2.715 ± 0.048	2.783LysThr: 2.783 ± 0.053	3.562LysVal: 3.562 ± 0.067	0.491LysTrp: 0.491 ± 0.023	1.249LysTyr: 1.249 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	12.548LeuAla: 12.548 ± 0.127	1.05LeuCys: 1.05 ± 0.034	5.587LeuAsp: 5.587 ± 0.072	5.297LeuGlu: 5.297 ± 0.083	4.286LeuPhe: 4.286 ± 0.077	6.688LeuGly: 6.688 ± 0.095	2.251LeuHis: 2.251 ± 0.049	6.62LeuIle: 6.62 ± 0.088	5.063LeuLys: 5.063 ± 0.077	12.755LeuLeu: 12.755 ± 0.179	2.688LeuMet: 2.688 ± 0.06	4.646LeuAsn: 4.646 ± 0.062	5.197LeuPro: 5.197 ± 0.093	6.49LeuGln: 6.49 ± 0.131	4.668LeuArg: 4.668 ± 0.075	7.836LeuSer: 7.836 ± 0.111	6.89LeuThr: 6.89 ± 0.089	7.192LeuVal: 7.192 ± 0.088	1.234LeuTrp: 1.234 ± 0.041	2.904LeuTyr: 2.904 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.602MetAla: 2.602 ± 0.055	0.169MetCys: 0.169 ± 0.012	0.978MetAsp: 0.978 ± 0.032	0.88MetGlu: 0.88 ± 0.028	0.838MetPhe: 0.838 ± 0.03	1.399MetGly: 1.399 ± 0.039	0.53MetHis: 0.53 ± 0.023	1.243MetIle: 1.243 ± 0.041	1.063MetLys: 1.063 ± 0.031	3.174MetLeu: 3.174 ± 0.055	0.581MetMet: 0.581 ± 0.023	0.829MetAsn: 0.829 ± 0.029	1.325MetPro: 1.325 ± 0.034	1.731MetGln: 1.731 ± 0.043	1.241MetArg: 1.241 ± 0.036	1.628MetSer: 1.628 ± 0.037	1.347MetThr: 1.347 ± 0.039	1.511MetVal: 1.511 ± 0.046	0.206MetTrp: 0.206 ± 0.016	0.523MetTyr: 0.523 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.731AsnAla: 3.731 ± 0.068	0.407AsnCys: 0.407 ± 0.023	2.165AsnAsp: 2.165 ± 0.048	2.034AsnGlu: 2.034 ± 0.046	1.589AsnPhe: 1.589 ± 0.04	2.796AsnGly: 2.796 ± 0.057	0.839AsnHis: 0.839 ± 0.027	2.988AsnIle: 2.988 ± 0.056	2.291AsnLys: 2.291 ± 0.048	4.176AsnLeu: 4.176 ± 0.073	1.002AsnMet: 1.002 ± 0.03	2.162AsnAsn: 2.162 ± 0.058	1.887AsnPro: 1.887 ± 0.045	2.368AsnGln: 2.368 ± 0.052	1.906AsnArg: 1.906 ± 0.043	2.9AsnSer: 2.9 ± 0.057	2.412AsnThr: 2.412 ± 0.049	2.584AsnVal: 2.584 ± 0.049	0.718AsnTrp: 0.718 ± 0.027	1.404AsnTyr: 1.404 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.983ProAla: 3.983 ± 0.069	0.308ProCys: 0.308 ± 0.019	2.379ProAsp: 2.379 ± 0.055	2.927ProGlu: 2.927 ± 0.055	1.633ProPhe: 1.633 ± 0.046	2.41ProGly: 2.41 ± 0.048	0.764ProHis: 0.764 ± 0.031	2.435ProIle: 2.435 ± 0.054	1.786ProLys: 1.786 ± 0.045	4.438ProLeu: 4.438 ± 0.075	0.908ProMet: 0.908 ± 0.027	1.635ProAsn: 1.635 ± 0.042	1.103ProPro: 1.103 ± 0.039	1.829ProGln: 1.829 ± 0.048	1.376ProArg: 1.376 ± 0.038	2.369ProSer: 2.369 ± 0.047	2.106ProThr: 2.106 ± 0.044	3.011ProVal: 3.011 ± 0.06	0.499ProTrp: 0.499 ± 0.023	1.229ProTyr: 1.229 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.932GlnAla: 5.932 ± 0.103	0.411GlnCys: 0.411 ± 0.02	2.297GlnAsp: 2.297 ± 0.048	1.957GlnGlu: 1.957 ± 0.043	2.302GlnPhe: 2.302 ± 0.051	3.245GlnGly: 3.245 ± 0.055	2.207GlnHis: 2.207 ± 0.05	2.869GlnIle: 2.869 ± 0.051	2.056GlnLys: 2.056 ± 0.051	8.466GlnLeu: 8.466 ± 0.148	1.082GlnMet: 1.082 ± 0.037	1.762GlnAsn: 1.762 ± 0.043	2.513GlnPro: 2.513 ± 0.058	7.952GlnGln: 7.952 ± 0.202	3.322GlnArg: 3.322 ± 0.064	2.967GlnSer: 2.967 ± 0.064	2.465GlnThr: 2.465 ± 0.05	3.703GlnVal: 3.703 ± 0.067	0.789GlnTrp: 0.789 ± 0.029	1.785GlnTyr: 1.785 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	3.427ArgAla: 3.427 ± 0.062	0.434ArgCys: 0.434 ± 0.018	2.356ArgAsp: 2.356 ± 0.05	2.444ArgGlu: 2.444 ± 0.052	2.257ArgPhe: 2.257 ± 0.051	2.52ArgGly: 2.52 ± 0.053	1.137ArgHis: 1.137 ± 0.036	2.948ArgIle: 2.948 ± 0.057	2.044ArgLys: 2.044 ± 0.046	5.406ArgLeu: 5.406 ± 0.074	1.043ArgMet: 1.043 ± 0.034	1.834ArgAsn: 1.834 ± 0.044	1.556ArgPro: 1.556 ± 0.044	2.848ArgGln: 2.848 ± 0.063	2.301ArgArg: 2.301 ± 0.056	2.624ArgSer: 2.624 ± 0.054	1.988ArgThr: 1.988 ± 0.041	2.855ArgVal: 2.855 ± 0.059	0.641ArgTrp: 0.641 ± 0.027	1.899ArgTyr: 1.899 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.262SerAla: 6.262 ± 0.085	0.614SerCys: 0.614 ± 0.026	3.265SerAsp: 3.265 ± 0.063	3.32SerGlu: 3.32 ± 0.059	2.918SerPhe: 2.918 ± 0.061	4.755SerGly: 4.755 ± 0.089	1.394SerHis: 1.394 ± 0.037	4.012SerIle: 4.012 ± 0.062	2.923SerLys: 2.923 ± 0.046	7.136SerLeu: 7.136 ± 0.092	1.517SerMet: 1.517 ± 0.039	2.656SerAsn: 2.656 ± 0.052	2.321SerPro: 2.321 ± 0.044	3.404SerGln: 3.404 ± 0.076	2.994SerArg: 2.994 ± 0.059	4.408SerSer: 4.408 ± 0.075	3.401SerThr: 3.401 ± 0.064	4.262SerVal: 4.262 ± 0.068	0.928SerTrp: 0.928 ± 0.031	2.134SerTyr: 2.134 ± 0.054	0.001SerXaa: 0.001 ± 0.001
Thr	6.051ThrAla: 6.051 ± 0.094	0.374ThrCys: 0.374 ± 0.019	3.384ThrAsp: 3.384 ± 0.061	3.62ThrGlu: 3.62 ± 0.063	1.702ThrPhe: 1.702 ± 0.04	3.929ThrGly: 3.929 ± 0.072	0.944ThrHis: 0.944 ± 0.033	3.266ThrIle: 3.266 ± 0.065	2.371ThrLys: 2.371 ± 0.05	6.059ThrLeu: 6.059 ± 0.089	1.068ThrMet: 1.068 ± 0.031	2.032ThrAsn: 2.032 ± 0.054	2.577ThrPro: 2.577 ± 0.046	2.116ThrGln: 2.116 ± 0.042	1.997ThrArg: 1.997 ± 0.043	3.284ThrSer: 3.284 ± 0.07	2.909ThrThr: 2.909 ± 0.058	4.063ThrVal: 4.063 ± 0.08	0.528ThrTrp: 0.528 ± 0.024	1.284ThrTyr: 1.284 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	6.637ValAla: 6.637 ± 0.082	0.705ValCys: 0.705 ± 0.025	3.606ValAsp: 3.606 ± 0.067	3.571ValGlu: 3.571 ± 0.068	2.72ValPhe: 2.72 ± 0.057	4.072ValGly: 4.072 ± 0.081	1.193ValHis: 1.193 ± 0.038	4.619ValIle: 4.619 ± 0.072	3.339ValLys: 3.339 ± 0.065	7.291ValLeu: 7.291 ± 0.113	1.784ValMet: 1.784 ± 0.049	2.996ValAsn: 2.996 ± 0.056	2.531ValPro: 2.531 ± 0.049	2.854ValGln: 2.854 ± 0.053	2.763ValArg: 2.763 ± 0.056	4.707ValSer: 4.707 ± 0.067	3.984ValThr: 3.984 ± 0.068	4.766ValVal: 4.766 ± 0.076	0.741ValTrp: 0.741 ± 0.029	1.737ValTyr: 1.737 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.808TrpAla: 0.808 ± 0.028	0.138TrpCys: 0.138 ± 0.011	0.503TrpAsp: 0.503 ± 0.02	0.309TrpGlu: 0.309 ± 0.017	0.635TrpPhe: 0.635 ± 0.027	0.635TrpGly: 0.635 ± 0.025	0.412TrpHis: 0.412 ± 0.02	0.585TrpIle: 0.585 ± 0.025	0.278TrpLys: 0.278 ± 0.015	2.17TrpLeu: 2.17 ± 0.065	0.252TrpMet: 0.252 ± 0.015	0.322TrpAsn: 0.322 ± 0.019	0.581TrpPro: 0.581 ± 0.028	1.731TrpGln: 1.731 ± 0.053	0.75TrpArg: 0.75 ± 0.03	0.71TrpSer: 0.71 ± 0.028	0.424TrpThr: 0.424 ± 0.019	0.731TrpVal: 0.731 ± 0.03	0.208TrpTrp: 0.208 ± 0.017	0.394TrpTyr: 0.394 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.694TyrAla: 2.694 ± 0.055	0.352TyrCys: 0.352 ± 0.022	1.501TyrAsp: 1.501 ± 0.045	1.254TyrGlu: 1.254 ± 0.044	1.387TyrPhe: 1.387 ± 0.039	2.067TyrGly: 2.067 ± 0.042	0.732TyrHis: 0.732 ± 0.025	1.761TyrIle: 1.761 ± 0.046	1.295TyrLys: 1.295 ± 0.04	3.507TyrLeu: 3.507 ± 0.061	0.599TyrMet: 0.599 ± 0.024	1.236TyrAsn: 1.236 ± 0.035	1.339TyrPro: 1.339 ± 0.039	2.422TyrGln: 2.422 ± 0.055	1.683TyrArg: 1.683 ± 0.039	2.132TyrSer: 2.132 ± 0.047	1.458TyrThr: 1.458 ± 0.041	1.715TyrVal: 1.715 ± 0.047	0.474TyrTrp: 0.474 ± 0.023	1.055TyrTyr: 1.055 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3027 proteins (992880 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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