Amino acid dipepetide frequency for Streptomyces dysideae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.937AlaAla: 19.937 ± 0.133	1.095AlaCys: 1.095 ± 0.022	8.299AlaAsp: 8.299 ± 0.058	8.709AlaGlu: 8.709 ± 0.068	3.426AlaPhe: 3.426 ± 0.036	12.179AlaGly: 12.179 ± 0.077	2.867AlaHis: 2.867 ± 0.033	3.501AlaIle: 3.501 ± 0.047	2.932AlaLys: 2.932 ± 0.044	13.959AlaLeu: 13.959 ± 0.098	2.483AlaMet: 2.483 ± 0.033	2.027AlaAsn: 2.027 ± 0.032	6.748AlaPro: 6.748 ± 0.058	3.85AlaGln: 3.85 ± 0.044	9.984AlaArg: 9.984 ± 0.069	5.907AlaSer: 5.907 ± 0.05	7.068AlaThr: 7.068 ± 0.053	11.893AlaVal: 11.893 ± 0.089	1.898AlaTrp: 1.898 ± 0.027	2.85AlaTyr: 2.85 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.043CysAla: 1.043 ± 0.023	0.098CysCys: 0.098 ± 0.006	0.47CysAsp: 0.47 ± 0.014	0.437CysGlu: 0.437 ± 0.012	0.219CysPhe: 0.219 ± 0.009	0.993CysGly: 0.993 ± 0.024	0.211CysHis: 0.211 ± 0.009	0.17CysIle: 0.17 ± 0.007	0.118CysLys: 0.118 ± 0.007	0.805CysLeu: 0.805 ± 0.019	0.127CysMet: 0.127 ± 0.006	0.144CysAsn: 0.144 ± 0.008	0.53CysPro: 0.53 ± 0.014	0.175CysGln: 0.175 ± 0.008	0.625CysArg: 0.625 ± 0.015	0.462CysSer: 0.462 ± 0.013	0.547CysThr: 0.547 ± 0.016	0.687CysVal: 0.687 ± 0.015	0.131CysTrp: 0.131 ± 0.008	0.167CysTyr: 0.167 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.588AspAla: 7.588 ± 0.059	0.464AspCys: 0.464 ± 0.013	3.747AspAsp: 3.747 ± 0.037	3.945AspGlu: 3.945 ± 0.045	1.718AspPhe: 1.718 ± 0.025	6.471AspGly: 6.471 ± 0.06	1.443AspHis: 1.443 ± 0.021	2.018AspIle: 2.018 ± 0.028	1.252AspLys: 1.252 ± 0.024	6.224AspLeu: 6.224 ± 0.05	0.845AspMet: 0.845 ± 0.016	1.041AspAsn: 1.041 ± 0.021	4.409AspPro: 4.409 ± 0.044	1.644AspGln: 1.644 ± 0.027	4.782AspArg: 4.782 ± 0.044	2.648AspSer: 2.648 ± 0.033	3.306AspThr: 3.306 ± 0.036	4.767AspVal: 4.767 ± 0.05	1.103AspTrp: 1.103 ± 0.02	1.189AspTyr: 1.189 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.407GluAla: 7.407 ± 0.07	0.381GluCys: 0.381 ± 0.011	2.902GluAsp: 2.902 ± 0.035	3.617GluGlu: 3.617 ± 0.044	1.5GluPhe: 1.5 ± 0.023	4.366GluGly: 4.366 ± 0.043	1.557GluHis: 1.557 ± 0.026	2.259GluIle: 2.259 ± 0.034	1.524GluLys: 1.524 ± 0.026	6.827GluLeu: 6.827 ± 0.058	0.896GluMet: 0.896 ± 0.018	1.095GluAsn: 1.095 ± 0.023	3.419GluPro: 3.419 ± 0.041	2.343GluGln: 2.343 ± 0.033	5.375GluArg: 5.375 ± 0.053	2.651GluSer: 2.651 ± 0.032	3.013GluThr: 3.013 ± 0.034	4.495GluVal: 4.495 ± 0.047	0.833GluTrp: 0.833 ± 0.016	1.206GluTyr: 1.206 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.579PheAla: 3.579 ± 0.039	0.263PheCys: 0.263 ± 0.01	1.958PheAsp: 1.958 ± 0.029	1.493PheGlu: 1.493 ± 0.025	0.851PhePhe: 0.851 ± 0.023	2.942PheGly: 2.942 ± 0.035	0.649PheHis: 0.649 ± 0.015	0.731PheIle: 0.731 ± 0.019	0.555PheLys: 0.555 ± 0.015	2.573PheLeu: 2.573 ± 0.028	0.412PheMet: 0.412 ± 0.014	0.6PheAsn: 0.6 ± 0.015	1.376PhePro: 1.376 ± 0.023	0.716PheGln: 0.716 ± 0.016	1.88PheArg: 1.88 ± 0.027	1.457PheSer: 1.457 ± 0.022	2.097PheThr: 2.097 ± 0.027	2.202PheVal: 2.202 ± 0.031	0.442PheTrp: 0.442 ± 0.013	0.573PheTyr: 0.573 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.463GlyAla: 10.463 ± 0.081	0.837GlyCys: 0.837 ± 0.021	5.208GlyAsp: 5.208 ± 0.046	5.089GlyGlu: 5.089 ± 0.05	2.838GlyPhe: 2.838 ± 0.034	8.412GlyGly: 8.412 ± 0.067	2.299GlyHis: 2.299 ± 0.029	3.494GlyIle: 3.494 ± 0.038	2.51GlyLys: 2.51 ± 0.032	9.137GlyLeu: 9.137 ± 0.072	1.951GlyMet: 1.951 ± 0.026	1.84GlyAsn: 1.84 ± 0.032	4.865GlyPro: 4.865 ± 0.044	2.724GlyGln: 2.724 ± 0.037	7.503GlyArg: 7.503 ± 0.055	5.313GlySer: 5.313 ± 0.053	6.417GlyThr: 6.417 ± 0.053	7.425GlyVal: 7.425 ± 0.054	1.766GlyTrp: 1.766 ± 0.029	2.286GlyTyr: 2.286 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.787HisAla: 2.787 ± 0.033	0.221HisCys: 0.221 ± 0.009	1.356HisAsp: 1.356 ± 0.021	1.235HisGlu: 1.235 ± 0.021	0.679HisPhe: 0.679 ± 0.016	2.414HisGly: 2.414 ± 0.031	0.737HisHis: 0.737 ± 0.016	0.76HisIle: 0.76 ± 0.016	0.386HisLys: 0.386 ± 0.013	2.465HisLeu: 2.465 ± 0.029	0.334HisMet: 0.334 ± 0.011	0.422HisAsn: 0.422 ± 0.012	1.87HisPro: 1.87 ± 0.03	0.701HisGln: 0.701 ± 0.015	2.138HisArg: 2.138 ± 0.032	1.05HisSer: 1.05 ± 0.019	1.397HisThr: 1.397 ± 0.027	1.695HisVal: 1.695 ± 0.027	0.397HisTrp: 0.397 ± 0.011	0.516HisTyr: 0.516 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.792IleAla: 4.792 ± 0.045	0.296IleCys: 0.296 ± 0.011	2.32IleAsp: 2.32 ± 0.031	2.034IleGlu: 2.034 ± 0.03	0.704IlePhe: 0.704 ± 0.018	3.452IleGly: 3.452 ± 0.04	0.655IleHis: 0.655 ± 0.015	0.916IleIle: 0.916 ± 0.021	0.763IleLys: 0.763 ± 0.019	2.492IleLeu: 2.492 ± 0.033	0.47IleMet: 0.47 ± 0.014	0.738IleAsn: 0.738 ± 0.016	1.872IlePro: 1.872 ± 0.029	0.813IleGln: 0.813 ± 0.018	2.393IleArg: 2.393 ± 0.031	1.727IleSer: 1.727 ± 0.024	2.351IleThr: 2.351 ± 0.028	2.688IleVal: 2.688 ± 0.037	0.407IleTrp: 0.407 ± 0.014	0.548IleTyr: 0.548 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.046LysAla: 3.046 ± 0.041	0.134LysCys: 0.134 ± 0.007	1.347LysAsp: 1.347 ± 0.026	1.272LysGlu: 1.272 ± 0.026	0.475LysPhe: 0.475 ± 0.016	1.893LysGly: 1.893 ± 0.03	0.459LysHis: 0.459 ± 0.012	0.892LysIle: 0.892 ± 0.021	0.897LysLys: 0.897 ± 0.021	2.127LysLeu: 2.127 ± 0.027	0.383LysMet: 0.383 ± 0.013	0.574LysAsn: 0.574 ± 0.016	1.427LysPro: 1.427 ± 0.02	0.741LysGln: 0.741 ± 0.018	1.528LysArg: 1.528 ± 0.026	1.215LysSer: 1.215 ± 0.024	1.384LysThr: 1.384 ± 0.026	1.996LysVal: 1.996 ± 0.03	0.314LysTrp: 0.314 ± 0.011	0.527LysTyr: 0.527 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	14.717LeuAla: 14.717 ± 0.09	0.873LeuCys: 0.873 ± 0.017	6.623LeuAsp: 6.623 ± 0.054	4.683LeuGlu: 4.683 ± 0.044	2.576LeuPhe: 2.576 ± 0.031	8.996LeuGly: 8.996 ± 0.069	2.34LeuHis: 2.34 ± 0.03	3.298LeuIle: 3.298 ± 0.042	2.17LeuLys: 2.17 ± 0.031	11.088LeuLeu: 11.088 ± 0.088	1.677LeuMet: 1.677 ± 0.021	1.781LeuAsn: 1.781 ± 0.025	6.403LeuPro: 6.403 ± 0.054	2.305LeuGln: 2.305 ± 0.028	8.607LeuArg: 8.607 ± 0.068	5.326LeuSer: 5.326 ± 0.048	6.946LeuThr: 6.946 ± 0.056	8.536LeuVal: 8.536 ± 0.07	1.33LeuTrp: 1.33 ± 0.025	1.98LeuTyr: 1.98 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.217MetAla: 2.217 ± 0.027	0.129MetCys: 0.129 ± 0.006	0.894MetAsp: 0.894 ± 0.018	0.762MetGlu: 0.762 ± 0.018	0.451MetPhe: 0.451 ± 0.014	1.324MetGly: 1.324 ± 0.022	0.382MetHis: 0.382 ± 0.012	0.663MetIle: 0.663 ± 0.017	0.446MetLys: 0.446 ± 0.013	1.683MetLeu: 1.683 ± 0.029	0.29MetMet: 0.29 ± 0.011	0.454MetAsn: 0.454 ± 0.011	1.144MetPro: 1.144 ± 0.02	0.455MetGln: 0.455 ± 0.014	1.482MetArg: 1.482 ± 0.021	1.312MetSer: 1.312 ± 0.02	1.595MetThr: 1.595 ± 0.021	1.284MetVal: 1.284 ± 0.02	0.223MetTrp: 0.223 ± 0.009	0.336MetTyr: 0.336 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.3AsnAla: 2.3 ± 0.03	0.185AsnCys: 0.185 ± 0.008	1.034AsnAsp: 1.034 ± 0.02	0.878AsnGlu: 0.878 ± 0.015	0.506AsnPhe: 0.506 ± 0.015	2.043AsnGly: 2.043 ± 0.037	0.417AsnHis: 0.417 ± 0.011	0.693AsnIle: 0.693 ± 0.018	0.45AsnLys: 0.45 ± 0.015	1.726AsnLeu: 1.726 ± 0.025	0.327AsnMet: 0.327 ± 0.01	0.502AsnAsn: 0.502 ± 0.014	1.427AsnPro: 1.427 ± 0.022	0.582AsnGln: 0.582 ± 0.017	1.322AsnArg: 1.322 ± 0.023	1.076AsnSer: 1.076 ± 0.021	1.183AsnThr: 1.183 ± 0.023	1.431AsnVal: 1.431 ± 0.024	0.345AsnTrp: 0.345 ± 0.014	0.456AsnTyr: 0.456 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.999ProAla: 7.999 ± 0.069	0.348ProCys: 0.348 ± 0.013	4.585ProAsp: 4.585 ± 0.047	4.397ProGlu: 4.397 ± 0.048	1.521ProPhe: 1.521 ± 0.021	6.273ProGly: 6.273 ± 0.056	1.439ProHis: 1.439 ± 0.022	1.327ProIle: 1.327 ± 0.023	1.239ProLys: 1.239 ± 0.023	5.28ProLeu: 5.28 ± 0.047	0.983ProMet: 0.983 ± 0.017	0.969ProAsn: 0.969 ± 0.017	3.479ProPro: 3.479 ± 0.053	1.805ProGln: 1.805 ± 0.03	3.854ProArg: 3.854 ± 0.043	3.268ProSer: 3.268 ± 0.038	3.413ProThr: 3.413 ± 0.04	5.462ProVal: 5.462 ± 0.049	0.944ProTrp: 0.944 ± 0.02	1.493ProTyr: 1.493 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.842GlnAla: 3.842 ± 0.041	0.194GlnCys: 0.194 ± 0.009	1.485GlnAsp: 1.485 ± 0.023	1.526GlnGlu: 1.526 ± 0.024	0.716GlnPhe: 0.716 ± 0.017	2.359GlnGly: 2.359 ± 0.031	0.71GlnHis: 0.71 ± 0.016	1.134GlnIle: 1.134 ± 0.018	0.649GlnLys: 0.649 ± 0.019	3.25GlnLeu: 3.25 ± 0.029	0.524GlnMet: 0.524 ± 0.015	0.553GlnAsn: 0.553 ± 0.016	1.772GlnPro: 1.772 ± 0.031	1.333GlnGln: 1.333 ± 0.034	2.427GlnArg: 2.427 ± 0.034	1.33GlnSer: 1.33 ± 0.022	1.488GlnThr: 1.488 ± 0.025	2.456GlnVal: 2.456 ± 0.028	0.542GlnTrp: 0.542 ± 0.015	0.659GlnTyr: 0.659 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.432ArgAla: 9.432 ± 0.065	0.603ArgCys: 0.603 ± 0.014	4.278ArgAsp: 4.278 ± 0.04	4.703ArgGlu: 4.703 ± 0.053	2.335ArgPhe: 2.335 ± 0.03	5.661ArgGly: 5.661 ± 0.049	2.224ArgHis: 2.224 ± 0.033	3.29ArgIle: 3.29 ± 0.035	1.71ArgLys: 1.71 ± 0.025	8.808ArgLeu: 8.808 ± 0.068	1.747ArgMet: 1.747 ± 0.026	1.409ArgAsn: 1.409 ± 0.024	4.793ArgPro: 4.793 ± 0.048	2.43ArgGln: 2.43 ± 0.03	7.598ArgArg: 7.598 ± 0.069	3.975ArgSer: 3.975 ± 0.04	5.459ArgThr: 5.459 ± 0.046	5.84ArgVal: 5.84 ± 0.052	1.399ArgTrp: 1.399 ± 0.025	1.858ArgTyr: 1.858 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.737SerAla: 6.737 ± 0.051	0.436SerCys: 0.436 ± 0.013	2.794SerAsp: 2.794 ± 0.029	2.575SerGlu: 2.575 ± 0.034	1.53SerPhe: 1.53 ± 0.023	5.961SerGly: 5.961 ± 0.053	1.054SerHis: 1.054 ± 0.02	1.437SerIle: 1.437 ± 0.022	1.118SerLys: 1.118 ± 0.023	4.844SerLeu: 4.844 ± 0.046	1.099SerMet: 1.099 ± 0.019	0.972SerAsn: 0.972 ± 0.017	3.17SerPro: 3.17 ± 0.035	1.297SerGln: 1.297 ± 0.022	3.693SerArg: 3.693 ± 0.035	2.982SerSer: 2.982 ± 0.039	3.22SerThr: 3.22 ± 0.037	4.322SerVal: 4.322 ± 0.041	0.941SerTrp: 0.941 ± 0.02	1.285SerTyr: 1.285 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.878ThrAla: 8.878 ± 0.058	0.478ThrCys: 0.478 ± 0.013	3.86ThrAsp: 3.86 ± 0.042	3.436ThrGlu: 3.436 ± 0.033	1.681ThrPhe: 1.681 ± 0.029	6.68ThrGly: 6.68 ± 0.062	1.286ThrHis: 1.286 ± 0.021	1.823ThrIle: 1.823 ± 0.029	1.279ThrLys: 1.279 ± 0.019	5.729ThrLeu: 5.729 ± 0.05	0.971ThrMet: 0.971 ± 0.021	1.123ThrAsn: 1.123 ± 0.023	4.276ThrPro: 4.276 ± 0.045	1.464ThrGln: 1.464 ± 0.027	4.01ThrArg: 4.01 ± 0.042	3.414ThrSer: 3.414 ± 0.036	4.045ThrThr: 4.045 ± 0.05	6.165ThrVal: 6.165 ± 0.055	0.976ThrTrp: 0.976 ± 0.021	1.519ThrTyr: 1.519 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.301ValAla: 10.301 ± 0.082	0.764ValCys: 0.764 ± 0.018	4.862ValAsp: 4.862 ± 0.043	4.737ValGlu: 4.737 ± 0.051	2.409ValPhe: 2.409 ± 0.033	6.463ValGly: 6.463 ± 0.051	2.009ValHis: 2.009 ± 0.028	2.906ValIle: 2.906 ± 0.039	1.785ValLys: 1.785 ± 0.029	9.275ValLeu: 9.275 ± 0.072	1.427ValMet: 1.427 ± 0.023	1.727ValAsn: 1.727 ± 0.029	5.204ValPro: 5.204 ± 0.055	2.19ValGln: 2.19 ± 0.026	7.124ValArg: 7.124 ± 0.064	4.356ValSer: 4.356 ± 0.041	5.701ValThr: 5.701 ± 0.047	7.816ValVal: 7.816 ± 0.07	1.198ValTrp: 1.198 ± 0.022	1.647ValTyr: 1.647 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.684TrpAla: 1.684 ± 0.025	0.164TrpCys: 0.164 ± 0.007	0.9TrpAsp: 0.9 ± 0.017	0.764TrpGlu: 0.764 ± 0.019	0.517TrpPhe: 0.517 ± 0.013	1.125TrpGly: 1.125 ± 0.022	0.412TrpHis: 0.412 ± 0.011	0.596TrpIle: 0.596 ± 0.016	0.398TrpLys: 0.398 ± 0.013	1.827TrpLeu: 1.827 ± 0.026	0.308TrpMet: 0.308 ± 0.011	0.449TrpAsn: 0.449 ± 0.014	0.821TrpPro: 0.821 ± 0.013	0.698TrpGln: 0.698 ± 0.016	1.361TrpArg: 1.361 ± 0.021	0.982TrpSer: 0.982 ± 0.02	1.154TrpThr: 1.154 ± 0.024	0.995TrpVal: 0.995 ± 0.022	0.362TrpTrp: 0.362 ± 0.012	0.402TrpTyr: 0.402 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.865TyrAla: 2.865 ± 0.034	0.195TyrCys: 0.195 ± 0.008	1.681TyrAsp: 1.681 ± 0.03	1.372TyrGlu: 1.372 ± 0.022	0.696TyrPhe: 0.696 ± 0.016	2.371TyrGly: 2.371 ± 0.032	0.411TyrHis: 0.411 ± 0.012	0.525TyrIle: 0.525 ± 0.014	0.45TyrLys: 0.45 ± 0.012	2.136TyrLeu: 2.136 ± 0.028	0.271TyrMet: 0.271 ± 0.01	0.462TyrAsn: 0.462 ± 0.015	1.074TyrPro: 1.074 ± 0.02	0.681TyrGln: 0.681 ± 0.019	1.867TyrArg: 1.867 ± 0.028	1.014TyrSer: 1.014 ± 0.023	1.309TyrThr: 1.309 ± 0.025	1.747TyrVal: 1.747 ± 0.025	0.369TyrTrp: 0.369 ± 0.012	0.5TyrTyr: 0.5 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8992 proteins (2870677 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---