Amino acid dipepetide frequency for Clostridium uliginosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.379AlaAla: 3.379 ± 0.084	0.745AlaCys: 0.745 ± 0.025	2.581AlaAsp: 2.581 ± 0.058	3.192AlaGlu: 3.192 ± 0.061	2.487AlaPhe: 2.487 ± 0.054	3.551AlaGly: 3.551 ± 0.076	0.803AlaHis: 0.803 ± 0.029	5.84AlaIle: 5.84 ± 0.093	4.68AlaLys: 4.68 ± 0.077	5.716AlaLeu: 5.716 ± 0.085	1.596AlaMet: 1.596 ± 0.041	2.734AlaAsn: 2.734 ± 0.052	1.37AlaPro: 1.37 ± 0.039	1.408AlaGln: 1.408 ± 0.039	1.684AlaArg: 1.684 ± 0.042	3.378AlaSer: 3.378 ± 0.063	3.114AlaThr: 3.114 ± 0.065	3.646AlaVal: 3.646 ± 0.07	0.351AlaTrp: 0.351 ± 0.018	1.953AlaTyr: 1.953 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.674CysAla: 0.674 ± 0.026	0.221CysCys: 0.221 ± 0.019	0.71CysAsp: 0.71 ± 0.027	0.842CysGlu: 0.842 ± 0.03	0.496CysPhe: 0.496 ± 0.021	1.142CysGly: 1.142 ± 0.034	0.195CysHis: 0.195 ± 0.014	1.254CysIle: 1.254 ± 0.033	1.051CysLys: 1.051 ± 0.035	0.92CysLeu: 0.92 ± 0.027	0.282CysMet: 0.282 ± 0.015	0.828CysAsn: 0.828 ± 0.03	0.455CysPro: 0.455 ± 0.023	0.225CysGln: 0.225 ± 0.014	0.373CysArg: 0.373 ± 0.022	0.81CysSer: 0.81 ± 0.032	0.656CysThr: 0.656 ± 0.027	0.663CysVal: 0.663 ± 0.027	0.066CysTrp: 0.066 ± 0.008	0.473CysTyr: 0.473 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.675AspAla: 2.675 ± 0.049	0.603AspCys: 0.603 ± 0.026	2.886AspAsp: 2.886 ± 0.063	4.637AspGlu: 4.637 ± 0.074	2.724AspPhe: 2.724 ± 0.053	3.52AspGly: 3.52 ± 0.068	0.513AspHis: 0.513 ± 0.021	6.264AspIle: 6.264 ± 0.089	5.798AspLys: 5.798 ± 0.08	5.109AspLeu: 5.109 ± 0.068	1.529AspMet: 1.529 ± 0.036	3.734AspAsn: 3.734 ± 0.071	1.237AspPro: 1.237 ± 0.033	0.918AspGln: 0.918 ± 0.03	1.706AspArg: 1.706 ± 0.045	3.264AspSer: 3.264 ± 0.063	2.619AspThr: 2.619 ± 0.049	3.622AspVal: 3.622 ± 0.059	0.36AspTrp: 0.36 ± 0.018	2.599AspTyr: 2.599 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	3.834GluAla: 3.834 ± 0.082	0.809GluCys: 0.809 ± 0.028	4.335GluAsp: 4.335 ± 0.069	6.743GluGlu: 6.743 ± 0.113	3.067GluPhe: 3.067 ± 0.06	4.046GluGly: 4.046 ± 0.074	0.981GluHis: 0.981 ± 0.031	7.285GluIle: 7.285 ± 0.103	7.51GluLys: 7.51 ± 0.1	6.812GluLeu: 6.812 ± 0.082	1.88GluMet: 1.88 ± 0.044	5.385GluAsn: 5.385 ± 0.076	1.29GluPro: 1.29 ± 0.037	1.935GluGln: 1.935 ± 0.047	2.375GluArg: 2.375 ± 0.048	3.702GluSer: 3.702 ± 0.058	2.996GluThr: 2.996 ± 0.054	4.887GluVal: 4.887 ± 0.066	0.45GluTrp: 0.45 ± 0.022	3.12GluTyr: 3.12 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.16PheAla: 2.16 ± 0.049	0.52PheCys: 0.52 ± 0.023	2.533PheAsp: 2.533 ± 0.055	2.758PheGlu: 2.758 ± 0.052	1.868PhePhe: 1.868 ± 0.054	2.841PheGly: 2.841 ± 0.065	0.529PheHis: 0.529 ± 0.022	4.611PheIle: 4.611 ± 0.08	4.078PheLys: 4.078 ± 0.062	3.979PheLeu: 3.979 ± 0.075	1.145PheMet: 1.145 ± 0.039	3.091PheAsn: 3.091 ± 0.062	1.087PhePro: 1.087 ± 0.035	0.926PheGln: 0.926 ± 0.026	1.154PheArg: 1.154 ± 0.032	3.105PheSer: 3.105 ± 0.059	2.303PheThr: 2.303 ± 0.049	2.469PheVal: 2.469 ± 0.045	0.267PheTrp: 0.267 ± 0.016	1.641PheTyr: 1.641 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.073GlyAla: 4.073 ± 0.071	0.874GlyCys: 0.874 ± 0.036	3.271GlyAsp: 3.271 ± 0.054	4.273GlyGlu: 4.273 ± 0.082	2.9GlyPhe: 2.9 ± 0.059	4.188GlyGly: 4.188 ± 0.089	0.922GlyHis: 0.922 ± 0.035	6.836GlyIle: 6.836 ± 0.104	5.492GlyLys: 5.492 ± 0.074	5.443GlyLeu: 5.443 ± 0.083	1.819GlyMet: 1.819 ± 0.056	3.356GlyAsn: 3.356 ± 0.057	1.133GlyPro: 1.133 ± 0.041	1.407GlyGln: 1.407 ± 0.032	2.015GlyArg: 2.015 ± 0.048	3.559GlySer: 3.559 ± 0.062	3.468GlyThr: 3.468 ± 0.056	4.602GlyVal: 4.602 ± 0.079	0.6GlyTrp: 0.6 ± 0.031	2.939GlyTyr: 2.939 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.614HisAla: 0.614 ± 0.026	0.232HisCys: 0.232 ± 0.015	0.696HisAsp: 0.696 ± 0.027	0.866HisGlu: 0.866 ± 0.031	0.596HisPhe: 0.596 ± 0.022	0.989HisGly: 0.989 ± 0.032	0.27HisHis: 0.27 ± 0.017	1.309HisIle: 1.309 ± 0.038	1.048HisLys: 1.048 ± 0.034	1.164HisLeu: 1.164 ± 0.035	0.329HisMet: 0.329 ± 0.016	0.837HisAsn: 0.837 ± 0.03	0.524HisPro: 0.524 ± 0.023	0.317HisGln: 0.317 ± 0.017	0.473HisArg: 0.473 ± 0.023	0.863HisSer: 0.863 ± 0.027	0.658HisThr: 0.658 ± 0.025	0.726HisVal: 0.726 ± 0.027	0.083HisTrp: 0.083 ± 0.01	0.562HisTyr: 0.562 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.697IleAla: 5.697 ± 0.092	1.337IleCys: 1.337 ± 0.03	6.052IleAsp: 6.052 ± 0.082	7.1IleGlu: 7.1 ± 0.09	4.348IlePhe: 4.348 ± 0.073	6.44IleGly: 6.44 ± 0.078	1.202IleHis: 1.202 ± 0.035	9.989IleIle: 9.989 ± 0.138	9.389IleLys: 9.389 ± 0.129	9.457IleLeu: 9.457 ± 0.113	2.37IleMet: 2.37 ± 0.048	6.981IleAsn: 6.981 ± 0.095	3.279IlePro: 3.279 ± 0.058	2.405IleGln: 2.405 ± 0.047	2.892IleArg: 2.892 ± 0.058	7.428IleSer: 7.428 ± 0.092	5.246IleThr: 5.246 ± 0.072	6.205IleVal: 6.205 ± 0.08	0.534IleTrp: 0.534 ± 0.021	3.669IleTyr: 3.669 ± 0.073	0.0IleXaa: 0.0 ± 0.0
Lys	4.711LysAla: 4.711 ± 0.075	1.017LysCys: 1.017 ± 0.032	6.31LysAsp: 6.31 ± 0.081	9.037LysGlu: 9.037 ± 0.112	3.322LysPhe: 3.322 ± 0.052	4.973LysGly: 4.973 ± 0.062	1.161LysHis: 1.161 ± 0.032	8.849LysIle: 8.849 ± 0.104	8.541LysLys: 8.541 ± 0.11	7.893LysLeu: 7.893 ± 0.095	2.436LysMet: 2.436 ± 0.042	6.869LysAsn: 6.869 ± 0.089	2.005LysPro: 2.005 ± 0.045	2.458LysGln: 2.458 ± 0.061	2.922LysArg: 2.922 ± 0.055	5.527LysSer: 5.527 ± 0.073	4.173LysThr: 4.173 ± 0.071	6.13LysVal: 6.13 ± 0.082	0.67LysTrp: 0.67 ± 0.029	4.111LysTyr: 4.111 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	4.978LeuAla: 4.978 ± 0.066	1.133LeuCys: 1.133 ± 0.032	5.291LeuAsp: 5.291 ± 0.076	6.452LeuGlu: 6.452 ± 0.077	3.687LeuPhe: 3.687 ± 0.072	5.969LeuGly: 5.969 ± 0.092	1.088LeuHis: 1.088 ± 0.035	8.925LeuIle: 8.925 ± 0.111	9.005LeuLys: 9.005 ± 0.112	7.838LeuLeu: 7.838 ± 0.095	2.292LeuMet: 2.292 ± 0.052	6.34LeuAsn: 6.34 ± 0.094	2.62LeuPro: 2.62 ± 0.047	2.161LeuGln: 2.161 ± 0.046	2.871LeuArg: 2.871 ± 0.052	6.601LeuSer: 6.601 ± 0.087	4.621LeuThr: 4.621 ± 0.069	5.312LeuVal: 5.312 ± 0.077	0.55LeuTrp: 0.55 ± 0.023	3.183LeuTyr: 3.183 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.668MetAla: 1.668 ± 0.046	0.284MetCys: 0.284 ± 0.017	1.429MetAsp: 1.429 ± 0.038	1.66MetGlu: 1.66 ± 0.039	1.089MetPhe: 1.089 ± 0.034	1.715MetGly: 1.715 ± 0.042	0.347MetHis: 0.347 ± 0.018	2.442MetIle: 2.442 ± 0.05	2.543MetLys: 2.543 ± 0.05	2.285MetLeu: 2.285 ± 0.049	0.643MetMet: 0.643 ± 0.024	1.776MetAsn: 1.776 ± 0.048	0.908MetPro: 0.908 ± 0.031	0.77MetGln: 0.77 ± 0.033	0.812MetArg: 0.812 ± 0.027	1.704MetSer: 1.704 ± 0.04	1.173MetThr: 1.173 ± 0.037	1.518MetVal: 1.518 ± 0.037	0.157MetTrp: 0.157 ± 0.013	0.899MetTyr: 0.899 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.074AsnAla: 3.074 ± 0.057	0.777AsnCys: 0.777 ± 0.029	3.464AsnAsp: 3.464 ± 0.068	4.778AsnGlu: 4.778 ± 0.075	2.714AsnPhe: 2.714 ± 0.055	3.857AsnGly: 3.857 ± 0.072	0.811AsnHis: 0.811 ± 0.031	7.503AsnIle: 7.503 ± 0.099	6.924AsnLys: 6.924 ± 0.098	5.958AsnLeu: 5.958 ± 0.087	1.701AsnMet: 1.701 ± 0.04	5.184AsnAsn: 5.184 ± 0.099	2.066AsnPro: 2.066 ± 0.046	1.573AsnGln: 1.573 ± 0.037	1.822AsnArg: 1.822 ± 0.044	4.338AsnSer: 4.338 ± 0.08	3.153AsnThr: 3.153 ± 0.06	3.79AsnVal: 3.79 ± 0.057	0.47AsnTrp: 0.47 ± 0.023	2.741AsnTyr: 2.741 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.282ProAla: 1.282 ± 0.041	0.318ProCys: 0.318 ± 0.016	1.343ProAsp: 1.343 ± 0.037	1.95ProGlu: 1.95 ± 0.044	1.294ProPhe: 1.294 ± 0.036	1.525ProGly: 1.525 ± 0.046	0.408ProHis: 0.408 ± 0.021	2.702ProIle: 2.702 ± 0.048	2.174ProLys: 2.174 ± 0.05	2.443ProLeu: 2.443 ± 0.053	0.663ProMet: 0.663 ± 0.021	1.65ProAsn: 1.65 ± 0.045	0.545ProPro: 0.545 ± 0.024	0.77ProGln: 0.77 ± 0.027	0.725ProArg: 0.725 ± 0.028	1.748ProSer: 1.748 ± 0.042	1.495ProThr: 1.495 ± 0.041	1.805ProVal: 1.805 ± 0.046	0.231ProTrp: 0.231 ± 0.017	1.169ProTyr: 1.169 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.369GlnAla: 1.369 ± 0.039	0.272GlnCys: 0.272 ± 0.018	1.377GlnAsp: 1.377 ± 0.035	1.887GlnGlu: 1.887 ± 0.043	0.913GlnPhe: 0.913 ± 0.032	1.648GlnGly: 1.648 ± 0.043	0.328GlnHis: 0.328 ± 0.018	2.314GlnIle: 2.314 ± 0.045	2.119GlnLys: 2.119 ± 0.05	2.106GlnLeu: 2.106 ± 0.047	0.633GlnMet: 0.633 ± 0.024	1.6GlnAsn: 1.6 ± 0.038	0.514GlnPro: 0.514 ± 0.023	0.651GlnGln: 0.651 ± 0.025	0.875GlnArg: 0.875 ± 0.027	1.425GlnSer: 1.425 ± 0.04	1.194GlnThr: 1.194 ± 0.036	1.582GlnVal: 1.582 ± 0.046	0.202GlnTrp: 0.202 ± 0.012	1.088GlnTyr: 1.088 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.723ArgAla: 1.723 ± 0.041	0.391ArgCys: 0.391 ± 0.02	1.741ArgAsp: 1.741 ± 0.047	2.618ArgGlu: 2.618 ± 0.058	1.367ArgPhe: 1.367 ± 0.04	1.874ArgGly: 1.874 ± 0.047	0.423ArgHis: 0.423 ± 0.022	3.01ArgIle: 3.01 ± 0.062	2.738ArgLys: 2.738 ± 0.053	2.599ArgLeu: 2.599 ± 0.053	0.865ArgMet: 0.865 ± 0.029	1.902ArgAsn: 1.902 ± 0.047	0.734ArgPro: 0.734 ± 0.031	0.788ArgGln: 0.788 ± 0.027	1.239ArgArg: 1.239 ± 0.035	1.536ArgSer: 1.536 ± 0.037	1.498ArgThr: 1.498 ± 0.036	2.04ArgVal: 2.04 ± 0.045	0.211ArgTrp: 0.211 ± 0.013	1.301ArgTyr: 1.301 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.251SerAla: 3.251 ± 0.056	0.723SerCys: 0.723 ± 0.029	3.319SerAsp: 3.319 ± 0.064	4.16SerGlu: 4.16 ± 0.07	2.99SerPhe: 2.99 ± 0.051	4.241SerGly: 4.241 ± 0.077	0.912SerHis: 0.912 ± 0.031	6.863SerIle: 6.863 ± 0.09	6.122SerLys: 6.122 ± 0.081	6.053SerLeu: 6.053 ± 0.078	1.706SerMet: 1.706 ± 0.041	4.282SerAsn: 4.282 ± 0.078	1.53SerPro: 1.53 ± 0.041	1.609SerGln: 1.609 ± 0.045	1.92SerArg: 1.92 ± 0.043	4.537SerSer: 4.537 ± 0.078	3.29SerThr: 3.29 ± 0.063	3.696SerVal: 3.696 ± 0.067	0.452SerTrp: 0.452 ± 0.024	2.587SerTyr: 2.587 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	2.917ThrAla: 2.917 ± 0.075	0.553ThrCys: 0.553 ± 0.025	2.456ThrAsp: 2.456 ± 0.047	3.069ThrGlu: 3.069 ± 0.053	2.258ThrPhe: 2.258 ± 0.047	3.679ThrGly: 3.679 ± 0.067	0.776ThrHis: 0.776 ± 0.025	5.067ThrIle: 5.067 ± 0.078	4.049ThrLys: 4.049 ± 0.063	4.948ThrLeu: 4.948 ± 0.064	1.178ThrMet: 1.178 ± 0.031	3.004ThrAsn: 3.004 ± 0.055	1.777ThrPro: 1.777 ± 0.045	1.256ThrGln: 1.256 ± 0.032	1.419ThrArg: 1.419 ± 0.037	3.391ThrSer: 3.391 ± 0.071	2.87ThrThr: 2.87 ± 0.061	3.25ThrVal: 3.25 ± 0.061	0.397ThrTrp: 0.397 ± 0.022	1.945ThrTyr: 1.945 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	3.889ValAla: 3.889 ± 0.075	0.865ValCys: 0.865 ± 0.026	3.699ValAsp: 3.699 ± 0.06	4.176ValGlu: 4.176 ± 0.068	2.705ValPhe: 2.705 ± 0.059	4.092ValGly: 4.092 ± 0.079	0.827ValHis: 0.827 ± 0.028	6.263ValIle: 6.263 ± 0.081	5.465ValLys: 5.465 ± 0.079	5.804ValLeu: 5.804 ± 0.082	1.567ValMet: 1.567 ± 0.04	3.727ValAsn: 3.727 ± 0.073	1.805ValPro: 1.805 ± 0.046	1.453ValGln: 1.453 ± 0.04	1.811ValArg: 1.811 ± 0.038	4.245ValSer: 4.245 ± 0.058	3.397ValThr: 3.397 ± 0.065	4.249ValVal: 4.249 ± 0.073	0.382ValTrp: 0.382 ± 0.018	2.339ValTyr: 2.339 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.35TrpAla: 0.35 ± 0.017	0.102TrpCys: 0.102 ± 0.012	0.411TrpAsp: 0.411 ± 0.021	0.384TrpGlu: 0.384 ± 0.02	0.319TrpPhe: 0.319 ± 0.019	0.474TrpGly: 0.474 ± 0.026	0.121TrpHis: 0.121 ± 0.01	0.719TrpIle: 0.719 ± 0.03	0.514TrpLys: 0.514 ± 0.023	0.573TrpLeu: 0.573 ± 0.025	0.208TrpMet: 0.208 ± 0.015	0.474TrpAsn: 0.474 ± 0.019	0.152TrpPro: 0.152 ± 0.012	0.199TrpGln: 0.199 ± 0.014	0.22TrpArg: 0.22 ± 0.011	0.41TrpSer: 0.41 ± 0.02	0.297TrpThr: 0.297 ± 0.019	0.386TrpVal: 0.386 ± 0.02	0.072TrpTrp: 0.072 ± 0.009	0.401TrpTyr: 0.401 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.892TyrAla: 1.892 ± 0.041	0.558TyrCys: 0.558 ± 0.022	2.415TyrAsp: 2.415 ± 0.05	2.859TyrGlu: 2.859 ± 0.058	1.922TyrPhe: 1.922 ± 0.045	2.407TyrGly: 2.407 ± 0.048	0.538TyrHis: 0.538 ± 0.023	3.976TyrIle: 3.976 ± 0.075	3.875TyrLys: 3.875 ± 0.064	3.818TyrLeu: 3.818 ± 0.063	0.979TyrMet: 0.979 ± 0.032	2.944TyrAsn: 2.944 ± 0.063	1.206TyrPro: 1.206 ± 0.037	0.868TyrGln: 0.868 ± 0.031	1.29TyrArg: 1.29 ± 0.031	2.672TyrSer: 2.672 ± 0.056	2.04TyrThr: 2.04 ± 0.049	2.179TyrVal: 2.179 ± 0.046	0.282TyrTrp: 0.282 ± 0.017	2.027TyrTyr: 2.027 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3511 proteins (1079236 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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