Amino acid dipepetide frequency for Xinzhou toro-like virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.76AlaAla: 4.76 ± 1.704
1.107AlaCys: 1.107 ± 0.751
2.546AlaAsp: 2.546 ± 0.882
2.546AlaGlu: 2.546 ± 0.526
2.103AlaPhe: 2.103 ± 0.84
0.996AlaGly: 0.996 ± 0.33
2.214AlaHis: 2.214 ± 0.494
3.1AlaIle: 3.1 ± 1.332
2.989AlaLys: 2.989 ± 0.489
5.757AlaLeu: 5.757 ± 1.087
1.439AlaMet: 1.439 ± 0.682
3.653AlaAsn: 3.653 ± 0.609
1.993AlaPro: 1.993 ± 0.9
1.882AlaGln: 1.882 ± 0.525
1.218AlaArg: 1.218 ± 0.614
2.989AlaSer: 2.989 ± 0.513
4.318AlaThr: 4.318 ± 0.049
3.321AlaVal: 3.321 ± 0.936
0.886AlaTrp: 0.886 ± 0.418
3.764AlaTyr: 3.764 ± 0.718
0.0AlaXaa: 0.0 ± 0.0
Cys
1.328CysAla: 1.328 ± 0.436
0.886CysCys: 0.886 ± 0.446
1.55CysAsp: 1.55 ± 0.506
1.218CysGlu: 1.218 ± 0.364
1.328CysPhe: 1.328 ± 0.658
0.996CysGly: 0.996 ± 0.33
0.443CysHis: 0.443 ± 0.223
1.882CysIle: 1.882 ± 0.9
1.993CysLys: 1.993 ± 0.659
2.214CysLeu: 2.214 ± 1.085
0.554CysMet: 0.554 ± 0.21
1.328CysAsn: 1.328 ± 0.471
1.107CysPro: 1.107 ± 0.374
0.886CysGln: 0.886 ± 0.786
0.554CysArg: 0.554 ± 0.809
2.325CysSer: 2.325 ± 0.404
2.214CysThr: 2.214 ± 0.407
1.55CysVal: 1.55 ± 0.487
0.0CysTrp: 0.0 ± 0.0
1.55CysTyr: 1.55 ± 0.492
0.0CysXaa: 0.0 ± 0.0
Asp
3.321AspAla: 3.321 ± 0.731
1.55AspCys: 1.55 ± 0.487
2.768AspAsp: 2.768 ± 0.926
2.878AspGlu: 2.878 ± 1.044
2.436AspPhe: 2.436 ± 0.541
1.661AspGly: 1.661 ± 0.979
1.55AspHis: 1.55 ± 0.524
3.432AspIle: 3.432 ± 1.189
2.103AspLys: 2.103 ± 0.701
5.535AspLeu: 5.535 ± 0.867
1.439AspMet: 1.439 ± 0.714
2.436AspAsn: 2.436 ± 0.975
2.436AspPro: 2.436 ± 0.476
2.214AspGln: 2.214 ± 0.544
1.55AspArg: 1.55 ± 0.574
3.432AspSer: 3.432 ± 0.787
3.432AspThr: 3.432 ± 0.896
5.092AspVal: 5.092 ± 0.987
1.107AspTrp: 1.107 ± 0.374
4.207AspTyr: 4.207 ± 0.911
0.0AspXaa: 0.0 ± 0.0
Glu
2.214GluAla: 2.214 ± 0.822
1.439GluCys: 1.439 ± 0.522
1.661GluAsp: 1.661 ± 0.57
2.768GluGlu: 2.768 ± 1.395
2.546GluPhe: 2.546 ± 0.893
1.993GluGly: 1.993 ± 0.444
1.771GluHis: 1.771 ± 0.619
3.432GluIle: 3.432 ± 0.933
2.214GluLys: 2.214 ± 0.728
3.543GluLeu: 3.543 ± 0.986
0.554GluMet: 0.554 ± 0.279
3.21GluAsn: 3.21 ± 1.235
1.328GluPro: 1.328 ± 0.451
2.436GluGln: 2.436 ± 1.227
1.55GluArg: 1.55 ± 0.689
3.875GluSer: 3.875 ± 1.364
3.321GluThr: 3.321 ± 0.742
2.768GluVal: 2.768 ± 0.993
0.775GluTrp: 0.775 ± 0.391
2.214GluTyr: 2.214 ± 0.749
0.0GluXaa: 0.0 ± 0.0
Phe
3.1PheAla: 3.1 ± 0.687
0.886PheCys: 0.886 ± 0.446
2.989PheAsp: 2.989 ± 0.649
2.214PheGlu: 2.214 ± 0.822
1.107PhePhe: 1.107 ± 1.305
3.21PheGly: 3.21 ± 0.653
1.107PheHis: 1.107 ± 1.311
3.543PheIle: 3.543 ± 1.295
2.768PheLys: 2.768 ± 0.829
3.543PheLeu: 3.543 ± 1.386
1.439PheMet: 1.439 ± 1.22
3.432PheAsn: 3.432 ± 0.911
2.103PhePro: 2.103 ± 0.994
1.882PheGln: 1.882 ± 0.476
1.328PheArg: 1.328 ± 0.764
3.1PheSer: 3.1 ± 1.032
4.982PheThr: 4.982 ± 0.965
3.21PheVal: 3.21 ± 0.699
0.664PheTrp: 0.664 ± 0.226
2.989PheTyr: 2.989 ± 1.047
0.0PheXaa: 0.0 ± 0.0
Gly
0.996GlyAla: 0.996 ± 0.61
1.439GlyCys: 1.439 ± 1.08
3.653GlyAsp: 3.653 ± 1.643
1.661GlyGlu: 1.661 ± 0.606
2.325GlyPhe: 2.325 ± 0.519
1.661GlyGly: 1.661 ± 0.685
1.107GlyHis: 1.107 ± 0.558
3.985GlyIle: 3.985 ± 0.725
2.768GlyLys: 2.768 ± 0.72
3.764GlyLeu: 3.764 ± 1.501
0.554GlyMet: 0.554 ± 0.475
3.21GlyAsn: 3.21 ± 0.589
1.661GlyPro: 1.661 ± 0.57
1.882GlyGln: 1.882 ± 0.617
1.771GlyArg: 1.771 ± 1.089
1.993GlySer: 1.993 ± 0.462
2.768GlyThr: 2.768 ± 0.578
2.768GlyVal: 2.768 ± 0.905
0.332GlyTrp: 0.332 ± 0.527
2.546GlyTyr: 2.546 ± 0.827
0.0GlyXaa: 0.0 ± 0.0
His
0.996HisAla: 0.996 ± 0.333
0.886HisCys: 0.886 ± 0.288
1.661HisAsp: 1.661 ± 1.236
1.439HisGlu: 1.439 ± 0.51
1.661HisPhe: 1.661 ± 0.626
2.103HisGly: 2.103 ± 0.84
1.771HisHis: 1.771 ± 1.152
3.432HisIle: 3.432 ± 0.263
1.439HisLys: 1.439 ± 0.725
3.1HisLeu: 3.1 ± 0.775
0.554HisMet: 0.554 ± 0.21
2.103HisAsn: 2.103 ± 0.424
1.439HisPro: 1.439 ± 0.476
1.993HisGln: 1.993 ± 0.646
0.554HisArg: 0.554 ± 0.279
1.882HisSer: 1.882 ± 0.948
1.882HisThr: 1.882 ± 0.745
1.218HisVal: 1.218 ± 0.397
0.443HisTrp: 0.443 ± 0.209
1.882HisTyr: 1.882 ± 0.745
0.0HisXaa: 0.0 ± 0.0
Ile
4.096IleAla: 4.096 ± 0.953
1.328IleCys: 1.328 ± 0.471
5.092IleAsp: 5.092 ± 0.773
4.65IleGlu: 4.65 ± 0.774
3.653IlePhe: 3.653 ± 1.05
2.657IleGly: 2.657 ± 0.771
1.993IleHis: 1.993 ± 0.786
4.539IleIle: 4.539 ± 2.44
5.092IleLys: 5.092 ± 0.703
6.974IleLeu: 6.974 ± 1.385
0.996IleMet: 0.996 ± 0.502
3.875IleAsn: 3.875 ± 1.275
5.425IlePro: 5.425 ± 0.929
2.989IleGln: 2.989 ± 0.749
2.103IleArg: 2.103 ± 0.787
3.1IleSer: 3.1 ± 1.438
5.314IleThr: 5.314 ± 0.877
5.535IleVal: 5.535 ± 0.556
0.886IleTrp: 0.886 ± 0.251
3.1IleTyr: 3.1 ± 2.77
0.0IleXaa: 0.0 ± 0.0
Lys
2.768LysAla: 2.768 ± 0.327
1.882LysCys: 1.882 ± 0.476
2.436LysAsp: 2.436 ± 0.541
2.878LysGlu: 2.878 ± 1.222
4.539LysPhe: 4.539 ± 1.064
2.436LysGly: 2.436 ± 0.445
1.882LysHis: 1.882 ± 0.732
4.207LysIle: 4.207 ± 0.693
2.103LysLys: 2.103 ± 0.436
4.982LysLeu: 4.982 ± 1.846
1.218LysMet: 1.218 ± 0.617
3.1LysAsn: 3.1 ± 1.032
4.871LysPro: 4.871 ± 1.122
4.539LysGln: 4.539 ± 0.982
1.771LysArg: 1.771 ± 0.642
2.989LysSer: 2.989 ± 1.195
3.321LysThr: 3.321 ± 0.946
3.543LysVal: 3.543 ± 1.14
0.554LysTrp: 0.554 ± 0.655
3.1LysTyr: 3.1 ± 0.465
0.0LysXaa: 0.0 ± 0.0
Leu
5.314LeuAla: 5.314 ± 1.162
2.436LeuCys: 2.436 ± 0.493
5.978LeuAsp: 5.978 ± 0.613
3.432LeuGlu: 3.432 ± 0.759
4.428LeuPhe: 4.428 ± 1.151
4.207LeuGly: 4.207 ± 1.129
2.657LeuHis: 2.657 ± 1.396
5.314LeuIle: 5.314 ± 0.835
6.199LeuLys: 6.199 ± 1.637
6.421LeuLeu: 6.421 ± 2.123
1.993LeuMet: 1.993 ± 1.177
5.757LeuAsn: 5.757 ± 1.293
5.425LeuPro: 5.425 ± 0.85
3.432LeuGln: 3.432 ± 0.445
2.546LeuArg: 2.546 ± 0.522
7.971LeuSer: 7.971 ± 2.212
7.971LeuThr: 7.971 ± 1.452
4.096LeuVal: 4.096 ± 2.283
0.443LeuTrp: 0.443 ± 0.223
4.318LeuTyr: 4.318 ± 1.402
0.0LeuXaa: 0.0 ± 0.0
Met
1.107MetAla: 1.107 ± 0.374
0.443MetCys: 0.443 ± 0.321
0.996MetAsp: 0.996 ± 0.787
0.996MetGlu: 0.996 ± 0.502
1.328MetPhe: 1.328 ± 0.496
0.554MetGly: 0.554 ± 0.279
0.664MetHis: 0.664 ± 0.692
1.218MetIle: 1.218 ± 0.617
1.439MetLys: 1.439 ± 0.476
1.661MetLeu: 1.661 ± 0.685
0.664MetMet: 0.664 ± 0.226
0.886MetAsn: 0.886 ± 0.446
0.664MetPro: 0.664 ± 0.805
1.328MetGln: 1.328 ± 0.618
0.332MetArg: 0.332 ± 0.167
1.439MetSer: 1.439 ± 0.623
0.996MetThr: 0.996 ± 0.61
1.107MetVal: 1.107 ± 1.305
0.443MetTrp: 0.443 ± 0.223
0.996MetTyr: 0.996 ± 1.268
0.0MetXaa: 0.0 ± 0.0
Asn
3.432AsnAla: 3.432 ± 0.323
1.771AsnCys: 1.771 ± 0.783
1.882AsnAsp: 1.882 ± 0.657
2.657AsnGlu: 2.657 ± 0.943
2.325AsnPhe: 2.325 ± 0.611
3.764AsnGly: 3.764 ± 1.39
2.214AsnHis: 2.214 ± 0.749
5.757AsnIle: 5.757 ± 1.57
3.875AsnLys: 3.875 ± 1.305
6.31AsnLeu: 6.31 ± 0.843
0.332AsnMet: 0.332 ± 0.635
3.321AsnAsn: 3.321 ± 0.568
1.993AsnPro: 1.993 ± 0.988
3.432AsnGln: 3.432 ± 1.054
2.103AsnArg: 2.103 ± 0.74
4.539AsnSer: 4.539 ± 0.718
3.985AsnThr: 3.985 ± 0.95
3.985AsnVal: 3.985 ± 0.801
0.332AsnTrp: 0.332 ± 0.222
3.875AsnTyr: 3.875 ± 1.275
0.0AsnXaa: 0.0 ± 0.0
Pro
2.325ProAla: 2.325 ± 0.404
0.664ProCys: 0.664 ± 0.226
1.882ProAsp: 1.882 ± 0.831
1.439ProGlu: 1.439 ± 0.476
2.546ProPhe: 2.546 ± 2.597
1.55ProGly: 1.55 ± 1.421
1.218ProHis: 1.218 ± 0.614
5.535ProIle: 5.535 ± 1.681
3.432ProLys: 3.432 ± 0.445
4.539ProLeu: 4.539 ± 1.272
0.996ProMet: 0.996 ± 0.502
4.318ProAsn: 4.318 ± 0.92
2.768ProPro: 2.768 ± 0.663
2.878ProGln: 2.878 ± 0.513
1.55ProArg: 1.55 ± 0.574
4.871ProSer: 4.871 ± 0.9
4.207ProThr: 4.207 ± 1.52
2.657ProVal: 2.657 ± 0.52
0.443ProTrp: 0.443 ± 0.209
2.546ProTyr: 2.546 ± 0.473
0.0ProXaa: 0.0 ± 0.0
Gln
3.321GlnAla: 3.321 ± 0.242
1.328GlnCys: 1.328 ± 0.332
1.661GlnAsp: 1.661 ± 0.63
1.771GlnGlu: 1.771 ± 0.36
3.543GlnPhe: 3.543 ± 0.535
2.325GlnGly: 2.325 ± 0.748
1.661GlnHis: 1.661 ± 0.539
2.768GlnIle: 2.768 ± 1.425
1.439GlnLys: 1.439 ± 0.699
5.535GlnLeu: 5.535 ± 1.809
0.443GlnMet: 0.443 ± 0.321
2.989GlnAsn: 2.989 ± 0.981
2.436GlnPro: 2.436 ± 0.445
1.661GlnGln: 1.661 ± 0.626
1.328GlnArg: 1.328 ± 0.451
3.653GlnSer: 3.653 ± 0.843
3.985GlnThr: 3.985 ± 0.734
1.771GlnVal: 1.771 ± 1.948
0.332GlnTrp: 0.332 ± 0.346
1.55GlnTyr: 1.55 ± 0.29
0.0GlnXaa: 0.0 ± 0.0
Arg
1.439ArgAla: 1.439 ± 0.725
0.886ArgCys: 0.886 ± 0.582
0.996ArgAsp: 0.996 ± 0.33
1.107ArgGlu: 1.107 ± 0.42
1.328ArgPhe: 1.328 ± 0.215
1.218ArgGly: 1.218 ± 0.635
0.996ArgHis: 0.996 ± 0.33
1.439ArgIle: 1.439 ± 0.52
2.546ArgLys: 2.546 ± 0.676
3.1ArgLeu: 3.1 ± 0.641
0.443ArgMet: 0.443 ± 0.223
1.107ArgAsn: 1.107 ± 0.558
2.657ArgPro: 2.657 ± 0.431
1.107ArgGln: 1.107 ± 0.205
0.554ArgArg: 0.554 ± 0.279
1.55ArgSer: 1.55 ± 1.878
2.989ArgThr: 2.989 ± 0.457
0.996ArgVal: 0.996 ± 0.621
0.111ArgTrp: 0.111 ± 0.416
1.55ArgTyr: 1.55 ± 0.624
0.0ArgXaa: 0.0 ± 0.0
Ser
3.1SerAla: 3.1 ± 0.46
1.882SerCys: 1.882 ± 0.476
4.76SerAsp: 4.76 ± 0.915
2.768SerGlu: 2.768 ± 1.167
3.764SerPhe: 3.764 ± 0.718
3.1SerGly: 3.1 ± 0.7
1.771SerHis: 1.771 ± 0.495
4.871SerIle: 4.871 ± 1.189
3.321SerLys: 3.321 ± 0.742
6.199SerLeu: 6.199 ± 0.7
0.775SerMet: 0.775 ± 0.391
4.871SerAsn: 4.871 ± 1.278
2.546SerPro: 2.546 ± 0.473
3.321SerGln: 3.321 ± 1.454
2.214SerArg: 2.214 ± 0.407
3.764SerSer: 3.764 ± 1.102
4.318SerThr: 4.318 ± 0.934
3.432SerVal: 3.432 ± 1.101
0.443SerTrp: 0.443 ± 0.423
5.314SerTyr: 5.314 ± 0.95
0.0SerXaa: 0.0 ± 0.0
Thr
3.321ThrAla: 3.321 ± 0.791
1.328ThrCys: 1.328 ± 0.471
3.764ThrAsp: 3.764 ± 0.73
4.096ThrGlu: 4.096 ± 1.483
3.321ThrPhe: 3.321 ± 1.092
2.657ThrGly: 2.657 ± 1.111
3.653ThrHis: 3.653 ± 0.752
7.196ThrIle: 7.196 ± 1.602
5.425ThrLys: 5.425 ± 0.61
4.982ThrLeu: 4.982 ± 0.43
1.55ThrMet: 1.55 ± 1.195
4.318ThrAsn: 4.318 ± 0.978
5.867ThrPro: 5.867 ± 2.239
2.878ThrGln: 2.878 ± 0.685
1.661ThrArg: 1.661 ± 0.539
4.207ThrSer: 4.207 ± 1.005
5.646ThrThr: 5.646 ± 1.038
4.539ThrVal: 4.539 ± 0.893
0.664ThrTrp: 0.664 ± 1.408
3.21ThrTyr: 3.21 ± 0.979
0.0ThrXaa: 0.0 ± 0.0
Val
3.653ValAla: 3.653 ± 1.128
1.439ValCys: 1.439 ± 0.591
3.764ValAsp: 3.764 ± 0.961
3.1ValGlu: 3.1 ± 0.564
1.993ValPhe: 1.993 ± 1.837
2.546ValGly: 2.546 ± 0.526
0.996ValHis: 0.996 ± 0.333
4.539ValIle: 4.539 ± 3.11
3.764ValLys: 3.764 ± 1.059
6.642ValLeu: 6.642 ± 1.844
1.55ValMet: 1.55 ± 0.781
3.653ValAsn: 3.653 ± 1.193
3.1ValPro: 3.1 ± 0.581
2.103ValGln: 2.103 ± 0.873
1.771ValArg: 1.771 ± 0.679
4.428ValSer: 4.428 ± 1.006
3.432ValThr: 3.432 ± 1.198
4.096ValVal: 4.096 ± 4.612
0.664ValTrp: 0.664 ± 0.295
2.546ValTyr: 2.546 ± 0.476
0.0ValXaa: 0.0 ± 0.0
Trp
0.332TrpAla: 0.332 ± 0.222
0.332TrpCys: 0.332 ± 0.346
0.554TrpAsp: 0.554 ± 0.467
0.221TrpGlu: 0.221 ± 0.112
0.664TrpPhe: 0.664 ± 0.335
0.443TrpGly: 0.443 ± 0.678
0.221TrpHis: 0.221 ± 0.112
0.664TrpIle: 0.664 ± 0.335
0.664TrpLys: 0.664 ± 0.335
1.439TrpLeu: 1.439 ± 1.155
0.111TrpMet: 0.111 ± 0.056
0.443TrpAsn: 0.443 ± 0.678
0.221TrpPro: 0.221 ± 0.734
0.775TrpGln: 0.775 ± 0.391
0.332TrpArg: 0.332 ± 0.527
0.886TrpSer: 0.886 ± 0.486
0.886TrpThr: 0.886 ± 1.154
0.443TrpVal: 0.443 ± 0.321
0.111TrpTrp: 0.111 ± 0.056
0.443TrpTyr: 0.443 ± 0.223
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.657TyrAla: 2.657 ± 0.326
1.993TyrCys: 1.993 ± 0.775
3.985TyrAsp: 3.985 ± 0.727
1.771TyrGlu: 1.771 ± 0.619
2.657TyrPhe: 2.657 ± 0.543
2.768TyrGly: 2.768 ± 1.815
2.546TyrHis: 2.546 ± 1.058
2.546TyrIle: 2.546 ± 0.882
3.543TyrLys: 3.543 ± 1.429
4.096TyrLeu: 4.096 ± 1.256
1.55TyrMet: 1.55 ± 0.595
3.985TyrAsn: 3.985 ± 0.198
2.325TyrPro: 2.325 ± 0.819
1.882TyrGln: 1.882 ± 0.657
1.328TyrArg: 1.328 ± 0.536
3.543TyrSer: 3.543 ± 1.473
4.318TyrThr: 4.318 ± 0.648
3.653TyrVal: 3.653 ± 1.193
0.554TyrTrp: 0.554 ± 0.689
2.989TyrTyr: 2.989 ± 0.697
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (9034 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski