Amino acid dipepetide frequency for Microlunatus sp. KUDC0627

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.668AlaAla: 17.668 ± 0.147	0.824AlaCys: 0.824 ± 0.023	8.84AlaAsp: 8.84 ± 0.099	8.229AlaGlu: 8.229 ± 0.094	3.158AlaPhe: 3.158 ± 0.05	12.003AlaGly: 12.003 ± 0.099	2.083AlaHis: 2.083 ± 0.037	5.606AlaIle: 5.606 ± 0.069	2.801AlaLys: 2.801 ± 0.066	11.321AlaLeu: 11.321 ± 0.104	2.601AlaMet: 2.601 ± 0.041	2.265AlaAsn: 2.265 ± 0.042	5.194AlaPro: 5.194 ± 0.063	3.616AlaGln: 3.616 ± 0.05	8.189AlaArg: 8.189 ± 0.086	5.709AlaSer: 5.709 ± 0.067	6.614AlaThr: 6.614 ± 0.089	10.235AlaVal: 10.235 ± 0.093	1.637AlaTrp: 1.637 ± 0.034	2.377AlaTyr: 2.377 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.769CysAla: 0.769 ± 0.027	0.109CysCys: 0.109 ± 0.009	0.459CysAsp: 0.459 ± 0.018	0.339CysGlu: 0.339 ± 0.017	0.227CysPhe: 0.227 ± 0.014	0.781CysGly: 0.781 ± 0.024	0.183CysHis: 0.183 ± 0.01	0.249CysIle: 0.249 ± 0.012	0.122CysLys: 0.122 ± 0.009	0.681CysLeu: 0.681 ± 0.022	0.118CysMet: 0.118 ± 0.009	0.173CysAsn: 0.173 ± 0.011	0.455CysPro: 0.455 ± 0.021	0.221CysGln: 0.221 ± 0.013	0.592CysArg: 0.592 ± 0.025	0.474CysSer: 0.474 ± 0.019	0.453CysThr: 0.453 ± 0.024	0.566CysVal: 0.566 ± 0.018	0.175CysTrp: 0.175 ± 0.013	0.181CysTyr: 0.181 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.087AspAla: 7.087 ± 0.074	0.412AspCys: 0.412 ± 0.019	4.61AspAsp: 4.61 ± 0.066	3.886AspGlu: 3.886 ± 0.053	1.91AspPhe: 1.91 ± 0.041	5.984AspGly: 5.984 ± 0.068	2.201AspHis: 2.201 ± 0.043	2.059AspIle: 2.059 ± 0.037	1.296AspLys: 1.296 ± 0.035	7.107AspLeu: 7.107 ± 0.072	0.679AspMet: 0.679 ± 0.025	1.252AspAsn: 1.252 ± 0.031	4.701AspPro: 4.701 ± 0.07	3.009AspGln: 3.009 ± 0.051	5.783AspArg: 5.783 ± 0.078	2.955AspSer: 2.955 ± 0.046	2.773AspThr: 2.773 ± 0.05	4.794AspVal: 4.794 ± 0.056	1.19AspTrp: 1.19 ± 0.033	1.5AspTyr: 1.5 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	5.609GluAla: 5.609 ± 0.074	0.29GluCys: 0.29 ± 0.014	2.501GluAsp: 2.501 ± 0.048	2.376GluGlu: 2.376 ± 0.043	1.558GluPhe: 1.558 ± 0.032	2.937GluGly: 2.937 ± 0.055	1.422GluHis: 1.422 ± 0.031	2.628GluIle: 2.628 ± 0.049	1.137GluLys: 1.137 ± 0.03	7.26GluLeu: 7.26 ± 0.079	0.837GluMet: 0.837 ± 0.021	0.976GluAsn: 0.976 ± 0.03	3.224GluPro: 3.224 ± 0.05	2.674GluGln: 2.674 ± 0.042	4.618GluArg: 4.618 ± 0.06	2.834GluSer: 2.834 ± 0.045	2.581GluThr: 2.581 ± 0.043	4.449GluVal: 4.449 ± 0.057	0.689GluTrp: 0.689 ± 0.021	0.998GluTyr: 0.998 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.732PheAla: 3.732 ± 0.056	0.319PheCys: 0.319 ± 0.013	2.33PheAsp: 2.33 ± 0.047	1.381PheGlu: 1.381 ± 0.038	0.991PhePhe: 0.991 ± 0.03	3.387PheGly: 3.387 ± 0.048	0.598PheHis: 0.598 ± 0.022	1.104PheIle: 1.104 ± 0.031	0.502PheLys: 0.502 ± 0.02	2.612PheLeu: 2.612 ± 0.052	0.45PheMet: 0.45 ± 0.02	0.753PheAsn: 0.753 ± 0.025	1.323PhePro: 1.323 ± 0.035	0.726PheGln: 0.726 ± 0.022	1.85PheArg: 1.85 ± 0.038	1.712PheSer: 1.712 ± 0.037	1.924PheThr: 1.924 ± 0.037	2.509PheVal: 2.509 ± 0.039	0.502PheTrp: 0.502 ± 0.018	0.704PheTyr: 0.704 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.932GlyAla: 8.932 ± 0.09	0.871GlyCys: 0.871 ± 0.028	5.001GlyAsp: 5.001 ± 0.059	4.363GlyGlu: 4.363 ± 0.059	3.128GlyPhe: 3.128 ± 0.046	7.346GlyGly: 7.346 ± 0.091	1.993GlyHis: 1.993 ± 0.039	4.233GlyIle: 4.233 ± 0.055	2.491GlyLys: 2.491 ± 0.045	9.188GlyLeu: 9.188 ± 0.077	1.972GlyMet: 1.972 ± 0.034	2.055GlyAsn: 2.055 ± 0.044	4.44GlyPro: 4.44 ± 0.06	2.986GlyGln: 2.986 ± 0.048	7.188GlyArg: 7.188 ± 0.071	5.809GlySer: 5.809 ± 0.074	5.014GlyThr: 5.014 ± 0.067	7.167GlyVal: 7.167 ± 0.065	1.965GlyTrp: 1.965 ± 0.043	2.464GlyTyr: 2.464 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.175HisAla: 2.175 ± 0.035	0.177HisCys: 0.177 ± 0.01	1.583HisAsp: 1.583 ± 0.032	1.039HisGlu: 1.039 ± 0.027	0.61HisPhe: 0.61 ± 0.02	2.16HisGly: 2.16 ± 0.039	0.647HisHis: 0.647 ± 0.021	0.658HisIle: 0.658 ± 0.021	0.376HisLys: 0.376 ± 0.016	2.147HisLeu: 2.147 ± 0.035	0.247HisMet: 0.247 ± 0.013	0.453HisAsn: 0.453 ± 0.019	1.802HisPro: 1.802 ± 0.039	0.865HisGln: 0.865 ± 0.027	2.123HisArg: 2.123 ± 0.04	1.013HisSer: 1.013 ± 0.028	1.085HisThr: 1.085 ± 0.028	1.478HisVal: 1.478 ± 0.031	0.411HisTrp: 0.411 ± 0.018	0.529HisTyr: 0.529 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.399IleAla: 6.399 ± 0.073	0.442IleCys: 0.442 ± 0.016	3.582IleAsp: 3.582 ± 0.057	2.699IleGlu: 2.699 ± 0.048	1.533IlePhe: 1.533 ± 0.039	5.313IleGly: 5.313 ± 0.066	0.733IleHis: 0.733 ± 0.022	2.301IleIle: 2.301 ± 0.044	1.388IleLys: 1.388 ± 0.033	3.595IleLeu: 3.595 ± 0.053	0.974IleMet: 0.974 ± 0.027	1.53IleAsn: 1.53 ± 0.033	2.159IlePro: 2.159 ± 0.041	0.971IleGln: 0.971 ± 0.027	2.965IleArg: 2.965 ± 0.046	2.755IleSer: 2.755 ± 0.049	3.501IleThr: 3.501 ± 0.051	3.754IleVal: 3.754 ± 0.062	0.618IleTrp: 0.618 ± 0.023	0.9IleTyr: 0.9 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.397LysAla: 2.397 ± 0.057	0.097LysCys: 0.097 ± 0.009	1.158LysAsp: 1.158 ± 0.03	0.964LysGlu: 0.964 ± 0.027	0.561LysPhe: 0.561 ± 0.019	1.557LysGly: 1.557 ± 0.042	0.482LysHis: 0.482 ± 0.018	1.882LysIle: 1.882 ± 0.041	0.861LysLys: 0.861 ± 0.033	2.398LysLeu: 2.398 ± 0.05	0.426LysMet: 0.426 ± 0.018	0.602LysAsn: 0.602 ± 0.021	1.447LysPro: 1.447 ± 0.034	0.947LysGln: 0.947 ± 0.028	1.379LysArg: 1.379 ± 0.032	1.43LysSer: 1.43 ± 0.04	1.421LysThr: 1.421 ± 0.039	1.845LysVal: 1.845 ± 0.038	0.263LysTrp: 0.263 ± 0.014	0.512LysTyr: 0.512 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.815LeuAla: 13.815 ± 0.101	0.725LeuCys: 0.725 ± 0.021	6.921LeuAsp: 6.921 ± 0.069	4.453LeuGlu: 4.453 ± 0.063	2.598LeuPhe: 2.598 ± 0.049	8.897LeuGly: 8.897 ± 0.077	1.986LeuHis: 1.986 ± 0.035	5.861LeuIle: 5.861 ± 0.074	1.914LeuLys: 1.914 ± 0.045	10.381LeuLeu: 10.381 ± 0.113	1.748LeuMet: 1.748 ± 0.035	2.14LeuAsn: 2.14 ± 0.04	5.919LeuPro: 5.919 ± 0.062	3.16LeuGln: 3.16 ± 0.05	7.535LeuArg: 7.535 ± 0.078	5.802LeuSer: 5.802 ± 0.07	6.434LeuThr: 6.434 ± 0.066	8.133LeuVal: 8.133 ± 0.091	1.281LeuTrp: 1.281 ± 0.032	1.786LeuTyr: 1.786 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.273MetAla: 2.273 ± 0.038	0.108MetCys: 0.108 ± 0.009	0.832MetAsp: 0.832 ± 0.023	0.647MetGlu: 0.647 ± 0.023	0.526MetPhe: 0.526 ± 0.017	1.173MetGly: 1.173 ± 0.031	0.34MetHis: 0.34 ± 0.016	1.712MetIle: 1.712 ± 0.039	0.439MetLys: 0.439 ± 0.018	1.857MetLeu: 1.857 ± 0.041	0.378MetMet: 0.378 ± 0.018	0.484MetAsn: 0.484 ± 0.016	1.202MetPro: 1.202 ± 0.029	0.591MetGln: 0.591 ± 0.018	1.328MetArg: 1.328 ± 0.032	1.463MetSer: 1.463 ± 0.028	1.539MetThr: 1.539 ± 0.03	1.419MetVal: 1.419 ± 0.031	0.2MetTrp: 0.2 ± 0.011	0.318MetTyr: 0.318 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.449AsnAla: 2.449 ± 0.044	0.172AsnCys: 0.172 ± 0.01	1.208AsnAsp: 1.208 ± 0.033	0.957AsnGlu: 0.957 ± 0.024	0.692AsnPhe: 0.692 ± 0.025	2.137AsnGly: 2.137 ± 0.046	0.446AsnHis: 0.446 ± 0.018	0.839AsnIle: 0.839 ± 0.025	0.543AsnLys: 0.543 ± 0.022	2.18AsnLeu: 2.18 ± 0.038	0.32AsnMet: 0.32 ± 0.014	0.599AsnAsn: 0.599 ± 0.024	1.696AsnPro: 1.696 ± 0.034	0.763AsnGln: 0.763 ± 0.024	1.683AsnArg: 1.683 ± 0.035	1.322AsnSer: 1.322 ± 0.031	1.327AsnThr: 1.327 ± 0.036	1.634AsnVal: 1.634 ± 0.035	0.403AsnTrp: 0.403 ± 0.016	0.604AsnTyr: 0.604 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.995ProAla: 6.995 ± 0.082	0.26ProCys: 0.26 ± 0.015	4.658ProAsp: 4.658 ± 0.057	3.474ProGlu: 3.474 ± 0.048	1.465ProPhe: 1.465 ± 0.035	5.369ProGly: 5.369 ± 0.068	1.143ProHis: 1.143 ± 0.03	2.394ProIle: 2.394 ± 0.039	1.286ProLys: 1.286 ± 0.035	4.468ProLeu: 4.468 ± 0.058	1.104ProMet: 1.104 ± 0.027	1.269ProAsn: 1.269 ± 0.03	2.743ProPro: 2.743 ± 0.051	1.991ProGln: 1.991 ± 0.038	3.468ProArg: 3.468 ± 0.054	3.272ProSer: 3.272 ± 0.052	3.66ProThr: 3.66 ± 0.054	4.727ProVal: 4.727 ± 0.057	0.876ProTrp: 0.876 ± 0.024	1.49ProTyr: 1.49 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.021GlnAla: 4.021 ± 0.057	0.177GlnCys: 0.177 ± 0.01	1.669GlnAsp: 1.669 ± 0.037	1.273GlnGlu: 1.273 ± 0.028	0.907GlnPhe: 0.907 ± 0.026	2.127GlnGly: 2.127 ± 0.039	0.894GlnHis: 0.894 ± 0.024	1.605GlnIle: 1.605 ± 0.031	0.719GlnLys: 0.719 ± 0.023	4.522GlnLeu: 4.522 ± 0.058	0.566GlnMet: 0.566 ± 0.02	0.693GlnAsn: 0.693 ± 0.023	2.376GlnPro: 2.376 ± 0.046	2.045GlnGln: 2.045 ± 0.045	3.047GlnArg: 3.047 ± 0.054	1.825GlnSer: 1.825 ± 0.036	1.924GlnThr: 1.924 ± 0.042	3.008GlnVal: 3.008 ± 0.043	0.576GlnTrp: 0.576 ± 0.021	0.709GlnTyr: 0.709 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.986ArgAla: 7.986 ± 0.087	0.528ArgCys: 0.528 ± 0.02	4.365ArgAsp: 4.365 ± 0.062	3.606ArgGlu: 3.606 ± 0.054	2.451ArgPhe: 2.451 ± 0.045	5.162ArgGly: 5.162 ± 0.059	1.786ArgHis: 1.786 ± 0.032	3.724ArgIle: 3.724 ± 0.055	1.595ArgLys: 1.595 ± 0.033	8.471ArgLeu: 8.471 ± 0.096	1.881ArgMet: 1.881 ± 0.035	1.624ArgAsn: 1.624 ± 0.034	4.527ArgPro: 4.527 ± 0.062	2.854ArgGln: 2.854 ± 0.046	7.758ArgArg: 7.758 ± 0.091	4.692ArgSer: 4.692 ± 0.055	4.693ArgThr: 4.693 ± 0.051	5.537ArgVal: 5.537 ± 0.065	1.467ArgTrp: 1.467 ± 0.032	1.822ArgTyr: 1.822 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.947SerAla: 6.947 ± 0.08	0.426SerCys: 0.426 ± 0.017	3.397SerAsp: 3.397 ± 0.046	2.681SerGlu: 2.681 ± 0.052	1.761SerPhe: 1.761 ± 0.035	5.965SerGly: 5.965 ± 0.065	1.057SerHis: 1.057 ± 0.029	2.407SerIle: 2.407 ± 0.04	1.346SerLys: 1.346 ± 0.032	5.028SerLeu: 5.028 ± 0.057	1.39SerMet: 1.39 ± 0.031	1.234SerAsn: 1.234 ± 0.029	3.02SerPro: 3.02 ± 0.057	1.725SerGln: 1.725 ± 0.035	4.093SerArg: 4.093 ± 0.062	3.609SerSer: 3.609 ± 0.056	3.567SerThr: 3.567 ± 0.058	4.498SerVal: 4.498 ± 0.055	1.107SerTrp: 1.107 ± 0.031	1.58SerTyr: 1.58 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.491ThrAla: 7.491 ± 0.084	0.389ThrCys: 0.389 ± 0.021	4.139ThrAsp: 4.139 ± 0.063	3.372ThrGlu: 3.372 ± 0.051	1.704ThrPhe: 1.704 ± 0.042	6.008ThrGly: 6.008 ± 0.067	1.07ThrHis: 1.07 ± 0.026	2.687ThrIle: 2.687 ± 0.044	1.488ThrLys: 1.488 ± 0.042	5.241ThrLeu: 5.241 ± 0.062	1.135ThrMet: 1.135 ± 0.027	1.26ThrAsn: 1.26 ± 0.043	3.415ThrPro: 3.415 ± 0.047	1.591ThrGln: 1.591 ± 0.037	3.492ThrArg: 3.492 ± 0.05	3.489ThrSer: 3.489 ± 0.062	3.481ThrThr: 3.481 ± 0.068	5.403ThrVal: 5.403 ± 0.07	0.857ThrTrp: 0.857 ± 0.024	1.265ThrTyr: 1.265 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.982ValAla: 9.982 ± 0.085	0.67ValCys: 0.67 ± 0.024	5.637ValAsp: 5.637 ± 0.062	4.202ValGlu: 4.202 ± 0.059	2.286ValPhe: 2.286 ± 0.043	7.069ValGly: 7.069 ± 0.08	1.643ValHis: 1.643 ± 0.034	4.812ValIle: 4.812 ± 0.065	1.572ValLys: 1.572 ± 0.035	8.507ValLeu: 8.507 ± 0.093	1.438ValMet: 1.438 ± 0.03	1.666ValAsn: 1.666 ± 0.037	4.341ValPro: 4.341 ± 0.058	2.311ValGln: 2.311 ± 0.037	6.082ValArg: 6.082 ± 0.071	4.545ValSer: 4.545 ± 0.057	4.833ValThr: 4.833 ± 0.073	7.183ValVal: 7.183 ± 0.077	1.032ValTrp: 1.032 ± 0.029	1.337ValTyr: 1.337 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.581TrpAla: 1.581 ± 0.032	0.154TrpCys: 0.154 ± 0.01	0.829TrpAsp: 0.829 ± 0.023	0.571TrpGlu: 0.571 ± 0.02	0.585TrpPhe: 0.585 ± 0.022	1.019TrpGly: 1.019 ± 0.027	0.438TrpHis: 0.438 ± 0.016	0.744TrpIle: 0.744 ± 0.024	0.373TrpLys: 0.373 ± 0.017	1.957TrpLeu: 1.957 ± 0.037	0.341TrpMet: 0.341 ± 0.015	0.413TrpAsn: 0.413 ± 0.016	0.871TrpPro: 0.871 ± 0.026	0.822TrpGln: 0.822 ± 0.022	1.344TrpArg: 1.344 ± 0.034	1.051TrpSer: 1.051 ± 0.026	1.023TrpThr: 1.023 ± 0.028	1.135TrpVal: 1.135 ± 0.031	0.388TrpTrp: 0.388 ± 0.019	0.383TrpTyr: 0.383 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.662TyrAla: 2.662 ± 0.044	0.179TyrCys: 0.179 ± 0.011	1.467TyrAsp: 1.467 ± 0.035	1.085TyrGlu: 1.085 ± 0.029	0.758TyrPhe: 0.758 ± 0.025	2.213TyrGly: 2.213 ± 0.041	0.43TyrHis: 0.43 ± 0.018	0.609TyrIle: 0.609 ± 0.02	0.382TyrLys: 0.382 ± 0.018	2.568TyrLeu: 2.568 ± 0.043	0.228TyrMet: 0.228 ± 0.012	0.533TyrAsn: 0.533 ± 0.021	1.258TyrPro: 1.258 ± 0.032	0.81TyrGln: 0.81 ± 0.024	2.013TyrArg: 2.013 ± 0.041	1.075TyrSer: 1.075 ± 0.03	1.131TyrThr: 1.131 ± 0.029	1.675TyrVal: 1.675 ± 0.038	0.384TyrTrp: 0.384 ± 0.016	0.52TyrTyr: 0.52 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4484 proteins (1478000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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