Amino acid dipepetide frequency for Tomato yellow leaf curl China virus (TYLCCNV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.65AlaAla: 3.65 ± 1.232
1.825AlaCys: 1.825 ± 1.395
0.912AlaAsp: 0.912 ± 0.697
1.825AlaGlu: 1.825 ± 0.967
1.825AlaPhe: 1.825 ± 1.126
0.0AlaGly: 0.0 ± 0.0
2.737AlaHis: 2.737 ± 1.881
2.737AlaIle: 2.737 ± 1.262
4.562AlaLys: 4.562 ± 1.368
6.387AlaLeu: 6.387 ± 1.453
0.0AlaMet: 0.0 ± 0.0
1.825AlaAsn: 1.825 ± 1.045
2.737AlaPro: 2.737 ± 1.188
2.737AlaGln: 2.737 ± 1.251
4.562AlaArg: 4.562 ± 1.485
3.65AlaSer: 3.65 ± 1.203
2.737AlaThr: 2.737 ± 1.328
1.825AlaVal: 1.825 ± 1.215
0.912AlaTrp: 0.912 ± 0.608
0.912AlaTyr: 0.912 ± 0.608
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.825CysCys: 1.825 ± 2.018
0.0CysAsp: 0.0 ± 0.0
1.825CysGlu: 1.825 ± 1.395
0.912CysPhe: 0.912 ± 0.946
1.825CysGly: 1.825 ± 0.955
1.825CysHis: 1.825 ± 1.412
0.912CysIle: 0.912 ± 0.946
2.737CysLys: 2.737 ± 1.328
0.912CysLeu: 0.912 ± 1.158
1.825CysMet: 1.825 ± 1.694
0.912CysAsn: 0.912 ± 0.608
1.825CysPro: 1.825 ± 2.018
1.825CysGln: 1.825 ± 0.954
0.912CysArg: 0.912 ± 0.608
2.737CysSer: 2.737 ± 1.759
0.912CysThr: 0.912 ± 0.697
1.825CysVal: 1.825 ± 1.395
0.0CysTrp: 0.0 ± 0.0
0.912CysTyr: 0.912 ± 0.697
0.0CysXaa: 0.0 ± 0.0
Asp
1.825AspAla: 1.825 ± 1.215
0.0AspCys: 0.0 ± 0.0
0.912AspAsp: 0.912 ± 0.608
1.825AspGlu: 1.825 ± 0.762
1.825AspPhe: 1.825 ± 0.762
3.65AspGly: 3.65 ± 1.82
0.912AspHis: 0.912 ± 0.608
2.737AspIle: 2.737 ± 1.976
0.0AspLys: 0.0 ± 0.0
6.387AspLeu: 6.387 ± 2.209
0.0AspMet: 0.0 ± 0.0
3.65AspAsn: 3.65 ± 1.149
1.825AspPro: 1.825 ± 0.967
0.912AspGln: 0.912 ± 0.608
4.562AspArg: 4.562 ± 1.404
5.474AspSer: 5.474 ± 1.222
1.825AspThr: 1.825 ± 1.412
9.124AspVal: 9.124 ± 2.013
0.912AspTrp: 0.912 ± 0.608
0.912AspTyr: 0.912 ± 1.009
0.0AspXaa: 0.0 ± 0.0
Glu
3.65GluAla: 3.65 ± 1.042
0.0GluCys: 0.0 ± 0.0
2.737GluAsp: 2.737 ± 1.258
6.387GluGlu: 6.387 ± 2.476
2.737GluPhe: 2.737 ± 1.473
3.65GluGly: 3.65 ± 1.042
0.0GluHis: 0.0 ± 0.0
0.0GluIle: 0.0 ± 0.0
3.65GluLys: 3.65 ± 1.776
4.562GluLeu: 4.562 ± 1.454
0.0GluMet: 0.0 ± 0.0
4.562GluAsn: 4.562 ± 2.123
1.825GluPro: 1.825 ± 0.973
1.825GluGln: 1.825 ± 1.395
0.912GluArg: 0.912 ± 0.946
1.825GluSer: 1.825 ± 1.517
4.562GluThr: 4.562 ± 2.507
0.912GluVal: 0.912 ± 1.158
1.825GluTrp: 1.825 ± 0.955
1.825GluTyr: 1.825 ± 1.215
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.912PheCys: 0.912 ± 0.697
2.737PheAsp: 2.737 ± 1.188
0.912PheGlu: 0.912 ± 0.608
1.825PhePhe: 1.825 ± 0.762
0.0PheGly: 0.0 ± 0.0
2.737PheHis: 2.737 ± 1.262
2.737PheIle: 2.737 ± 1.02
3.65PheLys: 3.65 ± 1.814
6.387PheLeu: 6.387 ± 2.381
0.912PheMet: 0.912 ± 0.608
3.65PheAsn: 3.65 ± 1.814
0.912PhePro: 0.912 ± 1.009
4.562PheGln: 4.562 ± 1.368
2.737PheArg: 2.737 ± 1.473
4.562PheSer: 4.562 ± 2.298
2.737PheThr: 2.737 ± 1.759
2.737PheVal: 2.737 ± 1.32
0.0PheTrp: 0.0 ± 0.0
1.825PheTyr: 1.825 ± 1.395
0.0PheXaa: 0.0 ± 0.0
Gly
3.65GlyAla: 3.65 ± 1.728
3.65GlyCys: 3.65 ± 1.609
2.737GlyAsp: 2.737 ± 1.32
1.825GlyGlu: 1.825 ± 1.304
1.825GlyPhe: 1.825 ± 1.412
2.737GlyGly: 2.737 ± 1.188
1.825GlyHis: 1.825 ± 0.955
2.737GlyIle: 2.737 ± 1.02
5.474GlyLys: 5.474 ± 2.285
0.912GlyLeu: 0.912 ± 1.158
0.912GlyMet: 0.912 ± 0.575
0.912GlyAsn: 0.912 ± 0.697
4.562GlyPro: 4.562 ± 1.435
2.737GlyGln: 2.737 ± 1.42
1.825GlyArg: 1.825 ± 0.762
3.65GlySer: 3.65 ± 1.728
2.737GlyThr: 2.737 ± 1.146
2.737GlyVal: 2.737 ± 1.8
0.0GlyTrp: 0.0 ± 0.0
0.912GlyTyr: 0.912 ± 1.009
0.0GlyXaa: 0.0 ± 0.0
His
0.912HisAla: 0.912 ± 0.697
2.737HisCys: 2.737 ± 1.279
3.65HisAsp: 3.65 ± 2.013
1.825HisGlu: 1.825 ± 0.954
3.65HisPhe: 3.65 ± 1.251
2.737HisGly: 2.737 ± 1.279
0.912HisHis: 0.912 ± 0.946
0.912HisIle: 0.912 ± 1.158
0.912HisLys: 0.912 ± 0.946
1.825HisLeu: 1.825 ± 1.215
0.912HisMet: 0.912 ± 1.158
4.562HisAsn: 4.562 ± 2.682
2.737HisPro: 2.737 ± 1.251
1.825HisGln: 1.825 ± 1.031
3.65HisArg: 3.65 ± 1.609
1.825HisSer: 1.825 ± 1.412
3.65HisThr: 3.65 ± 2.116
3.65HisVal: 3.65 ± 0.975
0.0HisTrp: 0.0 ± 0.0
0.912HisTyr: 0.912 ± 0.608
0.0HisXaa: 0.0 ± 0.0
Ile
0.912IleAla: 0.912 ± 0.905
1.825IleCys: 1.825 ± 0.762
2.737IleAsp: 2.737 ± 1.289
1.825IleGlu: 1.825 ± 0.954
2.737IlePhe: 2.737 ± 1.823
0.912IleGly: 0.912 ± 0.697
0.912IleHis: 0.912 ± 0.946
0.912IleIle: 0.912 ± 0.946
7.299IleLys: 7.299 ± 1.429
0.912IleLeu: 0.912 ± 0.608
1.825IleMet: 1.825 ± 1.411
2.737IleAsn: 2.737 ± 1.289
0.912IlePro: 0.912 ± 0.608
4.562IleGln: 4.562 ± 1.29
6.387IleArg: 6.387 ± 2.088
6.387IleSer: 6.387 ± 2.306
2.737IleThr: 2.737 ± 1.976
2.737IleVal: 2.737 ± 1.188
2.737IleTrp: 2.737 ± 1.976
3.65IleTyr: 3.65 ± 1.768
0.0IleXaa: 0.0 ± 0.0
Lys
3.65LysAla: 3.65 ± 1.304
0.912LysCys: 0.912 ± 0.946
2.737LysAsp: 2.737 ± 1.258
4.562LysGlu: 4.562 ± 1.435
4.562LysPhe: 4.562 ± 1.531
0.912LysGly: 0.912 ± 0.608
2.737LysHis: 2.737 ± 1.8
1.825LysIle: 1.825 ± 1.14
1.825LysLys: 1.825 ± 1.517
1.825LysLeu: 1.825 ± 1.045
0.0LysMet: 0.0 ± 0.0
6.387LysAsn: 6.387 ± 2.228
2.737LysPro: 2.737 ± 0.84
0.912LysGln: 0.912 ± 1.009
2.737LysArg: 2.737 ± 2.092
4.562LysSer: 4.562 ± 1.693
4.562LysThr: 4.562 ± 1.666
5.474LysVal: 5.474 ± 2.481
0.0LysTrp: 0.0 ± 0.0
4.562LysTyr: 4.562 ± 1.728
0.0LysXaa: 0.0 ± 0.0
Leu
1.825LeuAla: 1.825 ± 1.412
1.825LeuCys: 1.825 ± 1.215
6.387LeuAsp: 6.387 ± 2.357
3.65LeuGlu: 3.65 ± 1.486
0.912LeuPhe: 0.912 ± 0.608
4.562LeuGly: 4.562 ± 1.785
2.737LeuHis: 2.737 ± 1.289
3.65LeuIle: 3.65 ± 2.299
3.65LeuLys: 3.65 ± 1.104
4.562LeuLeu: 4.562 ± 1.886
0.0LeuMet: 0.0 ± 0.0
6.387LeuAsn: 6.387 ± 1.361
2.737LeuPro: 2.737 ± 2.215
2.737LeuGln: 2.737 ± 1.279
8.212LeuArg: 8.212 ± 2.36
1.825LeuSer: 1.825 ± 1.215
5.474LeuThr: 5.474 ± 2.032
2.737LeuVal: 2.737 ± 1.442
0.0LeuTrp: 0.0 ± 0.0
4.562LeuTyr: 4.562 ± 1.728
0.0LeuXaa: 0.0 ± 0.0
Met
2.737MetAla: 2.737 ± 1.328
0.0MetCys: 0.0 ± 0.0
2.737MetAsp: 2.737 ± 1.636
2.737MetGlu: 2.737 ± 2.121
2.737MetPhe: 2.737 ± 1.42
1.825MetGly: 1.825 ± 1.045
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
0.912MetLeu: 0.912 ± 1.009
0.912MetMet: 0.912 ± 0.697
0.912MetAsn: 0.912 ± 0.697
0.912MetPro: 0.912 ± 1.158
0.0MetGln: 0.0 ± 0.0
0.912MetArg: 0.912 ± 0.905
0.912MetSer: 0.912 ± 1.158
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
2.737MetTrp: 2.737 ± 0.84
2.737MetTyr: 2.737 ± 2.092
0.0MetXaa: 0.0 ± 0.0
Asn
2.737AsnAla: 2.737 ± 1.188
1.825AsnCys: 1.825 ± 1.14
2.737AsnAsp: 2.737 ± 1.188
1.825AsnGlu: 1.825 ± 1.031
0.912AsnPhe: 0.912 ± 0.697
3.65AsnGly: 3.65 ± 1.814
5.474AsnHis: 5.474 ± 2.294
3.65AsnIle: 3.65 ± 1.232
1.825AsnLys: 1.825 ± 1.215
5.474AsnLeu: 5.474 ± 1.807
0.912AsnMet: 0.912 ± 0.657
0.912AsnAsn: 0.912 ± 0.946
3.65AsnPro: 3.65 ± 1.132
2.737AsnGln: 2.737 ± 1.32
1.825AsnArg: 1.825 ± 0.762
4.562AsnSer: 4.562 ± 2.186
4.562AsnThr: 4.562 ± 1.196
2.737AsnVal: 2.737 ± 1.262
0.912AsnTrp: 0.912 ± 0.608
2.737AsnTyr: 2.737 ± 1.289
0.0AsnXaa: 0.0 ± 0.0
Pro
2.737ProAla: 2.737 ± 1.442
1.825ProCys: 1.825 ± 0.973
2.737ProAsp: 2.737 ± 1.917
3.65ProGlu: 3.65 ± 2.097
1.825ProPhe: 1.825 ± 0.954
0.912ProGly: 0.912 ± 0.608
6.387ProHis: 6.387 ± 2.599
2.737ProIle: 2.737 ± 1.759
2.737ProLys: 2.737 ± 1.258
4.562ProLeu: 4.562 ± 1.872
3.65ProMet: 3.65 ± 1.965
4.562ProAsn: 4.562 ± 2.371
1.825ProPro: 1.825 ± 1.215
0.912ProGln: 0.912 ± 0.946
4.562ProArg: 4.562 ± 2.38
3.65ProSer: 3.65 ± 1.645
3.65ProThr: 3.65 ± 1.97
4.562ProVal: 4.562 ± 1.617
0.0ProTrp: 0.0 ± 0.0
0.912ProTyr: 0.912 ± 0.697
0.0ProXaa: 0.0 ± 0.0
Gln
2.737GlnAla: 2.737 ± 1.442
0.912GlnCys: 0.912 ± 0.608
0.912GlnAsp: 0.912 ± 0.905
1.825GlnGlu: 1.825 ± 0.762
3.65GlnPhe: 3.65 ± 1.908
2.737GlnGly: 2.737 ± 1.258
1.825GlnHis: 1.825 ± 1.517
3.65GlnIle: 3.65 ± 1.776
2.737GlnLys: 2.737 ± 2.282
1.825GlnLeu: 1.825 ± 1.412
3.65GlnMet: 3.65 ± 1.645
0.0GlnAsn: 0.0 ± 0.0
1.825GlnPro: 1.825 ± 1.412
1.825GlnGln: 1.825 ± 1.189
1.825GlnArg: 1.825 ± 1.215
4.562GlnSer: 4.562 ± 1.069
2.737GlnThr: 2.737 ± 1.003
4.562GlnVal: 4.562 ± 1.233
0.0GlnTrp: 0.0 ± 0.0
0.912GlnTyr: 0.912 ± 0.697
0.0GlnXaa: 0.0 ± 0.0
Arg
1.825ArgAla: 1.825 ± 1.304
0.912ArgCys: 0.912 ± 1.009
4.562ArgAsp: 4.562 ± 1.78
4.562ArgGlu: 4.562 ± 2.01
3.65ArgPhe: 3.65 ± 1.98
3.65ArgGly: 3.65 ± 1.261
2.737ArgHis: 2.737 ± 1.296
5.474ArgIle: 5.474 ± 1.354
2.737ArgLys: 2.737 ± 1.636
5.474ArgLeu: 5.474 ± 2.408
0.912ArgMet: 0.912 ± 0.697
1.825ArgAsn: 1.825 ± 0.954
6.387ArgPro: 6.387 ± 1.716
3.65ArgGln: 3.65 ± 1.236
8.212ArgArg: 8.212 ± 3.665
5.474ArgSer: 5.474 ± 1.354
2.737ArgThr: 2.737 ± 1.251
5.474ArgVal: 5.474 ± 2.294
0.0ArgTrp: 0.0 ± 0.0
0.912ArgTyr: 0.912 ± 1.009
0.0ArgXaa: 0.0 ± 0.0
Ser
5.474SerAla: 5.474 ± 3.645
1.825SerCys: 1.825 ± 1.031
1.825SerAsp: 1.825 ± 0.973
1.825SerGlu: 1.825 ± 1.126
1.825SerPhe: 1.825 ± 0.955
2.737SerGly: 2.737 ± 1.188
3.65SerHis: 3.65 ± 2.167
8.212SerIle: 8.212 ± 4.511
2.737SerLys: 2.737 ± 0.944
2.737SerLeu: 2.737 ± 1.823
0.912SerMet: 0.912 ± 1.158
7.299SerAsn: 7.299 ± 1.784
10.036SerPro: 10.036 ± 2.683
1.825SerGln: 1.825 ± 0.762
4.562SerArg: 4.562 ± 2.308
11.861SerSer: 11.861 ± 5.311
5.474SerThr: 5.474 ± 2.12
2.737SerVal: 2.737 ± 1.997
0.0SerTrp: 0.0 ± 0.0
3.65SerTyr: 3.65 ± 1.82
0.0SerXaa: 0.0 ± 0.0
Thr
1.825ThrAla: 1.825 ± 1.14
2.737ThrCys: 2.737 ± 2.474
0.912ThrAsp: 0.912 ± 0.608
1.825ThrGlu: 1.825 ± 1.189
0.912ThrPhe: 0.912 ± 1.158
7.299ThrGly: 7.299 ± 1.353
5.474ThrHis: 5.474 ± 2.427
3.65ThrIle: 3.65 ± 1.7
2.737ThrLys: 2.737 ± 1.289
2.737ThrLeu: 2.737 ± 0.84
0.912ThrMet: 0.912 ± 0.608
1.825ThrAsn: 1.825 ± 1.031
5.474ThrPro: 5.474 ± 1.7
1.825ThrGln: 1.825 ± 1.811
3.65ThrArg: 3.65 ± 1.528
4.562ThrSer: 4.562 ± 1.847
4.562ThrThr: 4.562 ± 2.01
5.474ThrVal: 5.474 ± 2.718
0.912ThrTrp: 0.912 ± 1.158
1.825ThrTyr: 1.825 ± 0.967
0.0ThrXaa: 0.0 ± 0.0
Val
2.737ValAla: 2.737 ± 1.42
0.0ValCys: 0.0 ± 0.0
2.737ValAsp: 2.737 ± 1.32
1.825ValGlu: 1.825 ± 0.967
3.65ValPhe: 3.65 ± 0.882
1.825ValGly: 1.825 ± 0.973
0.912ValHis: 0.912 ± 1.009
7.299ValIle: 7.299 ± 2.06
6.387ValLys: 6.387 ± 1.65
4.562ValLeu: 4.562 ± 2.185
0.912ValMet: 0.912 ± 0.697
0.912ValAsn: 0.912 ± 0.608
4.562ValPro: 4.562 ± 1.835
4.562ValGln: 4.562 ± 0.92
5.474ValArg: 5.474 ± 3.382
4.562ValSer: 4.562 ± 1.902
2.737ValThr: 2.737 ± 2.092
2.737ValVal: 2.737 ± 0.84
0.0ValTrp: 0.0 ± 0.0
4.562ValTyr: 4.562 ± 1.233
0.0ValXaa: 0.0 ± 0.0
Trp
2.737TrpAla: 2.737 ± 1.823
0.0TrpCys: 0.0 ± 0.0
0.912TrpAsp: 0.912 ± 1.009
0.0TrpGlu: 0.0 ± 0.0
0.912TrpPhe: 0.912 ± 0.608
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.912TrpLys: 0.912 ± 1.158
0.0TrpLeu: 0.0 ± 0.0
0.912TrpMet: 0.912 ± 0.697
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.912TrpGln: 0.912 ± 0.608
0.912TrpArg: 0.912 ± 0.905
0.912TrpSer: 0.912 ± 0.697
1.825TrpThr: 1.825 ± 1.892
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.737TyrAla: 2.737 ± 1.328
0.912TyrCys: 0.912 ± 1.009
3.65TyrAsp: 3.65 ± 1.612
0.912TyrGlu: 0.912 ± 0.697
3.65TyrPhe: 3.65 ± 0.882
2.737TyrGly: 2.737 ± 1.881
0.0TyrHis: 0.0 ± 0.0
1.825TyrIle: 1.825 ± 0.954
0.912TyrLys: 0.912 ± 0.608
5.474TyrLeu: 5.474 ± 1.519
2.737TyrMet: 2.737 ± 1.007
1.825TyrAsn: 1.825 ± 1.14
0.912TyrPro: 0.912 ± 0.608
1.825TyrGln: 1.825 ± 0.954
2.737TyrArg: 2.737 ± 2.092
3.65TyrSer: 3.65 ± 1.042
0.912TyrThr: 0.912 ± 0.697
0.912TyrVal: 0.912 ± 0.697
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski