Amino acid dipepetide frequency for Eggerthella sp. CAG:298

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.178AlaAla: 11.178 ± 0.216
1.753AlaCys: 1.753 ± 0.059
5.367AlaAsp: 5.367 ± 0.114
6.964AlaGlu: 6.964 ± 0.146
4.1AlaPhe: 4.1 ± 0.098
7.398AlaGly: 7.398 ± 0.132
2.391AlaHis: 2.391 ± 0.073
6.524AlaIle: 6.524 ± 0.133
4.762AlaLys: 4.762 ± 0.132
11.54AlaLeu: 11.54 ± 0.186
2.623AlaMet: 2.623 ± 0.07
3.562AlaAsn: 3.562 ± 0.106
3.869AlaPro: 3.869 ± 0.104
4.262AlaGln: 4.262 ± 0.101
5.487AlaArg: 5.487 ± 0.121
6.372AlaSer: 6.372 ± 0.144
5.352AlaThr: 5.352 ± 0.115
6.902AlaVal: 6.902 ± 0.143
0.91AlaTrp: 0.91 ± 0.045
2.825AlaTyr: 2.825 ± 0.088
0.002AlaXaa: 0.002 ± 0.002
Cys
1.595CysAla: 1.595 ± 0.061
0.266CysCys: 0.266 ± 0.025
0.904CysAsp: 0.904 ± 0.045
0.924CysGlu: 0.924 ± 0.048
0.638CysPhe: 0.638 ± 0.037
1.471CysGly: 1.471 ± 0.061
0.293CysHis: 0.293 ± 0.022
0.916CysIle: 0.916 ± 0.045
0.577CysLys: 0.577 ± 0.036
1.211CysLeu: 1.211 ± 0.05
0.399CysMet: 0.399 ± 0.029
0.432CysAsn: 0.432 ± 0.024
0.733CysPro: 0.733 ± 0.044
0.353CysGln: 0.353 ± 0.026
0.59CysArg: 0.59 ± 0.039
0.852CysSer: 0.852 ± 0.046
0.81CysThr: 0.81 ± 0.046
1.263CysVal: 1.263 ± 0.052
0.135CysTrp: 0.135 ± 0.018
0.444CysTyr: 0.444 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
6.499AspAla: 6.499 ± 0.131
0.698AspCys: 0.698 ± 0.04
3.043AspAsp: 3.043 ± 0.105
5.022AspGlu: 5.022 ± 0.111
2.37AspPhe: 2.37 ± 0.064
4.004AspGly: 4.004 ± 0.118
1.19AspHis: 1.19 ± 0.051
3.73AspIle: 3.73 ± 0.081
2.519AspLys: 2.519 ± 0.08
5.718AspLeu: 5.718 ± 0.114
1.552AspMet: 1.552 ± 0.045
1.844AspAsn: 1.844 ± 0.069
3.124AspPro: 3.124 ± 0.089
1.822AspGln: 1.822 ± 0.075
2.831AspArg: 2.831 ± 0.094
3.126AspSer: 3.126 ± 0.074
2.993AspThr: 2.993 ± 0.091
4.089AspVal: 4.089 ± 0.085
0.611AspTrp: 0.611 ± 0.038
2.04AspTyr: 2.04 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
7.903GluAla: 7.903 ± 0.175
0.789GluCys: 0.789 ± 0.04
4.029GluAsp: 4.029 ± 0.1
5.996GluGlu: 5.996 ± 0.148
2.295GluPhe: 2.295 ± 0.069
5.186GluGly: 5.186 ± 0.115
1.601GluHis: 1.601 ± 0.059
4.029GluIle: 4.029 ± 0.097
3.441GluLys: 3.441 ± 0.082
6.6GluLeu: 6.6 ± 0.124
1.792GluMet: 1.792 ± 0.068
2.654GluAsn: 2.654 ± 0.081
2.449GluPro: 2.449 ± 0.078
3.088GluGln: 3.088 ± 0.088
4.524GluArg: 4.524 ± 0.114
3.493GluSer: 3.493 ± 0.077
3.628GluThr: 3.628 ± 0.092
5.294GluVal: 5.294 ± 0.118
0.565GluTrp: 0.565 ± 0.036
1.963GluTyr: 1.963 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
4.289PheAla: 4.289 ± 0.115
0.704PheCys: 0.704 ± 0.042
2.901PheAsp: 2.901 ± 0.08
2.7PheGlu: 2.7 ± 0.084
1.88PhePhe: 1.88 ± 0.078
3.487PheGly: 3.487 ± 0.109
0.646PheHis: 0.646 ± 0.036
2.532PheIle: 2.532 ± 0.088
1.552PheLys: 1.552 ± 0.058
3.394PheLeu: 3.394 ± 0.098
1.095PheMet: 1.095 ± 0.053
1.468PheAsn: 1.468 ± 0.058
1.433PhePro: 1.433 ± 0.06
0.876PheGln: 0.876 ± 0.044
1.402PheArg: 1.402 ± 0.047
2.733PheSer: 2.733 ± 0.077
2.436PheThr: 2.436 ± 0.077
3.149PheVal: 3.149 ± 0.096
0.426PheTrp: 0.426 ± 0.033
1.19PheTyr: 1.19 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
7.012GlyAla: 7.012 ± 0.145
1.315GlyCys: 1.315 ± 0.053
3.697GlyAsp: 3.697 ± 0.087
4.48GlyGlu: 4.48 ± 0.105
3.442GlyPhe: 3.442 ± 0.081
5.402GlyGly: 5.402 ± 0.142
1.358GlyHis: 1.358 ± 0.052
5.56GlyIle: 5.56 ± 0.112
3.982GlyLys: 3.982 ± 0.087
6.372GlyLeu: 6.372 ± 0.121
2.118GlyMet: 2.118 ± 0.071
2.548GlyAsn: 2.548 ± 0.084
1.992GlyPro: 1.992 ± 0.062
2.195GlyGln: 2.195 ± 0.069
3.282GlyArg: 3.282 ± 0.083
4.806GlySer: 4.806 ± 0.115
4.386GlyThr: 4.386 ± 0.123
6.029GlyVal: 6.029 ± 0.116
0.876GlyTrp: 0.876 ± 0.069
2.584GlyTyr: 2.584 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
2.017HisAla: 2.017 ± 0.068
0.318HisCys: 0.318 ± 0.026
1.296HisAsp: 1.296 ± 0.056
1.452HisGlu: 1.452 ± 0.059
0.835HisPhe: 0.835 ± 0.04
1.417HisGly: 1.417 ± 0.055
0.598HisHis: 0.598 ± 0.038
1.184HisIle: 1.184 ± 0.049
0.771HisLys: 0.771 ± 0.04
1.784HisLeu: 1.784 ± 0.061
0.513HisMet: 0.513 ± 0.029
0.588HisAsn: 0.588 ± 0.035
1.2HisPro: 1.2 ± 0.056
0.484HisGln: 0.484 ± 0.027
1.005HisArg: 1.005 ± 0.046
1.068HisSer: 1.068 ± 0.051
1.063HisThr: 1.063 ± 0.046
1.35HisVal: 1.35 ± 0.055
0.177HisTrp: 0.177 ± 0.018
0.661HisTyr: 0.661 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
7.411IleAla: 7.411 ± 0.142
1.153IleCys: 1.153 ± 0.052
4.517IleAsp: 4.517 ± 0.084
4.953IleGlu: 4.953 ± 0.107
2.237IlePhe: 2.237 ± 0.085
4.92IleGly: 4.92 ± 0.135
1.132IleHis: 1.132 ± 0.058
3.884IleIle: 3.884 ± 0.112
2.476IleLys: 2.476 ± 0.068
4.92IleLeu: 4.92 ± 0.131
1.62IleMet: 1.62 ± 0.066
2.002IleAsn: 2.002 ± 0.069
3.09IlePro: 3.09 ± 0.084
1.56IleGln: 1.56 ± 0.053
2.617IleArg: 2.617 ± 0.07
3.657IleSer: 3.657 ± 0.09
3.691IleThr: 3.691 ± 0.082
5.124IleVal: 5.124 ± 0.121
0.536IleTrp: 0.536 ± 0.039
1.66IleTyr: 1.66 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
4.445LysAla: 4.445 ± 0.112
0.409LysCys: 0.409 ± 0.028
2.7LysAsp: 2.7 ± 0.069
3.315LysGlu: 3.315 ± 0.095
1.105LysPhe: 1.105 ± 0.049
3.049LysGly: 3.049 ± 0.078
0.924LysHis: 0.924 ± 0.043
2.536LysIle: 2.536 ± 0.077
2.854LysLys: 2.854 ± 0.105
3.93LysLeu: 3.93 ± 0.094
1.13LysMet: 1.13 ± 0.045
1.971LysAsn: 1.971 ± 0.074
1.988LysPro: 1.988 ± 0.065
1.784LysGln: 1.784 ± 0.059
3.211LysArg: 3.211 ± 0.073
2.378LysSer: 2.378 ± 0.067
2.829LysThr: 2.829 ± 0.078
3.113LysVal: 3.113 ± 0.09
0.386LysTrp: 0.386 ± 0.035
1.07LysTyr: 1.07 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
10.09LeuAla: 10.09 ± 0.173
1.462LeuCys: 1.462 ± 0.05
6.087LeuAsp: 6.087 ± 0.124
6.432LeuGlu: 6.432 ± 0.147
3.946LeuPhe: 3.946 ± 0.128
6.804LeuGly: 6.804 ± 0.134
1.722LeuHis: 1.722 ± 0.067
5.83LeuIle: 5.83 ± 0.138
3.915LeuLys: 3.915 ± 0.099
8.372LeuLeu: 8.372 ± 0.221
2.407LeuMet: 2.407 ± 0.07
2.887LeuAsn: 2.887 ± 0.074
4.2LeuPro: 4.2 ± 0.088
2.605LeuGln: 2.605 ± 0.07
4.698LeuArg: 4.698 ± 0.119
6.235LeuSer: 6.235 ± 0.124
4.762LeuThr: 4.762 ± 0.095
7.315LeuVal: 7.315 ± 0.149
0.737LeuTrp: 0.737 ± 0.038
2.499LeuTyr: 2.499 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.636MetAla: 2.636 ± 0.066
0.334MetCys: 0.334 ± 0.024
1.375MetAsp: 1.375 ± 0.052
1.568MetGlu: 1.568 ± 0.069
0.858MetPhe: 0.858 ± 0.044
1.89MetGly: 1.89 ± 0.066
0.48MetHis: 0.48 ± 0.03
1.498MetIle: 1.498 ± 0.059
1.477MetLys: 1.477 ± 0.052
2.447MetLeu: 2.447 ± 0.089
0.634MetMet: 0.634 ± 0.039
1.194MetAsn: 1.194 ± 0.047
1.279MetPro: 1.279 ± 0.043
0.922MetGln: 0.922 ± 0.042
1.643MetArg: 1.643 ± 0.063
1.601MetSer: 1.601 ± 0.058
1.452MetThr: 1.452 ± 0.052
1.778MetVal: 1.778 ± 0.069
0.216MetTrp: 0.216 ± 0.02
0.486MetTyr: 0.486 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.765AsnAla: 3.765 ± 0.114
0.434AsnCys: 0.434 ± 0.03
2.218AsnAsp: 2.218 ± 0.082
2.625AsnGlu: 2.625 ± 0.074
1.242AsnPhe: 1.242 ± 0.05
2.632AsnGly: 2.632 ± 0.1
0.617AsnHis: 0.617 ± 0.033
2.216AsnIle: 2.216 ± 0.065
1.608AsnLys: 1.608 ± 0.058
2.966AsnLeu: 2.966 ± 0.084
0.931AsnMet: 0.931 ± 0.044
1.329AsnAsn: 1.329 ± 0.066
2.065AsnPro: 2.065 ± 0.073
1.068AsnGln: 1.068 ± 0.052
1.689AsnArg: 1.689 ± 0.056
1.795AsnSer: 1.795 ± 0.083
2.054AsnThr: 2.054 ± 0.075
2.469AsnVal: 2.469 ± 0.072
0.372AsnTrp: 0.372 ± 0.027
1.12AsnTyr: 1.12 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
4.353ProAla: 4.353 ± 0.103
0.515ProCys: 0.515 ± 0.032
2.598ProAsp: 2.598 ± 0.083
3.824ProGlu: 3.824 ± 0.08
1.836ProPhe: 1.836 ± 0.068
2.96ProGly: 2.96 ± 0.093
1.005ProHis: 1.005 ± 0.046
2.407ProIle: 2.407 ± 0.066
1.651ProLys: 1.651 ± 0.06
3.795ProLeu: 3.795 ± 0.077
0.783ProMet: 0.783 ± 0.043
1.551ProAsn: 1.551 ± 0.059
1.078ProPro: 1.078 ± 0.047
1.466ProGln: 1.466 ± 0.054
1.826ProArg: 1.826 ± 0.06
2.54ProSer: 2.54 ± 0.074
2.58ProThr: 2.58 ± 0.087
3.226ProVal: 3.226 ± 0.086
0.407ProTrp: 0.407 ± 0.029
1.39ProTyr: 1.39 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.824GlnAla: 3.824 ± 0.104
0.316GlnCys: 0.316 ± 0.024
1.697GlnAsp: 1.697 ± 0.054
2.245GlnGlu: 2.245 ± 0.069
1.08GlnPhe: 1.08 ± 0.041
2.418GlnGly: 2.418 ± 0.071
0.623GlnHis: 0.623 ± 0.04
2.141GlnIle: 2.141 ± 0.062
1.61GlnLys: 1.61 ± 0.057
2.881GlnLeu: 2.881 ± 0.078
0.891GlnMet: 0.891 ± 0.041
1.19GlnAsn: 1.19 ± 0.052
1.36GlnPro: 1.36 ± 0.053
1.412GlnGln: 1.412 ± 0.052
1.767GlnArg: 1.767 ± 0.062
1.686GlnSer: 1.686 ± 0.061
1.886GlnThr: 1.886 ± 0.053
2.378GlnVal: 2.378 ± 0.066
0.324GlnTrp: 0.324 ± 0.03
0.789GlnTyr: 0.789 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
4.949ArgAla: 4.949 ± 0.124
0.766ArgCys: 0.766 ± 0.04
2.787ArgAsp: 2.787 ± 0.076
3.79ArgGlu: 3.79 ± 0.098
2.376ArgPhe: 2.376 ± 0.074
3.091ArgGly: 3.091 ± 0.083
0.953ArgHis: 0.953 ± 0.042
3.61ArgIle: 3.61 ± 0.091
2.594ArgLys: 2.594 ± 0.073
4.449ArgLeu: 4.449 ± 0.108
1.595ArgMet: 1.595 ± 0.056
1.809ArgAsn: 1.809 ± 0.059
1.72ArgPro: 1.72 ± 0.065
1.543ArgGln: 1.543 ± 0.055
2.802ArgArg: 2.802 ± 0.084
3.199ArgSer: 3.199 ± 0.079
2.802ArgThr: 2.802 ± 0.055
3.786ArgVal: 3.786 ± 0.088
0.442ArgTrp: 0.442 ± 0.03
1.701ArgTyr: 1.701 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.88SerAla: 5.88 ± 0.151
0.789SerCys: 0.789 ± 0.043
3.518SerAsp: 3.518 ± 0.087
3.882SerGlu: 3.882 ± 0.087
2.71SerPhe: 2.71 ± 0.086
4.671SerGly: 4.671 ± 0.106
1.119SerHis: 1.119 ± 0.043
3.901SerIle: 3.901 ± 0.089
2.424SerLys: 2.424 ± 0.064
5.915SerLeu: 5.915 ± 0.121
1.568SerMet: 1.568 ± 0.056
2.048SerAsn: 2.048 ± 0.06
2.368SerPro: 2.368 ± 0.071
1.944SerGln: 1.944 ± 0.064
2.96SerArg: 2.96 ± 0.08
4.384SerSer: 4.384 ± 0.131
3.473SerThr: 3.473 ± 0.103
4.299SerVal: 4.299 ± 0.094
0.629SerTrp: 0.629 ± 0.037
2.011SerTyr: 2.011 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
4.993ThrAla: 4.993 ± 0.14
0.795ThrCys: 0.795 ± 0.045
2.922ThrAsp: 2.922 ± 0.096
3.29ThrGlu: 3.29 ± 0.09
2.339ThrPhe: 2.339 ± 0.077
4.303ThrGly: 4.303 ± 0.145
1.128ThrHis: 1.128 ± 0.045
3.795ThrIle: 3.795 ± 0.097
2.453ThrLys: 2.453 ± 0.074
5.545ThrLeu: 5.545 ± 0.119
1.35ThrMet: 1.35 ± 0.06
2.089ThrAsn: 2.089 ± 0.077
3.028ThrPro: 3.028 ± 0.092
1.674ThrGln: 1.674 ± 0.048
2.6ThrArg: 2.6 ± 0.071
3.412ThrSer: 3.412 ± 0.086
3.442ThrThr: 3.442 ± 0.111
4.065ThrVal: 4.065 ± 0.106
0.548ThrTrp: 0.548 ± 0.031
1.747ThrTyr: 1.747 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
7.693ValAla: 7.693 ± 0.139
1.3ValCys: 1.3 ± 0.055
4.549ValAsp: 4.549 ± 0.1
5.186ValGlu: 5.186 ± 0.102
3.36ValPhe: 3.36 ± 0.085
5.219ValGly: 5.219 ± 0.116
1.211ValHis: 1.211 ± 0.059
4.675ValIle: 4.675 ± 0.112
3.022ValLys: 3.022 ± 0.072
7.222ValLeu: 7.222 ± 0.144
1.865ValMet: 1.865 ± 0.066
2.542ValAsn: 2.542 ± 0.081
3.259ValPro: 3.259 ± 0.091
2.027ValGln: 2.027 ± 0.068
3.653ValArg: 3.653 ± 0.089
4.989ValSer: 4.989 ± 0.104
3.838ValThr: 3.838 ± 0.112
6.761ValVal: 6.761 ± 0.151
0.675ValTrp: 0.675 ± 0.036
2.073ValTyr: 2.073 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.758TrpAla: 0.758 ± 0.041
0.158TrpCys: 0.158 ± 0.019
0.571TrpAsp: 0.571 ± 0.04
0.59TrpGlu: 0.59 ± 0.036
0.413TrpPhe: 0.413 ± 0.032
0.702TrpGly: 0.702 ± 0.047
0.214TrpHis: 0.214 ± 0.021
0.633TrpIle: 0.633 ± 0.041
0.417TrpLys: 0.417 ± 0.027
1.011TrpLeu: 1.011 ± 0.051
0.276TrpMet: 0.276 ± 0.024
0.413TrpAsn: 0.413 ± 0.036
0.318TrpPro: 0.318 ± 0.026
0.363TrpGln: 0.363 ± 0.022
0.492TrpArg: 0.492 ± 0.031
0.526TrpSer: 0.526 ± 0.037
0.43TrpThr: 0.43 ± 0.044
0.71TrpVal: 0.71 ± 0.042
0.133TrpTrp: 0.133 ± 0.017
0.26TrpTyr: 0.26 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.852TyrAla: 2.852 ± 0.081
0.534TyrCys: 0.534 ± 0.031
2.052TyrAsp: 2.052 ± 0.065
2.077TyrGlu: 2.077 ± 0.074
1.23TyrPhe: 1.23 ± 0.048
2.411TyrGly: 2.411 ± 0.067
0.579TyrHis: 0.579 ± 0.037
1.558TyrIle: 1.558 ± 0.066
1.024TyrLys: 1.024 ± 0.054
2.931TyrLeu: 2.931 ± 0.083
0.625TyrMet: 0.625 ± 0.036
1.099TyrAsn: 1.099 ± 0.053
1.238TyrPro: 1.238 ± 0.055
1.07TyrGln: 1.07 ± 0.05
1.684TyrArg: 1.684 ± 0.067
1.641TyrSer: 1.641 ± 0.059
1.61TyrThr: 1.61 ± 0.084
2.019TyrVal: 2.019 ± 0.058
0.282TyrTrp: 0.282 ± 0.023
1.009TyrTyr: 1.009 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.002XaaGlu: 0.002 ± 0.002
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1581 proteins (518525 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski