Amino acid dipepetide frequency for Flavobacterium dankookense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.832AlaAla: 3.832 ± 0.091
0.491AlaCys: 0.491 ± 0.024
3.015AlaAsp: 3.015 ± 0.061
3.801AlaGlu: 3.801 ± 0.077
3.273AlaPhe: 3.273 ± 0.064
3.916AlaGly: 3.916 ± 0.089
0.84AlaHis: 0.84 ± 0.034
5.283AlaIle: 5.283 ± 0.082
4.684AlaLys: 4.684 ± 0.086
5.444AlaLeu: 5.444 ± 0.086
1.399AlaMet: 1.399 ± 0.043
3.878AlaAsn: 3.878 ± 0.077
1.756AlaPro: 1.756 ± 0.066
2.31AlaGln: 2.31 ± 0.049
1.691AlaArg: 1.691 ± 0.043
3.971AlaSer: 3.971 ± 0.069
4.378AlaThr: 4.378 ± 0.114
3.828AlaVal: 3.828 ± 0.077
0.543AlaTrp: 0.543 ± 0.026
1.981AlaTyr: 1.981 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.469CysAla: 0.469 ± 0.027
0.085CysCys: 0.085 ± 0.009
0.487CysAsp: 0.487 ± 0.026
0.469CysGlu: 0.469 ± 0.023
0.5CysPhe: 0.5 ± 0.025
0.666CysGly: 0.666 ± 0.032
0.171CysHis: 0.171 ± 0.016
0.608CysIle: 0.608 ± 0.027
0.459CysLys: 0.459 ± 0.022
0.728CysLeu: 0.728 ± 0.03
0.117CysMet: 0.117 ± 0.011
0.499CysAsn: 0.499 ± 0.022
0.363CysPro: 0.363 ± 0.024
0.269CysGln: 0.269 ± 0.017
0.162CysArg: 0.162 ± 0.013
0.712CysSer: 0.712 ± 0.04
0.442CysThr: 0.442 ± 0.025
0.466CysVal: 0.466 ± 0.024
0.064CysTrp: 0.064 ± 0.008
0.339CysTyr: 0.339 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.298AspAla: 3.298 ± 0.066
0.467AspCys: 0.467 ± 0.027
2.924AspAsp: 2.924 ± 0.072
3.848AspGlu: 3.848 ± 0.073
3.891AspPhe: 3.891 ± 0.071
3.667AspGly: 3.667 ± 0.086
0.602AspHis: 0.602 ± 0.027
4.13AspIle: 4.13 ± 0.063
4.192AspLys: 4.192 ± 0.077
4.946AspLeu: 4.946 ± 0.081
0.951AspMet: 0.951 ± 0.029
3.448AspAsn: 3.448 ± 0.059
1.176AspPro: 1.176 ± 0.042
1.187AspGln: 1.187 ± 0.037
1.513AspArg: 1.513 ± 0.045
2.742AspSer: 2.742 ± 0.062
2.722AspThr: 2.722 ± 0.059
3.565AspVal: 3.565 ± 0.072
0.712AspTrp: 0.712 ± 0.031
2.856AspTyr: 2.856 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
3.713GluAla: 3.713 ± 0.075
0.36GluCys: 0.36 ± 0.02
3.05GluAsp: 3.05 ± 0.058
4.589GluGlu: 4.589 ± 0.091
3.026GluPhe: 3.026 ± 0.057
3.053GluGly: 3.053 ± 0.058
0.961GluHis: 0.961 ± 0.033
6.083GluIle: 6.083 ± 0.097
6.637GluLys: 6.637 ± 0.125
5.834GluLeu: 5.834 ± 0.096
1.664GluMet: 1.664 ± 0.042
5.414GluAsn: 5.414 ± 0.091
1.476GluPro: 1.476 ± 0.045
2.238GluGln: 2.238 ± 0.051
2.169GluArg: 2.169 ± 0.056
2.931GluSer: 2.931 ± 0.058
4.025GluThr: 4.025 ± 0.067
4.129GluVal: 4.129 ± 0.076
0.55GluTrp: 0.55 ± 0.024
2.419GluTyr: 2.419 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.282PheAla: 3.282 ± 0.071
0.546PheCys: 0.546 ± 0.029
3.57PheAsp: 3.57 ± 0.069
3.811PheGlu: 3.811 ± 0.068
3.122PhePhe: 3.122 ± 0.075
3.899PheGly: 3.899 ± 0.08
0.858PheHis: 0.858 ± 0.03
4.399PheIle: 4.399 ± 0.081
3.822PheLys: 3.822 ± 0.075
4.975PheLeu: 4.975 ± 0.101
1.074PheMet: 1.074 ± 0.039
3.63PheAsn: 3.63 ± 0.07
1.86PhePro: 1.86 ± 0.044
1.792PheGln: 1.792 ± 0.041
1.573PheArg: 1.573 ± 0.04
4.457PheSer: 4.457 ± 0.076
3.349PheThr: 3.349 ± 0.085
3.334PheVal: 3.334 ± 0.066
0.629PheTrp: 0.629 ± 0.029
2.448PheTyr: 2.448 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
3.578GlyAla: 3.578 ± 0.074
0.611GlyCys: 0.611 ± 0.031
2.936GlyAsp: 2.936 ± 0.067
3.196GlyGlu: 3.196 ± 0.065
3.812GlyPhe: 3.812 ± 0.08
4.167GlyGly: 4.167 ± 0.1
0.915GlyHis: 0.915 ± 0.033
5.432GlyIle: 5.432 ± 0.085
4.982GlyLys: 4.982 ± 0.085
5.241GlyLeu: 5.241 ± 0.093
1.486GlyMet: 1.486 ± 0.048
4.125GlyAsn: 4.125 ± 0.101
1.15GlyPro: 1.15 ± 0.035
1.868GlyGln: 1.868 ± 0.047
1.75GlyArg: 1.75 ± 0.054
4.194GlySer: 4.194 ± 0.09
4.552GlyThr: 4.552 ± 0.135
3.94GlyVal: 3.94 ± 0.084
0.639GlyTrp: 0.639 ± 0.032
2.63GlyTyr: 2.63 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
0.777HisAla: 0.777 ± 0.03
0.167HisCys: 0.167 ± 0.012
0.745HisAsp: 0.745 ± 0.029
0.82HisGlu: 0.82 ± 0.03
1.173HisPhe: 1.173 ± 0.038
0.901HisGly: 0.901 ± 0.033
0.392HisHis: 0.392 ± 0.023
1.165HisIle: 1.165 ± 0.044
1.039HisLys: 1.039 ± 0.036
1.533HisLeu: 1.533 ± 0.045
0.271HisMet: 0.271 ± 0.016
0.972HisAsn: 0.972 ± 0.035
0.742HisPro: 0.742 ± 0.03
0.663HisGln: 0.663 ± 0.026
0.511HisArg: 0.511 ± 0.021
0.949HisSer: 0.949 ± 0.033
0.785HisThr: 0.785 ± 0.032
0.764HisVal: 0.764 ± 0.031
0.194HisTrp: 0.194 ± 0.015
0.771HisTyr: 0.771 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.615IleAla: 5.615 ± 0.085
0.696IleCys: 0.696 ± 0.032
5.064IleAsp: 5.064 ± 0.08
5.72IleGlu: 5.72 ± 0.102
3.839IlePhe: 3.839 ± 0.072
5.238IleGly: 5.238 ± 0.096
1.31IleHis: 1.31 ± 0.041
6.783IleIle: 6.783 ± 0.115
6.121IleLys: 6.121 ± 0.101
6.977IleLeu: 6.977 ± 0.117
1.373IleMet: 1.373 ± 0.039
5.422IleAsn: 5.422 ± 0.098
3.31IlePro: 3.31 ± 0.058
2.909IleGln: 2.909 ± 0.065
2.413IleArg: 2.413 ± 0.053
6.023IleSer: 6.023 ± 0.101
5.317IleThr: 5.317 ± 0.086
5.16IleVal: 5.16 ± 0.073
0.694IleTrp: 0.694 ± 0.028
3.118IleTyr: 3.118 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
4.752LysAla: 4.752 ± 0.096
0.393LysCys: 0.393 ± 0.021
4.033LysAsp: 4.033 ± 0.084
6.001LysGlu: 6.001 ± 0.103
3.283LysPhe: 3.283 ± 0.069
4.075LysGly: 4.075 ± 0.077
1.21LysHis: 1.21 ± 0.04
7.225LysIle: 7.225 ± 0.121
7.567LysLys: 7.567 ± 0.154
6.675LysLeu: 6.675 ± 0.11
2.184LysMet: 2.184 ± 0.053
6.048LysAsn: 6.048 ± 0.086
2.564LysPro: 2.564 ± 0.057
2.689LysGln: 2.689 ± 0.062
2.509LysArg: 2.509 ± 0.063
4.916LysSer: 4.916 ± 0.087
4.827LysThr: 4.827 ± 0.092
4.868LysVal: 4.868 ± 0.083
0.753LysTrp: 0.753 ± 0.032
3.085LysTyr: 3.085 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
5.437LeuAla: 5.437 ± 0.086
0.664LeuCys: 0.664 ± 0.029
4.744LeuAsp: 4.744 ± 0.078
5.793LeuGlu: 5.793 ± 0.093
5.241LeuPhe: 5.241 ± 0.096
5.31LeuGly: 5.31 ± 0.085
1.419LeuHis: 1.419 ± 0.041
6.841LeuIle: 6.841 ± 0.101
7.348LeuLys: 7.348 ± 0.112
8.803LeuLeu: 8.803 ± 0.142
1.885LeuMet: 1.885 ± 0.043
5.937LeuAsn: 5.937 ± 0.098
3.461LeuPro: 3.461 ± 0.061
3.082LeuGln: 3.082 ± 0.063
2.726LeuArg: 2.726 ± 0.052
6.62LeuSer: 6.62 ± 0.098
5.268LeuThr: 5.268 ± 0.092
5.241LeuVal: 5.241 ± 0.077
0.766LeuTrp: 0.766 ± 0.038
3.071LeuTyr: 3.071 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
1.423MetAla: 1.423 ± 0.045
0.119MetCys: 0.119 ± 0.012
1.01MetAsp: 1.01 ± 0.035
1.349MetGlu: 1.349 ± 0.037
0.897MetPhe: 0.897 ± 0.033
1.17MetGly: 1.17 ± 0.038
0.346MetHis: 0.346 ± 0.021
1.623MetIle: 1.623 ± 0.038
2.335MetLys: 2.335 ± 0.048
1.856MetLeu: 1.856 ± 0.051
0.573MetMet: 0.573 ± 0.028
1.361MetAsn: 1.361 ± 0.041
0.748MetPro: 0.748 ± 0.03
0.819MetGln: 0.819 ± 0.03
0.757MetArg: 0.757 ± 0.03
1.419MetSer: 1.419 ± 0.043
1.132MetThr: 1.132 ± 0.038
1.253MetVal: 1.253 ± 0.042
0.152MetTrp: 0.152 ± 0.013
0.707MetTyr: 0.707 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.121AsnAla: 4.121 ± 0.082
0.621AsnCys: 0.621 ± 0.033
3.818AsnAsp: 3.818 ± 0.073
4.204AsnGlu: 4.204 ± 0.072
3.82AsnPhe: 3.82 ± 0.089
4.774AsnGly: 4.774 ± 0.108
1.154AsnHis: 1.154 ± 0.035
5.16AsnIle: 5.16 ± 0.076
4.738AsnLys: 4.738 ± 0.091
6.069AsnLeu: 6.069 ± 0.12
1.236AsnMet: 1.236 ± 0.039
4.988AsnAsn: 4.988 ± 0.108
3.286AsnPro: 3.286 ± 0.079
2.881AsnGln: 2.881 ± 0.058
2.11AsnArg: 2.11 ± 0.05
4.849AsnSer: 4.849 ± 0.096
3.923AsnThr: 3.923 ± 0.085
3.952AsnVal: 3.952 ± 0.062
0.888AsnTrp: 0.888 ± 0.036
3.286AsnTyr: 3.286 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
1.94ProAla: 1.94 ± 0.062
0.246ProCys: 0.246 ± 0.02
1.762ProAsp: 1.762 ± 0.048
2.428ProGlu: 2.428 ± 0.058
2.048ProPhe: 2.048 ± 0.048
1.697ProGly: 1.697 ± 0.059
0.48ProHis: 0.48 ± 0.023
2.853ProIle: 2.853 ± 0.055
2.456ProLys: 2.456 ± 0.053
2.685ProLeu: 2.685 ± 0.053
0.707ProMet: 0.707 ± 0.028
2.755ProAsn: 2.755 ± 0.067
0.74ProPro: 0.74 ± 0.04
1.023ProGln: 1.023 ± 0.034
0.792ProArg: 0.792 ± 0.032
2.21ProSer: 2.21 ± 0.049
2.451ProThr: 2.451 ± 0.077
2.199ProVal: 2.199 ± 0.051
0.248ProTrp: 0.248 ± 0.014
1.277ProTyr: 1.277 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.8GlnAla: 1.8 ± 0.048
0.219GlnCys: 0.219 ± 0.018
1.486GlnAsp: 1.486 ± 0.043
2.152GlnGlu: 2.152 ± 0.055
1.883GlnPhe: 1.883 ± 0.045
1.621GlnGly: 1.621 ± 0.043
0.526GlnHis: 0.526 ± 0.022
2.864GlnIle: 2.864 ± 0.059
3.158GlnLys: 3.158 ± 0.07
3.403GlnLeu: 3.403 ± 0.066
0.811GlnMet: 0.811 ± 0.028
2.823GlnAsn: 2.823 ± 0.054
1.076GlnPro: 1.076 ± 0.036
1.326GlnGln: 1.326 ± 0.044
1.076GlnArg: 1.076 ± 0.033
2.124GlnSer: 2.124 ± 0.045
2.136GlnThr: 2.136 ± 0.056
1.922GlnVal: 1.922 ± 0.046
0.319GlnTrp: 0.319 ± 0.021
1.318GlnTyr: 1.318 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
1.646ArgAla: 1.646 ± 0.041
0.192ArgCys: 0.192 ± 0.015
1.481ArgAsp: 1.481 ± 0.04
1.994ArgGlu: 1.994 ± 0.047
1.792ArgPhe: 1.792 ± 0.038
1.543ArgGly: 1.543 ± 0.045
0.468ArgHis: 0.468 ± 0.024
2.684ArgIle: 2.684 ± 0.049
2.536ArgLys: 2.536 ± 0.058
2.774ArgLeu: 2.774 ± 0.055
0.909ArgMet: 0.909 ± 0.033
2.07ArgAsn: 2.07 ± 0.051
0.882ArgPro: 0.882 ± 0.034
0.85ArgGln: 0.85 ± 0.031
1.107ArgArg: 1.107 ± 0.042
1.581ArgSer: 1.581 ± 0.045
1.688ArgThr: 1.688 ± 0.048
1.965ArgVal: 1.965 ± 0.046
0.341ArgTrp: 0.341 ± 0.019
1.281ArgTyr: 1.281 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
3.752SerAla: 3.752 ± 0.074
0.754SerCys: 0.754 ± 0.032
3.329SerAsp: 3.329 ± 0.062
3.906SerGlu: 3.906 ± 0.079
4.27SerPhe: 4.27 ± 0.069
4.701SerGly: 4.701 ± 0.108
0.997SerHis: 0.997 ± 0.033
5.492SerIle: 5.492 ± 0.092
5.152SerLys: 5.152 ± 0.09
5.999SerLeu: 5.999 ± 0.086
1.209SerMet: 1.209 ± 0.038
4.692SerAsn: 4.692 ± 0.085
2.203SerPro: 2.203 ± 0.059
2.368SerGln: 2.368 ± 0.056
1.83SerArg: 1.83 ± 0.046
4.777SerSer: 4.777 ± 0.106
3.942SerThr: 3.942 ± 0.102
4.059SerVal: 4.059 ± 0.063
0.647SerTrp: 0.647 ± 0.024
2.723SerTyr: 2.723 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
3.945ThrAla: 3.945 ± 0.113
0.427ThrCys: 0.427 ± 0.028
3.187ThrAsp: 3.187 ± 0.058
3.424ThrGlu: 3.424 ± 0.058
3.64ThrPhe: 3.64 ± 0.075
4.119ThrGly: 4.119 ± 0.117
0.873ThrHis: 0.873 ± 0.031
5.854ThrIle: 5.854 ± 0.109
4.17ThrLys: 4.17 ± 0.065
5.453ThrLeu: 5.453 ± 0.087
0.979ThrMet: 0.979 ± 0.035
4.283ThrAsn: 4.283 ± 0.094
2.589ThrPro: 2.589 ± 0.078
1.97ThrGln: 1.97 ± 0.054
1.481ThrArg: 1.481 ± 0.043
4.393ThrSer: 4.393 ± 0.103
4.566ThrThr: 4.566 ± 0.144
4.147ThrVal: 4.147 ± 0.098
0.623ThrTrp: 0.623 ± 0.03
2.411ThrTyr: 2.411 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.186ValAla: 4.186 ± 0.081
0.574ValCys: 0.574 ± 0.028
3.4ValAsp: 3.4 ± 0.065
3.987ValGlu: 3.987 ± 0.069
3.584ValPhe: 3.584 ± 0.063
3.741ValGly: 3.741 ± 0.076
0.876ValHis: 0.876 ± 0.036
5.014ValIle: 5.014 ± 0.075
4.533ValLys: 4.533 ± 0.082
5.618ValLeu: 5.618 ± 0.081
1.214ValMet: 1.214 ± 0.036
3.854ValAsn: 3.854 ± 0.079
2.007ValPro: 2.007 ± 0.049
1.765ValGln: 1.765 ± 0.041
1.821ValArg: 1.821 ± 0.043
4.465ValSer: 4.465 ± 0.074
3.99ValThr: 3.99 ± 0.107
4.225ValVal: 4.225 ± 0.074
0.562ValTrp: 0.562 ± 0.029
2.33ValTyr: 2.33 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.564TrpAla: 0.564 ± 0.028
0.095TrpCys: 0.095 ± 0.009
0.507TrpAsp: 0.507 ± 0.022
0.605TrpGlu: 0.605 ± 0.023
0.586TrpPhe: 0.586 ± 0.026
0.525TrpGly: 0.525 ± 0.027
0.201TrpHis: 0.201 ± 0.014
0.785TrpIle: 0.785 ± 0.032
0.775TrpLys: 0.775 ± 0.028
0.9TrpLeu: 0.9 ± 0.032
0.302TrpMet: 0.302 ± 0.017
0.807TrpAsn: 0.807 ± 0.03
0.185TrpPro: 0.185 ± 0.015
0.408TrpGln: 0.408 ± 0.023
0.369TrpArg: 0.369 ± 0.03
0.639TrpSer: 0.639 ± 0.028
0.573TrpThr: 0.573 ± 0.033
0.55TrpVal: 0.55 ± 0.029
0.135TrpTrp: 0.135 ± 0.013
0.432TrpTyr: 0.432 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.183TyrAla: 2.183 ± 0.053
0.35TyrCys: 0.35 ± 0.017
2.288TyrAsp: 2.288 ± 0.05
2.225TyrGlu: 2.225 ± 0.05
2.755TyrPhe: 2.755 ± 0.056
2.421TyrGly: 2.421 ± 0.055
0.735TyrHis: 0.735 ± 0.032
2.824TyrIle: 2.824 ± 0.054
2.951TyrLys: 2.951 ± 0.061
3.745TyrLeu: 3.745 ± 0.069
0.701TyrMet: 0.701 ± 0.028
2.868TyrAsn: 2.868 ± 0.067
1.424TyrPro: 1.424 ± 0.041
1.627TyrGln: 1.627 ± 0.049
1.424TyrArg: 1.424 ± 0.044
2.83TyrSer: 2.83 ± 0.055
2.467TyrThr: 2.467 ± 0.067
2.181TyrVal: 2.181 ± 0.05
0.485TyrTrp: 0.485 ± 0.023
1.809TyrTyr: 1.809 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2803 proteins (969894 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski