Amino acid dipepetide frequency for Brevirhabdus pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.509AlaAla: 17.509 ± 0.213
1.033AlaCys: 1.033 ± 0.038
7.15AlaAsp: 7.15 ± 0.101
9.044AlaGlu: 9.044 ± 0.135
4.064AlaPhe: 4.064 ± 0.077
11.703AlaGly: 11.703 ± 0.138
2.257AlaHis: 2.257 ± 0.053
5.827AlaIle: 5.827 ± 0.088
3.289AlaLys: 3.289 ± 0.075
13.923AlaLeu: 13.923 ± 0.15
3.735AlaMet: 3.735 ± 0.075
2.604AlaAsn: 2.604 ± 0.055
6.686AlaPro: 6.686 ± 0.106
4.055AlaGln: 4.055 ± 0.07
10.436AlaArg: 10.436 ± 0.132
5.588AlaSer: 5.588 ± 0.082
6.134AlaThr: 6.134 ± 0.081
8.215AlaVal: 8.215 ± 0.109
1.488AlaTrp: 1.488 ± 0.044
2.376AlaTyr: 2.376 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
1.01CysAla: 1.01 ± 0.034
0.104CysCys: 0.104 ± 0.011
0.59CysAsp: 0.59 ± 0.025
0.46CysGlu: 0.46 ± 0.02
0.295CysPhe: 0.295 ± 0.018
0.926CysGly: 0.926 ± 0.028
0.275CysHis: 0.275 ± 0.017
0.349CysIle: 0.349 ± 0.019
0.192CysLys: 0.192 ± 0.014
0.803CysLeu: 0.803 ± 0.035
0.143CysMet: 0.143 ± 0.012
0.208CysAsn: 0.208 ± 0.016
0.523CysPro: 0.523 ± 0.028
0.223CysGln: 0.223 ± 0.015
0.615CysArg: 0.615 ± 0.026
0.428CysSer: 0.428 ± 0.021
0.41CysThr: 0.41 ± 0.02
0.623CysVal: 0.623 ± 0.028
0.111CysTrp: 0.111 ± 0.012
0.197CysTyr: 0.197 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.446AspAla: 7.446 ± 0.11
0.514AspCys: 0.514 ± 0.022
3.308AspAsp: 3.308 ± 0.073
3.995AspGlu: 3.995 ± 0.071
2.043AspPhe: 2.043 ± 0.052
5.656AspGly: 5.656 ± 0.097
1.358AspHis: 1.358 ± 0.039
2.728AspIle: 2.728 ± 0.058
1.561AspLys: 1.561 ± 0.046
6.57AspLeu: 6.57 ± 0.093
1.598AspMet: 1.598 ± 0.048
1.198AspAsn: 1.198 ± 0.039
3.938AspPro: 3.938 ± 0.071
1.781AspGln: 1.781 ± 0.046
4.955AspArg: 4.955 ± 0.08
2.258AspSer: 2.258 ± 0.053
2.848AspThr: 2.848 ± 0.052
3.97AspVal: 3.97 ± 0.074
1.079AspTrp: 1.079 ± 0.033
1.418AspTyr: 1.418 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
8.895GluAla: 8.895 ± 0.114
0.407GluCys: 0.407 ± 0.023
3.431GluAsp: 3.431 ± 0.066
4.136GluGlu: 4.136 ± 0.083
1.892GluPhe: 1.892 ± 0.043
5.907GluGly: 5.907 ± 0.091
1.172GluHis: 1.172 ± 0.033
3.541GluIle: 3.541 ± 0.069
2.222GluLys: 2.222 ± 0.056
5.668GluLeu: 5.668 ± 0.082
1.909GluMet: 1.909 ± 0.042
1.592GluAsn: 1.592 ± 0.047
2.524GluPro: 2.524 ± 0.048
1.935GluGln: 1.935 ± 0.049
4.895GluArg: 4.895 ± 0.074
2.32GluSer: 2.32 ± 0.051
3.622GluThr: 3.622 ± 0.067
4.509GluVal: 4.509 ± 0.071
0.719GluTrp: 0.719 ± 0.029
1.055GluTyr: 1.055 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
4.345PheAla: 4.345 ± 0.076
0.41PheCys: 0.41 ± 0.022
2.709PheAsp: 2.709 ± 0.055
2.142PheGlu: 2.142 ± 0.049
1.323PhePhe: 1.323 ± 0.042
3.449PheGly: 3.449 ± 0.056
0.709PheHis: 0.709 ± 0.026
1.414PheIle: 1.414 ± 0.04
0.814PheLys: 0.814 ± 0.029
3.321PheLeu: 3.321 ± 0.066
0.8PheMet: 0.8 ± 0.031
0.95PheAsn: 0.95 ± 0.034
1.438PhePro: 1.438 ± 0.037
0.973PheGln: 0.973 ± 0.03
2.287PheArg: 2.287 ± 0.047
1.939PheSer: 1.939 ± 0.043
1.889PheThr: 1.889 ± 0.046
2.614PheVal: 2.614 ± 0.059
0.543PheTrp: 0.543 ± 0.028
0.848PheTyr: 0.848 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
10.904GlyAla: 10.904 ± 0.116
0.848GlyCys: 0.848 ± 0.031
4.864GlyAsp: 4.864 ± 0.082
5.027GlyGlu: 5.027 ± 0.085
3.615GlyPhe: 3.615 ± 0.067
8.197GlyGly: 8.197 ± 0.124
2.001GlyHis: 2.001 ± 0.05
4.303GlyIle: 4.303 ± 0.075
3.054GlyLys: 3.054 ± 0.08
9.494GlyLeu: 9.494 ± 0.114
2.737GlyMet: 2.737 ± 0.063
2.039GlyAsn: 2.039 ± 0.048
4.181GlyPro: 4.181 ± 0.076
3.219GlyGln: 3.219 ± 0.065
6.939GlyArg: 6.939 ± 0.094
4.414GlySer: 4.414 ± 0.076
4.906GlyThr: 4.906 ± 0.082
6.516GlyVal: 6.516 ± 0.09
1.487GlyTrp: 1.487 ± 0.043
2.207GlyTyr: 2.207 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
2.376HisAla: 2.376 ± 0.05
0.221HisCys: 0.221 ± 0.015
1.266HisAsp: 1.266 ± 0.041
1.154HisGlu: 1.154 ± 0.033
0.759HisPhe: 0.759 ± 0.03
1.93HisGly: 1.93 ± 0.048
0.544HisHis: 0.544 ± 0.028
0.814HisIle: 0.814 ± 0.028
0.421HisLys: 0.421 ± 0.021
2.047HisLeu: 2.047 ± 0.049
0.555HisMet: 0.555 ± 0.026
0.401HisAsn: 0.401 ± 0.022
1.423HisPro: 1.423 ± 0.036
0.607HisGln: 0.607 ± 0.028
1.544HisArg: 1.544 ± 0.042
0.884HisSer: 0.884 ± 0.032
0.72HisThr: 0.72 ± 0.028
1.575HisVal: 1.575 ± 0.043
0.316HisTrp: 0.316 ± 0.016
0.487HisTyr: 0.487 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.49IleAla: 6.49 ± 0.087
0.548IleCys: 0.548 ± 0.022
3.322IleAsp: 3.322 ± 0.064
3.494IleGlu: 3.494 ± 0.067
1.715IlePhe: 1.715 ± 0.047
4.488IleGly: 4.488 ± 0.075
0.871IleHis: 0.871 ± 0.032
1.883IleIle: 1.883 ± 0.057
1.21IleLys: 1.21 ± 0.039
4.676IleLeu: 4.676 ± 0.076
0.943IleMet: 0.943 ± 0.03
1.285IleAsn: 1.285 ± 0.04
2.241IlePro: 2.241 ± 0.05
1.085IleGln: 1.085 ± 0.036
3.281IleArg: 3.281 ± 0.061
2.549IleSer: 2.549 ± 0.057
2.532IleThr: 2.532 ± 0.055
3.569IleVal: 3.569 ± 0.075
0.622IleTrp: 0.622 ± 0.03
1.103IleTyr: 1.103 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.534LysAla: 3.534 ± 0.075
0.158LysCys: 0.158 ± 0.015
1.563LysAsp: 1.563 ± 0.049
1.456LysGlu: 1.456 ± 0.05
0.864LysPhe: 0.864 ± 0.03
2.574LysGly: 2.574 ± 0.057
0.499LysHis: 0.499 ± 0.024
1.449LysIle: 1.449 ± 0.046
1.077LysLys: 1.077 ± 0.041
2.705LysLeu: 2.705 ± 0.061
0.753LysMet: 0.753 ± 0.027
0.709LysAsn: 0.709 ± 0.032
1.748LysPro: 1.748 ± 0.049
0.785LysGln: 0.785 ± 0.033
2.019LysArg: 2.019 ± 0.052
1.657LysSer: 1.657 ± 0.043
1.749LysThr: 1.749 ± 0.046
2.209LysVal: 2.209 ± 0.045
0.326LysTrp: 0.326 ± 0.02
0.548LysTyr: 0.548 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
13.585LeuAla: 13.585 ± 0.16
0.918LeuCys: 0.918 ± 0.033
6.147LeuAsp: 6.147 ± 0.089
6.105LeuGlu: 6.105 ± 0.09
3.266LeuPhe: 3.266 ± 0.07
8.908LeuGly: 8.908 ± 0.11
1.867LeuHis: 1.867 ± 0.048
4.841LeuIle: 4.841 ± 0.082
2.925LeuLys: 2.925 ± 0.059
9.612LeuLeu: 9.612 ± 0.153
2.637LeuMet: 2.637 ± 0.054
2.398LeuAsn: 2.398 ± 0.048
5.702LeuPro: 5.702 ± 0.093
2.419LeuGln: 2.419 ± 0.049
8.006LeuArg: 8.006 ± 0.097
6.628LeuSer: 6.628 ± 0.093
5.672LeuThr: 5.672 ± 0.086
7.125LeuVal: 7.125 ± 0.112
1.225LeuTrp: 1.225 ± 0.039
1.895LeuTyr: 1.895 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
3.359MetAla: 3.359 ± 0.058
0.197MetCys: 0.197 ± 0.015
1.498MetAsp: 1.498 ± 0.047
1.39MetGlu: 1.39 ± 0.046
0.783MetPhe: 0.783 ± 0.033
2.367MetGly: 2.367 ± 0.059
0.475MetHis: 0.475 ± 0.023
1.334MetIle: 1.334 ± 0.039
0.949MetLys: 0.949 ± 0.033
2.701MetLeu: 2.701 ± 0.064
0.759MetMet: 0.759 ± 0.038
0.847MetAsn: 0.847 ± 0.031
1.582MetPro: 1.582 ± 0.04
0.892MetGln: 0.892 ± 0.032
2.035MetArg: 2.035 ± 0.042
1.671MetSer: 1.671 ± 0.042
1.902MetThr: 1.902 ± 0.045
1.785MetVal: 1.785 ± 0.042
0.236MetTrp: 0.236 ± 0.016
0.287MetTyr: 0.287 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.93AsnAla: 2.93 ± 0.058
0.229AsnCys: 0.229 ± 0.013
1.281AsnAsp: 1.281 ± 0.038
1.123AsnGlu: 1.123 ± 0.037
0.876AsnPhe: 0.876 ± 0.032
2.125AsnGly: 2.125 ± 0.055
0.48AsnHis: 0.48 ± 0.018
1.233AsnIle: 1.233 ± 0.039
0.573AsnLys: 0.573 ± 0.023
2.478AsnLeu: 2.478 ± 0.055
0.64AsnMet: 0.64 ± 0.027
0.648AsnAsn: 0.648 ± 0.031
1.782AsnPro: 1.782 ± 0.046
0.664AsnGln: 0.664 ± 0.028
1.862AsnArg: 1.862 ± 0.045
1.117AsnSer: 1.117 ± 0.045
1.171AsnThr: 1.171 ± 0.04
1.693AsnVal: 1.693 ± 0.049
0.396AsnTrp: 0.396 ± 0.023
0.563AsnTyr: 0.563 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
6.845ProAla: 6.845 ± 0.107
0.35ProCys: 0.35 ± 0.02
4.071ProAsp: 4.071 ± 0.072
4.526ProGlu: 4.526 ± 0.072
1.879ProPhe: 1.879 ± 0.047
5.298ProGly: 5.298 ± 0.086
1.041ProHis: 1.041 ± 0.035
2.036ProIle: 2.036 ± 0.049
1.33ProLys: 1.33 ± 0.041
4.956ProLeu: 4.956 ± 0.087
1.285ProMet: 1.285 ± 0.034
1.108ProAsn: 1.108 ± 0.035
2.655ProPro: 2.655 ± 0.07
1.511ProGln: 1.511 ± 0.036
3.53ProArg: 3.53 ± 0.069
2.427ProSer: 2.427 ± 0.047
2.367ProThr: 2.367 ± 0.057
4.422ProVal: 4.422 ± 0.065
0.659ProTrp: 0.659 ± 0.026
1.089ProTyr: 1.089 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.996GlnAla: 3.996 ± 0.067
0.186GlnCys: 0.186 ± 0.014
1.608GlnAsp: 1.608 ± 0.04
1.658GlnGlu: 1.658 ± 0.041
0.889GlnPhe: 0.889 ± 0.035
2.654GlnGly: 2.654 ± 0.061
0.53GlnHis: 0.53 ± 0.024
1.854GlnIle: 1.854 ± 0.043
1.014GlnLys: 1.014 ± 0.035
2.637GlnLeu: 2.637 ± 0.064
0.995GlnMet: 0.995 ± 0.032
0.828GlnAsn: 0.828 ± 0.029
1.578GlnPro: 1.578 ± 0.039
1.085GlnGln: 1.085 ± 0.043
2.169GlnArg: 2.169 ± 0.045
1.548GlnSer: 1.548 ± 0.041
1.593GlnThr: 1.593 ± 0.044
2.245GlnVal: 2.245 ± 0.051
0.376GlnTrp: 0.376 ± 0.02
0.502GlnTyr: 0.502 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
9.309ArgAla: 9.309 ± 0.113
0.519ArgCys: 0.519 ± 0.023
4.87ArgAsp: 4.87 ± 0.072
4.417ArgGlu: 4.417 ± 0.086
2.784ArgPhe: 2.784 ± 0.057
5.476ArgGly: 5.476 ± 0.087
1.827ArgHis: 1.827 ± 0.052
4.111ArgIle: 4.111 ± 0.069
2.327ArgLys: 2.327 ± 0.058
8.571ArgLeu: 8.571 ± 0.11
2.219ArgMet: 2.219 ± 0.048
1.868ArgAsn: 1.868 ± 0.045
4.075ArgPro: 4.075 ± 0.07
2.674ArgGln: 2.674 ± 0.054
6.52ArgArg: 6.52 ± 0.096
3.536ArgSer: 3.536 ± 0.061
3.26ArgThr: 3.26 ± 0.053
5.175ArgVal: 5.175 ± 0.074
0.977ArgTrp: 0.977 ± 0.034
1.511ArgTyr: 1.511 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
5.67SerAla: 5.67 ± 0.078
0.442SerCys: 0.442 ± 0.02
3.208SerAsp: 3.208 ± 0.062
2.7SerGlu: 2.7 ± 0.063
2.133SerPhe: 2.133 ± 0.051
5.399SerGly: 5.399 ± 0.092
1.025SerHis: 1.025 ± 0.035
2.268SerIle: 2.268 ± 0.052
1.363SerLys: 1.363 ± 0.046
4.812SerLeu: 4.812 ± 0.082
1.282SerMet: 1.282 ± 0.037
1.206SerAsn: 1.206 ± 0.038
2.512SerPro: 2.512 ± 0.046
1.549SerGln: 1.549 ± 0.036
3.747SerArg: 3.747 ± 0.063
2.489SerSer: 2.489 ± 0.053
2.352SerThr: 2.352 ± 0.056
3.719SerVal: 3.719 ± 0.068
0.636SerTrp: 0.636 ± 0.027
1.196SerTyr: 1.196 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
6.197ThrAla: 6.197 ± 0.072
0.461ThrCys: 0.461 ± 0.023
3.138ThrAsp: 3.138 ± 0.059
2.944ThrGlu: 2.944 ± 0.06
1.746ThrPhe: 1.746 ± 0.046
5.56ThrGly: 5.56 ± 0.075
0.97ThrHis: 0.97 ± 0.031
2.481ThrIle: 2.481 ± 0.063
1.222ThrLys: 1.222 ± 0.039
5.718ThrLeu: 5.718 ± 0.096
1.177ThrMet: 1.177 ± 0.037
1.17ThrAsn: 1.17 ± 0.043
3.492ThrPro: 3.492 ± 0.065
1.326ThrGln: 1.326 ± 0.038
3.66ThrArg: 3.66 ± 0.061
2.517ThrSer: 2.517 ± 0.052
2.63ThrThr: 2.63 ± 0.07
3.977ThrVal: 3.977 ± 0.073
0.626ThrTrp: 0.626 ± 0.024
1.127ThrTyr: 1.127 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
9.096ValAla: 9.096 ± 0.108
0.595ValCys: 0.595 ± 0.024
4.043ValAsp: 4.043 ± 0.077
4.725ValGlu: 4.725 ± 0.065
2.656ValPhe: 2.656 ± 0.049
5.39ValGly: 5.39 ± 0.092
1.34ValHis: 1.34 ± 0.043
3.932ValIle: 3.932 ± 0.067
1.872ValLys: 1.872 ± 0.046
7.528ValLeu: 7.528 ± 0.11
2.055ValMet: 2.055 ± 0.05
1.899ValAsn: 1.899 ± 0.05
3.691ValPro: 3.691 ± 0.07
1.952ValGln: 1.952 ± 0.053
4.774ValArg: 4.774 ± 0.079
3.802ValSer: 3.802 ± 0.062
4.611ValThr: 4.611 ± 0.076
5.598ValVal: 5.598 ± 0.092
0.872ValTrp: 0.872 ± 0.034
1.385ValTyr: 1.385 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.299TrpAla: 1.299 ± 0.043
0.129TrpCys: 0.129 ± 0.012
0.701TrpAsp: 0.701 ± 0.032
0.643TrpGlu: 0.643 ± 0.021
0.54TrpPhe: 0.54 ± 0.024
0.95TrpGly: 0.95 ± 0.033
0.299TrpHis: 0.299 ± 0.018
0.707TrpIle: 0.707 ± 0.029
0.448TrpLys: 0.448 ± 0.026
1.599TrpLeu: 1.599 ± 0.048
0.364TrpMet: 0.364 ± 0.021
0.381TrpAsn: 0.381 ± 0.019
0.634TrpPro: 0.634 ± 0.026
0.568TrpGln: 0.568 ± 0.034
1.13TrpArg: 1.13 ± 0.041
0.808TrpSer: 0.808 ± 0.03
0.761TrpThr: 0.761 ± 0.031
0.817TrpVal: 0.817 ± 0.034
0.228TrpTrp: 0.228 ± 0.017
0.24TrpTyr: 0.24 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.32TyrAla: 2.32 ± 0.056
0.218TyrCys: 0.218 ± 0.017
1.454TyrAsp: 1.454 ± 0.04
1.214TyrGlu: 1.214 ± 0.036
0.797TyrPhe: 0.797 ± 0.032
1.993TyrGly: 1.993 ± 0.045
0.503TyrHis: 0.503 ± 0.026
0.8TyrIle: 0.8 ± 0.032
0.52TyrLys: 0.52 ± 0.026
2.063TyrLeu: 2.063 ± 0.053
0.46TyrMet: 0.46 ± 0.024
0.525TyrAsn: 0.525 ± 0.025
0.981TyrPro: 0.981 ± 0.033
0.64TyrGln: 0.64 ± 0.027
1.622TyrArg: 1.622 ± 0.043
1.127TyrSer: 1.127 ± 0.037
1.009TyrThr: 1.009 ± 0.041
1.462TyrVal: 1.462 ± 0.043
0.323TyrTrp: 0.323 ± 0.021
0.529TyrTyr: 0.529 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2900 proteins (930718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski