Amino acid dipepetide frequency for Enterococcus faecium (strain ATCC BAA-472 / TX0016 / DO)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.311AlaAla: 5.311 ± 0.092	0.51AlaCys: 0.51 ± 0.028	3.494AlaAsp: 3.494 ± 0.068	4.748AlaGlu: 4.748 ± 0.083	3.206AlaPhe: 3.206 ± 0.071	4.762AlaGly: 4.762 ± 0.09	1.151AlaHis: 1.151 ± 0.042	5.498AlaIle: 5.498 ± 0.087	4.779AlaLys: 4.779 ± 0.081	6.415AlaLeu: 6.415 ± 0.094	1.96AlaMet: 1.96 ± 0.054	2.764AlaAsn: 2.764 ± 0.059	1.939AlaPro: 1.939 ± 0.049	2.609AlaGln: 2.609 ± 0.063	2.392AlaArg: 2.392 ± 0.059	4.033AlaSer: 4.033 ± 0.067	3.533AlaThr: 3.533 ± 0.065	5.094AlaVal: 5.094 ± 0.085	0.565AlaTrp: 0.565 ± 0.03	2.536AlaTyr: 2.536 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.394CysAla: 0.394 ± 0.024	0.115CysCys: 0.115 ± 0.011	0.318CysAsp: 0.318 ± 0.019	0.354CysGlu: 0.354 ± 0.023	0.365CysPhe: 0.365 ± 0.02	0.658CysGly: 0.658 ± 0.03	0.181CysHis: 0.181 ± 0.015	0.452CysIle: 0.452 ± 0.023	0.294CysLys: 0.294 ± 0.023	0.806CysLeu: 0.806 ± 0.038	0.181CysMet: 0.181 ± 0.014	0.224CysAsn: 0.224 ± 0.017	0.262CysPro: 0.262 ± 0.019	0.314CysGln: 0.314 ± 0.02	0.293CysArg: 0.293 ± 0.021	0.457CysSer: 0.457 ± 0.026	0.358CysThr: 0.358 ± 0.019	0.438CysVal: 0.438 ± 0.024	0.072CysTrp: 0.072 ± 0.01	0.325CysTyr: 0.325 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.08AspAla: 3.08 ± 0.065	0.352AspCys: 0.352 ± 0.02	2.337AspAsp: 2.337 ± 0.057	4.001AspGlu: 4.001 ± 0.077	2.703AspPhe: 2.703 ± 0.054	3.31AspGly: 3.31 ± 0.074	1.117AspHis: 1.117 ± 0.036	3.73AspIle: 3.73 ± 0.058	3.199AspLys: 3.199 ± 0.062	4.991AspLeu: 4.991 ± 0.069	1.258AspMet: 1.258 ± 0.044	1.946AspAsn: 1.946 ± 0.05	2.073AspPro: 2.073 ± 0.051	2.349AspGln: 2.349 ± 0.058	2.171AspArg: 2.171 ± 0.051	2.838AspSer: 2.838 ± 0.068	2.799AspThr: 2.799 ± 0.06	3.247AspVal: 3.247 ± 0.059	0.631AspTrp: 0.631 ± 0.029	2.464AspTyr: 2.464 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.273GluAla: 5.273 ± 0.097	0.364GluCys: 0.364 ± 0.021	3.591GluAsp: 3.591 ± 0.073	7.294GluGlu: 7.294 ± 0.128	2.678GluPhe: 2.678 ± 0.049	3.803GluGly: 3.803 ± 0.085	1.28GluHis: 1.28 ± 0.04	5.781GluIle: 5.781 ± 0.084	7.369GluLys: 7.369 ± 0.121	7.226GluLeu: 7.226 ± 0.106	2.381GluMet: 2.381 ± 0.054	4.218GluAsn: 4.218 ± 0.081	1.846GluPro: 1.846 ± 0.046	3.484GluGln: 3.484 ± 0.072	3.16GluArg: 3.16 ± 0.079	3.555GluSer: 3.555 ± 0.074	4.441GluThr: 4.441 ± 0.072	4.649GluVal: 4.649 ± 0.081	0.719GluTrp: 0.719 ± 0.031	2.457GluTyr: 2.457 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.059PheAla: 3.059 ± 0.069	0.43PheCys: 0.43 ± 0.022	2.711PheAsp: 2.711 ± 0.059	3.005PheGlu: 3.005 ± 0.062	2.829PhePhe: 2.829 ± 0.075	3.244PheGly: 3.244 ± 0.072	0.985PheHis: 0.985 ± 0.035	3.619PheIle: 3.619 ± 0.072	2.474PheLys: 2.474 ± 0.055	5.186PheLeu: 5.186 ± 0.107	1.21PheMet: 1.21 ± 0.037	1.823PheAsn: 1.823 ± 0.045	1.71PhePro: 1.71 ± 0.043	1.7PheGln: 1.7 ± 0.047	1.701PheArg: 1.701 ± 0.047	3.751PheSer: 3.751 ± 0.081	2.616PheThr: 2.616 ± 0.058	3.186PheVal: 3.186 ± 0.062	0.493PheTrp: 0.493 ± 0.023	2.032PheTyr: 2.032 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.161GlyAla: 4.161 ± 0.085	0.489GlyCys: 0.489 ± 0.023	2.791GlyAsp: 2.791 ± 0.064	4.02GlyGlu: 4.02 ± 0.078	3.303GlyPhe: 3.303 ± 0.073	4.298GlyGly: 4.298 ± 0.098	1.157GlyHis: 1.157 ± 0.038	5.845GlyIle: 5.845 ± 0.106	4.977GlyLys: 4.977 ± 0.079	6.246GlyLeu: 6.246 ± 0.098	1.969GlyMet: 1.969 ± 0.058	2.805GlyAsn: 2.805 ± 0.056	1.354GlyPro: 1.354 ± 0.046	2.23GlyGln: 2.23 ± 0.06	2.462GlyArg: 2.462 ± 0.064	3.632GlySer: 3.632 ± 0.065	4.106GlyThr: 4.106 ± 0.078	4.357GlyVal: 4.357 ± 0.077	0.672GlyTrp: 0.672 ± 0.029	2.773GlyTyr: 2.773 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.153HisAla: 1.153 ± 0.036	0.176HisCys: 0.176 ± 0.018	0.866HisAsp: 0.866 ± 0.033	1.283HisGlu: 1.283 ± 0.043	1.082HisPhe: 1.082 ± 0.038	1.245HisGly: 1.245 ± 0.041	0.537HisHis: 0.537 ± 0.027	1.257HisIle: 1.257 ± 0.044	0.923HisLys: 0.923 ± 0.034	2.086HisLeu: 2.086 ± 0.058	0.463HisMet: 0.463 ± 0.02	0.596HisAsn: 0.596 ± 0.022	1.002HisPro: 1.002 ± 0.035	0.944HisGln: 0.944 ± 0.035	0.858HisArg: 0.858 ± 0.029	1.126HisSer: 1.126 ± 0.036	1.046HisThr: 1.046 ± 0.035	1.181HisVal: 1.181 ± 0.036	0.219HisTrp: 0.219 ± 0.016	0.935HisTyr: 0.935 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.602IleAla: 5.602 ± 0.096	0.672IleCys: 0.672 ± 0.027	4.582IleAsp: 4.582 ± 0.078	5.441IleGlu: 5.441 ± 0.083	3.588IlePhe: 3.588 ± 0.084	5.352IleGly: 5.352 ± 0.089	1.621IleHis: 1.621 ± 0.052	5.552IleIle: 5.552 ± 0.107	4.71IleLys: 4.71 ± 0.071	7.357IleLeu: 7.357 ± 0.123	1.738IleMet: 1.738 ± 0.043	3.364IleAsn: 3.364 ± 0.061	3.262IlePro: 3.262 ± 0.068	3.157IleGln: 3.157 ± 0.066	3.226IleArg: 3.226 ± 0.068	4.95IleSer: 4.95 ± 0.08	4.335IleThr: 4.335 ± 0.065	5.138IleVal: 5.138 ± 0.085	0.66IleTrp: 0.66 ± 0.029	2.812IleTyr: 2.812 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.407LysAla: 4.407 ± 0.085	0.257LysCys: 0.257 ± 0.02	3.734LysAsp: 3.734 ± 0.079	7.822LysGlu: 7.822 ± 0.129	1.974LysPhe: 1.974 ± 0.053	3.913LysGly: 3.913 ± 0.062	1.229LysHis: 1.229 ± 0.036	5.443LysIle: 5.443 ± 0.085	7.339LysLys: 7.339 ± 0.102	5.612LysLeu: 5.612 ± 0.082	2.423LysMet: 2.423 ± 0.059	4.217LysAsn: 4.217 ± 0.075	1.972LysPro: 1.972 ± 0.051	3.39LysGln: 3.39 ± 0.07	3.513LysArg: 3.513 ± 0.071	3.371LysSer: 3.371 ± 0.065	3.929LysThr: 3.929 ± 0.075	4.27LysVal: 4.27 ± 0.07	0.73LysTrp: 0.73 ± 0.032	2.423LysTyr: 2.423 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	7.538LeuAla: 7.538 ± 0.105	0.707LeuCys: 0.707 ± 0.033	5.067LeuAsp: 5.067 ± 0.081	6.577LeuGlu: 6.577 ± 0.11	5.356LeuPhe: 5.356 ± 0.106	6.135LeuGly: 6.135 ± 0.097	1.598LeuHis: 1.598 ± 0.046	7.383LeuIle: 7.383 ± 0.115	6.615LeuLys: 6.615 ± 0.086	10.3LeuLeu: 10.3 ± 0.159	2.478LeuMet: 2.478 ± 0.056	4.47LeuAsn: 4.47 ± 0.071	4.175LeuPro: 4.175 ± 0.076	3.411LeuGln: 3.411 ± 0.064	3.49LeuArg: 3.49 ± 0.068	7.133LeuSer: 7.133 ± 0.104	6.021LeuThr: 6.021 ± 0.085	6.268LeuVal: 6.268 ± 0.1	0.77LeuTrp: 0.77 ± 0.031	3.19LeuTyr: 3.19 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	1.851MetAla: 1.851 ± 0.042	0.154MetCys: 0.154 ± 0.014	1.485MetAsp: 1.485 ± 0.036	1.911MetGlu: 1.911 ± 0.051	1.023MetPhe: 1.023 ± 0.033	1.649MetGly: 1.649 ± 0.049	0.403MetHis: 0.403 ± 0.021	2.52MetIle: 2.52 ± 0.064	2.457MetLys: 2.457 ± 0.055	2.382MetLeu: 2.382 ± 0.052	0.876MetMet: 0.876 ± 0.035	1.658MetAsn: 1.658 ± 0.046	0.953MetPro: 0.953 ± 0.032	0.933MetGln: 0.933 ± 0.032	1.074MetArg: 1.074 ± 0.038	1.572MetSer: 1.572 ± 0.048	1.722MetThr: 1.722 ± 0.04	1.673MetVal: 1.673 ± 0.044	0.196MetTrp: 0.196 ± 0.015	0.818MetTyr: 0.818 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.642AsnAla: 2.642 ± 0.057	0.392AsnCys: 0.392 ± 0.025	2.284AsnAsp: 2.284 ± 0.058	3.671AsnGlu: 3.671 ± 0.061	1.85AsnPhe: 1.85 ± 0.042	3.432AsnGly: 3.432 ± 0.078	1.167AsnHis: 1.167 ± 0.037	3.193AsnIle: 3.193 ± 0.072	3.036AsnLys: 3.036 ± 0.063	3.959AsnLeu: 3.959 ± 0.066	1.174AsnMet: 1.174 ± 0.039	2.033AsnAsn: 2.033 ± 0.061	1.895AsnPro: 1.895 ± 0.054	2.559AsnGln: 2.559 ± 0.057	2.142AsnArg: 2.142 ± 0.05	2.348AsnSer: 2.348 ± 0.057	2.298AsnThr: 2.298 ± 0.053	2.773AsnVal: 2.773 ± 0.055	0.572AsnTrp: 0.572 ± 0.024	2.033AsnTyr: 2.033 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.346ProAla: 2.346 ± 0.053	0.148ProCys: 0.148 ± 0.015	1.925ProAsp: 1.925 ± 0.05	3.357ProGlu: 3.357 ± 0.07	1.941ProPhe: 1.941 ± 0.052	1.863ProGly: 1.863 ± 0.052	0.589ProHis: 0.589 ± 0.025	2.634ProIle: 2.634 ± 0.058	2.397ProLys: 2.397 ± 0.056	3.245ProLeu: 3.245 ± 0.066	0.841ProMet: 0.841 ± 0.027	1.61ProAsn: 1.61 ± 0.048	0.639ProPro: 0.639 ± 0.028	1.257ProGln: 1.257 ± 0.038	1.127ProArg: 1.127 ± 0.034	2.054ProSer: 2.054 ± 0.05	1.984ProThr: 1.984 ± 0.044	2.648ProVal: 2.648 ± 0.059	0.338ProTrp: 0.338 ± 0.023	1.371ProTyr: 1.371 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.105GlnAla: 3.105 ± 0.068	0.169GlnCys: 0.169 ± 0.016	1.61GlnAsp: 1.61 ± 0.047	3.479GlnGlu: 3.479 ± 0.083	1.665GlnPhe: 1.665 ± 0.048	2.205GlnGly: 2.205 ± 0.055	0.721GlnHis: 0.721 ± 0.029	2.984GlnIle: 2.984 ± 0.058	3.358GlnLys: 3.358 ± 0.063	4.846GlnLeu: 4.846 ± 0.08	1.274GlnMet: 1.274 ± 0.039	1.756GlnAsn: 1.756 ± 0.045	1.317GlnPro: 1.317 ± 0.037	2.368GlnGln: 2.368 ± 0.068	1.833GlnArg: 1.833 ± 0.05	2.348GlnSer: 2.348 ± 0.054	2.669GlnThr: 2.669 ± 0.063	2.574GlnVal: 2.574 ± 0.052	0.435GlnTrp: 0.435 ± 0.024	1.286GlnTyr: 1.286 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.163ArgAla: 2.163 ± 0.05	0.28ArgCys: 0.28 ± 0.02	1.727ArgAsp: 1.727 ± 0.05	2.978ArgGlu: 2.978 ± 0.067	2.13ArgPhe: 2.13 ± 0.058	2.197ArgGly: 2.197 ± 0.061	0.76ArgHis: 0.76 ± 0.033	3.135ArgIle: 3.135 ± 0.064	3.48ArgLys: 3.48 ± 0.065	4.157ArgLeu: 4.157 ± 0.072	1.199ArgMet: 1.199 ± 0.039	1.959ArgAsn: 1.959 ± 0.042	1.34ArgPro: 1.34 ± 0.039	1.89ArgGln: 1.89 ± 0.054	2.05ArgArg: 2.05 ± 0.059	2.267ArgSer: 2.267 ± 0.051	2.256ArgThr: 2.256 ± 0.057	2.388ArgVal: 2.388 ± 0.053	0.409ArgTrp: 0.409 ± 0.022	1.839ArgTyr: 1.839 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.802SerAla: 3.802 ± 0.071	0.421SerCys: 0.421 ± 0.024	2.932SerAsp: 2.932 ± 0.065	4.102SerGlu: 4.102 ± 0.071	3.413SerPhe: 3.413 ± 0.071	4.377SerGly: 4.377 ± 0.086	1.171SerHis: 1.171 ± 0.041	4.702SerIle: 4.702 ± 0.083	3.775SerLys: 3.775 ± 0.062	6.168SerLeu: 6.168 ± 0.098	1.612SerMet: 1.612 ± 0.045	2.506SerAsn: 2.506 ± 0.058	1.833SerPro: 1.833 ± 0.046	2.27SerGln: 2.27 ± 0.053	2.41SerArg: 2.41 ± 0.052	3.994SerSer: 3.994 ± 0.096	3.375SerThr: 3.375 ± 0.085	4.101SerVal: 4.101 ± 0.072	0.717SerTrp: 0.717 ± 0.028	2.522SerTyr: 2.522 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.997ThrAla: 3.997 ± 0.078	0.325ThrCys: 0.325 ± 0.021	3.177ThrAsp: 3.177 ± 0.076	3.898ThrGlu: 3.898 ± 0.081	2.762ThrPhe: 2.762 ± 0.063	3.885ThrGly: 3.885 ± 0.081	1.116ThrHis: 1.116 ± 0.038	4.973ThrIle: 4.973 ± 0.081	3.858ThrLys: 3.858 ± 0.07	5.483ThrLeu: 5.483 ± 0.087	1.383ThrMet: 1.383 ± 0.046	2.658ThrAsn: 2.658 ± 0.055	2.378ThrPro: 2.378 ± 0.055	1.928ThrGln: 1.928 ± 0.049	1.924ThrArg: 1.924 ± 0.048	3.505ThrSer: 3.505 ± 0.076	3.424ThrThr: 3.424 ± 0.077	4.24ThrVal: 4.24 ± 0.08	0.515ThrTrp: 0.515 ± 0.027	2.181ThrTyr: 2.181 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.6ValAla: 4.6 ± 0.082	0.519ValCys: 0.519 ± 0.027	3.479ValAsp: 3.479 ± 0.077	4.384ValGlu: 4.384 ± 0.072	3.177ValPhe: 3.177 ± 0.058	4.169ValGly: 4.169 ± 0.081	1.102ValHis: 1.102 ± 0.036	5.384ValIle: 5.384 ± 0.082	4.231ValLys: 4.231 ± 0.076	6.629ValLeu: 6.629 ± 0.1	1.747ValMet: 1.747 ± 0.042	2.815ValAsn: 2.815 ± 0.061	2.616ValPro: 2.616 ± 0.059	2.325ValGln: 2.325 ± 0.065	2.451ValArg: 2.451 ± 0.051	4.46ValSer: 4.46 ± 0.073	4.108ValThr: 4.108 ± 0.086	4.597ValVal: 4.597 ± 0.076	0.557ValTrp: 0.557 ± 0.028	2.377ValTyr: 2.377 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.498TrpAla: 0.498 ± 0.029	0.079TrpCys: 0.079 ± 0.01	0.435TrpAsp: 0.435 ± 0.019	0.633TrpGlu: 0.633 ± 0.03	0.521TrpPhe: 0.521 ± 0.029	0.62TrpGly: 0.62 ± 0.03	0.225TrpHis: 0.225 ± 0.016	0.71TrpIle: 0.71 ± 0.029	0.729TrpLys: 0.729 ± 0.034	1.202TrpLeu: 1.202 ± 0.042	0.29TrpMet: 0.29 ± 0.02	0.548TrpAsn: 0.548 ± 0.03	0.216TrpPro: 0.216 ± 0.018	0.532TrpGln: 0.532 ± 0.027	0.448TrpArg: 0.448 ± 0.023	0.537TrpSer: 0.537 ± 0.029	0.546TrpThr: 0.546 ± 0.026	0.547TrpVal: 0.547 ± 0.025	0.127TrpTrp: 0.127 ± 0.012	0.391TrpTyr: 0.391 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.317TyrAla: 2.317 ± 0.056	0.304TyrCys: 0.304 ± 0.021	2.05TyrAsp: 2.05 ± 0.057	2.612TyrGlu: 2.612 ± 0.06	2.2TyrPhe: 2.2 ± 0.058	2.531TyrGly: 2.531 ± 0.056	0.87TyrHis: 0.87 ± 0.033	2.326TyrIle: 2.326 ± 0.058	1.965TyrLys: 1.965 ± 0.052	4.386TyrLeu: 4.386 ± 0.077	0.851TyrMet: 0.851 ± 0.029	1.485TyrAsn: 1.485 ± 0.048	1.533TyrPro: 1.533 ± 0.044	2.349TyrGln: 2.349 ± 0.066	1.877TyrArg: 1.877 ± 0.053	2.271TyrSer: 2.271 ± 0.056	2.045TyrThr: 2.045 ± 0.057	2.357TyrVal: 2.357 ± 0.05	0.435TyrTrp: 0.435 ± 0.027	1.699TyrTyr: 1.699 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3059 proteins (857693 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---