Amino acid dipepetide frequency for Spiroplasma mirum ATCC 29335

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.254AlaAla: 3.254 ± 0.121
0.649AlaCys: 0.649 ± 0.053
2.687AlaAsp: 2.687 ± 0.095
2.609AlaGlu: 2.609 ± 0.108
2.563AlaPhe: 2.563 ± 0.089
3.103AlaGly: 3.103 ± 0.122
0.996AlaHis: 0.996 ± 0.065
6.04AlaIle: 6.04 ± 0.156
5.286AlaLys: 5.286 ± 0.154
5.548AlaLeu: 5.548 ± 0.149
1.334AlaMet: 1.334 ± 0.076
4.005AlaAsn: 4.005 ± 0.13
1.58AlaPro: 1.58 ± 0.077
2.051AlaGln: 2.051 ± 0.082
1.871AlaArg: 1.871 ± 0.067
3.231AlaSer: 3.231 ± 0.116
3.526AlaThr: 3.526 ± 0.113
3.375AlaVal: 3.375 ± 0.12
0.564AlaTrp: 0.564 ± 0.049
2.022AlaTyr: 2.022 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.488CysAla: 0.488 ± 0.037
0.128CysCys: 0.128 ± 0.021
0.413CysAsp: 0.413 ± 0.04
0.459CysGlu: 0.459 ± 0.04
0.551CysPhe: 0.551 ± 0.037
0.528CysGly: 0.528 ± 0.039
0.262CysHis: 0.262 ± 0.031
0.521CysIle: 0.521 ± 0.04
0.544CysLys: 0.544 ± 0.042
0.898CysLeu: 0.898 ± 0.055
0.157CysMet: 0.157 ± 0.023
0.426CysAsn: 0.426 ± 0.034
0.265CysPro: 0.265 ± 0.031
0.429CysGln: 0.429 ± 0.041
0.272CysArg: 0.272 ± 0.029
0.514CysSer: 0.514 ± 0.04
0.341CysThr: 0.341 ± 0.033
0.442CysVal: 0.442 ± 0.04
0.111CysTrp: 0.111 ± 0.019
0.452CysTyr: 0.452 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
2.323AspAla: 2.323 ± 0.097
0.308AspCys: 0.308 ± 0.034
2.795AspAsp: 2.795 ± 0.098
3.5AspGlu: 3.5 ± 0.138
2.769AspPhe: 2.769 ± 0.089
2.513AspGly: 2.513 ± 0.109
1.154AspHis: 1.154 ± 0.063
4.637AspIle: 4.637 ± 0.128
3.942AspLys: 3.942 ± 0.114
5.938AspLeu: 5.938 ± 0.137
0.895AspMet: 0.895 ± 0.055
4.031AspAsn: 4.031 ± 0.136
1.835AspPro: 1.835 ± 0.079
2.186AspGln: 2.186 ± 0.083
1.314AspArg: 1.314 ± 0.07
2.631AspSer: 2.631 ± 0.094
2.006AspThr: 2.006 ± 0.078
3.035AspVal: 3.035 ± 0.091
0.606AspTrp: 0.606 ± 0.044
2.782AspTyr: 2.782 ± 0.12
0.0AspXaa: 0.0 ± 0.0
Glu
2.825GluAla: 2.825 ± 0.115
0.321GluCys: 0.321 ± 0.033
2.363GluAsp: 2.363 ± 0.094
3.982GluGlu: 3.982 ± 0.144
2.599GluPhe: 2.599 ± 0.092
2.346GluGly: 2.346 ± 0.103
1.019GluHis: 1.019 ± 0.059
6.269GluIle: 6.269 ± 0.155
5.315GluLys: 5.315 ± 0.151
6.243GluLeu: 6.243 ± 0.177
1.37GluMet: 1.37 ± 0.065
3.792GluAsn: 3.792 ± 0.111
1.514GluPro: 1.514 ± 0.076
2.72GluGln: 2.72 ± 0.117
1.848GluArg: 1.848 ± 0.083
2.222GluSer: 2.222 ± 0.099
2.72GluThr: 2.72 ± 0.111
3.792GluVal: 3.792 ± 0.14
0.639GluTrp: 0.639 ± 0.05
2.638GluTyr: 2.638 ± 0.097
0.0GluXaa: 0.0 ± 0.0
Phe
2.943PheAla: 2.943 ± 0.101
0.528PheCys: 0.528 ± 0.043
2.825PheAsp: 2.825 ± 0.095
2.235PheGlu: 2.235 ± 0.099
2.435PhePhe: 2.435 ± 0.109
2.9PheGly: 2.9 ± 0.105
0.639PheHis: 0.639 ± 0.043
4.758PheIle: 4.758 ± 0.167
4.024PheLys: 4.024 ± 0.116
5.063PheLeu: 5.063 ± 0.165
1.157PheMet: 1.157 ± 0.069
3.978PheAsn: 3.978 ± 0.134
1.36PhePro: 1.36 ± 0.062
1.481PheGln: 1.481 ± 0.064
1.235PheArg: 1.235 ± 0.058
3.172PheSer: 3.172 ± 0.11
2.884PheThr: 2.884 ± 0.101
2.979PheVal: 2.979 ± 0.108
0.537PheTrp: 0.537 ± 0.04
2.169PheTyr: 2.169 ± 0.098
0.0PheXaa: 0.0 ± 0.0
Gly
2.998GlyAla: 2.998 ± 0.111
0.413GlyCys: 0.413 ± 0.039
2.556GlyAsp: 2.556 ± 0.104
2.661GlyGlu: 2.661 ± 0.108
2.717GlyPhe: 2.717 ± 0.102
3.018GlyGly: 3.018 ± 0.132
0.921GlyHis: 0.921 ± 0.066
4.909GlyIle: 4.909 ± 0.135
4.208GlyLys: 4.208 ± 0.134
4.975GlyLeu: 4.975 ± 0.133
1.294GlyMet: 1.294 ± 0.075
2.73GlyAsn: 2.73 ± 0.096
1.226GlyPro: 1.226 ± 0.075
1.842GlyGln: 1.842 ± 0.081
1.537GlyArg: 1.537 ± 0.078
3.002GlySer: 3.002 ± 0.105
3.208GlyThr: 3.208 ± 0.118
3.598GlyVal: 3.598 ± 0.108
0.813GlyTrp: 0.813 ± 0.059
2.527GlyTyr: 2.527 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
0.921HisAla: 0.921 ± 0.049
0.2HisCys: 0.2 ± 0.029
0.973HisAsp: 0.973 ± 0.056
0.95HisGlu: 0.95 ± 0.059
0.908HisPhe: 0.908 ± 0.051
0.908HisGly: 0.908 ± 0.047
0.8HisHis: 0.8 ± 0.058
1.317HisIle: 1.317 ± 0.076
1.131HisLys: 1.131 ± 0.067
1.953HisLeu: 1.953 ± 0.084
0.301HisMet: 0.301 ± 0.033
1.403HisAsn: 1.403 ± 0.063
0.79HisPro: 0.79 ± 0.054
1.271HisGln: 1.271 ± 0.078
0.619HisArg: 0.619 ± 0.046
0.882HisSer: 0.882 ± 0.046
0.747HisThr: 0.747 ± 0.054
0.872HisVal: 0.872 ± 0.057
0.184HisTrp: 0.184 ± 0.025
0.865HisTyr: 0.865 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
6.203IleAla: 6.203 ± 0.169
1.032IleCys: 1.032 ± 0.059
4.906IleAsp: 4.906 ± 0.142
4.493IleGlu: 4.493 ± 0.131
4.925IlePhe: 4.925 ± 0.183
4.958IleGly: 4.958 ± 0.132
1.222IleHis: 1.222 ± 0.061
10.732IleIle: 10.732 ± 0.229
8.858IleLys: 8.858 ± 0.181
9.353IleLeu: 9.353 ± 0.197
2.137IleMet: 2.137 ± 0.078
8.153IleAsn: 8.153 ± 0.206
3.005IlePro: 3.005 ± 0.102
2.438IleGln: 2.438 ± 0.086
2.749IleArg: 2.749 ± 0.091
6.151IleSer: 6.151 ± 0.151
5.754IleThr: 5.754 ± 0.135
5.519IleVal: 5.519 ± 0.136
0.954IleTrp: 0.954 ± 0.072
3.48IleTyr: 3.48 ± 0.112
0.0IleXaa: 0.0 ± 0.0
Lys
4.49LysAla: 4.49 ± 0.134
0.41LysCys: 0.41 ± 0.036
4.123LysAsp: 4.123 ± 0.123
5.836LysGlu: 5.836 ± 0.148
3.212LysPhe: 3.212 ± 0.115
3.428LysGly: 3.428 ± 0.117
1.239LysHis: 1.239 ± 0.066
9.228LysIle: 9.228 ± 0.201
8.081LysLys: 8.081 ± 0.199
8.271LysLeu: 8.271 ± 0.183
2.589LysMet: 2.589 ± 0.086
6.561LysAsn: 6.561 ± 0.184
2.772LysPro: 2.772 ± 0.099
3.385LysGln: 3.385 ± 0.111
2.602LysArg: 2.602 ± 0.089
3.628LysSer: 3.628 ± 0.116
5.299LysThr: 5.299 ± 0.129
5.056LysVal: 5.056 ± 0.134
0.99LysTrp: 0.99 ± 0.058
4.195LysTyr: 4.195 ± 0.124
0.0LysXaa: 0.0 ± 0.0
Leu
6.977LeuAla: 6.977 ± 0.165
0.728LeuCys: 0.728 ± 0.05
4.994LeuAsp: 4.994 ± 0.123
5.286LeuGlu: 5.286 ± 0.14
4.889LeuPhe: 4.889 ± 0.159
5.207LeuGly: 5.207 ± 0.162
1.593LeuHis: 1.593 ± 0.08
9.503LeuIle: 9.503 ± 0.212
8.786LeuLys: 8.786 ± 0.175
10.024LeuLeu: 10.024 ± 0.241
2.258LeuMet: 2.258 ± 0.087
6.951LeuAsn: 6.951 ± 0.164
3.133LeuPro: 3.133 ± 0.136
3.808LeuGln: 3.808 ± 0.112
2.894LeuArg: 2.894 ± 0.095
5.928LeuSer: 5.928 ± 0.124
7.193LeuThr: 7.193 ± 0.172
6.554LeuVal: 6.554 ± 0.148
1.072LeuTrp: 1.072 ± 0.072
3.356LeuTyr: 3.356 ± 0.104
0.0LeuXaa: 0.0 ± 0.0
Met
1.622MetAla: 1.622 ± 0.077
0.157MetCys: 0.157 ± 0.022
0.914MetAsp: 0.914 ± 0.05
1.088MetGlu: 1.088 ± 0.061
1.17MetPhe: 1.17 ± 0.071
1.386MetGly: 1.386 ± 0.07
0.387MetHis: 0.387 ± 0.038
2.124MetIle: 2.124 ± 0.085
2.002MetLys: 2.002 ± 0.071
2.569MetLeu: 2.569 ± 0.102
0.573MetMet: 0.573 ± 0.045
1.524MetAsn: 1.524 ± 0.065
0.731MetPro: 0.731 ± 0.046
0.973MetGln: 0.973 ± 0.057
0.675MetArg: 0.675 ± 0.045
1.242MetSer: 1.242 ± 0.068
1.222MetThr: 1.222 ± 0.066
1.442MetVal: 1.442 ± 0.074
0.226MetTrp: 0.226 ± 0.023
0.678MetTyr: 0.678 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
3.329AsnAla: 3.329 ± 0.105
0.557AsnCys: 0.557 ± 0.041
4.188AsnAsp: 4.188 ± 0.138
4.218AsnGlu: 4.218 ± 0.135
4.024AsnPhe: 4.024 ± 0.12
3.13AsnGly: 3.13 ± 0.123
1.442AsnHis: 1.442 ± 0.077
6.761AsnIle: 6.761 ± 0.161
6.62AsnLys: 6.62 ± 0.176
7.567AsnLeu: 7.567 ± 0.181
1.504AsnMet: 1.504 ± 0.074
7.259AsnAsn: 7.259 ± 0.22
3.041AsnPro: 3.041 ± 0.096
3.175AsnGln: 3.175 ± 0.118
1.871AsnArg: 1.871 ± 0.072
4.211AsnSer: 4.211 ± 0.131
2.887AsnThr: 2.887 ± 0.101
3.801AsnVal: 3.801 ± 0.123
0.865AsnTrp: 0.865 ± 0.052
3.68AsnTyr: 3.68 ± 0.115
0.0AsnXaa: 0.0 ± 0.0
Pro
1.661ProAla: 1.661 ± 0.074
0.21ProCys: 0.21 ± 0.027
1.694ProAsp: 1.694 ± 0.076
1.956ProGlu: 1.956 ± 0.079
1.619ProPhe: 1.619 ± 0.076
1.671ProGly: 1.671 ± 0.071
0.731ProHis: 0.731 ± 0.046
2.874ProIle: 2.874 ± 0.101
2.176ProLys: 2.176 ± 0.084
2.759ProLeu: 2.759 ± 0.093
0.623ProMet: 0.623 ± 0.047
2.494ProAsn: 2.494 ± 0.093
0.868ProPro: 0.868 ± 0.061
1.426ProGln: 1.426 ± 0.082
0.809ProArg: 0.809 ± 0.055
1.943ProSer: 1.943 ± 0.079
2.376ProThr: 2.376 ± 0.091
2.32ProVal: 2.32 ± 0.094
0.37ProTrp: 0.37 ± 0.034
1.183ProTyr: 1.183 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
2.209GlnAla: 2.209 ± 0.086
0.233GlnCys: 0.233 ± 0.028
2.068GlnAsp: 2.068 ± 0.08
2.956GlnGlu: 2.956 ± 0.107
1.717GlnPhe: 1.717 ± 0.08
1.616GlnGly: 1.616 ± 0.076
0.793GlnHis: 0.793 ± 0.052
3.559GlnIle: 3.559 ± 0.105
3.601GlnLys: 3.601 ± 0.112
3.883GlnLeu: 3.883 ± 0.127
0.862GlnMet: 0.862 ± 0.053
2.641GlnAsn: 2.641 ± 0.102
1.534GlnPro: 1.534 ± 0.086
2.251GlnGln: 2.251 ± 0.102
1.278GlnArg: 1.278 ± 0.071
1.543GlnSer: 1.543 ± 0.079
2.317GlnThr: 2.317 ± 0.085
2.356GlnVal: 2.356 ± 0.095
0.511GlnTrp: 0.511 ± 0.044
1.865GlnTyr: 1.865 ± 0.087
0.0GlnXaa: 0.0 ± 0.0
Arg
1.573ArgAla: 1.573 ± 0.07
0.265ArgCys: 0.265 ± 0.028
1.432ArgAsp: 1.432 ± 0.072
2.006ArgGlu: 2.006 ± 0.096
1.347ArgPhe: 1.347 ± 0.067
1.586ArgGly: 1.586 ± 0.071
0.61ArgHis: 0.61 ± 0.044
2.887ArgIle: 2.887 ± 0.098
2.609ArgLys: 2.609 ± 0.106
2.802ArgLeu: 2.802 ± 0.103
0.855ArgMet: 0.855 ± 0.051
1.953ArgAsn: 1.953 ± 0.075
0.829ArgPro: 0.829 ± 0.05
1.258ArgGln: 1.258 ± 0.072
1.173ArgArg: 1.173 ± 0.062
1.462ArgSer: 1.462 ± 0.072
1.537ArgThr: 1.537 ± 0.071
1.766ArgVal: 1.766 ± 0.082
0.403ArgTrp: 0.403 ± 0.037
1.258ArgTyr: 1.258 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
3.123SerAla: 3.123 ± 0.12
0.495SerCys: 0.495 ± 0.037
2.917SerAsp: 2.917 ± 0.104
3.303SerGlu: 3.303 ± 0.106
3.159SerPhe: 3.159 ± 0.103
3.297SerGly: 3.297 ± 0.112
1.114SerHis: 1.114 ± 0.059
4.496SerIle: 4.496 ± 0.131
4.27SerLys: 4.27 ± 0.122
5.853SerLeu: 5.853 ± 0.158
1.15SerMet: 1.15 ± 0.062
3.542SerAsn: 3.542 ± 0.11
1.652SerPro: 1.652 ± 0.083
2.241SerGln: 2.241 ± 0.09
1.583SerArg: 1.583 ± 0.08
3.431SerSer: 3.431 ± 0.122
2.956SerThr: 2.956 ± 0.117
3.12SerVal: 3.12 ± 0.114
0.777SerTrp: 0.777 ± 0.056
2.756SerTyr: 2.756 ± 0.098
0.0SerXaa: 0.0 ± 0.0
Thr
3.077ThrAla: 3.077 ± 0.106
0.419ThrCys: 0.419 ± 0.039
2.661ThrAsp: 2.661 ± 0.097
2.458ThrGlu: 2.458 ± 0.088
2.71ThrPhe: 2.71 ± 0.103
3.257ThrGly: 3.257 ± 0.099
0.878ThrHis: 0.878 ± 0.053
5.951ThrIle: 5.951 ± 0.128
4.857ThrLys: 4.857 ± 0.119
5.342ThrLeu: 5.342 ± 0.143
1.209ThrMet: 1.209 ± 0.063
4.322ThrAsn: 4.322 ± 0.132
2.281ThrPro: 2.281 ± 0.093
1.688ThrGln: 1.688 ± 0.076
1.779ThrArg: 1.779 ± 0.081
3.66ThrSer: 3.66 ± 0.112
4.126ThrThr: 4.126 ± 0.129
3.457ThrVal: 3.457 ± 0.099
0.59ThrTrp: 0.59 ± 0.044
2.215ThrTyr: 2.215 ± 0.094
0.0ThrXaa: 0.0 ± 0.0
Val
3.687ValAla: 3.687 ± 0.123
0.616ValCys: 0.616 ± 0.042
3.336ValAsp: 3.336 ± 0.118
3.49ValGlu: 3.49 ± 0.129
2.671ValPhe: 2.671 ± 0.101
3.467ValGly: 3.467 ± 0.115
0.786ValHis: 0.786 ± 0.057
6.371ValIle: 6.371 ± 0.154
5.279ValLys: 5.279 ± 0.126
5.925ValLeu: 5.925 ± 0.146
1.288ValMet: 1.288 ± 0.062
4.447ValAsn: 4.447 ± 0.122
1.829ValPro: 1.829 ± 0.068
1.734ValGln: 1.734 ± 0.065
1.724ValArg: 1.724 ± 0.079
3.572ValSer: 3.572 ± 0.093
3.28ValThr: 3.28 ± 0.108
4.25ValVal: 4.25 ± 0.128
0.632ValTrp: 0.632 ± 0.046
2.219ValTyr: 2.219 ± 0.083
0.0ValXaa: 0.0 ± 0.0
Trp
0.587TrpAla: 0.587 ± 0.051
0.111TrpCys: 0.111 ± 0.022
0.59TrpAsp: 0.59 ± 0.048
0.619TrpGlu: 0.619 ± 0.046
0.741TrpPhe: 0.741 ± 0.055
0.564TrpGly: 0.564 ± 0.042
0.17TrpHis: 0.17 ± 0.022
1.121TrpIle: 1.121 ± 0.076
1.003TrpLys: 1.003 ± 0.067
1.18TrpLeu: 1.18 ± 0.069
0.328TrpMet: 0.328 ± 0.034
0.937TrpAsn: 0.937 ± 0.057
0.292TrpPro: 0.292 ± 0.028
0.436TrpGln: 0.436 ± 0.039
0.344TrpArg: 0.344 ± 0.029
0.537TrpSer: 0.537 ± 0.047
0.691TrpThr: 0.691 ± 0.049
0.606TrpVal: 0.606 ± 0.05
0.265TrpTrp: 0.265 ± 0.042
0.596TrpTyr: 0.596 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.002TyrAla: 2.002 ± 0.085
0.423TyrCys: 0.423 ± 0.034
2.766TyrAsp: 2.766 ± 0.1
2.432TyrGlu: 2.432 ± 0.09
2.579TyrPhe: 2.579 ± 0.105
2.268TyrGly: 2.268 ± 0.074
1.239TyrHis: 1.239 ± 0.064
2.969TyrIle: 2.969 ± 0.098
2.802TyrLys: 2.802 ± 0.104
4.988TyrLeu: 4.988 ± 0.122
0.819TyrMet: 0.819 ± 0.059
2.982TyrAsn: 2.982 ± 0.11
1.229TyrPro: 1.229 ± 0.076
2.998TyrGln: 2.998 ± 0.108
1.432TyrArg: 1.432 ± 0.069
2.271TyrSer: 2.271 ± 0.088
1.868TyrThr: 1.868 ± 0.084
2.261TyrVal: 2.261 ± 0.098
0.61TyrTrp: 0.61 ± 0.045
2.333TyrTyr: 2.333 ± 0.096
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1384 proteins (305154 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski