Amino acid dipepetide frequency for Ralstonia phage P-PSG-11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.63AlaAla: 12.63 ± 1.258
0.339AlaCys: 0.339 ± 0.188
6.612AlaAsp: 6.612 ± 0.672
5.849AlaGlu: 5.849 ± 0.816
3.052AlaPhe: 3.052 ± 0.444
8.731AlaGly: 8.731 ± 1.074
1.187AlaHis: 1.187 ± 0.278
4.832AlaIle: 4.832 ± 0.674
6.103AlaLys: 6.103 ± 0.792
8.222AlaLeu: 8.222 ± 0.887
2.204AlaMet: 2.204 ± 0.609
5.086AlaAsn: 5.086 ± 0.649
3.56AlaPro: 3.56 ± 0.704
4.323AlaGln: 4.323 ± 0.885
4.493AlaArg: 4.493 ± 0.593
6.527AlaSer: 6.527 ± 0.675
5.001AlaThr: 5.001 ± 0.785
6.951AlaVal: 6.951 ± 0.813
1.272AlaTrp: 1.272 ± 0.337
3.475AlaTyr: 3.475 ± 0.59
0.0AlaXaa: 0.0 ± 0.0
Cys
0.763CysAla: 0.763 ± 0.219
0.0CysCys: 0.0 ± 0.0
0.254CysAsp: 0.254 ± 0.125
0.424CysGlu: 0.424 ± 0.163
0.424CysPhe: 0.424 ± 0.216
0.254CysGly: 0.254 ± 0.189
0.0CysHis: 0.0 ± 0.0
0.593CysIle: 0.593 ± 0.234
0.17CysLys: 0.17 ± 0.115
0.509CysLeu: 0.509 ± 0.264
0.0CysMet: 0.0 ± 0.0
0.17CysAsn: 0.17 ± 0.11
0.339CysPro: 0.339 ± 0.192
0.254CysGln: 0.254 ± 0.192
0.593CysArg: 0.593 ± 0.278
0.509CysSer: 0.509 ± 0.204
0.17CysThr: 0.17 ± 0.109
0.509CysVal: 0.509 ± 0.242
0.085CysTrp: 0.085 ± 0.081
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.832AspAla: 4.832 ± 0.689
0.339AspCys: 0.339 ± 0.146
3.73AspAsp: 3.73 ± 0.824
3.899AspGlu: 3.899 ± 0.595
3.475AspPhe: 3.475 ± 0.583
4.917AspGly: 4.917 ± 0.83
1.017AspHis: 1.017 ± 0.249
3.73AspIle: 3.73 ± 0.598
3.984AspLys: 3.984 ± 0.857
5.425AspLeu: 5.425 ± 0.551
1.695AspMet: 1.695 ± 0.355
2.882AspAsn: 2.882 ± 0.403
2.543AspPro: 2.543 ± 0.452
1.526AspGln: 1.526 ± 0.347
3.221AspArg: 3.221 ± 0.358
2.797AspSer: 2.797 ± 0.601
3.899AspThr: 3.899 ± 0.586
3.815AspVal: 3.815 ± 0.595
0.763AspTrp: 0.763 ± 0.19
2.119AspTyr: 2.119 ± 0.426
0.0AspXaa: 0.0 ± 0.0
Glu
5.934GluAla: 5.934 ± 0.659
0.593GluCys: 0.593 ± 0.235
3.136GluAsp: 3.136 ± 0.747
4.577GluGlu: 4.577 ± 0.967
3.136GluPhe: 3.136 ± 0.561
4.323GluGly: 4.323 ± 0.86
1.356GluHis: 1.356 ± 0.418
2.373GluIle: 2.373 ± 0.422
4.917GluLys: 4.917 ± 0.747
5.595GluLeu: 5.595 ± 0.749
1.526GluMet: 1.526 ± 0.418
3.052GluAsn: 3.052 ± 0.45
2.034GluPro: 2.034 ± 0.435
2.289GluGln: 2.289 ± 0.512
3.899GluArg: 3.899 ± 0.656
3.136GluSer: 3.136 ± 0.429
2.967GluThr: 2.967 ± 0.439
3.73GluVal: 3.73 ± 0.608
1.611GluTrp: 1.611 ± 0.455
1.78GluTyr: 1.78 ± 0.394
0.0GluXaa: 0.0 ± 0.0
Phe
2.458PheAla: 2.458 ± 0.427
0.339PheCys: 0.339 ± 0.167
3.391PheAsp: 3.391 ± 0.562
2.204PheGlu: 2.204 ± 0.399
1.102PhePhe: 1.102 ± 0.377
2.967PheGly: 2.967 ± 0.629
0.424PheHis: 0.424 ± 0.191
1.78PheIle: 1.78 ± 0.444
2.204PheLys: 2.204 ± 0.556
2.628PheLeu: 2.628 ± 0.385
0.932PheMet: 0.932 ± 0.298
1.526PheAsn: 1.526 ± 0.318
2.034PhePro: 2.034 ± 0.404
1.611PheGln: 1.611 ± 0.327
2.967PheArg: 2.967 ± 0.523
3.052PheSer: 3.052 ± 0.495
2.797PheThr: 2.797 ± 0.452
2.628PheVal: 2.628 ± 0.436
0.424PheTrp: 0.424 ± 0.153
1.017PheTyr: 1.017 ± 0.378
0.0PheXaa: 0.0 ± 0.0
Gly
6.697GlyAla: 6.697 ± 0.663
0.424GlyCys: 0.424 ± 0.192
5.51GlyAsp: 5.51 ± 0.476
5.001GlyGlu: 5.001 ± 0.811
3.73GlyPhe: 3.73 ± 0.522
6.273GlyGly: 6.273 ± 1.022
1.187GlyHis: 1.187 ± 0.332
3.815GlyIle: 3.815 ± 0.543
5.595GlyLys: 5.595 ± 0.912
7.46GlyLeu: 7.46 ± 0.91
1.526GlyMet: 1.526 ± 0.436
3.984GlyAsn: 3.984 ± 0.718
1.695GlyPro: 1.695 ± 0.34
2.882GlyGln: 2.882 ± 0.581
4.323GlyArg: 4.323 ± 0.751
5.001GlySer: 5.001 ± 0.889
6.273GlyThr: 6.273 ± 1.077
5.849GlyVal: 5.849 ± 0.614
1.865GlyTrp: 1.865 ± 0.457
2.628GlyTyr: 2.628 ± 0.397
0.0GlyXaa: 0.0 ± 0.0
His
1.187HisAla: 1.187 ± 0.304
0.339HisCys: 0.339 ± 0.174
0.678HisAsp: 0.678 ± 0.243
0.932HisGlu: 0.932 ± 0.278
0.678HisPhe: 0.678 ± 0.193
1.611HisGly: 1.611 ± 0.565
0.085HisHis: 0.085 ± 0.079
1.187HisIle: 1.187 ± 0.331
0.848HisLys: 0.848 ± 0.265
2.713HisLeu: 2.713 ± 0.444
0.678HisMet: 0.678 ± 0.202
0.509HisAsn: 0.509 ± 0.175
0.593HisPro: 0.593 ± 0.225
0.424HisGln: 0.424 ± 0.189
1.187HisArg: 1.187 ± 0.321
0.848HisSer: 0.848 ± 0.252
0.848HisThr: 0.848 ± 0.234
1.272HisVal: 1.272 ± 0.275
0.254HisTrp: 0.254 ± 0.139
0.339HisTyr: 0.339 ± 0.159
0.0HisXaa: 0.0 ± 0.0
Ile
5.256IleAla: 5.256 ± 0.745
0.17IleCys: 0.17 ± 0.146
3.73IleAsp: 3.73 ± 0.603
3.391IleGlu: 3.391 ± 0.452
0.593IlePhe: 0.593 ± 0.21
4.408IleGly: 4.408 ± 0.535
0.763IleHis: 0.763 ± 0.271
2.458IleIle: 2.458 ± 0.558
2.628IleLys: 2.628 ± 0.447
3.645IleLeu: 3.645 ± 0.596
0.339IleMet: 0.339 ± 0.141
2.289IleAsn: 2.289 ± 0.344
2.034IlePro: 2.034 ± 0.404
2.119IleGln: 2.119 ± 0.402
2.458IleArg: 2.458 ± 0.446
2.797IleSer: 2.797 ± 0.477
3.815IleThr: 3.815 ± 0.933
3.306IleVal: 3.306 ± 0.533
0.848IleTrp: 0.848 ± 0.251
1.102IleTyr: 1.102 ± 0.271
0.0IleXaa: 0.0 ± 0.0
Lys
7.205LysAla: 7.205 ± 0.882
0.17LysCys: 0.17 ± 0.106
4.662LysAsp: 4.662 ± 0.646
3.391LysGlu: 3.391 ± 0.541
2.204LysPhe: 2.204 ± 0.359
4.747LysGly: 4.747 ± 0.961
1.695LysHis: 1.695 ± 0.449
2.543LysIle: 2.543 ± 0.497
3.391LysLys: 3.391 ± 0.582
5.34LysLeu: 5.34 ± 0.751
1.272LysMet: 1.272 ± 0.359
1.272LysAsn: 1.272 ± 0.362
2.628LysPro: 2.628 ± 0.54
2.628LysGln: 2.628 ± 0.466
3.815LysArg: 3.815 ± 0.415
3.136LysSer: 3.136 ± 0.67
3.391LysThr: 3.391 ± 0.458
4.832LysVal: 4.832 ± 0.639
1.356LysTrp: 1.356 ± 0.405
1.95LysTyr: 1.95 ± 0.338
0.0LysXaa: 0.0 ± 0.0
Leu
8.392LeuAla: 8.392 ± 0.906
0.085LeuCys: 0.085 ± 0.091
4.238LeuAsp: 4.238 ± 0.525
5.425LeuGlu: 5.425 ± 0.831
2.204LeuPhe: 2.204 ± 0.381
6.358LeuGly: 6.358 ± 0.767
1.78LeuHis: 1.78 ± 0.447
4.069LeuIle: 4.069 ± 0.593
6.358LeuLys: 6.358 ± 0.731
6.358LeuLeu: 6.358 ± 0.73
3.306LeuMet: 3.306 ± 0.528
3.052LeuAsn: 3.052 ± 0.509
4.493LeuPro: 4.493 ± 0.827
3.136LeuGln: 3.136 ± 0.521
4.577LeuArg: 4.577 ± 0.775
5.256LeuSer: 5.256 ± 0.471
4.917LeuThr: 4.917 ± 0.568
5.764LeuVal: 5.764 ± 0.647
0.678LeuTrp: 0.678 ± 0.29
3.475LeuTyr: 3.475 ± 0.605
0.0LeuXaa: 0.0 ± 0.0
Met
2.713MetAla: 2.713 ± 0.439
0.085MetCys: 0.085 ± 0.103
1.102MetAsp: 1.102 ± 0.35
1.272MetGlu: 1.272 ± 0.325
0.848MetPhe: 0.848 ± 0.287
1.95MetGly: 1.95 ± 0.656
0.254MetHis: 0.254 ± 0.18
1.017MetIle: 1.017 ± 0.366
1.187MetLys: 1.187 ± 0.283
1.526MetLeu: 1.526 ± 0.348
0.593MetMet: 0.593 ± 0.278
0.763MetAsn: 0.763 ± 0.305
1.102MetPro: 1.102 ± 0.262
1.102MetGln: 1.102 ± 0.311
1.695MetArg: 1.695 ± 0.52
1.611MetSer: 1.611 ± 0.367
1.95MetThr: 1.95 ± 0.347
1.695MetVal: 1.695 ± 0.348
0.424MetTrp: 0.424 ± 0.146
0.763MetTyr: 0.763 ± 0.278
0.0MetXaa: 0.0 ± 0.0
Asn
3.56AsnAla: 3.56 ± 0.555
0.339AsnCys: 0.339 ± 0.176
1.356AsnAsp: 1.356 ± 0.301
2.882AsnGlu: 2.882 ± 0.426
2.119AsnPhe: 2.119 ± 0.457
4.747AsnGly: 4.747 ± 0.898
0.848AsnHis: 0.848 ± 0.292
1.441AsnIle: 1.441 ± 0.436
2.967AsnLys: 2.967 ± 0.367
3.73AsnLeu: 3.73 ± 0.633
0.848AsnMet: 0.848 ± 0.248
1.95AsnAsn: 1.95 ± 0.386
2.628AsnPro: 2.628 ± 0.36
1.695AsnGln: 1.695 ± 0.418
2.034AsnArg: 2.034 ± 0.446
2.119AsnSer: 2.119 ± 0.401
2.628AsnThr: 2.628 ± 0.712
2.289AsnVal: 2.289 ± 0.448
0.254AsnTrp: 0.254 ± 0.144
1.017AsnTyr: 1.017 ± 0.295
0.0AsnXaa: 0.0 ± 0.0
Pro
5.086ProAla: 5.086 ± 0.726
0.254ProCys: 0.254 ± 0.134
2.797ProAsp: 2.797 ± 0.575
3.475ProGlu: 3.475 ± 0.744
1.95ProPhe: 1.95 ± 0.381
3.221ProGly: 3.221 ± 0.522
0.593ProHis: 0.593 ± 0.18
0.932ProIle: 0.932 ± 0.341
2.373ProLys: 2.373 ± 0.447
3.475ProLeu: 3.475 ± 0.66
1.187ProMet: 1.187 ± 0.318
1.95ProAsn: 1.95 ± 0.34
2.713ProPro: 2.713 ± 0.786
1.695ProGln: 1.695 ± 0.448
2.119ProArg: 2.119 ± 0.382
2.289ProSer: 2.289 ± 0.549
3.052ProThr: 3.052 ± 0.645
4.154ProVal: 4.154 ± 0.526
0.678ProTrp: 0.678 ± 0.239
1.356ProTyr: 1.356 ± 0.257
0.0ProXaa: 0.0 ± 0.0
Gln
5.34GlnAla: 5.34 ± 0.886
0.17GlnCys: 0.17 ± 0.121
2.034GlnAsp: 2.034 ± 0.515
2.458GlnGlu: 2.458 ± 0.552
2.458GlnPhe: 2.458 ± 0.465
2.882GlnGly: 2.882 ± 0.471
0.509GlnHis: 0.509 ± 0.242
2.119GlnIle: 2.119 ± 0.412
2.543GlnLys: 2.543 ± 0.534
3.052GlnLeu: 3.052 ± 0.415
0.932GlnMet: 0.932 ± 0.349
1.017GlnAsn: 1.017 ± 0.336
1.272GlnPro: 1.272 ± 0.309
2.882GlnGln: 2.882 ± 0.744
2.628GlnArg: 2.628 ± 0.481
1.78GlnSer: 1.78 ± 0.407
1.78GlnThr: 1.78 ± 0.383
2.204GlnVal: 2.204 ± 0.338
1.017GlnTrp: 1.017 ± 0.288
1.187GlnTyr: 1.187 ± 0.255
0.0GlnXaa: 0.0 ± 0.0
Arg
5.425ArgAla: 5.425 ± 0.754
0.509ArgCys: 0.509 ± 0.304
3.899ArgAsp: 3.899 ± 0.577
3.391ArgGlu: 3.391 ± 0.585
2.119ArgPhe: 2.119 ± 0.37
4.408ArgGly: 4.408 ± 0.647
0.932ArgHis: 0.932 ± 0.22
3.73ArgIle: 3.73 ± 0.559
3.306ArgLys: 3.306 ± 0.554
4.832ArgLeu: 4.832 ± 0.59
1.272ArgMet: 1.272 ± 0.331
1.95ArgAsn: 1.95 ± 0.376
2.373ArgPro: 2.373 ± 0.559
1.526ArgGln: 1.526 ± 0.401
3.306ArgArg: 3.306 ± 0.476
1.95ArgSer: 1.95 ± 0.536
2.458ArgThr: 2.458 ± 0.618
3.899ArgVal: 3.899 ± 0.53
1.017ArgTrp: 1.017 ± 0.325
2.034ArgTyr: 2.034 ± 0.344
0.0ArgXaa: 0.0 ± 0.0
Ser
5.679SerAla: 5.679 ± 0.978
0.339SerCys: 0.339 ± 0.188
3.052SerAsp: 3.052 ± 0.519
3.645SerGlu: 3.645 ± 0.708
2.204SerPhe: 2.204 ± 0.411
4.917SerGly: 4.917 ± 0.916
0.848SerHis: 0.848 ± 0.298
1.78SerIle: 1.78 ± 0.419
3.136SerLys: 3.136 ± 0.664
5.171SerLeu: 5.171 ± 0.505
1.272SerMet: 1.272 ± 0.307
2.034SerAsn: 2.034 ± 0.364
2.543SerPro: 2.543 ± 0.351
2.289SerGln: 2.289 ± 0.454
2.119SerArg: 2.119 ± 0.374
3.136SerSer: 3.136 ± 0.71
3.73SerThr: 3.73 ± 0.825
4.662SerVal: 4.662 ± 0.635
0.593SerTrp: 0.593 ± 0.201
1.865SerTyr: 1.865 ± 0.413
0.0SerXaa: 0.0 ± 0.0
Thr
5.679ThrAla: 5.679 ± 0.899
0.254ThrCys: 0.254 ± 0.131
4.154ThrAsp: 4.154 ± 0.464
3.56ThrGlu: 3.56 ± 0.695
2.373ThrPhe: 2.373 ± 0.537
5.34ThrGly: 5.34 ± 0.589
1.017ThrHis: 1.017 ± 0.346
3.391ThrIle: 3.391 ± 0.67
3.815ThrLys: 3.815 ± 0.584
4.832ThrLeu: 4.832 ± 0.59
1.017ThrMet: 1.017 ± 0.291
2.543ThrAsn: 2.543 ± 0.562
4.747ThrPro: 4.747 ± 0.641
2.204ThrGln: 2.204 ± 0.423
2.119ThrArg: 2.119 ± 0.541
2.373ThrSer: 2.373 ± 0.46
3.984ThrThr: 3.984 ± 0.706
5.934ThrVal: 5.934 ± 1.018
0.678ThrTrp: 0.678 ± 0.271
2.034ThrTyr: 2.034 ± 0.641
0.0ThrXaa: 0.0 ± 0.0
Val
7.29ValAla: 7.29 ± 0.87
0.932ValCys: 0.932 ± 0.285
3.306ValAsp: 3.306 ± 0.508
4.069ValGlu: 4.069 ± 0.62
2.713ValPhe: 2.713 ± 0.542
5.001ValGly: 5.001 ± 0.671
1.611ValHis: 1.611 ± 0.44
3.899ValIle: 3.899 ± 0.662
3.73ValLys: 3.73 ± 0.635
5.256ValLeu: 5.256 ± 0.791
2.034ValMet: 2.034 ± 0.386
3.56ValAsn: 3.56 ± 0.522
3.815ValPro: 3.815 ± 0.568
3.136ValGln: 3.136 ± 0.418
4.154ValArg: 4.154 ± 0.562
4.238ValSer: 4.238 ± 0.562
5.086ValThr: 5.086 ± 0.957
5.849ValVal: 5.849 ± 0.893
0.678ValTrp: 0.678 ± 0.256
1.78ValTyr: 1.78 ± 0.346
0.0ValXaa: 0.0 ± 0.0
Trp
2.034TrpAla: 2.034 ± 0.342
0.17TrpCys: 0.17 ± 0.143
1.102TrpAsp: 1.102 ± 0.282
0.509TrpGlu: 0.509 ± 0.158
0.254TrpPhe: 0.254 ± 0.128
1.017TrpGly: 1.017 ± 0.402
0.593TrpHis: 0.593 ± 0.245
0.763TrpIle: 0.763 ± 0.293
0.763TrpLys: 0.763 ± 0.297
1.187TrpLeu: 1.187 ± 0.401
0.593TrpMet: 0.593 ± 0.185
0.763TrpAsn: 0.763 ± 0.245
0.509TrpPro: 0.509 ± 0.208
0.763TrpGln: 0.763 ± 0.218
0.763TrpArg: 0.763 ± 0.233
0.848TrpSer: 0.848 ± 0.217
1.272TrpThr: 1.272 ± 0.233
0.763TrpVal: 0.763 ± 0.276
0.254TrpTrp: 0.254 ± 0.122
0.254TrpTyr: 0.254 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.289TyrAla: 2.289 ± 0.504
0.17TyrCys: 0.17 ± 0.112
1.865TyrAsp: 1.865 ± 0.424
1.611TyrGlu: 1.611 ± 0.43
0.848TyrPhe: 0.848 ± 0.189
3.645TyrGly: 3.645 ± 0.6
0.509TyrHis: 0.509 ± 0.246
1.695TyrIle: 1.695 ± 0.384
1.611TyrLys: 1.611 ± 0.335
2.967TyrLeu: 2.967 ± 0.45
0.339TyrMet: 0.339 ± 0.177
1.102TyrAsn: 1.102 ± 0.282
1.695TyrPro: 1.695 ± 0.35
1.78TyrGln: 1.78 ± 0.373
1.95TyrArg: 1.95 ± 0.434
1.611TyrSer: 1.611 ± 0.376
2.034TyrThr: 2.034 ± 0.759
2.034TyrVal: 2.034 ± 0.364
0.424TyrTrp: 0.424 ± 0.225
0.254TyrTyr: 0.254 ± 0.15
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (11798 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski