Amino acid dipepetide frequency for Dorea sp. CAG:317

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.622AlaAla: 6.622 ± 0.13
1.154AlaCys: 1.154 ± 0.051
4.31AlaAsp: 4.31 ± 0.089
5.548AlaGlu: 5.548 ± 0.102
2.979AlaPhe: 2.979 ± 0.067
6.208AlaGly: 6.208 ± 0.111
1.124AlaHis: 1.124 ± 0.038
5.237AlaIle: 5.237 ± 0.106
5.274AlaLys: 5.274 ± 0.099
6.776AlaLeu: 6.776 ± 0.107
2.498AlaMet: 2.498 ± 0.064
2.521AlaAsn: 2.521 ± 0.073
1.936AlaPro: 1.936 ± 0.055
2.157AlaGln: 2.157 ± 0.064
2.83AlaArg: 2.83 ± 0.066
3.93AlaSer: 3.93 ± 0.083
3.01AlaThr: 3.01 ± 0.072
6.302AlaVal: 6.302 ± 0.1
0.524AlaTrp: 0.524 ± 0.028
2.835AlaTyr: 2.835 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.994CysAla: 0.994 ± 0.04
0.283CysCys: 0.283 ± 0.021
0.796CysAsp: 0.796 ± 0.038
1.032CysGlu: 1.032 ± 0.04
0.618CysPhe: 0.618 ± 0.031
1.543CysGly: 1.543 ± 0.046
0.344CysHis: 0.344 ± 0.023
1.085CysIle: 1.085 ± 0.044
0.898CysLys: 0.898 ± 0.036
1.111CysLeu: 1.111 ± 0.04
0.441CysMet: 0.441 ± 0.028
0.555CysAsn: 0.555 ± 0.031
0.66CysPro: 0.66 ± 0.036
0.404CysGln: 0.404 ± 0.024
0.627CysArg: 0.627 ± 0.031
0.823CysSer: 0.823 ± 0.038
0.736CysThr: 0.736 ± 0.034
1.179CysVal: 1.179 ± 0.046
0.097CysTrp: 0.097 ± 0.012
0.578CysTyr: 0.578 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.1AspAla: 4.1 ± 0.098
0.764AspCys: 0.764 ± 0.033
2.671AspAsp: 2.671 ± 0.073
4.668AspGlu: 4.668 ± 0.097
2.435AspPhe: 2.435 ± 0.067
4.189AspGly: 4.189 ± 0.088
0.911AspHis: 0.911 ± 0.036
4.348AspIle: 4.348 ± 0.08
3.675AspLys: 3.675 ± 0.096
4.452AspLeu: 4.452 ± 0.091
1.94AspMet: 1.94 ± 0.049
1.949AspAsn: 1.949 ± 0.064
1.578AspPro: 1.578 ± 0.049
1.52AspGln: 1.52 ± 0.05
2.413AspArg: 2.413 ± 0.057
2.739AspSer: 2.739 ± 0.062
2.996AspThr: 2.996 ± 0.07
4.091AspVal: 4.091 ± 0.083
0.517AspTrp: 0.517 ± 0.03
2.763AspTyr: 2.763 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
6.105GluAla: 6.105 ± 0.119
0.878GluCys: 0.878 ± 0.038
4.71GluAsp: 4.71 ± 0.09
9.315GluGlu: 9.315 ± 0.174
2.716GluPhe: 2.716 ± 0.061
4.877GluGly: 4.877 ± 0.093
1.54GluHis: 1.54 ± 0.057
6.004GluIle: 6.004 ± 0.105
7.578GluLys: 7.578 ± 0.114
7.537GluLeu: 7.537 ± 0.115
2.666GluMet: 2.666 ± 0.064
4.007GluAsn: 4.007 ± 0.082
1.9GluPro: 1.9 ± 0.059
3.101GluGln: 3.101 ± 0.085
3.732GluArg: 3.732 ± 0.084
3.281GluSer: 3.281 ± 0.078
3.893GluThr: 3.893 ± 0.079
5.316GluVal: 5.316 ± 0.098
0.657GluTrp: 0.657 ± 0.031
3.28GluTyr: 3.28 ± 0.081
0.0GluXaa: 0.0 ± 0.0
Phe
2.974PheAla: 2.974 ± 0.075
0.72PheCys: 0.72 ± 0.03
2.394PheAsp: 2.394 ± 0.07
2.707PheGlu: 2.707 ± 0.062
1.785PhePhe: 1.785 ± 0.074
3.173PheGly: 3.173 ± 0.079
0.874PheHis: 0.874 ± 0.039
2.729PheIle: 2.729 ± 0.077
2.0PheLys: 2.0 ± 0.055
4.016PheLeu: 4.016 ± 0.086
1.095PheMet: 1.095 ± 0.04
1.268PheAsn: 1.268 ± 0.048
1.36PhePro: 1.36 ± 0.049
1.354PheGln: 1.354 ± 0.05
1.584PheArg: 1.584 ± 0.044
2.581PheSer: 2.581 ± 0.068
2.195PheThr: 2.195 ± 0.067
2.915PheVal: 2.915 ± 0.068
0.388PheTrp: 0.388 ± 0.025
1.637PheTyr: 1.637 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
5.427GlyAla: 5.427 ± 0.1
1.268GlyCys: 1.268 ± 0.05
3.338GlyAsp: 3.338 ± 0.076
5.256GlyGlu: 5.256 ± 0.096
3.13GlyPhe: 3.13 ± 0.076
4.946GlyGly: 4.946 ± 0.109
1.28GlyHis: 1.28 ± 0.045
6.427GlyIle: 6.427 ± 0.104
5.754GlyLys: 5.754 ± 0.101
5.979GlyLeu: 5.979 ± 0.097
2.675GlyMet: 2.675 ± 0.065
3.083GlyAsn: 3.083 ± 0.091
1.36GlyPro: 1.36 ± 0.049
2.094GlyGln: 2.094 ± 0.051
3.08GlyArg: 3.08 ± 0.076
3.681GlySer: 3.681 ± 0.064
4.384GlyThr: 4.384 ± 0.093
5.482GlyVal: 5.482 ± 0.101
0.599GlyTrp: 0.599 ± 0.034
3.247GlyTyr: 3.247 ± 0.068
0.001GlyXaa: 0.001 ± 0.002
His
1.24HisAla: 1.24 ± 0.042
0.309HisCys: 0.309 ± 0.024
0.898HisAsp: 0.898 ± 0.034
1.124HisGlu: 1.124 ± 0.043
0.801HisPhe: 0.801 ± 0.036
1.326HisGly: 1.326 ± 0.047
0.398HisHis: 0.398 ± 0.026
1.4HisIle: 1.4 ± 0.042
1.028HisLys: 1.028 ± 0.042
1.681HisLeu: 1.681 ± 0.063
0.662HisMet: 0.662 ± 0.035
0.681HisAsn: 0.681 ± 0.034
0.871HisPro: 0.871 ± 0.038
0.581HisGln: 0.581 ± 0.028
0.729HisArg: 0.729 ± 0.033
0.933HisSer: 0.933 ± 0.04
1.035HisThr: 1.035 ± 0.042
1.265HisVal: 1.265 ± 0.042
0.129HisTrp: 0.129 ± 0.015
0.763HisTyr: 0.763 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.752IleAla: 5.752 ± 0.113
1.324IleCys: 1.324 ± 0.041
4.187IleAsp: 4.187 ± 0.084
5.299IleGlu: 5.299 ± 0.093
3.041IlePhe: 3.041 ± 0.087
5.466IleGly: 5.466 ± 0.088
1.43IleHis: 1.43 ± 0.046
5.02IleIle: 5.02 ± 0.098
4.208IleLys: 4.208 ± 0.079
7.111IleLeu: 7.111 ± 0.108
2.037IleMet: 2.037 ± 0.051
2.594IleAsn: 2.594 ± 0.061
3.1IlePro: 3.1 ± 0.072
2.401IleGln: 2.401 ± 0.064
3.553IleArg: 3.553 ± 0.064
4.463IleSer: 4.463 ± 0.086
4.067IleThr: 4.067 ± 0.072
5.416IleVal: 5.416 ± 0.103
0.602IleTrp: 0.602 ± 0.032
2.796IleTyr: 2.796 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
5.158LysAla: 5.158 ± 0.108
0.766LysCys: 0.766 ± 0.038
4.075LysAsp: 4.075 ± 0.088
8.129LysGlu: 8.129 ± 0.123
1.862LysPhe: 1.862 ± 0.059
4.388LysGly: 4.388 ± 0.087
1.12LysHis: 1.12 ± 0.039
5.201LysIle: 5.201 ± 0.095
6.755LysLys: 6.755 ± 0.109
5.837LysLeu: 5.837 ± 0.084
2.419LysMet: 2.419 ± 0.059
3.733LysAsn: 3.733 ± 0.077
1.925LysPro: 1.925 ± 0.06
2.294LysGln: 2.294 ± 0.069
3.381LysArg: 3.381 ± 0.083
3.288LysSer: 3.288 ± 0.077
3.798LysThr: 3.798 ± 0.093
4.827LysVal: 4.827 ± 0.088
0.558LysTrp: 0.558 ± 0.026
2.988LysTyr: 2.988 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
6.804LeuAla: 6.804 ± 0.12
1.473LeuCys: 1.473 ± 0.054
4.99LeuAsp: 4.99 ± 0.096
6.526LeuGlu: 6.526 ± 0.102
3.817LeuPhe: 3.817 ± 0.101
6.321LeuGly: 6.321 ± 0.096
1.596LeuHis: 1.596 ± 0.047
6.028LeuIle: 6.028 ± 0.132
6.628LeuLys: 6.628 ± 0.105
8.439LeuLeu: 8.439 ± 0.12
2.691LeuMet: 2.691 ± 0.06
3.646LeuAsn: 3.646 ± 0.076
3.537LeuPro: 3.537 ± 0.078
2.662LeuGln: 2.662 ± 0.071
3.731LeuArg: 3.731 ± 0.08
5.978LeuSer: 5.978 ± 0.101
5.17LeuThr: 5.17 ± 0.094
5.719LeuVal: 5.719 ± 0.096
0.685LeuTrp: 0.685 ± 0.034
3.319LeuTyr: 3.319 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
2.413MetAla: 2.413 ± 0.062
0.4MetCys: 0.4 ± 0.024
1.9MetAsp: 1.9 ± 0.046
2.87MetGlu: 2.87 ± 0.068
1.088MetPhe: 1.088 ± 0.041
2.211MetGly: 2.211 ± 0.065
0.448MetHis: 0.448 ± 0.025
2.357MetIle: 2.357 ± 0.069
2.917MetLys: 2.917 ± 0.067
2.83MetLeu: 2.83 ± 0.082
1.066MetMet: 1.066 ± 0.041
1.565MetAsn: 1.565 ± 0.048
1.082MetPro: 1.082 ± 0.041
1.06MetGln: 1.06 ± 0.036
1.246MetArg: 1.246 ± 0.047
1.864MetSer: 1.864 ± 0.05
1.821MetThr: 1.821 ± 0.047
2.022MetVal: 2.022 ± 0.058
0.247MetTrp: 0.247 ± 0.018
1.022MetTyr: 1.022 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.906AsnAla: 2.906 ± 0.069
0.615AsnCys: 0.615 ± 0.032
2.056AsnAsp: 2.056 ± 0.055
2.862AsnGlu: 2.862 ± 0.065
1.469AsnPhe: 1.469 ± 0.046
3.244AsnGly: 3.244 ± 0.08
0.886AsnHis: 0.886 ± 0.035
3.237AsnIle: 3.237 ± 0.073
2.473AsnLys: 2.473 ± 0.064
3.687AsnLeu: 3.687 ± 0.072
1.388AsnMet: 1.388 ± 0.044
1.543AsnAsn: 1.543 ± 0.055
1.846AsnPro: 1.846 ± 0.059
1.406AsnGln: 1.406 ± 0.041
1.861AsnArg: 1.861 ± 0.057
2.088AsnSer: 2.088 ± 0.061
2.157AsnThr: 2.157 ± 0.061
2.902AsnVal: 2.902 ± 0.065
0.365AsnTrp: 0.365 ± 0.019
1.814AsnTyr: 1.814 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
2.307ProAla: 2.307 ± 0.06
0.458ProCys: 0.458 ± 0.028
1.991ProAsp: 1.991 ± 0.054
3.223ProGlu: 3.223 ± 0.077
1.428ProPhe: 1.428 ± 0.048
2.209ProGly: 2.209 ± 0.058
0.539ProHis: 0.539 ± 0.03
2.12ProIle: 2.12 ± 0.052
2.015ProLys: 2.015 ± 0.051
2.722ProLeu: 2.722 ± 0.071
0.934ProMet: 0.934 ± 0.035
1.306ProAsn: 1.306 ± 0.042
0.64ProPro: 0.64 ± 0.033
0.928ProGln: 0.928 ± 0.039
0.943ProArg: 0.943 ± 0.036
1.753ProSer: 1.753 ± 0.061
1.511ProThr: 1.511 ± 0.051
2.78ProVal: 2.78 ± 0.067
0.286ProTrp: 0.286 ± 0.022
1.419ProTyr: 1.419 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.206GlnAla: 2.206 ± 0.056
0.379GlnCys: 0.379 ± 0.023
1.466GlnAsp: 1.466 ± 0.05
2.946GlnGlu: 2.946 ± 0.081
1.202GlnPhe: 1.202 ± 0.04
2.013GlnGly: 2.013 ± 0.06
0.461GlnHis: 0.461 ± 0.025
2.71GlnIle: 2.71 ± 0.064
2.65GlnLys: 2.65 ± 0.074
2.773GlnLeu: 2.773 ± 0.067
1.305GlnMet: 1.305 ± 0.047
1.422GlnAsn: 1.422 ± 0.047
0.83GlnPro: 0.83 ± 0.04
1.076GlnGln: 1.076 ± 0.042
1.288GlnArg: 1.288 ± 0.045
1.527GlnSer: 1.527 ± 0.045
1.599GlnThr: 1.599 ± 0.048
2.201GlnVal: 2.201 ± 0.058
0.29GlnTrp: 0.29 ± 0.023
1.221GlnTyr: 1.221 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.662ArgAla: 2.662 ± 0.058
0.529ArgCys: 0.529 ± 0.029
2.022ArgAsp: 2.022 ± 0.056
4.053ArgGlu: 4.053 ± 0.093
1.695ArgPhe: 1.695 ± 0.048
2.602ArgGly: 2.602 ± 0.057
0.782ArgHis: 0.782 ± 0.034
3.398ArgIle: 3.398 ± 0.064
3.731ArgLys: 3.731 ± 0.08
3.692ArgLeu: 3.692 ± 0.084
1.552ArgMet: 1.552 ± 0.052
1.906ArgAsn: 1.906 ± 0.055
1.24ArgPro: 1.24 ± 0.051
1.66ArgGln: 1.66 ± 0.058
2.319ArgArg: 2.319 ± 0.066
2.107ArgSer: 2.107 ± 0.059
2.179ArgThr: 2.179 ± 0.057
2.687ArgVal: 2.687 ± 0.069
0.331ArgTrp: 0.331 ± 0.023
1.753ArgTyr: 1.753 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
3.795SerAla: 3.795 ± 0.083
0.835SerCys: 0.835 ± 0.038
3.039SerAsp: 3.039 ± 0.08
4.003SerGlu: 4.003 ± 0.085
2.394SerPhe: 2.394 ± 0.069
4.736SerGly: 4.736 ± 0.092
1.019SerHis: 1.019 ± 0.043
3.946SerIle: 3.946 ± 0.084
3.451SerLys: 3.451 ± 0.079
4.817SerLeu: 4.817 ± 0.083
1.773SerMet: 1.773 ± 0.059
2.064SerAsn: 2.064 ± 0.059
1.574SerPro: 1.574 ± 0.056
1.606SerGln: 1.606 ± 0.047
2.362SerArg: 2.362 ± 0.057
3.12SerSer: 3.12 ± 0.082
2.543SerThr: 2.543 ± 0.078
4.288SerVal: 4.288 ± 0.089
0.454SerTrp: 0.454 ± 0.027
2.324SerTyr: 2.324 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
4.148ThrAla: 4.148 ± 0.098
0.681ThrCys: 0.681 ± 0.035
2.921ThrAsp: 2.921 ± 0.088
3.956ThrGlu: 3.956 ± 0.076
2.151ThrPhe: 2.151 ± 0.059
4.665ThrGly: 4.665 ± 0.091
0.845ThrHis: 0.845 ± 0.034
3.845ThrIle: 3.845 ± 0.079
3.297ThrLys: 3.297 ± 0.071
4.855ThrLeu: 4.855 ± 0.084
1.483ThrMet: 1.483 ± 0.044
1.925ThrAsn: 1.925 ± 0.058
2.053ThrPro: 2.053 ± 0.055
1.4ThrGln: 1.4 ± 0.045
1.871ThrArg: 1.871 ± 0.051
2.871ThrSer: 2.871 ± 0.071
2.883ThrThr: 2.883 ± 0.092
4.304ThrVal: 4.304 ± 0.07
0.414ThrTrp: 0.414 ± 0.028
2.205ThrTyr: 2.205 ± 0.098
0.0ThrXaa: 0.0 ± 0.0
Val
4.947ValAla: 4.947 ± 0.105
1.212ValCys: 1.212 ± 0.04
3.962ValAsp: 3.962 ± 0.078
5.397ValGlu: 5.397 ± 0.101
3.039ValPhe: 3.039 ± 0.079
4.751ValGly: 4.751 ± 0.105
1.215ValHis: 1.215 ± 0.049
5.403ValIle: 5.403 ± 0.105
5.075ValLys: 5.075 ± 0.1
7.01ValLeu: 7.01 ± 0.11
2.316ValMet: 2.316 ± 0.057
2.924ValAsn: 2.924 ± 0.064
2.49ValPro: 2.49 ± 0.061
2.032ValGln: 2.032 ± 0.057
2.988ValArg: 2.988 ± 0.072
4.587ValSer: 4.587 ± 0.085
4.23ValThr: 4.23 ± 0.089
5.284ValVal: 5.284 ± 0.097
0.632ValTrp: 0.632 ± 0.032
2.714ValTyr: 2.714 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.51TrpAla: 0.51 ± 0.032
0.141TrpCys: 0.141 ± 0.016
0.464TrpAsp: 0.464 ± 0.026
0.671TrpGlu: 0.671 ± 0.031
0.366TrpPhe: 0.366 ± 0.024
0.592TrpGly: 0.592 ± 0.033
0.139TrpHis: 0.139 ± 0.014
0.592TrpIle: 0.592 ± 0.03
0.775TrpLys: 0.775 ± 0.039
0.769TrpLeu: 0.769 ± 0.033
0.318TrpMet: 0.318 ± 0.019
0.419TrpAsn: 0.419 ± 0.025
0.182TrpPro: 0.182 ± 0.015
0.307TrpGln: 0.307 ± 0.022
0.337TrpArg: 0.337 ± 0.027
0.403TrpSer: 0.403 ± 0.027
0.366TrpThr: 0.366 ± 0.023
0.473TrpVal: 0.473 ± 0.028
0.083TrpTrp: 0.083 ± 0.012
0.296TrpTyr: 0.296 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.703TyrAla: 2.703 ± 0.059
0.616TyrCys: 0.616 ± 0.034
2.527TyrAsp: 2.527 ± 0.117
3.514TyrGlu: 3.514 ± 0.091
1.734TyrPhe: 1.734 ± 0.056
3.034TyrGly: 3.034 ± 0.066
0.903TyrHis: 0.903 ± 0.038
2.78TyrIle: 2.78 ± 0.063
2.322TyrLys: 2.322 ± 0.063
3.662TyrLeu: 3.662 ± 0.089
1.17TyrMet: 1.17 ± 0.041
1.691TyrAsn: 1.691 ± 0.058
1.346TyrPro: 1.346 ± 0.042
1.521TyrGln: 1.521 ± 0.055
2.023TyrArg: 2.023 ± 0.067
2.127TyrSer: 2.127 ± 0.06
2.201TyrThr: 2.201 ± 0.07
2.758TyrVal: 2.758 ± 0.062
0.341TyrTrp: 0.341 ± 0.024
1.88TyrTyr: 1.88 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.001XaaLys: 0.001 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.003
Statistics based on 2206 proteins (683009 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski