Amino acid dipepetide frequency for Klebsiella phage ST11-OXA245phi3.2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.897AlaAla: 12.897 ± 1.324
0.893AlaCys: 0.893 ± 0.213
6.7AlaAsp: 6.7 ± 0.608
6.03AlaGlu: 6.03 ± 0.692
2.903AlaPhe: 2.903 ± 0.465
8.096AlaGly: 8.096 ± 0.858
1.619AlaHis: 1.619 ± 0.349
4.746AlaIle: 4.746 ± 0.487
4.299AlaLys: 4.299 ± 0.488
9.212AlaLeu: 9.212 ± 1.033
3.741AlaMet: 3.741 ± 0.369
4.355AlaAsn: 4.355 ± 0.533
4.634AlaPro: 4.634 ± 0.936
5.695AlaGln: 5.695 ± 0.692
6.086AlaArg: 6.086 ± 0.621
5.583AlaSer: 5.583 ± 0.621
5.639AlaThr: 5.639 ± 0.537
5.751AlaVal: 5.751 ± 0.625
1.452AlaTrp: 1.452 ± 0.298
3.294AlaTyr: 3.294 ± 0.553
0.0AlaXaa: 0.0 ± 0.0
Cys
1.061CysAla: 1.061 ± 0.228
0.223CysCys: 0.223 ± 0.096
0.614CysAsp: 0.614 ± 0.179
0.558CysGlu: 0.558 ± 0.219
0.447CysPhe: 0.447 ± 0.144
1.061CysGly: 1.061 ± 0.262
0.335CysHis: 0.335 ± 0.165
0.447CysIle: 0.447 ± 0.153
0.447CysLys: 0.447 ± 0.174
1.061CysLeu: 1.061 ± 0.265
0.167CysMet: 0.167 ± 0.089
0.335CysAsn: 0.335 ± 0.137
0.614CysPro: 0.614 ± 0.173
0.614CysGln: 0.614 ± 0.199
0.614CysArg: 0.614 ± 0.222
0.67CysSer: 0.67 ± 0.227
0.447CysThr: 0.447 ± 0.126
0.726CysVal: 0.726 ± 0.162
0.279CysTrp: 0.279 ± 0.109
0.167CysTyr: 0.167 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
6.476AspAla: 6.476 ± 0.627
0.837AspCys: 0.837 ± 0.255
4.243AspAsp: 4.243 ± 0.666
3.741AspGlu: 3.741 ± 0.468
2.122AspPhe: 2.122 ± 0.368
5.527AspGly: 5.527 ± 0.784
1.061AspHis: 1.061 ± 0.209
3.406AspIle: 3.406 ± 0.347
2.792AspLys: 2.792 ± 0.347
5.025AspLeu: 5.025 ± 0.539
1.563AspMet: 1.563 ± 0.35
1.898AspAsn: 1.898 ± 0.348
2.68AspPro: 2.68 ± 0.417
2.624AspGln: 2.624 ± 0.516
3.238AspArg: 3.238 ± 0.546
3.127AspSer: 3.127 ± 0.378
3.573AspThr: 3.573 ± 0.438
4.802AspVal: 4.802 ± 0.574
1.005AspTrp: 1.005 ± 0.284
1.842AspTyr: 1.842 ± 0.367
0.0AspXaa: 0.0 ± 0.0
Glu
5.974GluAla: 5.974 ± 0.666
0.614GluCys: 0.614 ± 0.185
3.517GluAsp: 3.517 ± 0.5
3.573GluGlu: 3.573 ± 0.62
2.345GluPhe: 2.345 ± 0.298
4.243GluGly: 4.243 ± 0.495
0.67GluHis: 0.67 ± 0.229
3.462GluIle: 3.462 ± 0.49
3.517GluLys: 3.517 ± 0.494
5.751GluLeu: 5.751 ± 0.698
1.898GluMet: 1.898 ± 0.36
2.122GluAsn: 2.122 ± 0.384
1.731GluPro: 1.731 ± 0.345
4.187GluGln: 4.187 ± 0.525
4.467GluArg: 4.467 ± 0.532
3.462GluSer: 3.462 ± 0.571
2.847GluThr: 2.847 ± 0.424
3.797GluVal: 3.797 ± 0.482
1.005GluTrp: 1.005 ± 0.249
1.787GluTyr: 1.787 ± 0.258
0.0GluXaa: 0.0 ± 0.0
Phe
3.406PheAla: 3.406 ± 0.444
0.502PheCys: 0.502 ± 0.171
2.512PheAsp: 2.512 ± 0.41
1.954PheGlu: 1.954 ± 0.347
1.172PhePhe: 1.172 ± 0.296
2.457PheGly: 2.457 ± 0.488
0.502PheHis: 0.502 ± 0.14
2.345PheIle: 2.345 ± 0.38
1.563PheLys: 1.563 ± 0.279
1.731PheLeu: 1.731 ± 0.33
0.558PheMet: 0.558 ± 0.16
1.619PheAsn: 1.619 ± 0.224
1.284PhePro: 1.284 ± 0.297
1.005PheGln: 1.005 ± 0.271
2.01PheArg: 2.01 ± 0.355
2.233PheSer: 2.233 ± 0.341
2.066PheThr: 2.066 ± 0.333
1.675PheVal: 1.675 ± 0.326
0.335PheTrp: 0.335 ± 0.125
1.061PheTyr: 1.061 ± 0.277
0.0PheXaa: 0.0 ± 0.0
Gly
5.751GlyAla: 5.751 ± 0.704
0.837GlyCys: 0.837 ± 0.224
4.522GlyAsp: 4.522 ± 0.43
5.36GlyGlu: 5.36 ± 0.623
3.182GlyPhe: 3.182 ± 0.423
5.862GlyGly: 5.862 ± 0.587
1.675GlyHis: 1.675 ± 0.278
4.522GlyIle: 4.522 ± 0.52
4.076GlyLys: 4.076 ± 0.494
6.365GlyLeu: 6.365 ± 0.55
2.122GlyMet: 2.122 ± 0.396
4.02GlyAsn: 4.02 ± 0.497
1.675GlyPro: 1.675 ± 0.317
4.02GlyGln: 4.02 ± 0.652
4.578GlyArg: 4.578 ± 0.564
4.187GlySer: 4.187 ± 0.54
4.578GlyThr: 4.578 ± 0.535
5.36GlyVal: 5.36 ± 0.575
1.563GlyTrp: 1.563 ± 0.275
2.345GlyTyr: 2.345 ± 0.31
0.0GlyXaa: 0.0 ± 0.0
His
1.228HisAla: 1.228 ± 0.299
0.279HisCys: 0.279 ± 0.126
1.34HisAsp: 1.34 ± 0.267
1.172HisGlu: 1.172 ± 0.262
0.614HisPhe: 0.614 ± 0.173
1.842HisGly: 1.842 ± 0.346
0.391HisHis: 0.391 ± 0.141
0.67HisIle: 0.67 ± 0.186
0.558HisLys: 0.558 ± 0.183
1.731HisLeu: 1.731 ± 0.313
0.391HisMet: 0.391 ± 0.155
0.837HisAsn: 0.837 ± 0.21
1.005HisPro: 1.005 ± 0.284
0.782HisGln: 0.782 ± 0.288
1.172HisArg: 1.172 ± 0.259
0.558HisSer: 0.558 ± 0.173
0.726HisThr: 0.726 ± 0.192
1.34HisVal: 1.34 ± 0.268
0.447HisTrp: 0.447 ± 0.151
0.558HisTyr: 0.558 ± 0.173
0.0HisXaa: 0.0 ± 0.0
Ile
4.69IleAla: 4.69 ± 0.587
0.502IleCys: 0.502 ± 0.186
3.797IleAsp: 3.797 ± 0.553
2.959IleGlu: 2.959 ± 0.386
1.228IlePhe: 1.228 ± 0.254
5.025IleGly: 5.025 ± 0.635
0.949IleHis: 0.949 ± 0.198
2.903IleIle: 2.903 ± 0.322
2.289IleLys: 2.289 ± 0.314
2.512IleLeu: 2.512 ± 0.421
1.507IleMet: 1.507 ± 0.246
2.959IleAsn: 2.959 ± 0.425
2.736IlePro: 2.736 ± 0.352
1.563IleGln: 1.563 ± 0.252
3.517IleArg: 3.517 ± 0.415
3.741IleSer: 3.741 ± 0.404
3.294IleThr: 3.294 ± 0.493
3.573IleVal: 3.573 ± 0.511
0.67IleTrp: 0.67 ± 0.184
1.507IleTyr: 1.507 ± 0.216
0.0IleXaa: 0.0 ± 0.0
Lys
5.471LysAla: 5.471 ± 0.703
0.391LysCys: 0.391 ± 0.15
2.177LysAsp: 2.177 ± 0.3
2.512LysGlu: 2.512 ± 0.435
1.172LysPhe: 1.172 ± 0.224
2.959LysGly: 2.959 ± 0.42
0.837LysHis: 0.837 ± 0.192
2.066LysIle: 2.066 ± 0.337
1.731LysLys: 1.731 ± 0.272
3.741LysLeu: 3.741 ± 0.426
1.061LysMet: 1.061 ± 0.243
1.507LysAsn: 1.507 ± 0.272
2.68LysPro: 2.68 ± 0.351
2.066LysGln: 2.066 ± 0.319
3.462LysArg: 3.462 ± 0.478
2.847LysSer: 2.847 ± 0.482
3.127LysThr: 3.127 ± 0.475
3.238LysVal: 3.238 ± 0.443
1.172LysTrp: 1.172 ± 0.21
1.563LysTyr: 1.563 ± 0.257
0.0LysXaa: 0.0 ± 0.0
Leu
8.431LeuAla: 8.431 ± 0.784
1.061LeuCys: 1.061 ± 0.265
4.969LeuAsp: 4.969 ± 0.593
5.081LeuGlu: 5.081 ± 0.57
2.345LeuPhe: 2.345 ± 0.363
5.192LeuGly: 5.192 ± 0.65
1.842LeuHis: 1.842 ± 0.302
3.964LeuIle: 3.964 ± 0.428
4.299LeuLys: 4.299 ± 0.501
7.537LeuLeu: 7.537 ± 0.805
1.563LeuMet: 1.563 ± 0.241
4.522LeuAsn: 4.522 ± 0.595
4.076LeuPro: 4.076 ± 0.478
3.852LeuGln: 3.852 ± 0.519
5.862LeuArg: 5.862 ± 0.706
5.806LeuSer: 5.806 ± 0.594
4.969LeuThr: 4.969 ± 0.503
4.913LeuVal: 4.913 ± 0.548
0.893LeuTrp: 0.893 ± 0.201
1.954LeuTyr: 1.954 ± 0.27
0.0LeuXaa: 0.0 ± 0.0
Met
3.406MetAla: 3.406 ± 0.545
0.279MetCys: 0.279 ± 0.141
1.228MetAsp: 1.228 ± 0.253
1.452MetGlu: 1.452 ± 0.327
1.005MetPhe: 1.005 ± 0.231
1.731MetGly: 1.731 ± 0.324
0.391MetHis: 0.391 ± 0.155
1.061MetIle: 1.061 ± 0.269
1.34MetLys: 1.34 ± 0.251
2.289MetLeu: 2.289 ± 0.34
0.837MetMet: 0.837 ± 0.285
1.787MetAsn: 1.787 ± 0.351
1.117MetPro: 1.117 ± 0.272
1.117MetGln: 1.117 ± 0.255
1.563MetArg: 1.563 ± 0.271
1.842MetSer: 1.842 ± 0.276
1.954MetThr: 1.954 ± 0.346
1.563MetVal: 1.563 ± 0.343
0.223MetTrp: 0.223 ± 0.106
0.782MetTyr: 0.782 ± 0.205
0.0MetXaa: 0.0 ± 0.0
Asn
4.578AsnAla: 4.578 ± 0.515
0.502AsnCys: 0.502 ± 0.149
2.568AsnAsp: 2.568 ± 0.399
2.345AsnGlu: 2.345 ± 0.355
1.005AsnPhe: 1.005 ± 0.224
3.908AsnGly: 3.908 ± 0.623
0.949AsnHis: 0.949 ± 0.277
2.568AsnIle: 2.568 ± 0.377
2.01AsnLys: 2.01 ± 0.294
3.127AsnLeu: 3.127 ± 0.585
0.726AsnMet: 0.726 ± 0.201
1.731AsnAsn: 1.731 ± 0.496
3.182AsnPro: 3.182 ± 0.537
2.289AsnGln: 2.289 ± 0.373
2.457AsnArg: 2.457 ± 0.321
2.457AsnSer: 2.457 ± 0.295
2.624AsnThr: 2.624 ± 0.389
2.233AsnVal: 2.233 ± 0.418
0.335AsnTrp: 0.335 ± 0.172
1.172AsnTyr: 1.172 ± 0.212
0.0AsnXaa: 0.0 ± 0.0
Pro
5.304ProAla: 5.304 ± 0.773
0.167ProCys: 0.167 ± 0.09
3.127ProAsp: 3.127 ± 0.524
3.964ProGlu: 3.964 ± 0.599
1.619ProPhe: 1.619 ± 0.291
3.573ProGly: 3.573 ± 0.37
0.726ProHis: 0.726 ± 0.294
2.066ProIle: 2.066 ± 0.395
1.061ProLys: 1.061 ± 0.31
3.182ProLeu: 3.182 ± 0.391
1.228ProMet: 1.228 ± 0.233
1.284ProAsn: 1.284 ± 0.343
2.233ProPro: 2.233 ± 0.431
2.457ProGln: 2.457 ± 0.366
1.396ProArg: 1.396 ± 0.29
2.512ProSer: 2.512 ± 0.48
3.294ProThr: 3.294 ± 0.45
3.908ProVal: 3.908 ± 0.504
0.837ProTrp: 0.837 ± 0.251
1.061ProTyr: 1.061 ± 0.244
0.0ProXaa: 0.0 ± 0.0
Gln
5.583GlnAla: 5.583 ± 0.809
0.614GlnCys: 0.614 ± 0.198
2.066GlnAsp: 2.066 ± 0.394
2.68GlnGlu: 2.68 ± 0.413
1.452GlnPhe: 1.452 ± 0.334
2.903GlnGly: 2.903 ± 0.459
0.837GlnHis: 0.837 ± 0.224
2.457GlnIle: 2.457 ± 0.386
2.01GlnLys: 2.01 ± 0.38
5.192GlnLeu: 5.192 ± 0.809
1.507GlnMet: 1.507 ± 0.283
1.675GlnAsn: 1.675 ± 0.337
2.289GlnPro: 2.289 ± 0.35
4.857GlnGln: 4.857 ± 0.745
3.908GlnArg: 3.908 ± 0.585
2.512GlnSer: 2.512 ± 0.401
2.624GlnThr: 2.624 ± 0.485
2.68GlnVal: 2.68 ± 0.452
0.782GlnTrp: 0.782 ± 0.198
1.731GlnTyr: 1.731 ± 0.341
0.0GlnXaa: 0.0 ± 0.0
Arg
5.471ArgAla: 5.471 ± 0.63
0.893ArgCys: 0.893 ± 0.245
4.02ArgAsp: 4.02 ± 0.481
4.187ArgGlu: 4.187 ± 0.603
2.289ArgPhe: 2.289 ± 0.391
3.908ArgGly: 3.908 ± 0.404
1.117ArgHis: 1.117 ± 0.211
4.132ArgIle: 4.132 ± 0.604
3.629ArgLys: 3.629 ± 0.451
5.416ArgLeu: 5.416 ± 0.743
1.842ArgMet: 1.842 ± 0.29
2.847ArgAsn: 2.847 ± 0.416
1.954ArgPro: 1.954 ± 0.305
3.797ArgGln: 3.797 ± 0.642
4.02ArgArg: 4.02 ± 0.434
2.512ArgSer: 2.512 ± 0.31
2.568ArgThr: 2.568 ± 0.339
4.522ArgVal: 4.522 ± 0.503
0.837ArgTrp: 0.837 ± 0.22
2.289ArgTyr: 2.289 ± 0.408
0.0ArgXaa: 0.0 ± 0.0
Ser
6.644SerAla: 6.644 ± 0.568
0.614SerCys: 0.614 ± 0.181
3.797SerAsp: 3.797 ± 0.472
3.517SerGlu: 3.517 ± 0.531
1.842SerPhe: 1.842 ± 0.426
5.137SerGly: 5.137 ± 0.501
1.172SerHis: 1.172 ± 0.242
2.457SerIle: 2.457 ± 0.361
2.624SerLys: 2.624 ± 0.328
4.746SerLeu: 4.746 ± 0.61
1.396SerMet: 1.396 ± 0.274
2.289SerAsn: 2.289 ± 0.413
2.792SerPro: 2.792 ± 0.355
2.512SerGln: 2.512 ± 0.369
3.852SerArg: 3.852 ± 0.414
3.406SerSer: 3.406 ± 0.452
3.35SerThr: 3.35 ± 0.397
4.02SerVal: 4.02 ± 0.504
0.782SerTrp: 0.782 ± 0.232
1.619SerTyr: 1.619 ± 0.379
0.0SerXaa: 0.0 ± 0.0
Thr
6.7ThrAla: 6.7 ± 0.619
0.502ThrCys: 0.502 ± 0.189
3.852ThrAsp: 3.852 ± 0.515
2.847ThrGlu: 2.847 ± 0.417
1.731ThrPhe: 1.731 ± 0.35
5.527ThrGly: 5.527 ± 0.614
0.726ThrHis: 0.726 ± 0.219
3.406ThrIle: 3.406 ± 0.371
1.898ThrLys: 1.898 ± 0.361
5.806ThrLeu: 5.806 ± 0.491
1.005ThrMet: 1.005 ± 0.195
1.954ThrAsn: 1.954 ± 0.288
3.182ThrPro: 3.182 ± 0.342
2.568ThrGln: 2.568 ± 0.514
2.736ThrArg: 2.736 ± 0.424
3.629ThrSer: 3.629 ± 0.643
3.406ThrThr: 3.406 ± 0.686
4.913ThrVal: 4.913 ± 0.538
0.782ThrTrp: 0.782 ± 0.265
1.228ThrTyr: 1.228 ± 0.378
0.0ThrXaa: 0.0 ± 0.0
Val
6.086ValAla: 6.086 ± 0.58
0.614ValCys: 0.614 ± 0.173
3.852ValAsp: 3.852 ± 0.47
4.802ValGlu: 4.802 ± 0.486
1.898ValPhe: 1.898 ± 0.395
4.187ValGly: 4.187 ± 0.484
0.949ValHis: 0.949 ± 0.245
3.406ValIle: 3.406 ± 0.414
3.741ValLys: 3.741 ± 0.44
5.192ValLeu: 5.192 ± 0.498
2.289ValMet: 2.289 ± 0.37
3.462ValAsn: 3.462 ± 0.478
2.959ValPro: 2.959 ± 0.381
2.233ValGln: 2.233 ± 0.339
4.467ValArg: 4.467 ± 0.498
4.243ValSer: 4.243 ± 0.463
4.522ValThr: 4.522 ± 0.456
5.695ValVal: 5.695 ± 0.748
0.949ValTrp: 0.949 ± 0.224
1.842ValTyr: 1.842 ± 0.307
0.0ValXaa: 0.0 ± 0.0
Trp
1.731TrpAla: 1.731 ± 0.335
0.112TrpCys: 0.112 ± 0.073
0.67TrpAsp: 0.67 ± 0.207
0.614TrpGlu: 0.614 ± 0.175
0.502TrpPhe: 0.502 ± 0.151
1.117TrpGly: 1.117 ± 0.274
0.335TrpHis: 0.335 ± 0.119
0.67TrpIle: 0.67 ± 0.192
0.558TrpLys: 0.558 ± 0.157
1.675TrpLeu: 1.675 ± 0.396
0.502TrpMet: 0.502 ± 0.143
0.447TrpAsn: 0.447 ± 0.152
0.447TrpPro: 0.447 ± 0.202
0.726TrpGln: 0.726 ± 0.179
0.949TrpArg: 0.949 ± 0.241
1.284TrpSer: 1.284 ± 0.301
0.837TrpThr: 0.837 ± 0.22
0.893TrpVal: 0.893 ± 0.198
0.391TrpTrp: 0.391 ± 0.165
0.558TrpTyr: 0.558 ± 0.181
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.736TyrAla: 2.736 ± 0.387
0.447TyrCys: 0.447 ± 0.174
2.01TyrAsp: 2.01 ± 0.418
1.619TyrGlu: 1.619 ± 0.307
1.117TyrPhe: 1.117 ± 0.331
2.345TyrGly: 2.345 ± 0.258
0.558TyrHis: 0.558 ± 0.237
1.172TyrIle: 1.172 ± 0.231
1.34TyrLys: 1.34 ± 0.257
1.842TyrLeu: 1.842 ± 0.331
1.005TyrMet: 1.005 ± 0.229
1.117TyrAsn: 1.117 ± 0.23
1.731TyrPro: 1.731 ± 0.368
1.396TyrGln: 1.396 ± 0.316
1.954TyrArg: 1.954 ± 0.323
1.954TyrSer: 1.954 ± 0.401
1.954TyrThr: 1.954 ± 0.427
1.787TyrVal: 1.787 ± 0.34
0.279TyrTrp: 0.279 ± 0.119
0.782TyrTyr: 0.782 ± 0.233
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (17912 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski