Amino acid dipepetide frequency for Gynuella sunshinyii YC6258

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.173AlaAla: 8.173 ± 0.124
1.003AlaCys: 1.003 ± 0.028
5.331AlaAsp: 5.331 ± 0.081
5.621AlaGlu: 5.621 ± 0.07
3.345AlaPhe: 3.345 ± 0.05
6.855AlaGly: 6.855 ± 0.109
1.755AlaHis: 1.755 ± 0.042
5.434AlaIle: 5.434 ± 0.065
3.223AlaLys: 3.223 ± 0.054
9.251AlaLeu: 9.251 ± 0.099
2.508AlaMet: 2.508 ± 0.042
3.13AlaAsn: 3.13 ± 0.041
2.709AlaPro: 2.709 ± 0.052
3.568AlaGln: 3.568 ± 0.062
4.578AlaArg: 4.578 ± 0.067
5.173AlaSer: 5.173 ± 0.067
4.414AlaThr: 4.414 ± 0.066
6.198AlaVal: 6.198 ± 0.064
1.093AlaTrp: 1.093 ± 0.023
2.404AlaTyr: 2.404 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.842CysAla: 0.842 ± 0.027
0.187CysCys: 0.187 ± 0.011
0.613CysAsp: 0.613 ± 0.019
0.595CysGlu: 0.595 ± 0.022
0.489CysPhe: 0.489 ± 0.019
0.868CysGly: 0.868 ± 0.024
0.399CysHis: 0.399 ± 0.016
0.576CysIle: 0.576 ± 0.015
0.348CysLys: 0.348 ± 0.013
1.123CysLeu: 1.123 ± 0.027
0.242CysMet: 0.242 ± 0.012
0.36CysAsn: 0.36 ± 0.017
0.478CysPro: 0.478 ± 0.019
0.594CysGln: 0.594 ± 0.02
0.676CysArg: 0.676 ± 0.024
0.783CysSer: 0.783 ± 0.023
0.473CysThr: 0.473 ± 0.014
0.661CysVal: 0.661 ± 0.02
0.185CysTrp: 0.185 ± 0.01
0.394CysTyr: 0.394 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.633AspAla: 4.633 ± 0.083
0.609AspCys: 0.609 ± 0.021
3.372AspAsp: 3.372 ± 0.072
3.525AspGlu: 3.525 ± 0.051
2.378AspPhe: 2.378 ± 0.039
4.285AspGly: 4.285 ± 0.103
1.559AspHis: 1.559 ± 0.031
4.067AspIle: 4.067 ± 0.058
2.262AspLys: 2.262 ± 0.045
5.329AspLeu: 5.329 ± 0.06
1.411AspMet: 1.411 ± 0.03
2.421AspAsn: 2.421 ± 0.068
2.667AspPro: 2.667 ± 0.051
3.005AspGln: 3.005 ± 0.049
2.824AspArg: 2.824 ± 0.038
3.703AspSer: 3.703 ± 0.066
3.069AspThr: 3.069 ± 0.076
3.541AspVal: 3.541 ± 0.05
1.0AspTrp: 1.0 ± 0.027
2.156AspTyr: 2.156 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
4.975GluAla: 4.975 ± 0.064
0.513GluCys: 0.513 ± 0.017
2.784GluAsp: 2.784 ± 0.04
3.161GluGlu: 3.161 ± 0.057
2.276GluPhe: 2.276 ± 0.04
3.212GluGly: 3.212 ± 0.052
1.596GluHis: 1.596 ± 0.027
3.723GluIle: 3.723 ± 0.051
2.875GluLys: 2.875 ± 0.056
6.495GluLeu: 6.495 ± 0.066
1.499GluMet: 1.499 ± 0.032
2.509GluAsn: 2.509 ± 0.047
2.142GluPro: 2.142 ± 0.039
3.981GluGln: 3.981 ± 0.063
3.219GluArg: 3.219 ± 0.05
3.481GluSer: 3.481 ± 0.046
3.238GluThr: 3.238 ± 0.048
3.843GluVal: 3.843 ± 0.049
0.815GluTrp: 0.815 ± 0.023
2.041GluTyr: 2.041 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.271PheAla: 3.271 ± 0.055
0.555PheCys: 0.555 ± 0.019
2.736PheAsp: 2.736 ± 0.034
2.416PheGlu: 2.416 ± 0.038
1.854PhePhe: 1.854 ± 0.033
3.052PheGly: 3.052 ± 0.045
0.889PheHis: 0.889 ± 0.022
2.477PheIle: 2.477 ± 0.04
1.685PheLys: 1.685 ± 0.039
3.575PheLeu: 3.575 ± 0.057
1.101PheMet: 1.101 ± 0.025
1.829PheAsn: 1.829 ± 0.035
1.563PhePro: 1.563 ± 0.033
1.468PheGln: 1.468 ± 0.034
1.868PheArg: 1.868 ± 0.034
3.309PheSer: 3.309 ± 0.047
2.028PheThr: 2.028 ± 0.035
2.567PheVal: 2.567 ± 0.043
0.659PheTrp: 0.659 ± 0.024
1.398PheTyr: 1.398 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
5.129GlyAla: 5.129 ± 0.055
0.909GlyCys: 0.909 ± 0.025
3.891GlyAsp: 3.891 ± 0.085
3.943GlyGlu: 3.943 ± 0.059
3.32GlyPhe: 3.32 ± 0.046
5.044GlyGly: 5.044 ± 0.105
1.866GlyHis: 1.866 ± 0.037
4.707GlyIle: 4.707 ± 0.052
3.179GlyLys: 3.179 ± 0.047
7.087GlyLeu: 7.087 ± 0.056
2.01GlyMet: 2.01 ± 0.038
2.867GlyAsn: 2.867 ± 0.113
1.922GlyPro: 1.922 ± 0.04
3.265GlyGln: 3.265 ± 0.055
3.688GlyArg: 3.688 ± 0.061
4.624GlySer: 4.624 ± 0.082
3.731GlyThr: 3.731 ± 0.058
4.978GlyVal: 4.978 ± 0.062
1.094GlyTrp: 1.094 ± 0.029
2.825GlyTyr: 2.825 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
1.703HisAla: 1.703 ± 0.04
0.383HisCys: 0.383 ± 0.018
1.286HisAsp: 1.286 ± 0.029
1.312HisGlu: 1.312 ± 0.024
1.133HisPhe: 1.133 ± 0.025
1.778HisGly: 1.778 ± 0.044
0.887HisHis: 0.887 ± 0.03
1.478HisIle: 1.478 ± 0.025
0.885HisLys: 0.885 ± 0.023
2.514HisLeu: 2.514 ± 0.041
0.556HisMet: 0.556 ± 0.016
0.968HisAsn: 0.968 ± 0.022
1.326HisPro: 1.326 ± 0.032
1.402HisGln: 1.402 ± 0.031
1.422HisArg: 1.422 ± 0.032
1.554HisSer: 1.554 ± 0.033
1.151HisThr: 1.151 ± 0.026
1.273HisVal: 1.273 ± 0.029
0.492HisTrp: 0.492 ± 0.017
0.963HisTyr: 0.963 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.707IleAla: 5.707 ± 0.061
0.748IleCys: 0.748 ± 0.021
4.121IleAsp: 4.121 ± 0.052
4.079IleGlu: 4.079 ± 0.055
2.198IlePhe: 2.198 ± 0.051
4.46IleGly: 4.46 ± 0.062
1.475IleHis: 1.475 ± 0.027
3.396IleIle: 3.396 ± 0.062
2.745IleLys: 2.745 ± 0.049
5.5IleLeu: 5.5 ± 0.075
1.279IleMet: 1.279 ± 0.032
2.868IleAsn: 2.868 ± 0.044
2.816IlePro: 2.816 ± 0.048
2.531IleGln: 2.531 ± 0.044
3.451IleArg: 3.451 ± 0.046
4.654IleSer: 4.654 ± 0.053
3.407IleThr: 3.407 ± 0.048
3.814IleVal: 3.814 ± 0.054
0.766IleTrp: 0.766 ± 0.021
1.83IleTyr: 1.83 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.758LysAla: 3.758 ± 0.061
0.294LysCys: 0.294 ± 0.013
2.277LysAsp: 2.277 ± 0.045
2.253LysGlu: 2.253 ± 0.048
1.235LysPhe: 1.235 ± 0.032
2.624LysGly: 2.624 ± 0.044
0.994LysHis: 0.994 ± 0.026
2.669LysIle: 2.669 ± 0.052
2.134LysLys: 2.134 ± 0.06
4.028LysLeu: 4.028 ± 0.067
1.024LysMet: 1.024 ± 0.027
1.848LysAsn: 1.848 ± 0.039
2.038LysPro: 2.038 ± 0.034
2.201LysGln: 2.201 ± 0.04
2.155LysArg: 2.155 ± 0.042
2.605LysSer: 2.605 ± 0.049
2.809LysThr: 2.809 ± 0.042
3.02LysVal: 3.02 ± 0.054
0.484LysTrp: 0.484 ± 0.015
1.245LysTyr: 1.245 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
9.72LeuAla: 9.72 ± 0.121
1.153LeuCys: 1.153 ± 0.029
5.611LeuAsp: 5.611 ± 0.064
5.888LeuGlu: 5.888 ± 0.07
4.103LeuPhe: 4.103 ± 0.061
6.397LeuGly: 6.397 ± 0.064
2.193LeuHis: 2.193 ± 0.052
6.298LeuIle: 6.298 ± 0.08
5.114LeuLys: 5.114 ± 0.076
10.761LeuLeu: 10.761 ± 0.118
2.668LeuMet: 2.668 ± 0.044
4.588LeuAsn: 4.588 ± 0.051
4.973LeuPro: 4.973 ± 0.077
4.811LeuGln: 4.811 ± 0.089
4.778LeuArg: 4.778 ± 0.06
8.002LeuSer: 8.002 ± 0.067
6.206LeuThr: 6.206 ± 0.059
6.628LeuVal: 6.628 ± 0.076
1.287LeuTrp: 1.287 ± 0.028
2.794LeuTyr: 2.794 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.703MetAla: 2.703 ± 0.041
0.179MetCys: 0.179 ± 0.01
1.393MetAsp: 1.393 ± 0.032
1.305MetGlu: 1.305 ± 0.029
0.852MetPhe: 0.852 ± 0.026
1.598MetGly: 1.598 ± 0.036
0.497MetHis: 0.497 ± 0.018
1.637MetIle: 1.637 ± 0.032
1.226MetLys: 1.226 ± 0.029
2.59MetLeu: 2.59 ± 0.04
0.673MetMet: 0.673 ± 0.024
1.157MetAsn: 1.157 ± 0.024
1.188MetPro: 1.188 ± 0.028
1.11MetGln: 1.11 ± 0.023
1.07MetArg: 1.07 ± 0.026
1.856MetSer: 1.856 ± 0.04
1.697MetThr: 1.697 ± 0.033
1.816MetVal: 1.816 ± 0.035
0.2MetTrp: 0.2 ± 0.011
0.505MetTyr: 0.505 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.208AsnAla: 3.208 ± 0.049
0.416AsnCys: 0.416 ± 0.017
2.399AsnAsp: 2.399 ± 0.079
2.027AsnGlu: 2.027 ± 0.035
1.377AsnPhe: 1.377 ± 0.03
3.439AsnGly: 3.439 ± 0.078
1.081AsnHis: 1.081 ± 0.023
2.713AsnIle: 2.713 ± 0.044
1.578AsnLys: 1.578 ± 0.037
3.834AsnLeu: 3.834 ± 0.052
0.974AsnMet: 0.974 ± 0.026
1.845AsnAsn: 1.845 ± 0.055
2.188AsnPro: 2.188 ± 0.036
2.019AsnGln: 2.019 ± 0.041
2.37AsnArg: 2.37 ± 0.039
2.484AsnSer: 2.484 ± 0.048
2.319AsnThr: 2.319 ± 0.041
2.33AsnVal: 2.33 ± 0.043
0.637AsnTrp: 0.637 ± 0.021
1.313AsnTyr: 1.313 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
3.922ProAla: 3.922 ± 0.084
0.309ProCys: 0.309 ± 0.014
3.106ProAsp: 3.106 ± 0.049
3.458ProGlu: 3.458 ± 0.049
1.747ProPhe: 1.747 ± 0.037
3.102ProGly: 3.102 ± 0.046
0.849ProHis: 0.849 ± 0.022
2.186ProIle: 2.186 ± 0.039
1.652ProLys: 1.652 ± 0.034
4.151ProLeu: 4.151 ± 0.07
1.018ProMet: 1.018 ± 0.024
1.439ProAsn: 1.439 ± 0.03
1.357ProPro: 1.357 ± 0.034
1.803ProGln: 1.803 ± 0.048
1.607ProArg: 1.607 ± 0.032
2.456ProSer: 2.456 ± 0.037
1.943ProThr: 1.943 ± 0.039
3.677ProVal: 3.677 ± 0.056
0.61ProTrp: 0.61 ± 0.02
1.333ProTyr: 1.333 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.614GlnAla: 4.614 ± 0.083
0.46GlnCys: 0.46 ± 0.016
2.148GlnAsp: 2.148 ± 0.038
2.352GlnGlu: 2.352 ± 0.039
1.721GlnPhe: 1.721 ± 0.03
2.854GlnGly: 2.854 ± 0.048
1.424GlnHis: 1.424 ± 0.032
2.793GlnIle: 2.793 ± 0.048
2.1GlnLys: 2.1 ± 0.046
5.75GlnLeu: 5.75 ± 0.082
1.151GlnMet: 1.151 ± 0.022
1.846GlnAsn: 1.846 ± 0.034
2.28GlnPro: 2.28 ± 0.053
4.191GlnGln: 4.191 ± 0.104
2.89GlnArg: 2.89 ± 0.059
3.021GlnSer: 3.021 ± 0.044
2.757GlnThr: 2.757 ± 0.048
3.218GlnVal: 3.218 ± 0.043
0.93GlnTrp: 0.93 ± 0.025
1.627GlnTyr: 1.627 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
3.7ArgAla: 3.7 ± 0.052
0.605ArgCys: 0.605 ± 0.024
2.626ArgAsp: 2.626 ± 0.041
3.129ArgGlu: 3.129 ± 0.044
2.479ArgPhe: 2.479 ± 0.04
2.679ArgGly: 2.679 ± 0.036
1.496ArgHis: 1.496 ± 0.034
3.468ArgIle: 3.468 ± 0.047
2.293ArgLys: 2.293 ± 0.042
6.113ArgLeu: 6.113 ± 0.074
1.408ArgMet: 1.408 ± 0.03
2.041ArgAsn: 2.041 ± 0.033
1.959ArgPro: 1.959 ± 0.041
3.242ArgGln: 3.242 ± 0.056
2.795ArgArg: 2.795 ± 0.046
3.11ArgSer: 3.11 ± 0.039
2.53ArgThr: 2.53 ± 0.045
3.266ArgVal: 3.266 ± 0.045
0.881ArgTrp: 0.881 ± 0.026
2.135ArgTyr: 2.135 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.688SerAla: 5.688 ± 0.072
0.736SerCys: 0.736 ± 0.02
4.131SerAsp: 4.131 ± 0.08
3.862SerGlu: 3.862 ± 0.057
2.77SerPhe: 2.77 ± 0.041
5.772SerGly: 5.772 ± 0.079
1.618SerHis: 1.618 ± 0.032
3.983SerIle: 3.983 ± 0.05
2.465SerLys: 2.465 ± 0.046
7.055SerLeu: 7.055 ± 0.067
1.703SerMet: 1.703 ± 0.034
2.448SerAsn: 2.448 ± 0.053
2.565SerPro: 2.565 ± 0.041
2.921SerGln: 2.921 ± 0.045
3.544SerArg: 3.544 ± 0.05
4.631SerSer: 4.631 ± 0.071
3.449SerThr: 3.449 ± 0.046
4.544SerVal: 4.544 ± 0.051
0.975SerTrp: 0.975 ± 0.024
2.195SerTyr: 2.195 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.908ThrAla: 4.908 ± 0.077
0.474ThrCys: 0.474 ± 0.017
3.372ThrAsp: 3.372 ± 0.059
3.232ThrGlu: 3.232 ± 0.052
2.008ThrPhe: 2.008 ± 0.039
4.568ThrGly: 4.568 ± 0.063
1.243ThrHis: 1.243 ± 0.03
3.299ThrIle: 3.299 ± 0.057
1.584ThrLys: 1.584 ± 0.031
6.323ThrLeu: 6.323 ± 0.077
1.192ThrMet: 1.192 ± 0.028
1.85ThrAsn: 1.85 ± 0.037
2.695ThrPro: 2.695 ± 0.04
2.251ThrGln: 2.251 ± 0.043
2.792ThrArg: 2.792 ± 0.043
3.328ThrSer: 3.328 ± 0.046
3.022ThrThr: 3.022 ± 0.063
4.087ThrVal: 4.087 ± 0.06
0.642ThrTrp: 0.642 ± 0.02
1.494ThrTyr: 1.494 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.978ValAla: 5.978 ± 0.06
0.756ValCys: 0.756 ± 0.021
3.972ValAsp: 3.972 ± 0.047
3.946ValGlu: 3.946 ± 0.054
2.869ValPhe: 2.869 ± 0.049
4.216ValGly: 4.216 ± 0.057
1.353ValHis: 1.353 ± 0.032
4.546ValIle: 4.546 ± 0.057
2.764ValLys: 2.764 ± 0.044
6.898ValLeu: 6.898 ± 0.08
1.81ValMet: 1.81 ± 0.039
2.792ValAsn: 2.792 ± 0.041
2.723ValPro: 2.723 ± 0.043
2.484ValGln: 2.484 ± 0.043
3.249ValArg: 3.249 ± 0.046
5.124ValSer: 5.124 ± 0.049
4.049ValThr: 4.049 ± 0.066
4.935ValVal: 4.935 ± 0.052
0.898ValTrp: 0.898 ± 0.023
1.908ValTyr: 1.908 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
0.863TrpAla: 0.863 ± 0.025
0.167TrpCys: 0.167 ± 0.01
0.666TrpAsp: 0.666 ± 0.021
0.59TrpGlu: 0.59 ± 0.02
0.653TrpPhe: 0.653 ± 0.021
0.866TrpGly: 0.866 ± 0.022
0.42TrpHis: 0.42 ± 0.016
0.81TrpIle: 0.81 ± 0.023
0.566TrpLys: 0.566 ± 0.021
1.986TrpLeu: 1.986 ± 0.046
0.358TrpMet: 0.358 ± 0.013
0.608TrpAsn: 0.608 ± 0.022
0.644TrpPro: 0.644 ± 0.022
1.173TrpGln: 1.173 ± 0.03
0.824TrpArg: 0.824 ± 0.024
0.989TrpSer: 0.989 ± 0.024
0.607TrpThr: 0.607 ± 0.016
0.977TrpVal: 0.977 ± 0.027
0.257TrpTrp: 0.257 ± 0.013
0.442TrpTyr: 0.442 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.274TyrAla: 2.274 ± 0.036
0.431TyrCys: 0.431 ± 0.015
1.977TyrAsp: 1.977 ± 0.116
1.685TyrGlu: 1.685 ± 0.028
1.491TyrPhe: 1.491 ± 0.038
2.41TyrGly: 2.41 ± 0.057
0.873TyrHis: 0.873 ± 0.021
1.584TyrIle: 1.584 ± 0.031
1.018TyrLys: 1.018 ± 0.027
3.61TyrLeu: 3.61 ± 0.043
0.666TyrMet: 0.666 ± 0.02
1.138TyrAsn: 1.138 ± 0.039
1.493TyrPro: 1.493 ± 0.03
2.106TyrGln: 2.106 ± 0.04
2.155TyrArg: 2.155 ± 0.035
2.168TyrSer: 2.168 ± 0.039
1.465TyrThr: 1.465 ± 0.037
1.897TyrVal: 1.897 ± 0.034
0.562TyrTrp: 0.562 ± 0.019
1.029TyrTyr: 1.029 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5913 proteins (1865711 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski