Amino acid dipepetide frequency for Bluetongue virus 9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.711AlaAla: 6.711 ± 1.317
0.688AlaCys: 0.688 ± 0.256
3.27AlaAsp: 3.27 ± 0.489
4.991AlaGlu: 4.991 ± 0.914
1.893AlaPhe: 1.893 ± 0.663
2.581AlaGly: 2.581 ± 0.748
0.516AlaHis: 0.516 ± 0.214
4.646AlaIle: 4.646 ± 1.28
3.442AlaLys: 3.442 ± 0.814
7.744AlaLeu: 7.744 ± 0.929
2.237AlaMet: 2.237 ± 0.595
2.925AlaAsn: 2.925 ± 0.28
3.27AlaPro: 3.27 ± 0.613
2.065AlaGln: 2.065 ± 0.419
3.958AlaArg: 3.958 ± 0.956
2.237AlaSer: 2.237 ± 0.501
5.335AlaThr: 5.335 ± 0.803
4.13AlaVal: 4.13 ± 0.599
0.86AlaTrp: 0.86 ± 0.254
3.442AlaTyr: 3.442 ± 0.282
0.0AlaXaa: 0.0 ± 0.0
Cys
0.688CysAla: 0.688 ± 0.334
0.344CysCys: 0.344 ± 0.282
0.172CysAsp: 0.172 ± 0.153
0.344CysGlu: 0.344 ± 0.255
0.86CysPhe: 0.86 ± 0.399
1.549CysGly: 1.549 ± 0.497
0.172CysHis: 0.172 ± 0.141
0.344CysIle: 0.344 ± 0.249
0.516CysLys: 0.516 ± 0.26
1.033CysLeu: 1.033 ± 0.299
0.344CysMet: 0.344 ± 0.202
0.516CysAsn: 0.516 ± 0.211
0.344CysPro: 0.344 ± 0.227
0.344CysGln: 0.344 ± 0.255
0.172CysArg: 0.172 ± 0.199
0.688CysSer: 0.688 ± 0.387
0.516CysThr: 0.516 ± 0.23
0.688CysVal: 0.688 ± 0.292
0.172CysTrp: 0.172 ± 0.141
1.205CysTyr: 1.205 ± 0.716
0.0CysXaa: 0.0 ± 0.0
Asp
3.958AspAla: 3.958 ± 0.972
0.344AspCys: 0.344 ± 0.181
5.335AspAsp: 5.335 ± 0.815
7.228AspGlu: 7.228 ± 1.655
2.925AspPhe: 2.925 ± 0.802
3.098AspGly: 3.098 ± 0.578
1.377AspHis: 1.377 ± 0.358
4.302AspIle: 4.302 ± 0.566
2.753AspLys: 2.753 ± 0.917
5.507AspLeu: 5.507 ± 1.311
2.409AspMet: 2.409 ± 0.935
0.344AspAsn: 0.344 ± 0.306
3.786AspPro: 3.786 ± 0.941
0.86AspGln: 0.86 ± 0.305
3.27AspArg: 3.27 ± 0.628
2.753AspSer: 2.753 ± 0.537
3.27AspThr: 3.27 ± 0.866
5.851AspVal: 5.851 ± 0.977
0.688AspTrp: 0.688 ± 0.377
2.237AspTyr: 2.237 ± 0.552
0.0AspXaa: 0.0 ± 0.0
Glu
5.851GluAla: 5.851 ± 1.221
0.344GluCys: 0.344 ± 0.306
3.27GluAsp: 3.27 ± 0.848
7.572GluGlu: 7.572 ± 1.408
3.27GluPhe: 3.27 ± 1.11
3.098GluGly: 3.098 ± 0.716
1.033GluHis: 1.033 ± 0.327
5.335GluIle: 5.335 ± 1.421
2.925GluLys: 2.925 ± 0.584
5.851GluLeu: 5.851 ± 0.587
2.925GluMet: 2.925 ± 0.574
1.893GluAsn: 1.893 ± 0.379
3.442GluPro: 3.442 ± 0.99
2.409GluGln: 2.409 ± 0.824
6.367GluArg: 6.367 ± 1.05
3.958GluSer: 3.958 ± 0.777
1.893GluThr: 1.893 ± 0.457
4.818GluVal: 4.818 ± 0.574
1.377GluTrp: 1.377 ± 0.569
2.065GluTyr: 2.065 ± 0.472
0.0GluXaa: 0.0 ± 0.0
Phe
2.065PheAla: 2.065 ± 0.819
0.344PheCys: 0.344 ± 0.204
2.753PheAsp: 2.753 ± 0.917
3.27PheGlu: 3.27 ± 0.462
2.237PhePhe: 2.237 ± 0.788
2.753PheGly: 2.753 ± 0.646
1.377PheHis: 1.377 ± 0.43
2.753PheIle: 2.753 ± 0.784
2.925PheLys: 2.925 ± 0.668
3.614PheLeu: 3.614 ± 1.057
1.205PheMet: 1.205 ± 0.501
1.721PheAsn: 1.721 ± 0.479
1.377PhePro: 1.377 ± 0.408
1.377PheGln: 1.377 ± 0.342
3.27PheArg: 3.27 ± 1.133
2.237PheSer: 2.237 ± 0.547
2.409PheThr: 2.409 ± 0.736
1.721PheVal: 1.721 ± 0.625
0.344PheTrp: 0.344 ± 0.213
2.753PheTyr: 2.753 ± 0.587
0.0PheXaa: 0.0 ± 0.0
Gly
4.302GlyAla: 4.302 ± 0.973
0.86GlyCys: 0.86 ± 0.354
4.646GlyAsp: 4.646 ± 0.577
3.442GlyGlu: 3.442 ± 0.553
2.753GlyPhe: 2.753 ± 0.375
2.581GlyGly: 2.581 ± 0.507
1.033GlyHis: 1.033 ± 0.364
4.302GlyIle: 4.302 ± 0.837
2.581GlyLys: 2.581 ± 0.755
3.614GlyLeu: 3.614 ± 0.677
2.237GlyMet: 2.237 ± 0.424
1.721GlyAsn: 1.721 ± 0.578
2.065GlyPro: 2.065 ± 0.71
1.377GlyGln: 1.377 ± 0.537
3.958GlyArg: 3.958 ± 0.814
2.925GlySer: 2.925 ± 0.544
1.893GlyThr: 1.893 ± 0.442
3.614GlyVal: 3.614 ± 1.506
0.86GlyTrp: 0.86 ± 0.284
2.925GlyTyr: 2.925 ± 0.615
0.0GlyXaa: 0.0 ± 0.0
His
1.549HisAla: 1.549 ± 0.487
0.688HisCys: 0.688 ± 0.254
1.205HisAsp: 1.205 ± 0.559
0.344HisGlu: 0.344 ± 0.186
1.033HisPhe: 1.033 ± 0.62
1.377HisGly: 1.377 ± 0.658
0.0HisHis: 0.0 ± 0.0
1.549HisIle: 1.549 ± 0.484
0.86HisLys: 0.86 ± 0.466
2.065HisLeu: 2.065 ± 0.788
0.86HisMet: 0.86 ± 0.471
1.377HisAsn: 1.377 ± 0.305
1.377HisPro: 1.377 ± 0.364
1.033HisGln: 1.033 ± 0.368
1.893HisArg: 1.893 ± 0.593
1.549HisSer: 1.549 ± 0.388
1.033HisThr: 1.033 ± 0.411
1.721HisVal: 1.721 ± 0.709
0.344HisTrp: 0.344 ± 0.194
0.516HisTyr: 0.516 ± 0.303
0.0HisXaa: 0.0 ± 0.0
Ile
5.679IleAla: 5.679 ± 0.674
0.172IleCys: 0.172 ± 0.153
5.163IleAsp: 5.163 ± 1.077
3.442IleGlu: 3.442 ± 0.599
3.098IlePhe: 3.098 ± 0.745
3.958IleGly: 3.958 ± 0.381
1.721IleHis: 1.721 ± 0.619
3.786IleIle: 3.786 ± 0.572
5.163IleLys: 5.163 ± 0.745
5.679IleLeu: 5.679 ± 0.84
2.237IleMet: 2.237 ± 0.565
3.27IleAsn: 3.27 ± 0.812
2.237IlePro: 2.237 ± 0.423
2.925IleGln: 2.925 ± 0.463
4.646IleArg: 4.646 ± 0.779
4.818IleSer: 4.818 ± 0.634
3.098IleThr: 3.098 ± 0.725
3.27IleVal: 3.27 ± 0.527
1.033IleTrp: 1.033 ± 0.422
3.786IleTyr: 3.786 ± 0.901
0.0IleXaa: 0.0 ± 0.0
Lys
3.098LysAla: 3.098 ± 0.689
0.516LysCys: 0.516 ± 0.329
2.753LysAsp: 2.753 ± 0.792
3.786LysGlu: 3.786 ± 0.909
2.409LysPhe: 2.409 ± 0.605
3.442LysGly: 3.442 ± 0.6
1.721LysHis: 1.721 ± 0.557
5.507LysIle: 5.507 ± 1.17
4.646LysLys: 4.646 ± 1.202
3.614LysLeu: 3.614 ± 0.612
2.409LysMet: 2.409 ± 0.931
1.893LysAsn: 1.893 ± 0.541
0.516LysPro: 0.516 ± 0.286
2.065LysGln: 2.065 ± 0.658
3.958LysArg: 3.958 ± 1.054
2.409LysSer: 2.409 ± 0.864
2.581LysThr: 2.581 ± 0.456
4.646LysVal: 4.646 ± 0.701
0.688LysTrp: 0.688 ± 0.456
2.065LysTyr: 2.065 ± 0.454
0.0LysXaa: 0.0 ± 0.0
Leu
4.818LeuAla: 4.818 ± 1.086
1.377LeuCys: 1.377 ± 0.381
4.991LeuAsp: 4.991 ± 0.697
4.991LeuGlu: 4.991 ± 0.596
3.27LeuPhe: 3.27 ± 0.831
4.302LeuGly: 4.302 ± 1.023
1.721LeuHis: 1.721 ± 0.412
5.163LeuIle: 5.163 ± 1.047
6.539LeuLys: 6.539 ± 0.925
5.679LeuLeu: 5.679 ± 1.094
2.237LeuMet: 2.237 ± 0.599
4.991LeuAsn: 4.991 ± 0.579
5.335LeuPro: 5.335 ± 0.877
3.27LeuGln: 3.27 ± 0.786
7.744LeuArg: 7.744 ± 0.818
6.883LeuSer: 6.883 ± 1.353
4.991LeuThr: 4.991 ± 0.801
4.13LeuVal: 4.13 ± 0.567
0.688LeuTrp: 0.688 ± 0.335
2.237LeuTyr: 2.237 ± 0.693
0.0LeuXaa: 0.0 ± 0.0
Met
2.065MetAla: 2.065 ± 0.448
0.516MetCys: 0.516 ± 0.236
2.753MetAsp: 2.753 ± 0.602
1.893MetGlu: 1.893 ± 0.547
1.721MetPhe: 1.721 ± 0.424
1.549MetGly: 1.549 ± 0.808
1.549MetHis: 1.549 ± 0.454
3.27MetIle: 3.27 ± 0.567
1.721MetLys: 1.721 ± 0.572
4.646MetLeu: 4.646 ± 0.77
2.065MetMet: 2.065 ± 0.507
1.377MetAsn: 1.377 ± 0.397
1.549MetPro: 1.549 ± 0.749
1.549MetGln: 1.549 ± 0.293
4.13MetArg: 4.13 ± 0.578
2.237MetSer: 2.237 ± 0.538
1.893MetThr: 1.893 ± 0.859
2.237MetVal: 2.237 ± 0.439
0.516MetTrp: 0.516 ± 0.212
0.688MetTyr: 0.688 ± 0.2
0.0MetXaa: 0.0 ± 0.0
Asn
2.753AsnAla: 2.753 ± 0.846
0.344AsnCys: 0.344 ± 0.366
3.098AsnAsp: 3.098 ± 0.475
4.302AsnGlu: 4.302 ± 0.858
1.893AsnPhe: 1.893 ± 0.621
2.753AsnGly: 2.753 ± 0.596
0.86AsnHis: 0.86 ± 0.372
2.409AsnIle: 2.409 ± 0.655
0.688AsnLys: 0.688 ± 0.301
3.098AsnLeu: 3.098 ± 0.73
1.377AsnMet: 1.377 ± 0.421
1.549AsnAsn: 1.549 ± 0.564
2.753AsnPro: 2.753 ± 0.47
1.721AsnGln: 1.721 ± 0.366
2.237AsnArg: 2.237 ± 0.418
2.065AsnSer: 2.065 ± 1.028
2.237AsnThr: 2.237 ± 0.525
3.098AsnVal: 3.098 ± 0.579
0.516AsnTrp: 0.516 ± 0.238
1.033AsnTyr: 1.033 ± 0.411
0.0AsnXaa: 0.0 ± 0.0
Pro
1.893ProAla: 1.893 ± 0.472
0.516ProCys: 0.516 ± 0.329
3.786ProAsp: 3.786 ± 0.754
2.409ProGlu: 2.409 ± 0.789
1.377ProPhe: 1.377 ± 0.386
2.925ProGly: 2.925 ± 0.595
0.688ProHis: 0.688 ± 0.284
3.098ProIle: 3.098 ± 0.833
2.065ProLys: 2.065 ± 0.575
3.614ProLeu: 3.614 ± 0.564
1.205ProMet: 1.205 ± 0.463
1.377ProAsn: 1.377 ± 0.411
1.377ProPro: 1.377 ± 0.521
2.581ProGln: 2.581 ± 0.313
3.098ProArg: 3.098 ± 0.682
1.721ProSer: 1.721 ± 0.619
3.098ProThr: 3.098 ± 1.148
2.753ProVal: 2.753 ± 0.465
0.516ProTrp: 0.516 ± 0.23
2.753ProTyr: 2.753 ± 0.666
0.0ProXaa: 0.0 ± 0.0
Gln
1.721GlnAla: 1.721 ± 0.582
0.516GlnCys: 0.516 ± 0.311
1.549GlnAsp: 1.549 ± 0.408
2.753GlnGlu: 2.753 ± 0.732
1.033GlnPhe: 1.033 ± 0.201
2.409GlnGly: 2.409 ± 0.583
0.86GlnHis: 0.86 ± 0.338
3.958GlnIle: 3.958 ± 1.012
1.893GlnLys: 1.893 ± 0.378
3.098GlnLeu: 3.098 ± 0.689
1.893GlnMet: 1.893 ± 0.807
1.893GlnAsn: 1.893 ± 0.515
1.721GlnPro: 1.721 ± 0.596
1.377GlnGln: 1.377 ± 0.676
3.098GlnArg: 3.098 ± 0.694
1.893GlnSer: 1.893 ± 0.622
1.377GlnThr: 1.377 ± 0.691
2.925GlnVal: 2.925 ± 0.851
0.344GlnTrp: 0.344 ± 0.242
1.377GlnTyr: 1.377 ± 0.28
0.0GlnXaa: 0.0 ± 0.0
Arg
4.302ArgAla: 4.302 ± 0.99
0.516ArgCys: 0.516 ± 0.389
4.13ArgAsp: 4.13 ± 0.545
4.991ArgGlu: 4.991 ± 0.986
4.818ArgPhe: 4.818 ± 0.737
2.925ArgGly: 2.925 ± 0.355
1.377ArgHis: 1.377 ± 0.488
5.851ArgIle: 5.851 ± 0.712
3.786ArgLys: 3.786 ± 0.969
4.474ArgLeu: 4.474 ± 0.545
2.925ArgMet: 2.925 ± 0.628
4.474ArgAsn: 4.474 ± 0.547
1.549ArgPro: 1.549 ± 0.44
2.237ArgGln: 2.237 ± 0.559
3.786ArgArg: 3.786 ± 0.42
3.614ArgSer: 3.614 ± 0.779
4.646ArgThr: 4.646 ± 0.823
7.056ArgVal: 7.056 ± 0.697
1.377ArgTrp: 1.377 ± 0.684
2.409ArgTyr: 2.409 ± 0.573
0.0ArgXaa: 0.0 ± 0.0
Ser
3.786SerAla: 3.786 ± 0.687
0.0SerCys: 0.0 ± 0.0
3.27SerAsp: 3.27 ± 0.891
3.442SerGlu: 3.442 ± 0.601
2.065SerPhe: 2.065 ± 0.478
3.442SerGly: 3.442 ± 0.722
1.721SerHis: 1.721 ± 0.454
3.786SerIle: 3.786 ± 0.445
1.893SerLys: 1.893 ± 0.475
5.335SerLeu: 5.335 ± 0.96
2.065SerMet: 2.065 ± 0.317
2.237SerAsn: 2.237 ± 0.556
2.065SerPro: 2.065 ± 0.53
3.098SerGln: 3.098 ± 0.423
3.958SerArg: 3.958 ± 1.012
4.818SerSer: 4.818 ± 1.061
3.442SerThr: 3.442 ± 0.786
4.646SerVal: 4.646 ± 0.571
0.86SerTrp: 0.86 ± 0.252
1.721SerTyr: 1.721 ± 0.56
0.0SerXaa: 0.0 ± 0.0
Thr
2.753ThrAla: 2.753 ± 0.615
0.86ThrCys: 0.86 ± 0.737
2.925ThrAsp: 2.925 ± 0.877
3.442ThrGlu: 3.442 ± 0.71
1.205ThrPhe: 1.205 ± 0.61
2.753ThrGly: 2.753 ± 0.824
1.377ThrHis: 1.377 ± 0.434
3.442ThrIle: 3.442 ± 0.582
3.27ThrLys: 3.27 ± 0.873
6.023ThrLeu: 6.023 ± 1.205
2.065ThrMet: 2.065 ± 0.482
1.893ThrAsn: 1.893 ± 0.507
2.753ThrPro: 2.753 ± 0.483
2.065ThrGln: 2.065 ± 0.66
3.614ThrArg: 3.614 ± 0.41
2.581ThrSer: 2.581 ± 0.812
3.098ThrThr: 3.098 ± 0.625
3.27ThrVal: 3.27 ± 0.514
0.688ThrTrp: 0.688 ± 0.433
2.237ThrTyr: 2.237 ± 0.741
0.0ThrXaa: 0.0 ± 0.0
Val
4.474ValAla: 4.474 ± 1.118
1.033ValCys: 1.033 ± 0.489
3.27ValAsp: 3.27 ± 0.449
4.302ValGlu: 4.302 ± 0.452
2.753ValPhe: 2.753 ± 0.7
3.958ValGly: 3.958 ± 0.483
1.721ValHis: 1.721 ± 0.481
2.409ValIle: 2.409 ± 0.438
3.614ValLys: 3.614 ± 0.488
7.228ValLeu: 7.228 ± 1.162
4.474ValMet: 4.474 ± 0.457
1.893ValAsn: 1.893 ± 0.512
3.786ValPro: 3.786 ± 0.403
3.786ValGln: 3.786 ± 0.453
5.507ValArg: 5.507 ± 1.076
4.13ValSer: 4.13 ± 0.923
2.753ValThr: 2.753 ± 0.934
3.098ValVal: 3.098 ± 0.591
0.86ValTrp: 0.86 ± 0.239
2.581ValTyr: 2.581 ± 0.646
0.0ValXaa: 0.0 ± 0.0
Trp
0.516TrpAla: 0.516 ± 0.303
0.172TrpCys: 0.172 ± 0.141
1.033TrpAsp: 1.033 ± 0.349
0.86TrpGlu: 0.86 ± 0.416
0.86TrpPhe: 0.86 ± 0.287
0.344TrpGly: 0.344 ± 0.186
0.86TrpHis: 0.86 ± 0.685
1.033TrpIle: 1.033 ± 0.409
1.033TrpLys: 1.033 ± 0.361
1.033TrpLeu: 1.033 ± 0.611
0.688TrpMet: 0.688 ± 0.348
1.205TrpAsn: 1.205 ± 0.457
0.172TrpPro: 0.172 ± 0.153
0.516TrpGln: 0.516 ± 0.401
0.344TrpArg: 0.344 ± 0.216
0.688TrpSer: 0.688 ± 0.331
0.516TrpThr: 0.516 ± 0.27
0.86TrpVal: 0.86 ± 0.389
0.172TrpTrp: 0.172 ± 0.199
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.13TyrAla: 4.13 ± 0.995
0.86TyrCys: 0.86 ± 0.572
2.925TyrAsp: 2.925 ± 0.784
1.893TyrGlu: 1.893 ± 0.573
1.033TyrPhe: 1.033 ± 0.358
1.893TyrGly: 1.893 ± 0.389
0.688TyrHis: 0.688 ± 0.301
2.237TyrIle: 2.237 ± 0.328
2.409TyrLys: 2.409 ± 0.551
2.409TyrLeu: 2.409 ± 0.524
1.893TyrMet: 1.893 ± 0.359
2.237TyrAsn: 2.237 ± 0.649
1.377TyrPro: 1.377 ± 0.542
1.033TyrGln: 1.033 ± 0.51
2.237TyrArg: 2.237 ± 0.363
3.442TyrSer: 3.442 ± 0.584
2.237TyrThr: 2.237 ± 0.456
3.098TyrVal: 3.098 ± 0.828
0.0TyrTrp: 0.0 ± 0.0
1.205TyrTyr: 1.205 ± 0.522
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (5812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski