Amino acid dipepetide frequency for Gottschalkia purinilytica (Clostridium purinilyticum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.711AlaAla: 2.711 ± 0.067	0.551AlaCys: 0.551 ± 0.025	2.212AlaAsp: 2.212 ± 0.05	3.034AlaGlu: 3.034 ± 0.065	2.197AlaPhe: 2.197 ± 0.056	3.376AlaGly: 3.376 ± 0.073	0.728AlaHis: 0.728 ± 0.025	5.491AlaIle: 5.491 ± 0.086	4.383AlaLys: 4.383 ± 0.079	5.31AlaLeu: 5.31 ± 0.092	1.409AlaMet: 1.409 ± 0.043	2.415AlaAsn: 2.415 ± 0.054	1.251AlaPro: 1.251 ± 0.038	1.291AlaGln: 1.291 ± 0.038	1.857AlaArg: 1.857 ± 0.045	3.255AlaSer: 3.255 ± 0.062	2.703AlaThr: 2.703 ± 0.071	3.236AlaVal: 3.236 ± 0.079	0.316AlaTrp: 0.316 ± 0.017	1.879AlaTyr: 1.879 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.46CysAla: 0.46 ± 0.022	0.184CysCys: 0.184 ± 0.02	0.569CysAsp: 0.569 ± 0.028	0.656CysGlu: 0.656 ± 0.028	0.367CysPhe: 0.367 ± 0.021	0.891CysGly: 0.891 ± 0.036	0.205CysHis: 0.205 ± 0.014	0.955CysIle: 0.955 ± 0.032	0.85CysLys: 0.85 ± 0.032	0.73CysLeu: 0.73 ± 0.03	0.24CysMet: 0.24 ± 0.016	0.629CysAsn: 0.629 ± 0.026	0.452CysPro: 0.452 ± 0.029	0.217CysGln: 0.217 ± 0.016	0.374CysArg: 0.374 ± 0.026	0.707CysSer: 0.707 ± 0.028	0.523CysThr: 0.523 ± 0.026	0.576CysVal: 0.576 ± 0.025	0.078CysTrp: 0.078 ± 0.009	0.373CysTyr: 0.373 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.257AspAla: 2.257 ± 0.053	0.55AspCys: 0.55 ± 0.028	2.916AspAsp: 2.916 ± 0.06	4.705AspGlu: 4.705 ± 0.08	2.637AspPhe: 2.637 ± 0.051	3.201AspGly: 3.201 ± 0.069	0.712AspHis: 0.712 ± 0.03	7.177AspIle: 7.177 ± 0.091	5.929AspLys: 5.929 ± 0.091	4.844AspLeu: 4.844 ± 0.077	1.593AspMet: 1.593 ± 0.045	3.337AspAsn: 3.337 ± 0.058	1.482AspPro: 1.482 ± 0.037	0.923AspGln: 0.923 ± 0.035	1.925AspArg: 1.925 ± 0.044	3.145AspSer: 3.145 ± 0.062	2.768AspThr: 2.768 ± 0.058	3.534AspVal: 3.534 ± 0.069	0.431AspTrp: 0.431 ± 0.022	2.577AspTyr: 2.577 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	3.817GluAla: 3.817 ± 0.08	0.62GluCys: 0.62 ± 0.03	4.504GluAsp: 4.504 ± 0.081	7.329GluGlu: 7.329 ± 0.119	2.861GluPhe: 2.861 ± 0.057	4.166GluGly: 4.166 ± 0.065	1.028GluHis: 1.028 ± 0.036	7.619GluIle: 7.619 ± 0.112	8.186GluLys: 8.186 ± 0.112	7.027GluLeu: 7.027 ± 0.097	1.877GluMet: 1.877 ± 0.046	5.431GluAsn: 5.431 ± 0.092	1.482GluPro: 1.482 ± 0.047	1.854GluGln: 1.854 ± 0.054	2.785GluArg: 2.785 ± 0.068	3.944GluSer: 3.944 ± 0.067	3.135GluThr: 3.135 ± 0.058	5.098GluVal: 5.098 ± 0.084	0.454GluTrp: 0.454 ± 0.025	3.093GluTyr: 3.093 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	1.96PheAla: 1.96 ± 0.048	0.452PheCys: 0.452 ± 0.022	2.344PheAsp: 2.344 ± 0.05	2.868PheGlu: 2.868 ± 0.053	1.843PhePhe: 1.843 ± 0.056	2.747PheGly: 2.747 ± 0.062	0.562PheHis: 0.562 ± 0.025	4.723PheIle: 4.723 ± 0.084	3.716PheLys: 3.716 ± 0.069	3.802PheLeu: 3.802 ± 0.074	1.026PheMet: 1.026 ± 0.033	2.656PheAsn: 2.656 ± 0.066	1.217PhePro: 1.217 ± 0.04	0.89PheGln: 0.89 ± 0.028	1.29PheArg: 1.29 ± 0.037	3.02PheSer: 3.02 ± 0.054	2.357PheThr: 2.357 ± 0.052	2.437PheVal: 2.437 ± 0.054	0.293PheTrp: 0.293 ± 0.02	1.692PheTyr: 1.692 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	3.756GlyAla: 3.756 ± 0.086	0.825GlyCys: 0.825 ± 0.033	3.08GlyAsp: 3.08 ± 0.06	4.133GlyGlu: 4.133 ± 0.082	2.861GlyPhe: 2.861 ± 0.062	4.168GlyGly: 4.168 ± 0.089	1.016GlyHis: 1.016 ± 0.034	7.098GlyIle: 7.098 ± 0.102	5.792GlyLys: 5.792 ± 0.087	5.871GlyLeu: 5.871 ± 0.087	1.693GlyMet: 1.693 ± 0.042	3.14GlyAsn: 3.14 ± 0.059	1.332GlyPro: 1.332 ± 0.065	1.521GlyGln: 1.521 ± 0.044	2.208GlyArg: 2.208 ± 0.05	3.667GlySer: 3.667 ± 0.066	3.49GlyThr: 3.49 ± 0.069	4.479GlyVal: 4.479 ± 0.074	0.499GlyTrp: 0.499 ± 0.028	2.984GlyTyr: 2.984 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	0.66HisAla: 0.66 ± 0.029	0.216HisCys: 0.216 ± 0.015	0.792HisAsp: 0.792 ± 0.029	0.919HisGlu: 0.919 ± 0.029	0.629HisPhe: 0.629 ± 0.026	0.966HisGly: 0.966 ± 0.031	0.282HisHis: 0.282 ± 0.018	1.59HisIle: 1.59 ± 0.04	1.117HisLys: 1.117 ± 0.032	1.197HisLeu: 1.197 ± 0.041	0.365HisMet: 0.365 ± 0.02	0.834HisAsn: 0.834 ± 0.028	0.639HisPro: 0.639 ± 0.028	0.329HisGln: 0.329 ± 0.019	0.551HisArg: 0.551 ± 0.026	0.912HisSer: 0.912 ± 0.034	0.692HisThr: 0.692 ± 0.03	0.756HisVal: 0.756 ± 0.029	0.129HisTrp: 0.129 ± 0.012	0.558HisTyr: 0.558 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.497IleAla: 5.497 ± 0.089	1.048IleCys: 1.048 ± 0.036	6.693IleAsp: 6.693 ± 0.083	7.951IleGlu: 7.951 ± 0.106	4.248IlePhe: 4.248 ± 0.088	6.765IleGly: 6.765 ± 0.087	1.368IleHis: 1.368 ± 0.037	10.231IleIle: 10.231 ± 0.147	9.454IleLys: 9.454 ± 0.104	9.811IleLeu: 9.811 ± 0.139	2.405IleMet: 2.405 ± 0.049	6.329IleAsn: 6.329 ± 0.093	3.392IlePro: 3.392 ± 0.067	2.354IleGln: 2.354 ± 0.05	3.392IleArg: 3.392 ± 0.062	7.623IleSer: 7.623 ± 0.106	5.144IleThr: 5.144 ± 0.078	6.889IleVal: 6.889 ± 0.095	0.582IleTrp: 0.582 ± 0.026	3.623IleTyr: 3.623 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	4.228LysAla: 4.228 ± 0.069	0.736LysCys: 0.736 ± 0.034	6.493LysAsp: 6.493 ± 0.101	9.591LysGlu: 9.591 ± 0.122	3.047LysPhe: 3.047 ± 0.06	5.491LysGly: 5.491 ± 0.078	1.265LysHis: 1.265 ± 0.041	8.874LysIle: 8.874 ± 0.107	8.907LysLys: 8.907 ± 0.113	8.085LysLeu: 8.085 ± 0.108	2.356LysMet: 2.356 ± 0.049	6.384LysAsn: 6.384 ± 0.098	2.089LysPro: 2.089 ± 0.049	2.356LysGln: 2.356 ± 0.057	3.261LysArg: 3.261 ± 0.066	5.383LysSer: 5.383 ± 0.088	4.216LysThr: 4.216 ± 0.068	6.169LysVal: 6.169 ± 0.079	0.661LysTrp: 0.661 ± 0.03	4.065LysTyr: 4.065 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	4.942LeuAla: 4.942 ± 0.082	0.915LeuCys: 0.915 ± 0.033	5.547LeuAsp: 5.547 ± 0.093	6.886LeuGlu: 6.886 ± 0.107	3.677LeuPhe: 3.677 ± 0.077	6.278LeuGly: 6.278 ± 0.1	1.131LeuHis: 1.131 ± 0.034	8.46LeuIle: 8.46 ± 0.117	8.685LeuLys: 8.685 ± 0.109	8.124LeuLeu: 8.124 ± 0.12	2.114LeuMet: 2.114 ± 0.04	5.701LeuAsn: 5.701 ± 0.09	2.814LeuPro: 2.814 ± 0.053	2.106LeuGln: 2.106 ± 0.048	3.258LeuArg: 3.258 ± 0.059	7.073LeuSer: 7.073 ± 0.088	4.564LeuThr: 4.564 ± 0.069	5.542LeuVal: 5.542 ± 0.084	0.553LeuTrp: 0.553 ± 0.027	3.08LeuTyr: 3.08 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.468MetAla: 1.468 ± 0.036	0.238MetCys: 0.238 ± 0.015	1.356MetAsp: 1.356 ± 0.045	1.688MetGlu: 1.688 ± 0.042	1.044MetPhe: 1.044 ± 0.033	1.609MetGly: 1.609 ± 0.049	0.299MetHis: 0.299 ± 0.017	2.528MetIle: 2.528 ± 0.05	2.63MetLys: 2.63 ± 0.053	2.182MetLeu: 2.182 ± 0.054	0.628MetMet: 0.628 ± 0.026	1.652MetAsn: 1.652 ± 0.046	0.686MetPro: 0.686 ± 0.026	0.569MetGln: 0.569 ± 0.021	0.867MetArg: 0.867 ± 0.027	1.827MetSer: 1.827 ± 0.046	1.25MetThr: 1.25 ± 0.037	1.382MetVal: 1.382 ± 0.038	0.129MetTrp: 0.129 ± 0.011	0.814MetTyr: 0.814 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.493AsnAla: 2.493 ± 0.047	0.547AsnCys: 0.547 ± 0.024	3.039AsnAsp: 3.039 ± 0.064	4.323AsnGlu: 4.323 ± 0.077	2.43AsnPhe: 2.43 ± 0.057	3.343AsnGly: 3.343 ± 0.072	0.805AsnHis: 0.805 ± 0.03	7.852AsnIle: 7.852 ± 0.109	6.385AsnLys: 6.385 ± 0.095	5.532AsnLeu: 5.532 ± 0.088	1.602AsnMet: 1.602 ± 0.043	4.234AsnAsn: 4.234 ± 0.094	2.155AsnPro: 2.155 ± 0.055	1.521AsnGln: 1.521 ± 0.045	2.114AsnArg: 2.114 ± 0.054	3.672AsnSer: 3.672 ± 0.066	2.971AsnThr: 2.971 ± 0.061	3.575AsnVal: 3.575 ± 0.061	0.462AsnTrp: 0.462 ± 0.022	2.375AsnTyr: 2.375 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	1.229ProAla: 1.229 ± 0.041	0.325ProCys: 0.325 ± 0.019	1.537ProAsp: 1.537 ± 0.044	2.157ProGlu: 2.157 ± 0.051	1.388ProPhe: 1.388 ± 0.042	1.752ProGly: 1.752 ± 0.044	0.476ProHis: 0.476 ± 0.021	2.925ProIle: 2.925 ± 0.064	2.424ProLys: 2.424 ± 0.057	2.401ProLeu: 2.401 ± 0.056	0.653ProMet: 0.653 ± 0.026	1.663ProAsn: 1.663 ± 0.056	0.662ProPro: 0.662 ± 0.027	0.768ProGln: 0.768 ± 0.031	0.911ProArg: 0.911 ± 0.036	1.811ProSer: 1.811 ± 0.05	1.619ProThr: 1.619 ± 0.073	2.004ProVal: 2.004 ± 0.053	0.223ProTrp: 0.223 ± 0.017	1.23ProTyr: 1.23 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.376GlnAla: 1.376 ± 0.049	0.204GlnCys: 0.204 ± 0.017	1.25GlnAsp: 1.25 ± 0.038	1.856GlnGlu: 1.856 ± 0.045	0.939GlnPhe: 0.939 ± 0.031	1.519GlnGly: 1.519 ± 0.044	0.349GlnHis: 0.349 ± 0.02	2.254GlnIle: 2.254 ± 0.054	2.157GlnLys: 2.157 ± 0.049	2.206GlnLeu: 2.206 ± 0.058	0.658GlnMet: 0.658 ± 0.027	1.496GlnAsn: 1.496 ± 0.04	0.597GlnPro: 0.597 ± 0.026	0.801GlnGln: 0.801 ± 0.031	0.972GlnArg: 0.972 ± 0.034	1.52GlnSer: 1.52 ± 0.044	1.091GlnThr: 1.091 ± 0.034	1.545GlnVal: 1.545 ± 0.045	0.17GlnTrp: 0.17 ± 0.013	0.954GlnTyr: 0.954 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.74ArgAla: 1.74 ± 0.044	0.363ArgCys: 0.363 ± 0.023	1.912ArgAsp: 1.912 ± 0.044	2.899ArgGlu: 2.899 ± 0.058	1.517ArgPhe: 1.517 ± 0.039	2.062ArgGly: 2.062 ± 0.055	0.554ArgHis: 0.554 ± 0.025	3.262ArgIle: 3.262 ± 0.058	3.467ArgLys: 3.467 ± 0.065	3.183ArgLeu: 3.183 ± 0.061	0.924ArgMet: 0.924 ± 0.028	2.117ArgAsn: 2.117 ± 0.047	0.889ArgPro: 0.889 ± 0.039	1.035ArgGln: 1.035 ± 0.037	1.534ArgArg: 1.534 ± 0.049	1.809ArgSer: 1.809 ± 0.049	1.651ArgThr: 1.651 ± 0.044	2.365ArgVal: 2.365 ± 0.053	0.257ArgTrp: 0.257 ± 0.018	1.533ArgTyr: 1.533 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	2.829SerAla: 2.829 ± 0.061	0.638SerCys: 0.638 ± 0.032	3.233SerAsp: 3.233 ± 0.053	4.156SerGlu: 4.156 ± 0.061	3.057SerPhe: 3.057 ± 0.061	4.208SerGly: 4.208 ± 0.08	1.007SerHis: 1.007 ± 0.036	7.428SerIle: 7.428 ± 0.106	6.13SerLys: 6.13 ± 0.093	6.197SerLeu: 6.197 ± 0.095	1.617SerMet: 1.617 ± 0.036	4.06SerAsn: 4.06 ± 0.075	1.765SerPro: 1.765 ± 0.045	1.821SerGln: 1.821 ± 0.048	2.259SerArg: 2.259 ± 0.046	4.419SerSer: 4.419 ± 0.079	3.21SerThr: 3.21 ± 0.068	3.753SerVal: 3.753 ± 0.063	0.45SerTrp: 0.45 ± 0.022	2.538SerTyr: 2.538 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	2.502ThrAla: 2.502 ± 0.064	0.405ThrCys: 0.405 ± 0.018	2.58ThrAsp: 2.58 ± 0.053	3.095ThrGlu: 3.095 ± 0.065	2.258ThrPhe: 2.258 ± 0.044	3.763ThrGly: 3.763 ± 0.144	0.793ThrHis: 0.793 ± 0.028	5.412ThrIle: 5.412 ± 0.081	3.813ThrLys: 3.813 ± 0.06	5.018ThrLeu: 5.018 ± 0.075	1.072ThrMet: 1.072 ± 0.033	2.815ThrAsn: 2.815 ± 0.061	1.81ThrPro: 1.81 ± 0.05	1.169ThrGln: 1.169 ± 0.037	1.675ThrArg: 1.675 ± 0.044	3.339ThrSer: 3.339 ± 0.058	2.763ThrThr: 2.763 ± 0.051	3.337ThrVal: 3.337 ± 0.061	0.334ThrTrp: 0.334 ± 0.022	1.826ThrTyr: 1.826 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	3.626ValAla: 3.626 ± 0.081	0.698ValCys: 0.698 ± 0.029	3.802ValAsp: 3.802 ± 0.064	4.596ValGlu: 4.596 ± 0.096	2.733ValPhe: 2.733 ± 0.056	4.228ValGly: 4.228 ± 0.079	0.843ValHis: 0.843 ± 0.032	6.147ValIle: 6.147 ± 0.099	5.546ValLys: 5.546 ± 0.082	5.851ValLeu: 5.851 ± 0.087	1.479ValMet: 1.479 ± 0.04	3.435ValAsn: 3.435 ± 0.07	2.027ValPro: 2.027 ± 0.048	1.376ValGln: 1.376 ± 0.039	2.096ValArg: 2.096 ± 0.043	4.642ValSer: 4.642 ± 0.071	3.412ValThr: 3.412 ± 0.073	4.377ValVal: 4.377 ± 0.083	0.393ValTrp: 0.393 ± 0.02	2.331ValTyr: 2.331 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.358TrpAla: 0.358 ± 0.022	0.075TrpCys: 0.075 ± 0.01	0.398TrpAsp: 0.398 ± 0.022	0.529TrpGlu: 0.529 ± 0.023	0.279TrpPhe: 0.279 ± 0.019	0.513TrpGly: 0.513 ± 0.022	0.116TrpHis: 0.116 ± 0.011	0.713TrpIle: 0.713 ± 0.026	0.56TrpLys: 0.56 ± 0.022	0.571TrpLeu: 0.571 ± 0.025	0.188TrpMet: 0.188 ± 0.014	0.489TrpAsn: 0.489 ± 0.025	0.151TrpPro: 0.151 ± 0.015	0.184TrpGln: 0.184 ± 0.013	0.233TrpArg: 0.233 ± 0.015	0.377TrpSer: 0.377 ± 0.02	0.309TrpThr: 0.309 ± 0.018	0.381TrpVal: 0.381 ± 0.021	0.087TrpTrp: 0.087 ± 0.01	0.269TrpTyr: 0.269 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.697TyrAla: 1.697 ± 0.04	0.445TyrCys: 0.445 ± 0.024	2.386TyrAsp: 2.386 ± 0.045	2.937TyrGlu: 2.937 ± 0.06	1.883TyrPhe: 1.883 ± 0.046	2.567TyrGly: 2.567 ± 0.056	0.592TyrHis: 0.592 ± 0.026	4.063TyrIle: 4.063 ± 0.067	3.526TyrLys: 3.526 ± 0.062	3.508TyrLeu: 3.508 ± 0.077	0.944TyrMet: 0.944 ± 0.03	2.616TyrAsn: 2.616 ± 0.06	1.265TyrPro: 1.265 ± 0.046	0.83TyrGln: 0.83 ± 0.032	1.509TyrArg: 1.509 ± 0.041	2.632TyrSer: 2.632 ± 0.057	1.906TyrThr: 1.906 ± 0.041	2.207TyrVal: 2.207 ± 0.053	0.28TyrTrp: 0.28 ± 0.016	1.672TyrTyr: 1.672 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3284 proteins (939259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---