Amino acid dipepetide frequency for Azoarcus communis SWub3 = DSM 12120

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.988AlaAla: 15.988 ± 0.14	1.428AlaCys: 1.428 ± 0.032	7.017AlaAsp: 7.017 ± 0.097	7.385AlaGlu: 7.385 ± 0.097	4.062AlaPhe: 4.062 ± 0.056	10.436AlaGly: 10.436 ± 0.118	2.672AlaHis: 2.672 ± 0.046	5.439AlaIle: 5.439 ± 0.068	2.925AlaLys: 2.925 ± 0.057	14.357AlaLeu: 14.357 ± 0.125	3.308AlaMet: 3.308 ± 0.04	2.808AlaAsn: 2.808 ± 0.051	5.243AlaPro: 5.243 ± 0.065	4.532AlaGln: 4.532 ± 0.065	9.361AlaArg: 9.361 ± 0.093	6.429AlaSer: 6.429 ± 0.075	5.524AlaThr: 5.524 ± 0.064	8.63AlaVal: 8.63 ± 0.078	1.775AlaTrp: 1.775 ± 0.041	2.542AlaTyr: 2.542 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.192CysAla: 1.192 ± 0.026	0.153CysCys: 0.153 ± 0.01	0.618CysAsp: 0.618 ± 0.02	0.567CysGlu: 0.567 ± 0.02	0.348CysPhe: 0.348 ± 0.013	1.061CysGly: 1.061 ± 0.03	0.331CysHis: 0.331 ± 0.015	0.461CysIle: 0.461 ± 0.018	0.243CysLys: 0.243 ± 0.014	0.962CysLeu: 0.962 ± 0.03	0.216CysMet: 0.216 ± 0.012	0.3CysAsn: 0.3 ± 0.015	0.591CysPro: 0.591 ± 0.024	0.289CysGln: 0.289 ± 0.012	0.723CysArg: 0.723 ± 0.022	0.561CysSer: 0.561 ± 0.021	0.505CysThr: 0.505 ± 0.018	0.737CysVal: 0.737 ± 0.024	0.149CysTrp: 0.149 ± 0.011	0.242CysTyr: 0.242 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.011AspAla: 7.011 ± 0.091	0.57AspCys: 0.57 ± 0.021	3.146AspAsp: 3.146 ± 0.057	3.596AspGlu: 3.596 ± 0.057	2.207AspPhe: 2.207 ± 0.04	5.034AspGly: 5.034 ± 0.07	1.319AspHis: 1.319 ± 0.032	2.835AspIle: 2.835 ± 0.044	1.695AspLys: 1.695 ± 0.038	5.569AspLeu: 5.569 ± 0.062	1.247AspMet: 1.247 ± 0.029	1.381AspAsn: 1.381 ± 0.029	3.078AspPro: 3.078 ± 0.05	1.735AspGln: 1.735 ± 0.031	3.84AspArg: 3.84 ± 0.058	2.427AspSer: 2.427 ± 0.043	2.849AspThr: 2.849 ± 0.048	3.945AspVal: 3.945 ± 0.06	1.012AspTrp: 1.012 ± 0.027	1.55AspTyr: 1.55 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.521GluAla: 7.521 ± 0.083	0.481GluCys: 0.481 ± 0.02	2.61GluAsp: 2.61 ± 0.046	2.702GluGlu: 2.702 ± 0.048	1.747GluPhe: 1.747 ± 0.035	4.153GluGly: 4.153 ± 0.052	1.547GluHis: 1.547 ± 0.033	3.099GluIle: 3.099 ± 0.051	1.699GluLys: 1.699 ± 0.037	6.358GluLeu: 6.358 ± 0.078	1.367GluMet: 1.367 ± 0.03	1.298GluAsn: 1.298 ± 0.031	2.441GluPro: 2.441 ± 0.049	2.699GluGln: 2.699 ± 0.053	5.24GluArg: 5.24 ± 0.071	2.765GluSer: 2.765 ± 0.044	2.938GluThr: 2.938 ± 0.048	4.396GluVal: 4.396 ± 0.065	0.774GluTrp: 0.774 ± 0.025	1.134GluTyr: 1.134 ± 0.03	0.001GluXaa: 0.001 ± 0.001
Phe	4.278PheAla: 4.278 ± 0.065	0.434PheCys: 0.434 ± 0.018	2.651PheAsp: 2.651 ± 0.04	2.233PheGlu: 2.233 ± 0.04	1.378PhePhe: 1.378 ± 0.032	3.425PheGly: 3.425 ± 0.051	0.812PheHis: 0.812 ± 0.023	1.663PheIle: 1.663 ± 0.038	0.979PheLys: 0.979 ± 0.024	3.028PheLeu: 3.028 ± 0.055	0.763PheMet: 0.763 ± 0.023	1.118PheAsn: 1.118 ± 0.028	1.5PhePro: 1.5 ± 0.032	0.984PheGln: 0.984 ± 0.028	2.259PheArg: 2.259 ± 0.045	2.203PheSer: 2.203 ± 0.037	1.667PheThr: 1.667 ± 0.035	2.791PheVal: 2.791 ± 0.044	0.453PheTrp: 0.453 ± 0.017	0.829PheTyr: 0.829 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.454GlyAla: 8.454 ± 0.103	1.01GlyCys: 1.01 ± 0.029	4.175GlyAsp: 4.175 ± 0.061	5.05GlyGlu: 5.05 ± 0.061	3.346GlyPhe: 3.346 ± 0.053	6.862GlyGly: 6.862 ± 0.091	2.003GlyHis: 2.003 ± 0.039	4.131GlyIle: 4.131 ± 0.052	3.199GlyLys: 3.199 ± 0.059	9.248GlyLeu: 9.248 ± 0.099	2.434GlyMet: 2.434 ± 0.043	2.249GlyAsn: 2.249 ± 0.056	2.806GlyPro: 2.806 ± 0.044	3.13GlyGln: 3.13 ± 0.047	6.202GlyArg: 6.202 ± 0.063	4.427GlySer: 4.427 ± 0.064	4.027GlyThr: 4.027 ± 0.059	6.585GlyVal: 6.585 ± 0.074	1.347GlyTrp: 1.347 ± 0.032	2.212GlyTyr: 2.212 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.927HisAla: 2.927 ± 0.049	0.297HisCys: 0.297 ± 0.014	1.41HisAsp: 1.41 ± 0.033	1.137HisGlu: 1.137 ± 0.026	0.976HisPhe: 0.976 ± 0.026	2.127HisGly: 2.127 ± 0.042	0.748HisHis: 0.748 ± 0.025	0.984HisIle: 0.984 ± 0.027	0.549HisLys: 0.549 ± 0.02	2.573HisLeu: 2.573 ± 0.048	0.439HisMet: 0.439 ± 0.018	0.547HisAsn: 0.547 ± 0.019	1.608HisPro: 1.608 ± 0.04	0.783HisGln: 0.783 ± 0.023	1.679HisArg: 1.679 ± 0.031	0.998HisSer: 0.998 ± 0.028	1.087HisThr: 1.087 ± 0.026	1.558HisVal: 1.558 ± 0.032	0.409HisTrp: 0.409 ± 0.016	0.765HisTyr: 0.765 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.342IleAla: 6.342 ± 0.074	0.482IleCys: 0.482 ± 0.02	3.511IleAsp: 3.511 ± 0.051	3.615IleGlu: 3.615 ± 0.053	1.36IlePhe: 1.36 ± 0.035	4.603IleGly: 4.603 ± 0.061	1.065IleHis: 1.065 ± 0.026	1.796IleIle: 1.796 ± 0.039	1.437IleLys: 1.437 ± 0.033	3.907IleLeu: 3.907 ± 0.052	0.81IleMet: 0.81 ± 0.025	1.512IleAsn: 1.512 ± 0.033	2.204IlePro: 2.204 ± 0.043	1.34IleGln: 1.34 ± 0.026	3.296IleArg: 3.296 ± 0.054	2.546IleSer: 2.546 ± 0.041	2.525IleThr: 2.525 ± 0.042	3.557IleVal: 3.557 ± 0.051	0.478IleTrp: 0.478 ± 0.018	0.987IleTyr: 0.987 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.491LysAla: 3.491 ± 0.061	0.195LysCys: 0.195 ± 0.012	1.485LysAsp: 1.485 ± 0.041	1.37LysGlu: 1.37 ± 0.037	0.735LysPhe: 0.735 ± 0.023	2.237LysGly: 2.237 ± 0.04	0.655LysHis: 0.655 ± 0.02	1.348LysIle: 1.348 ± 0.033	1.031LysLys: 1.031 ± 0.035	3.264LysLeu: 3.264 ± 0.051	0.677LysMet: 0.677 ± 0.024	0.804LysAsn: 0.804 ± 0.028	1.833LysPro: 1.833 ± 0.039	1.086LysGln: 1.086 ± 0.031	2.144LysArg: 2.144 ± 0.041	1.458LysSer: 1.458 ± 0.04	1.58LysThr: 1.58 ± 0.036	2.459LysVal: 2.459 ± 0.051	0.327LysTrp: 0.327 ± 0.016	0.622LysTyr: 0.622 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.834LeuAla: 14.834 ± 0.134	1.078LeuCys: 1.078 ± 0.029	6.434LeuAsp: 6.434 ± 0.072	5.955LeuGlu: 5.955 ± 0.076	3.71LeuPhe: 3.71 ± 0.056	8.951LeuGly: 8.951 ± 0.106	2.359LeuHis: 2.359 ± 0.045	5.195LeuIle: 5.195 ± 0.061	3.417LeuLys: 3.417 ± 0.05	11.544LeuLeu: 11.544 ± 0.136	2.576LeuMet: 2.576 ± 0.042	2.875LeuAsn: 2.875 ± 0.043	6.341LeuPro: 6.341 ± 0.071	3.907LeuGln: 3.907 ± 0.061	7.951LeuArg: 7.951 ± 0.091	6.625LeuSer: 6.625 ± 0.079	5.634LeuThr: 5.634 ± 0.073	7.467LeuVal: 7.467 ± 0.086	1.211LeuTrp: 1.211 ± 0.031	2.198LeuTyr: 2.198 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.747MetAla: 2.747 ± 0.04	0.188MetCys: 0.188 ± 0.012	1.11MetAsp: 1.11 ± 0.028	1.117MetGlu: 1.117 ± 0.028	0.673MetPhe: 0.673 ± 0.023	1.726MetGly: 1.726 ± 0.036	0.517MetHis: 0.517 ± 0.02	1.143MetIle: 1.143 ± 0.031	0.964MetLys: 0.964 ± 0.024	2.839MetLeu: 2.839 ± 0.045	0.643MetMet: 0.643 ± 0.019	0.867MetAsn: 0.867 ± 0.022	1.387MetPro: 1.387 ± 0.03	1.052MetGln: 1.052 ± 0.026	1.775MetArg: 1.775 ± 0.032	1.723MetSer: 1.723 ± 0.031	1.459MetThr: 1.459 ± 0.03	1.766MetVal: 1.766 ± 0.036	0.214MetTrp: 0.214 ± 0.011	0.366MetTyr: 0.366 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.152AsnAla: 3.152 ± 0.047	0.294AsnCys: 0.294 ± 0.016	1.35AsnAsp: 1.35 ± 0.033	1.307AsnGlu: 1.307 ± 0.032	0.882AsnPhe: 0.882 ± 0.025	2.223AsnGly: 2.223 ± 0.039	0.569AsnHis: 0.569 ± 0.021	1.231AsnIle: 1.231 ± 0.031	0.739AsnLys: 0.739 ± 0.025	2.856AsnLeu: 2.856 ± 0.051	0.591AsnMet: 0.591 ± 0.02	0.731AsnAsn: 0.731 ± 0.026	1.839AsnPro: 1.839 ± 0.041	0.864AsnGln: 0.864 ± 0.024	1.935AsnArg: 1.935 ± 0.036	1.095AsnSer: 1.095 ± 0.028	1.446AsnThr: 1.446 ± 0.034	1.827AsnVal: 1.827 ± 0.04	0.42AsnTrp: 0.42 ± 0.015	0.668AsnTyr: 0.668 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.497ProAla: 6.497 ± 0.084	0.41ProCys: 0.41 ± 0.017	3.351ProAsp: 3.351 ± 0.048	3.461ProGlu: 3.461 ± 0.06	1.736ProPhe: 1.736 ± 0.033	4.334ProGly: 4.334 ± 0.062	1.052ProHis: 1.052 ± 0.025	2.066ProIle: 2.066 ± 0.04	1.251ProLys: 1.251 ± 0.031	5.213ProLeu: 5.213 ± 0.063	1.21ProMet: 1.21 ± 0.026	1.242ProAsn: 1.242 ± 0.029	2.654ProPro: 2.654 ± 0.054	1.801ProGln: 1.801 ± 0.036	2.914ProArg: 2.914 ± 0.051	2.489ProSer: 2.489 ± 0.039	2.429ProThr: 2.429 ± 0.042	4.336ProVal: 4.336 ± 0.058	0.756ProTrp: 0.756 ± 0.028	1.176ProTyr: 1.176 ± 0.028	0.001ProXaa: 0.001 ± 0.001
Gln	5.093GlnAla: 5.093 ± 0.065	0.31GlnCys: 0.31 ± 0.015	1.591GlnAsp: 1.591 ± 0.034	1.452GlnGlu: 1.452 ± 0.032	1.165GlnPhe: 1.165 ± 0.028	2.788GlnGly: 2.788 ± 0.045	0.975GlnHis: 0.975 ± 0.024	1.837GlnIle: 1.837 ± 0.032	0.908GlnLys: 0.908 ± 0.024	4.15GlnLeu: 4.15 ± 0.061	0.876GlnMet: 0.876 ± 0.023	0.742GlnAsn: 0.742 ± 0.024	1.958GlnPro: 1.958 ± 0.041	1.763GlnGln: 1.763 ± 0.038	3.111GlnArg: 3.111 ± 0.052	1.747GlnSer: 1.747 ± 0.038	1.943GlnThr: 1.943 ± 0.039	2.786GlnVal: 2.786 ± 0.041	0.567GlnTrp: 0.567 ± 0.019	0.745GlnTyr: 0.745 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.77ArgAla: 7.77 ± 0.089	0.715ArgCys: 0.715 ± 0.022	4.067ArgAsp: 4.067 ± 0.052	4.523ArgGlu: 4.523 ± 0.058	3.212ArgPhe: 3.212 ± 0.05	4.743ArgGly: 4.743 ± 0.058	2.142ArgHis: 2.142 ± 0.042	4.2ArgIle: 4.2 ± 0.046	2.204ArgLys: 2.204 ± 0.044	9.034ArgLeu: 9.034 ± 0.1	1.949ArgMet: 1.949 ± 0.036	2.122ArgAsn: 2.122 ± 0.039	3.338ArgPro: 3.338 ± 0.051	3.069ArgGln: 3.069 ± 0.053	5.598ArgArg: 5.598 ± 0.07	3.716ArgSer: 3.716 ± 0.049	3.364ArgThr: 3.364 ± 0.048	5.306ArgVal: 5.306 ± 0.065	1.116ArgTrp: 1.116 ± 0.026	2.084ArgTyr: 2.084 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.341SerAla: 6.341 ± 0.065	0.526SerCys: 0.526 ± 0.017	2.63SerAsp: 2.63 ± 0.045	2.571SerGlu: 2.571 ± 0.047	1.964SerPhe: 1.964 ± 0.04	5.156SerGly: 5.156 ± 0.07	1.194SerHis: 1.194 ± 0.026	2.622SerIle: 2.622 ± 0.044	1.347SerLys: 1.347 ± 0.03	5.823SerLeu: 5.823 ± 0.067	1.37SerMet: 1.37 ± 0.033	1.406SerAsn: 1.406 ± 0.034	2.842SerPro: 2.842 ± 0.046	1.721SerGln: 1.721 ± 0.033	3.952SerArg: 3.952 ± 0.046	3.062SerSer: 3.062 ± 0.051	2.81SerThr: 2.81 ± 0.053	3.868SerVal: 3.868 ± 0.052	0.75SerTrp: 0.75 ± 0.023	1.18SerTyr: 1.18 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.588ThrAla: 5.588 ± 0.067	0.445ThrCys: 0.445 ± 0.018	2.611ThrAsp: 2.611 ± 0.04	2.672ThrGlu: 2.672 ± 0.043	1.624ThrPhe: 1.624 ± 0.034	4.539ThrGly: 4.539 ± 0.061	1.23ThrHis: 1.23 ± 0.034	2.088ThrIle: 2.088 ± 0.045	1.012ThrLys: 1.012 ± 0.029	6.587ThrLeu: 6.587 ± 0.067	0.981ThrMet: 0.981 ± 0.025	1.128ThrAsn: 1.128 ± 0.033	3.272ThrPro: 3.272 ± 0.054	1.766ThrGln: 1.766 ± 0.034	3.661ThrArg: 3.661 ± 0.052	2.438ThrSer: 2.438 ± 0.049	2.698ThrThr: 2.698 ± 0.054	4.126ThrVal: 4.126 ± 0.063	0.611ThrTrp: 0.611 ± 0.02	1.043ThrTyr: 1.043 ± 0.025	0.001ThrXaa: 0.001 ± 0.001
Val	8.902ValAla: 8.902 ± 0.088	0.792ValCys: 0.792 ± 0.027	4.251ValAsp: 4.251 ± 0.057	4.589ValGlu: 4.589 ± 0.057	2.892ValPhe: 2.892 ± 0.047	5.633ValGly: 5.633 ± 0.069	1.478ValHis: 1.478 ± 0.029	3.729ValIle: 3.729 ± 0.059	2.164ValLys: 2.164 ± 0.043	8.423ValLeu: 8.423 ± 0.104	1.996ValMet: 1.996 ± 0.037	1.883ValAsn: 1.883 ± 0.037	3.599ValPro: 3.599 ± 0.047	2.378ValGln: 2.378 ± 0.04	5.403ValArg: 5.403 ± 0.07	4.556ValSer: 4.556 ± 0.047	3.782ValThr: 3.782 ± 0.051	6.304ValVal: 6.304 ± 0.076	0.962ValTrp: 0.962 ± 0.033	1.421ValTyr: 1.421 ± 0.033	0.001ValXaa: 0.001 ± 0.001
Trp	1.233TrpAla: 1.233 ± 0.032	0.18TrpCys: 0.18 ± 0.012	0.636TrpAsp: 0.636 ± 0.02	0.59TrpGlu: 0.59 ± 0.022	0.499TrpPhe: 0.499 ± 0.018	0.89TrpGly: 0.89 ± 0.027	0.374TrpHis: 0.374 ± 0.015	0.649TrpIle: 0.649 ± 0.02	0.42TrpLys: 0.42 ± 0.017	1.986TrpLeu: 1.986 ± 0.044	0.403TrpMet: 0.403 ± 0.017	0.398TrpAsn: 0.398 ± 0.018	0.663TrpPro: 0.663 ± 0.021	0.764TrpGln: 0.764 ± 0.025	1.228TrpArg: 1.228 ± 0.034	0.735TrpSer: 0.735 ± 0.02	0.671TrpThr: 0.671 ± 0.02	1.083TrpVal: 1.083 ± 0.03	0.237TrpTrp: 0.237 ± 0.014	0.296TrpTyr: 0.296 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.042	0.259TyrCys: 0.259 ± 0.014	1.394TyrAsp: 1.394 ± 0.032	1.077TyrGlu: 1.077 ± 0.023	0.932TyrPhe: 0.932 ± 0.026	1.974TyrGly: 1.974 ± 0.035	0.562TyrHis: 0.562 ± 0.02	0.856TyrIle: 0.856 ± 0.024	0.617TyrLys: 0.617 ± 0.022	2.542TyrLeu: 2.542 ± 0.041	0.421TyrMet: 0.421 ± 0.02	0.606TyrAsn: 0.606 ± 0.021	1.183TyrPro: 1.183 ± 0.028	0.845TyrGln: 0.845 ± 0.023	2.0TyrArg: 2.0 ± 0.043	1.131TyrSer: 1.131 ± 0.029	1.184TyrThr: 1.184 ± 0.029	1.611TyrVal: 1.611 ± 0.034	0.366TyrTrp: 0.366 ± 0.016	0.646TyrTyr: 0.646 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4610 proteins (1498312 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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