Amino acid dipepetide frequency for Muribacter muris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.448AlaAla: 7.448 ± 0.145
1.157AlaCys: 1.157 ± 0.044
5.138AlaAsp: 5.138 ± 0.108
6.719AlaGlu: 6.719 ± 0.122
3.938AlaPhe: 3.938 ± 0.081
5.967AlaGly: 5.967 ± 0.111
1.79AlaHis: 1.79 ± 0.043
6.408AlaIle: 6.408 ± 0.102
5.886AlaLys: 5.886 ± 0.103
10.574AlaLeu: 10.574 ± 0.155
2.424AlaMet: 2.424 ± 0.067
3.914AlaAsn: 3.914 ± 0.066
2.676AlaPro: 2.676 ± 0.068
4.796AlaGln: 4.796 ± 0.1
3.929AlaArg: 3.929 ± 0.097
4.069AlaSer: 4.069 ± 0.077
4.406AlaThr: 4.406 ± 0.081
6.573AlaVal: 6.573 ± 0.123
0.849AlaTrp: 0.849 ± 0.037
2.681AlaTyr: 2.681 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.837CysAla: 0.837 ± 0.037
0.175CysCys: 0.175 ± 0.014
0.549CysAsp: 0.549 ± 0.031
0.657CysGlu: 0.657 ± 0.034
0.478CysPhe: 0.478 ± 0.03
0.906CysGly: 0.906 ± 0.035
0.324CysHis: 0.324 ± 0.023
0.558CysIle: 0.558 ± 0.03
0.403CysLys: 0.403 ± 0.022
1.124CysLeu: 1.124 ± 0.04
0.153CysMet: 0.153 ± 0.015
0.339CysAsn: 0.339 ± 0.025
0.474CysPro: 0.474 ± 0.025
0.543CysGln: 0.543 ± 0.03
0.522CysArg: 0.522 ± 0.027
0.568CysSer: 0.568 ± 0.027
0.499CysThr: 0.499 ± 0.029
0.675CysVal: 0.675 ± 0.035
0.127CysTrp: 0.127 ± 0.015
0.381CysTyr: 0.381 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.594AspAla: 3.594 ± 0.071
0.522AspCys: 0.522 ± 0.028
2.511AspAsp: 2.511 ± 0.074
3.531AspGlu: 3.531 ± 0.082
2.576AspPhe: 2.576 ± 0.065
3.0AspGly: 3.0 ± 0.069
1.025AspHis: 1.025 ± 0.041
3.783AspIle: 3.783 ± 0.082
3.127AspLys: 3.127 ± 0.075
5.202AspLeu: 5.202 ± 0.082
1.061AspMet: 1.061 ± 0.041
2.388AspAsn: 2.388 ± 0.062
2.139AspPro: 2.139 ± 0.057
1.853AspGln: 1.853 ± 0.055
2.373AspArg: 2.373 ± 0.059
2.396AspSer: 2.396 ± 0.055
2.406AspThr: 2.406 ± 0.068
3.22AspVal: 3.22 ± 0.067
0.769AspTrp: 0.769 ± 0.032
2.279AspTyr: 2.279 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
5.166GluAla: 5.166 ± 0.11
0.444GluCys: 0.444 ± 0.027
2.253GluAsp: 2.253 ± 0.061
3.123GluGlu: 3.123 ± 0.084
2.168GluPhe: 2.168 ± 0.059
3.268GluGly: 3.268 ± 0.076
1.339GluHis: 1.339 ± 0.048
4.525GluIle: 4.525 ± 0.084
4.576GluLys: 4.576 ± 0.092
6.186GluLeu: 6.186 ± 0.116
1.832GluMet: 1.832 ± 0.048
3.258GluAsn: 3.258 ± 0.071
2.052GluPro: 2.052 ± 0.065
4.297GluGln: 4.297 ± 0.091
3.508GluArg: 3.508 ± 0.088
2.84GluSer: 2.84 ± 0.068
3.001GluThr: 3.001 ± 0.072
3.823GluVal: 3.823 ± 0.089
0.828GluTrp: 0.828 ± 0.039
1.618GluTyr: 1.618 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
4.079PheAla: 4.079 ± 0.08
0.624PheCys: 0.624 ± 0.032
2.789PheAsp: 2.789 ± 0.066
2.648PheGlu: 2.648 ± 0.065
1.934PhePhe: 1.934 ± 0.07
3.526PheGly: 3.526 ± 0.084
0.925PheHis: 0.925 ± 0.039
3.33PheIle: 3.33 ± 0.081
2.099PheLys: 2.099 ± 0.055
3.917PheLeu: 3.917 ± 0.091
0.919PheMet: 0.919 ± 0.037
2.19PheAsn: 2.19 ± 0.063
1.528PhePro: 1.528 ± 0.052
1.577PheGln: 1.577 ± 0.054
1.706PheArg: 1.706 ± 0.046
3.288PheSer: 3.288 ± 0.078
2.195PheThr: 2.195 ± 0.058
2.729PheVal: 2.729 ± 0.07
0.583PheTrp: 0.583 ± 0.027
1.564PheTyr: 1.564 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.078GlyAla: 5.078 ± 0.115
0.811GlyCys: 0.811 ± 0.036
3.126GlyAsp: 3.126 ± 0.065
4.481GlyGlu: 4.481 ± 0.094
3.19GlyPhe: 3.19 ± 0.071
4.85GlyGly: 4.85 ± 0.102
1.232GlyHis: 1.232 ± 0.045
5.31GlyIle: 5.31 ± 0.098
4.829GlyLys: 4.829 ± 0.077
7.178GlyLeu: 7.178 ± 0.108
1.805GlyMet: 1.805 ± 0.052
2.742GlyAsn: 2.742 ± 0.065
1.063GlyPro: 1.063 ± 0.045
2.706GlyGln: 2.706 ± 0.071
2.938GlyArg: 2.938 ± 0.072
3.606GlySer: 3.606 ± 0.073
3.412GlyThr: 3.412 ± 0.078
5.103GlyVal: 5.103 ± 0.094
0.909GlyTrp: 0.909 ± 0.037
2.591GlyTyr: 2.591 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.406HisAla: 1.406 ± 0.053
0.42HisCys: 0.42 ± 0.025
0.843HisAsp: 0.843 ± 0.037
0.802HisGlu: 0.802 ± 0.04
1.3HisPhe: 1.3 ± 0.046
1.34HisGly: 1.34 ± 0.046
0.751HisHis: 0.751 ± 0.041
1.873HisIle: 1.873 ± 0.054
1.099HisLys: 1.099 ± 0.044
2.553HisLeu: 2.553 ± 0.061
0.322HisMet: 0.322 ± 0.021
1.048HisAsn: 1.048 ± 0.044
1.058HisPro: 1.058 ± 0.036
1.447HisGln: 1.447 ± 0.046
1.184HisArg: 1.184 ± 0.041
1.481HisSer: 1.481 ± 0.044
1.211HisThr: 1.211 ± 0.036
0.673HisVal: 0.673 ± 0.032
0.372HisTrp: 0.372 ± 0.022
1.139HisTyr: 1.139 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
7.222IleAla: 7.222 ± 0.12
0.762IleCys: 0.762 ± 0.037
4.057IleAsp: 4.057 ± 0.075
4.582IleGlu: 4.582 ± 0.094
2.777IlePhe: 2.777 ± 0.071
5.384IleGly: 5.384 ± 0.105
1.432IleHis: 1.432 ± 0.045
4.478IleIle: 4.478 ± 0.107
3.574IleLys: 3.574 ± 0.069
6.456IleLeu: 6.456 ± 0.126
1.378IleMet: 1.378 ± 0.043
2.901IleAsn: 2.901 ± 0.071
2.601IlePro: 2.601 ± 0.072
2.759IleGln: 2.759 ± 0.076
3.055IleArg: 3.055 ± 0.069
4.499IleSer: 4.499 ± 0.091
3.756IleThr: 3.756 ± 0.081
4.405IleVal: 4.405 ± 0.104
0.676IleTrp: 0.676 ± 0.035
2.072IleTyr: 2.072 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.652LysAla: 5.652 ± 0.117
0.376LysCys: 0.376 ± 0.026
2.447LysAsp: 2.447 ± 0.065
3.234LysGlu: 3.234 ± 0.089
1.781LysPhe: 1.781 ± 0.058
3.818LysGly: 3.818 ± 0.092
1.261LysHis: 1.261 ± 0.045
3.838LysIle: 3.838 ± 0.075
3.324LysLys: 3.324 ± 0.08
5.708LysLeu: 5.708 ± 0.092
1.876LysMet: 1.876 ± 0.053
2.63LysAsn: 2.63 ± 0.068
2.486LysPro: 2.486 ± 0.067
3.361LysGln: 3.361 ± 0.083
3.102LysArg: 3.102 ± 0.072
3.057LysSer: 3.057 ± 0.079
3.324LysThr: 3.324 ± 0.076
3.805LysVal: 3.805 ± 0.078
0.69LysTrp: 0.69 ± 0.032
1.64LysTyr: 1.64 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
11.532LeuAla: 11.532 ± 0.154
1.12LeuCys: 1.12 ± 0.046
5.712LeuAsp: 5.712 ± 0.102
5.733LeuGlu: 5.733 ± 0.09
4.998LeuPhe: 4.998 ± 0.103
7.126LeuGly: 7.126 ± 0.131
2.181LeuHis: 2.181 ± 0.056
6.853LeuIle: 6.853 ± 0.139
5.953LeuLys: 5.953 ± 0.093
11.072LeuLeu: 11.072 ± 0.196
2.427LeuMet: 2.427 ± 0.065
5.261LeuAsn: 5.261 ± 0.083
5.018LeuPro: 5.018 ± 0.085
4.22LeuGln: 4.22 ± 0.091
4.658LeuArg: 4.658 ± 0.079
7.166LeuSer: 7.166 ± 0.113
6.262LeuThr: 6.262 ± 0.095
6.636LeuVal: 6.636 ± 0.111
1.159LeuTrp: 1.159 ± 0.052
2.694LeuTyr: 2.694 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.544MetAla: 2.544 ± 0.057
0.187MetCys: 0.187 ± 0.015
0.939MetAsp: 0.939 ± 0.03
1.015MetGlu: 1.015 ± 0.043
0.88MetPhe: 0.88 ± 0.032
1.573MetGly: 1.573 ± 0.049
0.433MetHis: 0.433 ± 0.026
1.568MetIle: 1.568 ± 0.051
1.522MetLys: 1.522 ± 0.051
2.684MetLeu: 2.684 ± 0.067
0.709MetMet: 0.709 ± 0.035
1.025MetAsn: 1.025 ± 0.037
1.135MetPro: 1.135 ± 0.045
1.336MetGln: 1.336 ± 0.045
1.067MetArg: 1.067 ± 0.038
1.439MetSer: 1.439 ± 0.044
1.4MetThr: 1.4 ± 0.045
1.414MetVal: 1.414 ± 0.04
0.25MetTrp: 0.25 ± 0.017
0.469MetTyr: 0.469 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
4.154AsnAla: 4.154 ± 0.075
0.376AsnCys: 0.376 ± 0.026
2.181AsnAsp: 2.181 ± 0.06
2.511AsnGlu: 2.511 ± 0.064
1.61AsnPhe: 1.61 ± 0.047
3.441AsnGly: 3.441 ± 0.074
0.991AsnHis: 0.991 ± 0.035
3.129AsnIle: 3.129 ± 0.075
2.198AsnLys: 2.198 ± 0.069
4.453AsnLeu: 4.453 ± 0.089
0.901AsnMet: 0.901 ± 0.041
1.784AsnAsn: 1.784 ± 0.064
2.444AsnPro: 2.444 ± 0.072
2.316AsnGln: 2.316 ± 0.058
2.232AsnArg: 2.232 ± 0.059
2.268AsnSer: 2.268 ± 0.062
2.073AsnThr: 2.073 ± 0.054
3.001AsnVal: 3.001 ± 0.077
0.579AsnTrp: 0.579 ± 0.03
1.496AsnTyr: 1.496 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
3.291ProAla: 3.291 ± 0.082
0.289ProCys: 0.289 ± 0.024
2.184ProAsp: 2.184 ± 0.059
2.777ProGlu: 2.777 ± 0.068
2.012ProPhe: 2.012 ± 0.058
1.315ProGly: 1.315 ± 0.049
1.061ProHis: 1.061 ± 0.045
2.835ProIle: 2.835 ± 0.067
2.298ProLys: 2.298 ± 0.06
4.357ProLeu: 4.357 ± 0.091
1.015ProMet: 1.015 ± 0.035
2.193ProAsn: 2.193 ± 0.062
1.385ProPro: 1.385 ± 0.047
2.124ProGln: 2.124 ± 0.062
1.397ProArg: 1.397 ± 0.051
2.19ProSer: 2.19 ± 0.062
2.411ProThr: 2.411 ± 0.064
2.433ProVal: 2.433 ± 0.064
0.387ProTrp: 0.387 ± 0.021
1.42ProTyr: 1.42 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
5.399GlnAla: 5.399 ± 0.106
0.435GlnCys: 0.435 ± 0.025
2.099GlnAsp: 2.099 ± 0.061
2.274GlnGlu: 2.274 ± 0.069
2.3GlnPhe: 2.3 ± 0.063
3.315GlnGly: 3.315 ± 0.073
1.381GlnHis: 1.381 ± 0.045
3.321GlnIle: 3.321 ± 0.058
2.925GlnLys: 2.925 ± 0.071
5.454GlnLeu: 5.454 ± 0.089
1.105GlnMet: 1.105 ± 0.04
2.265GlnAsn: 2.265 ± 0.056
2.175GlnPro: 2.175 ± 0.066
3.685GlnGln: 3.685 ± 0.116
2.733GlnArg: 2.733 ± 0.069
2.642GlnSer: 2.642 ± 0.066
2.783GlnThr: 2.783 ± 0.075
2.795GlnVal: 2.795 ± 0.068
0.732GlnTrp: 0.732 ± 0.037
1.558GlnTyr: 1.558 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.4ArgAla: 3.4 ± 0.075
0.493ArgCys: 0.493 ± 0.026
2.252ArgAsp: 2.252 ± 0.061
3.067ArgGlu: 3.067 ± 0.087
2.597ArgPhe: 2.597 ± 0.059
2.495ArgGly: 2.495 ± 0.066
1.262ArgHis: 1.262 ± 0.048
3.247ArgIle: 3.247 ± 0.067
2.583ArgLys: 2.583 ± 0.062
5.758ArgLeu: 5.758 ± 0.107
0.991ArgMet: 0.991 ± 0.032
1.92ArgAsn: 1.92 ± 0.055
1.709ArgPro: 1.709 ± 0.053
2.997ArgGln: 2.997 ± 0.078
2.376ArgArg: 2.376 ± 0.073
2.33ArgSer: 2.33 ± 0.06
2.067ArgThr: 2.067 ± 0.056
2.869ArgVal: 2.869 ± 0.076
0.574ArgTrp: 0.574 ± 0.029
2.033ArgTyr: 2.033 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.139SerAla: 5.139 ± 0.076
0.499SerCys: 0.499 ± 0.029
2.793SerAsp: 2.793 ± 0.066
3.372SerGlu: 3.372 ± 0.065
2.342SerPhe: 2.342 ± 0.066
4.487SerGly: 4.487 ± 0.099
1.349SerHis: 1.349 ± 0.039
3.181SerIle: 3.181 ± 0.067
2.615SerLys: 2.615 ± 0.063
6.276SerLeu: 6.276 ± 0.114
1.151SerMet: 1.151 ± 0.038
2.18SerAsn: 2.18 ± 0.064
2.588SerPro: 2.588 ± 0.06
2.871SerGln: 2.871 ± 0.075
2.718SerArg: 2.718 ± 0.069
3.061SerSer: 3.061 ± 0.085
2.562SerThr: 2.562 ± 0.074
3.857SerVal: 3.857 ± 0.082
0.679SerTrp: 0.679 ± 0.027
1.877SerTyr: 1.877 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
5.309ThrAla: 5.309 ± 0.097
0.387ThrCys: 0.387 ± 0.026
2.574ThrAsp: 2.574 ± 0.062
3.108ThrGlu: 3.108 ± 0.075
2.348ThrPhe: 2.348 ± 0.051
3.649ThrGly: 3.649 ± 0.082
1.204ThrHis: 1.204 ± 0.045
3.214ThrIle: 3.214 ± 0.074
2.481ThrLys: 2.481 ± 0.06
6.538ThrLeu: 6.538 ± 0.14
1.108ThrMet: 1.108 ± 0.039
1.787ThrAsn: 1.787 ± 0.055
2.633ThrPro: 2.633 ± 0.06
2.586ThrGln: 2.586 ± 0.068
2.022ThrArg: 2.022 ± 0.064
2.373ThrSer: 2.373 ± 0.068
2.645ThrThr: 2.645 ± 0.067
3.489ThrVal: 3.489 ± 0.088
0.447ThrTrp: 0.447 ± 0.027
1.367ThrTyr: 1.367 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
6.339ValAla: 6.339 ± 0.114
0.708ValCys: 0.708 ± 0.032
3.252ValAsp: 3.252 ± 0.079
4.466ValGlu: 4.466 ± 0.086
2.64ValPhe: 2.64 ± 0.077
4.462ValGly: 4.462 ± 0.091
1.105ValHis: 1.105 ± 0.046
4.827ValIle: 4.827 ± 0.102
3.949ValLys: 3.949 ± 0.093
6.71ValLeu: 6.71 ± 0.115
1.7ValMet: 1.7 ± 0.054
2.751ValAsn: 2.751 ± 0.069
2.544ValPro: 2.544 ± 0.066
2.49ValGln: 2.49 ± 0.063
2.846ValArg: 2.846 ± 0.071
4.084ValSer: 4.084 ± 0.083
2.874ValThr: 2.874 ± 0.07
4.568ValVal: 4.568 ± 0.1
0.681ValTrp: 0.681 ± 0.034
1.714ValTyr: 1.714 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.995TrpAla: 0.995 ± 0.039
0.118TrpCys: 0.118 ± 0.012
0.537TrpAsp: 0.537 ± 0.032
0.531TrpGlu: 0.531 ± 0.03
0.576TrpPhe: 0.576 ± 0.031
0.789TrpGly: 0.789 ± 0.034
0.346TrpHis: 0.346 ± 0.021
0.718TrpIle: 0.718 ± 0.033
0.58TrpLys: 0.58 ± 0.032
1.853TrpLeu: 1.853 ± 0.056
0.178TrpMet: 0.178 ± 0.017
0.375TrpAsn: 0.375 ± 0.022
0.138TrpPro: 0.138 ± 0.014
1.219TrpGln: 1.219 ± 0.05
0.682TrpArg: 0.682 ± 0.033
0.559TrpSer: 0.559 ± 0.026
0.463TrpThr: 0.463 ± 0.029
0.793TrpVal: 0.793 ± 0.032
0.186TrpTrp: 0.186 ± 0.016
0.3TrpTyr: 0.3 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.759TyrAla: 2.759 ± 0.065
0.387TyrCys: 0.387 ± 0.024
1.522TyrAsp: 1.522 ± 0.055
1.474TyrGlu: 1.474 ± 0.05
1.705TyrPhe: 1.705 ± 0.051
2.252TyrGly: 2.252 ± 0.062
0.93TyrHis: 0.93 ± 0.038
1.828TyrIle: 1.828 ± 0.057
1.387TyrLys: 1.387 ± 0.052
3.729TyrLeu: 3.729 ± 0.072
0.532TyrMet: 0.532 ± 0.03
1.187TyrAsn: 1.187 ± 0.047
1.529TyrPro: 1.529 ± 0.049
2.192TyrGln: 2.192 ± 0.057
1.971TyrArg: 1.971 ± 0.051
1.682TyrSer: 1.682 ± 0.047
1.517TyrThr: 1.517 ± 0.052
1.849TyrVal: 1.849 ± 0.054
0.462TyrTrp: 0.462 ± 0.029
1.157TyrTyr: 1.157 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2190 proteins (667018 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski