Human papillomavirus 199

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 12

Average proteome isoelectric point is 6.11

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A0N9E2S0|A0A0N9E2S0_9PAPI Minor capsid protein L2 OS=Human papillomavirus 199 OX=1545700 GN=L2 PE=3 SV=1
MM1 pKa = 7.54SATTRR6 pKa = 11.84RR7 pKa = 11.84KK8 pKa = 9.3RR9 pKa = 11.84AAPVDD14 pKa = 4.38LYY16 pKa = 11.1KK17 pKa = 10.86SCLAGGDD24 pKa = 4.48CITDD28 pKa = 3.25VKK30 pKa = 11.4NKK32 pKa = 10.28FEE34 pKa = 4.24NTTLADD40 pKa = 3.09ILLKK44 pKa = 10.81VFGSIVYY51 pKa = 10.18FGGLGIGSGKK61 pKa = 10.63GSGGSLGYY69 pKa = 10.1RR70 pKa = 11.84PLGSEE75 pKa = 3.82PTTGRR80 pKa = 11.84VAPTAPVRR88 pKa = 11.84PSVIVDD94 pKa = 3.32PLVPPDD100 pKa = 4.09VITVEE105 pKa = 4.34PSAPSIIPLAEE116 pKa = 3.89GRR118 pKa = 11.84PNIDD122 pKa = 2.96FAAPDD127 pKa = 3.92GGPGLGAEE135 pKa = 4.46EE136 pKa = 4.36IEE138 pKa = 5.03LYY140 pKa = 9.76TIKK143 pKa = 10.12TPTTDD148 pKa = 2.55IGGVGSEE155 pKa = 4.0PTVISSEE162 pKa = 4.14EE163 pKa = 3.99GATAILPVDD172 pKa = 5.13PIPEE176 pKa = 3.87RR177 pKa = 11.84PAQVFYY183 pKa = 11.21DD184 pKa = 4.41PSAPSQYY191 pKa = 10.45EE192 pKa = 3.87LNIFAAHH199 pKa = 7.36PSTSSDD205 pKa = 2.67INVFVDD211 pKa = 3.33NSFSGKK217 pKa = 9.66VVGTFEE223 pKa = 4.86EE224 pKa = 4.74IPLEE228 pKa = 4.2KK229 pKa = 10.67YY230 pKa = 10.39NYY232 pKa = 8.11STFEE236 pKa = 3.81IEE238 pKa = 4.53EE239 pKa = 4.6PPSTSTPTRR248 pKa = 11.84SLEE251 pKa = 4.13RR252 pKa = 11.84VATRR256 pKa = 11.84AKK258 pKa = 10.46ALYY261 pKa = 10.44NKK263 pKa = 7.67FTRR266 pKa = 11.84QVSVKK271 pKa = 10.46DD272 pKa = 3.88PNFLLQPSRR281 pKa = 11.84LVQFEE286 pKa = 4.12FDD288 pKa = 3.54NPAFDD293 pKa = 5.43RR294 pKa = 11.84DD295 pKa = 3.46VTLQFEE301 pKa = 4.27QDD303 pKa = 3.75VQQVTAAPNPDD314 pKa = 3.59FADD317 pKa = 4.37VIQLGRR323 pKa = 11.84PILSQTEE330 pKa = 4.04EE331 pKa = 4.17GVVRR335 pKa = 11.84VSRR338 pKa = 11.84LGKK341 pKa = 9.83VGTVATRR348 pKa = 11.84SGRR351 pKa = 11.84VIGQPVHH358 pKa = 6.04YY359 pKa = 9.4FQDD362 pKa = 3.51LSVIEE367 pKa = 4.36PEE369 pKa = 4.28SIEE372 pKa = 3.74LHH374 pKa = 6.18GFAEE378 pKa = 4.75HH379 pKa = 6.97SNQTTIVDD387 pKa = 4.24DD388 pKa = 4.53LLSSSTFQNPVFDD401 pKa = 4.46SNAVFNEE408 pKa = 3.5DD409 pKa = 4.76LLLDD413 pKa = 4.65EE414 pKa = 4.87YY415 pKa = 11.86NEE417 pKa = 4.8DD418 pKa = 3.57FGNTNLVVATTDD430 pKa = 3.22EE431 pKa = 4.4AEE433 pKa = 4.26EE434 pKa = 4.33TFSFPILAPSPSVKK448 pKa = 10.3VFVTDD453 pKa = 3.1VGNIFVTSSKK463 pKa = 10.16DD464 pKa = 3.14AHH466 pKa = 5.57STITVLNTDD475 pKa = 5.08LVPLTPSIITSSYY488 pKa = 9.36NNFYY492 pKa = 10.92LEE494 pKa = 3.96PFYY497 pKa = 11.28VPRR500 pKa = 11.84KK501 pKa = 8.28KK502 pKa = 10.14RR503 pKa = 11.84RR504 pKa = 11.84RR505 pKa = 11.84LDD507 pKa = 3.23MFF509 pKa = 4.87

Molecular weight: 55.25 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A0N9E219|A0A0N9E219_9PAPI Protein E7 OS=Human papillomavirus 199 OX=1545700 GN=E7 PE=3 SV=1
MM1 pKa = 7.11EE2 pKa = 4.29TQEE5 pKa = 4.08TLTARR10 pKa = 11.84FTALQEE16 pKa = 3.99IQLTLIEE23 pKa = 4.74KK24 pKa = 10.53NSTDD28 pKa = 4.02LEE30 pKa = 4.18DD31 pKa = 6.21HH32 pKa = 5.53ITFWNAVRR40 pKa = 11.84KK41 pKa = 9.3EE42 pKa = 3.89NAIAYY47 pKa = 7.21YY48 pKa = 9.77SRR50 pKa = 11.84KK51 pKa = 9.16EE52 pKa = 3.91KK53 pKa = 10.17IYY55 pKa = 10.88KK56 pKa = 10.33LGLQPMPALAVSQYY70 pKa = 9.74KK71 pKa = 10.36AKK73 pKa = 10.09EE74 pKa = 3.97AIGIEE79 pKa = 4.05LLLRR83 pKa = 11.84SLKK86 pKa = 10.42NSQFGSEE93 pKa = 3.88RR94 pKa = 11.84WTLADD99 pKa = 4.21CSAEE103 pKa = 4.07LLHH106 pKa = 6.45TPPKK110 pKa = 10.81NCFKK114 pKa = 10.72KK115 pKa = 10.22NPYY118 pKa = 9.92SVTVLFDD125 pKa = 3.49NDD127 pKa = 3.15EE128 pKa = 4.26NKK130 pKa = 10.52AYY132 pKa = 9.49PYY134 pKa = 9.53TCWDD138 pKa = 3.63HH139 pKa = 8.03IYY141 pKa = 10.93YY142 pKa = 9.91QDD144 pKa = 5.29EE145 pKa = 3.98QNQWQKK151 pKa = 10.63VQGLVDD157 pKa = 4.07ANGMFYY163 pKa = 10.53KK164 pKa = 10.4EE165 pKa = 3.89KK166 pKa = 10.14TGDD169 pKa = 2.83IVYY172 pKa = 8.52FHH174 pKa = 6.65VFAPDD179 pKa = 3.03AEE181 pKa = 4.86TYY183 pKa = 11.2GDD185 pKa = 3.53TGEE188 pKa = 3.86WTVRR192 pKa = 11.84FKK194 pKa = 10.76NTTIFASIASSSRR207 pKa = 11.84SVSGPSEE214 pKa = 4.03QARR217 pKa = 11.84KK218 pKa = 7.7PTAHH222 pKa = 6.97SSPTPKK228 pKa = 9.89TPRR231 pKa = 11.84KK232 pKa = 8.7RR233 pKa = 11.84QRR235 pKa = 11.84EE236 pKa = 4.23TEE238 pKa = 3.99EE239 pKa = 4.11DD240 pKa = 4.1TEE242 pKa = 4.6SHH244 pKa = 6.41SPTSTSRR251 pKa = 11.84GFRR254 pKa = 11.84LRR256 pKa = 11.84RR257 pKa = 11.84GRR259 pKa = 11.84GEE261 pKa = 3.91QQGEE265 pKa = 4.58SATGPTPQRR274 pKa = 11.84RR275 pKa = 11.84RR276 pKa = 11.84RR277 pKa = 11.84TTAYY281 pKa = 9.2STVQSAPTAGEE292 pKa = 3.86VGRR295 pKa = 11.84DD296 pKa = 3.32TRR298 pKa = 11.84SVPRR302 pKa = 11.84HH303 pKa = 4.76GLDD306 pKa = 2.89RR307 pKa = 11.84LRR309 pKa = 11.84RR310 pKa = 11.84LQAEE314 pKa = 3.87ARR316 pKa = 11.84DD317 pKa = 3.89PFLVLLKK324 pKa = 10.78GPPNCLKK331 pKa = 10.21CWRR334 pKa = 11.84YY335 pKa = 9.62RR336 pKa = 11.84CKK338 pKa = 10.53QKK340 pKa = 11.15NNAMFLAVSSVFRR353 pKa = 11.84WIGDD357 pKa = 3.33EE358 pKa = 4.31SEE360 pKa = 4.03SHH362 pKa = 6.61ARR364 pKa = 11.84LLLAFSDD371 pKa = 3.23NRR373 pKa = 11.84QRR375 pKa = 11.84QTFLDD380 pKa = 3.54NVTFPKK386 pKa = 9.88GTTYY390 pKa = 11.32SLGNIDD396 pKa = 4.41SLL398 pKa = 4.54

Molecular weight: 45.45 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2248

97

598

374.7

42.4

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.361 ± 0.321

2.447 ± 0.877

6.272 ± 0.467

6.094 ± 0.542

5.605 ± 0.485

4.938 ± 0.859

1.824 ± 0.442

4.893 ± 0.424

5.472 ± 0.643

8.763 ± 0.709

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.69 ± 0.408

5.249 ± 0.593

5.694 ± 1.049

4.004 ± 0.313

5.516 ± 0.642

7.562 ± 0.421

6.673 ± 0.647

6.228 ± 0.724

1.201 ± 0.281

3.514 ± 0.262
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski