Amino acid dipepetide frequency for Firmicutes bacterium CAG:238

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.991AlaAla: 8.991 ± 0.177
1.421AlaCys: 1.421 ± 0.06
4.916AlaAsp: 4.916 ± 0.095
6.63AlaGlu: 6.63 ± 0.101
3.252AlaPhe: 3.252 ± 0.079
6.67AlaGly: 6.67 ± 0.123
1.202AlaHis: 1.202 ± 0.05
5.694AlaIle: 5.694 ± 0.102
5.79AlaLys: 5.79 ± 0.117
7.565AlaLeu: 7.565 ± 0.125
2.573AlaMet: 2.573 ± 0.078
2.697AlaAsn: 2.697 ± 0.067
2.153AlaPro: 2.153 ± 0.061
2.29AlaGln: 2.29 ± 0.066
3.242AlaArg: 3.242 ± 0.075
4.409AlaSer: 4.409 ± 0.09
3.269AlaThr: 3.269 ± 0.079
6.557AlaVal: 6.557 ± 0.104
0.598AlaTrp: 0.598 ± 0.029
2.975AlaTyr: 2.975 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
1.22CysAla: 1.22 ± 0.048
0.325CysCys: 0.325 ± 0.028
0.959CysAsp: 0.959 ± 0.045
1.053CysGlu: 1.053 ± 0.043
0.649CysPhe: 0.649 ± 0.033
1.792CysGly: 1.792 ± 0.062
0.258CysHis: 0.258 ± 0.022
1.139CysIle: 1.139 ± 0.05
0.894CysLys: 0.894 ± 0.038
1.134CysLeu: 1.134 ± 0.045
0.497CysMet: 0.497 ± 0.027
0.527CysAsn: 0.527 ± 0.033
0.768CysPro: 0.768 ± 0.043
0.283CysGln: 0.283 ± 0.024
0.773CysArg: 0.773 ± 0.043
0.854CysSer: 0.854 ± 0.044
0.727CysThr: 0.727 ± 0.037
1.04CysVal: 1.04 ± 0.048
0.116CysTrp: 0.116 ± 0.015
0.485CysTyr: 0.485 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
4.686AspAla: 4.686 ± 0.098
0.843AspCys: 0.843 ± 0.042
3.022AspAsp: 3.022 ± 0.087
5.055AspGlu: 5.055 ± 0.097
2.926AspPhe: 2.926 ± 0.073
4.492AspGly: 4.492 ± 0.097
0.777AspHis: 0.777 ± 0.041
4.726AspIle: 4.726 ± 0.1
3.846AspLys: 3.846 ± 0.082
4.495AspLeu: 4.495 ± 0.103
1.773AspMet: 1.773 ± 0.051
2.164AspAsn: 2.164 ± 0.058
1.745AspPro: 1.745 ± 0.057
0.899AspGln: 0.899 ± 0.04
2.288AspArg: 2.288 ± 0.054
2.765AspSer: 2.765 ± 0.073
2.881AspThr: 2.881 ± 0.087
3.767AspVal: 3.767 ± 0.086
0.543AspTrp: 0.543 ± 0.031
2.661AspTyr: 2.661 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
6.252GluAla: 6.252 ± 0.116
0.833GluCys: 0.833 ± 0.04
4.262GluAsp: 4.262 ± 0.09
7.176GluGlu: 7.176 ± 0.153
2.649GluPhe: 2.649 ± 0.063
4.635GluGly: 4.635 ± 0.097
1.248GluHis: 1.248 ± 0.045
6.401GluIle: 6.401 ± 0.12
7.171GluLys: 7.171 ± 0.121
6.342GluLeu: 6.342 ± 0.106
2.6GluMet: 2.6 ± 0.07
4.429GluAsn: 4.429 ± 0.088
2.002GluPro: 2.002 ± 0.061
2.201GluGln: 2.201 ± 0.071
3.63GluArg: 3.63 ± 0.089
3.423GluSer: 3.423 ± 0.078
3.954GluThr: 3.954 ± 0.085
4.486GluVal: 4.486 ± 0.08
0.568GluTrp: 0.568 ± 0.032
2.843GluTyr: 2.843 ± 0.063
0.002GluXaa: 0.002 ± 0.002
Phe
3.6PheAla: 3.6 ± 0.087
0.81PheCys: 0.81 ± 0.037
2.661PheAsp: 2.661 ± 0.073
2.932PheGlu: 2.932 ± 0.074
2.038PhePhe: 2.038 ± 0.067
3.267PheGly: 3.267 ± 0.085
0.647PheHis: 0.647 ± 0.031
2.641PheIle: 2.641 ± 0.072
2.379PheLys: 2.379 ± 0.074
3.618PheLeu: 3.618 ± 0.085
1.139PheMet: 1.139 ± 0.039
1.545PheAsn: 1.545 ± 0.052
1.399PhePro: 1.399 ± 0.054
1.008PheGln: 1.008 ± 0.042
1.707PheArg: 1.707 ± 0.06
2.648PheSer: 2.648 ± 0.066
2.494PheThr: 2.494 ± 0.063
2.868PheVal: 2.868 ± 0.08
0.339PheTrp: 0.339 ± 0.023
1.603PheTyr: 1.603 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.593GlyAla: 5.593 ± 0.117
1.275GlyCys: 1.275 ± 0.052
3.692GlyAsp: 3.692 ± 0.08
5.053GlyGlu: 5.053 ± 0.101
3.235GlyPhe: 3.235 ± 0.08
5.472GlyGly: 5.472 ± 0.111
1.181GlyHis: 1.181 ± 0.049
6.494GlyIle: 6.494 ± 0.116
5.79GlyLys: 5.79 ± 0.116
5.888GlyLeu: 5.888 ± 0.11
2.51GlyMet: 2.51 ± 0.078
2.972GlyAsn: 2.972 ± 0.081
1.485GlyPro: 1.485 ± 0.085
1.886GlyGln: 1.886 ± 0.057
3.562GlyArg: 3.562 ± 0.086
4.196GlySer: 4.196 ± 0.083
4.492GlyThr: 4.492 ± 0.106
5.085GlyVal: 5.085 ± 0.118
0.656GlyTrp: 0.656 ± 0.034
3.164GlyTyr: 3.164 ± 0.076
0.007GlyXaa: 0.007 ± 0.003
His
1.232HisAla: 1.232 ± 0.047
0.326HisCys: 0.326 ± 0.024
0.871HisAsp: 0.871 ± 0.04
1.043HisGlu: 1.043 ± 0.039
0.681HisPhe: 0.681 ± 0.031
1.207HisGly: 1.207 ± 0.057
0.303HisHis: 0.303 ± 0.032
1.303HisIle: 1.303 ± 0.049
0.975HisLys: 0.975 ± 0.048
1.321HisLeu: 1.321 ± 0.043
0.498HisMet: 0.498 ± 0.029
0.659HisAsn: 0.659 ± 0.032
0.798HisPro: 0.798 ± 0.039
0.399HisGln: 0.399 ± 0.024
0.773HisArg: 0.773 ± 0.037
0.883HisSer: 0.883 ± 0.036
0.883HisThr: 0.883 ± 0.039
0.97HisVal: 0.97 ± 0.043
0.127HisTrp: 0.127 ± 0.015
0.649HisTyr: 0.649 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.618IleAla: 6.618 ± 0.102
1.401IleCys: 1.401 ± 0.049
4.491IleAsp: 4.491 ± 0.091
5.544IleGlu: 5.544 ± 0.107
3.12IlePhe: 3.12 ± 0.08
5.497IleGly: 5.497 ± 0.094
1.186IleHis: 1.186 ± 0.042
5.343IleIle: 5.343 ± 0.107
4.908IleLys: 4.908 ± 0.098
6.918IleLeu: 6.918 ± 0.129
2.166IleMet: 2.166 ± 0.058
3.027IleAsn: 3.027 ± 0.079
3.072IlePro: 3.072 ± 0.081
1.894IleGln: 1.894 ± 0.072
3.245IleArg: 3.245 ± 0.088
4.686IleSer: 4.686 ± 0.095
4.509IleThr: 4.509 ± 0.086
5.027IleVal: 5.027 ± 0.106
0.53IleTrp: 0.53 ± 0.031
2.689IleTyr: 2.689 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
5.979LysAla: 5.979 ± 0.1
0.78LysCys: 0.78 ± 0.042
3.957LysAsp: 3.957 ± 0.085
6.461LysGlu: 6.461 ± 0.135
2.143LysPhe: 2.143 ± 0.059
4.443LysGly: 4.443 ± 0.101
1.103LysHis: 1.103 ± 0.042
5.477LysIle: 5.477 ± 0.103
6.355LysLys: 6.355 ± 0.125
5.833LysLeu: 5.833 ± 0.099
2.426LysMet: 2.426 ± 0.057
3.606LysAsn: 3.606 ± 0.086
2.252LysPro: 2.252 ± 0.063
2.202LysGln: 2.202 ± 0.061
3.098LysArg: 3.098 ± 0.075
3.737LysSer: 3.737 ± 0.088
4.247LysThr: 4.247 ± 0.091
4.558LysVal: 4.558 ± 0.1
0.543LysTrp: 0.543 ± 0.032
2.994LysTyr: 2.994 ± 0.072
0.002LysXaa: 0.002 ± 0.001
Leu
7.547LeuAla: 7.547 ± 0.126
1.474LeuCys: 1.474 ± 0.055
4.709LeuAsp: 4.709 ± 0.095
6.007LeuGlu: 6.007 ± 0.112
3.581LeuPhe: 3.581 ± 0.091
6.032LeuGly: 6.032 ± 0.122
1.353LeuHis: 1.353 ± 0.05
6.231LeuIle: 6.231 ± 0.125
6.231LeuLys: 6.231 ± 0.107
7.938LeuLeu: 7.938 ± 0.123
2.576LeuMet: 2.576 ± 0.056
3.588LeuAsn: 3.588 ± 0.081
3.25LeuPro: 3.25 ± 0.063
2.447LeuGln: 2.447 ± 0.063
4.019LeuArg: 4.019 ± 0.091
6.073LeuSer: 6.073 ± 0.116
4.967LeuThr: 4.967 ± 0.096
5.232LeuVal: 5.232 ± 0.088
0.725LeuTrp: 0.725 ± 0.037
3.101LeuTyr: 3.101 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
2.436MetAla: 2.436 ± 0.05
0.371MetCys: 0.371 ± 0.027
1.732MetAsp: 1.732 ± 0.057
2.28MetGlu: 2.28 ± 0.064
0.96MetPhe: 0.96 ± 0.043
2.239MetGly: 2.239 ± 0.063
0.498MetHis: 0.498 ± 0.026
2.146MetIle: 2.146 ± 0.068
2.615MetLys: 2.615 ± 0.065
2.76MetLeu: 2.76 ± 0.068
0.916MetMet: 0.916 ± 0.04
1.505MetAsn: 1.505 ± 0.053
1.194MetPro: 1.194 ± 0.047
1.096MetGln: 1.096 ± 0.042
1.436MetArg: 1.436 ± 0.042
1.732MetSer: 1.732 ± 0.049
1.729MetThr: 1.729 ± 0.056
1.823MetVal: 1.823 ± 0.064
0.207MetTrp: 0.207 ± 0.019
0.891MetTyr: 0.891 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.283AsnAla: 3.283 ± 0.069
0.646AsnCys: 0.646 ± 0.035
2.061AsnAsp: 2.061 ± 0.056
2.906AsnGlu: 2.906 ± 0.077
1.99AsnPhe: 1.99 ± 0.052
3.197AsnGly: 3.197 ± 0.079
0.729AsnHis: 0.729 ± 0.037
3.555AsnIle: 3.555 ± 0.082
2.661AsnLys: 2.661 ± 0.074
3.913AsnLeu: 3.913 ± 0.071
1.326AsnMet: 1.326 ± 0.039
1.671AsnAsn: 1.671 ± 0.058
2.037AsnPro: 2.037 ± 0.055
1.177AsnGln: 1.177 ± 0.044
1.901AsnArg: 1.901 ± 0.058
2.234AsnSer: 2.234 ± 0.067
2.239AsnThr: 2.239 ± 0.067
2.605AsnVal: 2.605 ± 0.068
0.364AsnTrp: 0.364 ± 0.024
1.745AsnTyr: 1.745 ± 0.054
0.002AsnXaa: 0.002 ± 0.002
Pro
2.711ProAla: 2.711 ± 0.068
0.498ProCys: 0.498 ± 0.03
2.189ProAsp: 2.189 ± 0.064
3.287ProGlu: 3.287 ± 0.085
1.505ProPhe: 1.505 ± 0.051
2.363ProGly: 2.363 ± 0.062
0.548ProHis: 0.548 ± 0.03
2.32ProIle: 2.32 ± 0.065
2.134ProLys: 2.134 ± 0.053
2.762ProLeu: 2.762 ± 0.075
0.826ProMet: 0.826 ± 0.041
1.247ProAsn: 1.247 ± 0.046
0.793ProPro: 0.793 ± 0.043
1.167ProGln: 1.167 ± 0.06
1.093ProArg: 1.093 ± 0.052
1.845ProSer: 1.845 ± 0.057
1.722ProThr: 1.722 ± 0.062
2.568ProVal: 2.568 ± 0.068
0.32ProTrp: 0.32 ± 0.023
1.417ProTyr: 1.417 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
2.151GlnAla: 2.151 ± 0.058
0.349GlnCys: 0.349 ± 0.025
1.345GlnAsp: 1.345 ± 0.047
2.047GlnGlu: 2.047 ± 0.062
0.954GlnPhe: 0.954 ± 0.032
1.81GlnGly: 1.81 ± 0.127
0.459GlnHis: 0.459 ± 0.029
2.144GlnIle: 2.144 ± 0.059
2.227GlnLys: 2.227 ± 0.064
2.361GlnLeu: 2.361 ± 0.065
0.959GlnMet: 0.959 ± 0.044
1.409GlnAsn: 1.409 ± 0.049
0.939GlnPro: 0.939 ± 0.047
0.99GlnGln: 0.99 ± 0.047
1.287GlnArg: 1.287 ± 0.045
1.485GlnSer: 1.485 ± 0.055
1.624GlnThr: 1.624 ± 0.053
1.732GlnVal: 1.732 ± 0.053
0.225GlnTrp: 0.225 ± 0.02
1.166GlnTyr: 1.166 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.984ArgAla: 2.984 ± 0.077
0.646ArgCys: 0.646 ± 0.033
2.235ArgAsp: 2.235 ± 0.061
3.803ArgGlu: 3.803 ± 0.092
1.795ArgPhe: 1.795 ± 0.054
2.666ArgGly: 2.666 ± 0.076
0.763ArgHis: 0.763 ± 0.03
3.577ArgIle: 3.577 ± 0.075
3.742ArgLys: 3.742 ± 0.078
3.868ArgLeu: 3.868 ± 0.086
1.429ArgMet: 1.429 ± 0.051
2.08ArgAsn: 2.08 ± 0.06
1.349ArgPro: 1.349 ± 0.056
1.484ArgGln: 1.484 ± 0.061
2.47ArgArg: 2.47 ± 0.078
2.139ArgSer: 2.139 ± 0.062
2.3ArgThr: 2.3 ± 0.062
2.654ArgVal: 2.654 ± 0.07
0.323ArgTrp: 0.323 ± 0.024
1.758ArgTyr: 1.758 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.553SerAla: 4.553 ± 0.087
0.858SerCys: 0.858 ± 0.043
3.199SerAsp: 3.199 ± 0.073
4.113SerGlu: 4.113 ± 0.085
2.629SerPhe: 2.629 ± 0.065
5.11SerGly: 5.11 ± 0.093
0.967SerHis: 0.967 ± 0.039
3.959SerIle: 3.959 ± 0.089
3.577SerLys: 3.577 ± 0.082
4.896SerLeu: 4.896 ± 0.104
1.686SerMet: 1.686 ± 0.058
2.078SerAsn: 2.078 ± 0.063
1.732SerPro: 1.732 ± 0.051
1.654SerGln: 1.654 ± 0.058
2.515SerArg: 2.515 ± 0.061
3.221SerSer: 3.221 ± 0.086
2.82SerThr: 2.82 ± 0.082
3.908SerVal: 3.908 ± 0.088
0.5SerTrp: 0.5 ± 0.026
2.207SerTyr: 2.207 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
4.651ThrAla: 4.651 ± 0.101
0.671ThrCys: 0.671 ± 0.034
3.252ThrAsp: 3.252 ± 0.077
3.921ThrGlu: 3.921 ± 0.084
2.159ThrPhe: 2.159 ± 0.06
4.678ThrGly: 4.678 ± 0.081
0.891ThrHis: 0.891 ± 0.037
3.916ThrIle: 3.916 ± 0.088
3.293ThrLys: 3.293 ± 0.087
4.891ThrLeu: 4.891 ± 0.09
1.489ThrMet: 1.489 ± 0.052
2.113ThrAsn: 2.113 ± 0.062
2.235ThrPro: 2.235 ± 0.063
1.542ThrGln: 1.542 ± 0.057
1.835ThrArg: 1.835 ± 0.06
2.797ThrSer: 2.797 ± 0.075
2.974ThrThr: 2.974 ± 0.072
4.474ThrVal: 4.474 ± 0.106
0.462ThrTrp: 0.462 ± 0.031
2.038ThrTyr: 2.038 ± 0.067
0.002ThrXaa: 0.002 ± 0.001
Val
4.847ValAla: 4.847 ± 0.113
1.27ValCys: 1.27 ± 0.05
3.717ValAsp: 3.717 ± 0.087
4.32ValGlu: 4.32 ± 0.096
3.019ValPhe: 3.019 ± 0.082
4.532ValGly: 4.532 ± 0.104
1.01ValHis: 1.01 ± 0.038
5.376ValIle: 5.376 ± 0.114
4.55ValLys: 4.55 ± 0.094
6.398ValLeu: 6.398 ± 0.127
1.906ValMet: 1.906 ± 0.059
2.76ValAsn: 2.76 ± 0.073
2.52ValPro: 2.52 ± 0.069
1.633ValGln: 1.633 ± 0.056
2.894ValArg: 2.894 ± 0.077
4.487ValSer: 4.487 ± 0.099
3.881ValThr: 3.881 ± 0.097
4.436ValVal: 4.436 ± 0.102
0.56ValTrp: 0.56 ± 0.032
2.53ValTyr: 2.53 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.571TrpAla: 0.571 ± 0.03
0.126TrpCys: 0.126 ± 0.013
0.472TrpAsp: 0.472 ± 0.03
0.586TrpGlu: 0.586 ± 0.031
0.354TrpPhe: 0.354 ± 0.026
0.594TrpGly: 0.594 ± 0.037
0.136TrpHis: 0.136 ± 0.014
0.621TrpIle: 0.621 ± 0.035
0.583TrpLys: 0.583 ± 0.035
0.785TrpLeu: 0.785 ± 0.042
0.245TrpMet: 0.245 ± 0.02
0.414TrpAsn: 0.414 ± 0.024
0.222TrpPro: 0.222 ± 0.019
0.354TrpGln: 0.354 ± 0.022
0.288TrpArg: 0.288 ± 0.023
0.485TrpSer: 0.485 ± 0.028
0.44TrpThr: 0.44 ± 0.032
0.462TrpVal: 0.462 ± 0.028
0.099TrpTrp: 0.099 ± 0.014
0.298TrpTyr: 0.298 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.987TyrAla: 2.987 ± 0.076
0.573TyrCys: 0.573 ± 0.034
2.613TyrAsp: 2.613 ± 0.063
2.888TyrGlu: 2.888 ± 0.072
1.702TyrPhe: 1.702 ± 0.052
2.992TyrGly: 2.992 ± 0.072
0.644TyrHis: 0.644 ± 0.034
2.803TyrIle: 2.803 ± 0.073
2.474TyrLys: 2.474 ± 0.072
3.396TyrLeu: 3.396 ± 0.07
1.023TyrMet: 1.023 ± 0.042
1.75TyrAsn: 1.75 ± 0.062
1.368TyrPro: 1.368 ± 0.053
1.055TyrGln: 1.055 ± 0.047
2.01TyrArg: 2.01 ± 0.066
2.083TyrSer: 2.083 ± 0.064
2.129TyrThr: 2.129 ± 0.068
2.394TyrVal: 2.394 ± 0.064
0.331TyrTrp: 0.331 ± 0.023
1.734TyrTyr: 1.734 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.003XaaPhe: 0.003 ± 0.002
0.003XaaGly: 0.003 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.002XaaIle: 0.002 ± 0.002
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.002XaaPro: 0.002 ± 0.002
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.002XaaThr: 0.002 ± 0.002
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.013XaaXaa: 0.013 ± 0.007
Statistics based on 2016 proteins (603940 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski