Amino acid dipepetide frequency for Rickettsiales endosymbiont of Peranema trichophorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.74AlaAla: 4.74 ± 0.132
0.835AlaCys: 0.835 ± 0.052
3.099AlaAsp: 3.099 ± 0.099
3.688AlaGlu: 3.688 ± 0.105
2.86AlaPhe: 2.86 ± 0.093
4.174AlaGly: 4.174 ± 0.124
1.519AlaHis: 1.519 ± 0.064
5.813AlaIle: 5.813 ± 0.146
4.376AlaLys: 4.376 ± 0.101
7.81AlaLeu: 7.81 ± 0.166
1.826AlaMet: 1.826 ± 0.073
2.502AlaAsn: 2.502 ± 0.085
2.072AlaPro: 2.072 ± 0.088
2.438AlaGln: 2.438 ± 0.092
3.173AlaArg: 3.173 ± 0.084
4.714AlaSer: 4.714 ± 0.119
3.736AlaThr: 3.736 ± 0.103
4.755AlaVal: 4.755 ± 0.13
0.451AlaTrp: 0.451 ± 0.031
2.266AlaTyr: 2.266 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.748CysAla: 0.748 ± 0.044
0.269CysCys: 0.269 ± 0.027
0.771CysAsp: 0.771 ± 0.053
0.625CysGlu: 0.625 ± 0.037
0.548CysPhe: 0.548 ± 0.04
1.091CysGly: 1.091 ± 0.057
0.32CysHis: 0.32 ± 0.03
1.06CysIle: 1.06 ± 0.057
0.781CysLys: 0.781 ± 0.05
1.27CysLeu: 1.27 ± 0.064
0.315CysMet: 0.315 ± 0.03
0.528CysAsn: 0.528 ± 0.033
0.412CysPro: 0.412 ± 0.034
0.417CysGln: 0.417 ± 0.038
0.551CysArg: 0.551 ± 0.036
0.937CysSer: 0.937 ± 0.056
0.796CysThr: 0.796 ± 0.043
0.837CysVal: 0.837 ± 0.047
0.1CysTrp: 0.1 ± 0.018
0.479CysTyr: 0.479 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
3.649AspAla: 3.649 ± 0.135
0.568AspCys: 0.568 ± 0.032
3.122AspAsp: 3.122 ± 0.117
3.431AspGlu: 3.431 ± 0.12
2.238AspPhe: 2.238 ± 0.085
3.826AspGly: 3.826 ± 0.128
1.111AspHis: 1.111 ± 0.051
5.065AspIle: 5.065 ± 0.118
3.339AspLys: 3.339 ± 0.101
4.609AspLeu: 4.609 ± 0.109
1.255AspMet: 1.255 ± 0.062
2.351AspAsn: 2.351 ± 0.085
1.588AspPro: 1.588 ± 0.079
1.777AspGln: 1.777 ± 0.078
2.261AspArg: 2.261 ± 0.077
3.106AspSer: 3.106 ± 0.084
3.035AspThr: 3.035 ± 0.1
4.883AspVal: 4.883 ± 0.122
0.43AspTrp: 0.43 ± 0.03
1.836AspTyr: 1.836 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
4.702GluAla: 4.702 ± 0.124
0.689GluCys: 0.689 ± 0.043
3.175GluAsp: 3.175 ± 0.108
5.142GluGlu: 5.142 ± 0.173
2.333GluPhe: 2.333 ± 0.097
4.054GluGly: 4.054 ± 0.135
1.759GluHis: 1.759 ± 0.081
4.684GluIle: 4.684 ± 0.11
4.379GluLys: 4.379 ± 0.13
6.912GluLeu: 6.912 ± 0.185
1.736GluMet: 1.736 ± 0.065
2.476GluAsn: 2.476 ± 0.086
1.685GluPro: 1.685 ± 0.072
2.883GluGln: 2.883 ± 0.138
3.593GluArg: 3.593 ± 0.127
3.954GluSer: 3.954 ± 0.111
2.512GluThr: 2.512 ± 0.091
5.024GluVal: 5.024 ± 0.188
0.848GluTrp: 0.848 ± 0.087
2.451GluTyr: 2.451 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
2.533PheAla: 2.533 ± 0.093
0.761PheCys: 0.761 ± 0.043
2.358PheAsp: 2.358 ± 0.086
2.538PheGlu: 2.538 ± 0.083
1.636PhePhe: 1.636 ± 0.069
3.109PheGly: 3.109 ± 0.104
0.825PheHis: 0.825 ± 0.042
3.122PheIle: 3.122 ± 0.122
2.504PheLys: 2.504 ± 0.088
3.554PheLeu: 3.554 ± 0.125
1.014PheMet: 1.014 ± 0.056
1.964PheAsn: 1.964 ± 0.114
1.147PhePro: 1.147 ± 0.058
1.314PheGln: 1.314 ± 0.057
1.593PheArg: 1.593 ± 0.068
2.53PheSer: 2.53 ± 0.073
2.023PheThr: 2.023 ± 0.082
2.919PheVal: 2.919 ± 0.103
0.469PheTrp: 0.469 ± 0.039
1.286PheTyr: 1.286 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
4.72GlyAla: 4.72 ± 0.132
0.917GlyCys: 0.917 ± 0.049
3.585GlyAsp: 3.585 ± 0.141
4.003GlyGlu: 4.003 ± 0.125
2.551GlyPhe: 2.551 ± 0.093
4.819GlyGly: 4.819 ± 0.167
1.501GlyHis: 1.501 ± 0.062
5.828GlyIle: 5.828 ± 0.119
4.72GlyLys: 4.72 ± 0.116
6.451GlyLeu: 6.451 ± 0.169
2.172GlyMet: 2.172 ± 0.083
2.717GlyAsn: 2.717 ± 0.105
1.429GlyPro: 1.429 ± 0.063
2.451GlyGln: 2.451 ± 0.088
3.055GlyArg: 3.055 ± 0.082
4.161GlySer: 4.161 ± 0.114
3.598GlyThr: 3.598 ± 0.099
5.326GlyVal: 5.326 ± 0.134
0.528GlyTrp: 0.528 ± 0.041
2.722GlyTyr: 2.722 ± 0.102
0.0GlyXaa: 0.0 ± 0.0
His
1.206HisAla: 1.206 ± 0.059
0.274HisCys: 0.274 ± 0.026
1.193HisAsp: 1.193 ± 0.044
1.155HisGlu: 1.155 ± 0.052
1.014HisPhe: 1.014 ± 0.056
1.516HisGly: 1.516 ± 0.071
0.753HisHis: 0.753 ± 0.043
1.823HisIle: 1.823 ± 0.076
1.467HisLys: 1.467 ± 0.066
2.361HisLeu: 2.361 ± 0.09
0.543HisMet: 0.543 ± 0.033
1.25HisAsn: 1.25 ± 0.064
0.886HisPro: 0.886 ± 0.052
1.076HisGln: 1.076 ± 0.053
1.014HisArg: 1.014 ± 0.053
1.626HisSer: 1.626 ± 0.064
1.293HisThr: 1.293 ± 0.056
1.536HisVal: 1.536 ± 0.066
0.172HisTrp: 0.172 ± 0.021
0.794HisTyr: 0.794 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.63IleAla: 6.63 ± 0.146
1.078IleCys: 1.078 ± 0.062
4.425IleAsp: 4.425 ± 0.099
5.045IleGlu: 5.045 ± 0.125
2.663IlePhe: 2.663 ± 0.091
5.877IleGly: 5.877 ± 0.13
1.391IleHis: 1.391 ± 0.056
5.004IleIle: 5.004 ± 0.159
5.127IleLys: 5.127 ± 0.146
7.211IleLeu: 7.211 ± 0.164
1.767IleMet: 1.767 ± 0.072
3.16IleAsn: 3.16 ± 0.108
3.047IlePro: 3.047 ± 0.092
2.574IleGln: 2.574 ± 0.079
3.503IleArg: 3.503 ± 0.114
6.008IleSer: 6.008 ± 0.122
4.279IleThr: 4.279 ± 0.116
5.447IleVal: 5.447 ± 0.142
0.658IleTrp: 0.658 ± 0.076
1.941IleTyr: 1.941 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
5.076LysAla: 5.076 ± 0.133
0.686LysCys: 0.686 ± 0.047
3.785LysAsp: 3.785 ± 0.117
5.483LysGlu: 5.483 ± 0.164
2.294LysPhe: 2.294 ± 0.084
3.954LysGly: 3.954 ± 0.116
1.57LysHis: 1.57 ± 0.062
4.807LysIle: 4.807 ± 0.122
4.384LysLys: 4.384 ± 0.124
6.845LysLeu: 6.845 ± 0.162
1.89LysMet: 1.89 ± 0.07
2.84LysAsn: 2.84 ± 0.083
1.944LysPro: 1.944 ± 0.075
2.709LysGln: 2.709 ± 0.09
3.216LysArg: 3.216 ± 0.093
4.323LysSer: 4.323 ± 0.108
3.091LysThr: 3.091 ± 0.091
4.873LysVal: 4.873 ± 0.117
0.543LysTrp: 0.543 ± 0.036
2.645LysTyr: 2.645 ± 0.087
0.0LysXaa: 0.0 ± 0.0
Leu
6.092LeuAla: 6.092 ± 0.155
1.531LeuCys: 1.531 ± 0.066
5.252LeuAsp: 5.252 ± 0.124
7.383LeuGlu: 7.383 ± 0.175
3.767LeuPhe: 3.767 ± 0.119
6.184LeuGly: 6.184 ± 0.131
2.32LeuHis: 2.32 ± 0.08
6.51LeuIle: 6.51 ± 0.155
7.495LeuLys: 7.495 ± 0.155
10.727LeuLeu: 10.727 ± 0.229
2.456LeuMet: 2.456 ± 0.091
4.551LeuAsn: 4.551 ± 0.111
3.785LeuPro: 3.785 ± 0.097
4.22LeuGln: 4.22 ± 0.161
4.615LeuArg: 4.615 ± 0.125
8.858LeuSer: 8.858 ± 0.178
4.576LeuThr: 4.576 ± 0.115
6.358LeuVal: 6.358 ± 0.152
0.827LeuTrp: 0.827 ± 0.048
3.585LeuTyr: 3.585 ± 0.114
0.0LeuXaa: 0.0 ± 0.0
Met
1.334MetAla: 1.334 ± 0.067
0.359MetCys: 0.359 ± 0.034
1.129MetAsp: 1.129 ± 0.052
1.649MetGlu: 1.649 ± 0.065
0.883MetPhe: 0.883 ± 0.04
1.552MetGly: 1.552 ± 0.072
0.576MetHis: 0.576 ± 0.03
1.813MetIle: 1.813 ± 0.069
1.764MetLys: 1.764 ± 0.078
3.05MetLeu: 3.05 ± 0.084
0.75MetMet: 0.75 ± 0.046
1.091MetAsn: 1.091 ± 0.052
0.981MetPro: 0.981 ± 0.055
0.909MetGln: 0.909 ± 0.046
1.262MetArg: 1.262 ± 0.059
2.113MetSer: 2.113 ± 0.085
1.383MetThr: 1.383 ± 0.056
1.785MetVal: 1.785 ± 0.062
0.241MetTrp: 0.241 ± 0.026
0.804MetTyr: 0.804 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
3.019AsnAla: 3.019 ± 0.086
0.489AsnCys: 0.489 ± 0.034
2.213AsnAsp: 2.213 ± 0.105
2.463AsnGlu: 2.463 ± 0.088
1.659AsnPhe: 1.659 ± 0.074
2.866AsnGly: 2.866 ± 0.095
0.955AsnHis: 0.955 ± 0.046
4.074AsnIle: 4.074 ± 0.122
3.193AsnLys: 3.193 ± 0.106
3.979AsnLeu: 3.979 ± 0.112
1.117AsnMet: 1.117 ± 0.046
2.1AsnAsn: 2.1 ± 0.086
1.626AsnPro: 1.626 ± 0.056
1.68AsnGln: 1.68 ± 0.071
2.051AsnArg: 2.051 ± 0.081
2.914AsnSer: 2.914 ± 0.122
2.755AsnThr: 2.755 ± 0.09
3.36AsnVal: 3.36 ± 0.085
0.351AsnTrp: 0.351 ± 0.032
1.319AsnTyr: 1.319 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
1.685ProAla: 1.685 ± 0.071
0.302ProCys: 0.302 ± 0.029
1.688ProAsp: 1.688 ± 0.066
2.21ProGlu: 2.21 ± 0.083
1.301ProPhe: 1.301 ± 0.06
1.954ProGly: 1.954 ± 0.073
0.827ProHis: 0.827 ± 0.045
2.74ProIle: 2.74 ± 0.092
2.151ProLys: 2.151 ± 0.079
3.093ProLeu: 3.093 ± 0.096
0.663ProMet: 0.663 ± 0.04
1.544ProAsn: 1.544 ± 0.065
1.027ProPro: 1.027 ± 0.064
1.321ProGln: 1.321 ± 0.068
1.242ProArg: 1.242 ± 0.06
2.351ProSer: 2.351 ± 0.104
1.926ProThr: 1.926 ± 0.129
2.389ProVal: 2.389 ± 0.08
0.297ProTrp: 0.297 ± 0.03
1.268ProTyr: 1.268 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
2.487GlnAla: 2.487 ± 0.088
0.379GlnCys: 0.379 ± 0.036
2.095GlnAsp: 2.095 ± 0.084
3.293GlnGlu: 3.293 ± 0.161
1.357GlnPhe: 1.357 ± 0.063
2.156GlnGly: 2.156 ± 0.071
1.117GlnHis: 1.117 ± 0.06
2.704GlnIle: 2.704 ± 0.095
2.656GlnLys: 2.656 ± 0.089
3.685GlnLeu: 3.685 ± 0.137
0.901GlnMet: 0.901 ± 0.045
1.997GlnAsn: 1.997 ± 0.077
1.157GlnPro: 1.157 ± 0.072
1.928GlnGln: 1.928 ± 0.175
1.877GlnArg: 1.877 ± 0.078
2.602GlnSer: 2.602 ± 0.1
1.575GlnThr: 1.575 ± 0.084
2.379GlnVal: 2.379 ± 0.093
0.266GlnTrp: 0.266 ± 0.029
1.718GlnTyr: 1.718 ± 0.085
0.0GlnXaa: 0.0 ± 0.0
Arg
2.999ArgAla: 2.999 ± 0.094
0.579ArgCys: 0.579 ± 0.034
2.74ArgAsp: 2.74 ± 0.111
3.198ArgGlu: 3.198 ± 0.125
2.241ArgPhe: 2.241 ± 0.077
2.891ArgGly: 2.891 ± 0.102
1.073ArgHis: 1.073 ± 0.052
3.278ArgIle: 3.278 ± 0.109
2.93ArgLys: 2.93 ± 0.091
4.927ArgLeu: 4.927 ± 0.131
1.134ArgMet: 1.134 ± 0.057
2.095ArgAsn: 2.095 ± 0.074
1.301ArgPro: 1.301 ± 0.064
1.764ArgGln: 1.764 ± 0.07
2.43ArgArg: 2.43 ± 0.099
3.073ArgSer: 3.073 ± 0.081
2.205ArgThr: 2.205 ± 0.09
3.104ArgVal: 3.104 ± 0.104
0.44ArgTrp: 0.44 ± 0.035
2.005ArgTyr: 2.005 ± 0.085
0.0ArgXaa: 0.0 ± 0.0
Ser
4.563SerAla: 4.563 ± 0.103
0.827SerCys: 0.827 ± 0.045
3.821SerAsp: 3.821 ± 0.117
4.018SerGlu: 4.018 ± 0.122
2.863SerPhe: 2.863 ± 0.091
5.524SerGly: 5.524 ± 0.135
1.549SerHis: 1.549 ± 0.064
6.041SerIle: 6.041 ± 0.153
4.679SerLys: 4.679 ± 0.121
7.068SerLeu: 7.068 ± 0.147
1.808SerMet: 1.808 ± 0.073
3.595SerAsn: 3.595 ± 0.122
2.141SerPro: 2.141 ± 0.08
2.609SerGln: 2.609 ± 0.098
3.065SerArg: 3.065 ± 0.09
5.557SerSer: 5.557 ± 0.155
4.11SerThr: 4.11 ± 0.129
4.863SerVal: 4.863 ± 0.124
0.592SerTrp: 0.592 ± 0.038
2.653SerTyr: 2.653 ± 0.098
0.0SerXaa: 0.0 ± 0.0
Thr
3.452ThrAla: 3.452 ± 0.102
0.615ThrCys: 0.615 ± 0.041
2.563ThrAsp: 2.563 ± 0.087
2.796ThrGlu: 2.796 ± 0.103
2.125ThrPhe: 2.125 ± 0.083
3.626ThrGly: 3.626 ± 0.105
1.188ThrHis: 1.188 ± 0.058
3.995ThrIle: 3.995 ± 0.112
3.36ThrLys: 3.36 ± 0.099
5.245ThrLeu: 5.245 ± 0.107
1.001ThrMet: 1.001 ± 0.055
2.423ThrAsn: 2.423 ± 0.074
2.3ThrPro: 2.3 ± 0.12
1.834ThrGln: 1.834 ± 0.104
2.366ThrArg: 2.366 ± 0.091
3.995ThrSer: 3.995 ± 0.106
3.155ThrThr: 3.155 ± 0.112
3.839ThrVal: 3.839 ± 0.101
0.392ThrTrp: 0.392 ± 0.034
1.677ThrTyr: 1.677 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
4.748ValAla: 4.748 ± 0.132
0.999ValCys: 0.999 ± 0.061
3.99ValAsp: 3.99 ± 0.107
4.494ValGlu: 4.494 ± 0.109
2.973ValPhe: 2.973 ± 0.103
5.009ValGly: 5.009 ± 0.124
1.49ValHis: 1.49 ± 0.065
5.198ValIle: 5.198 ± 0.12
4.794ValLys: 4.794 ± 0.131
7.88ValLeu: 7.88 ± 0.173
2.0ValMet: 2.0 ± 0.08
2.781ValAsn: 2.781 ± 0.089
2.202ValPro: 2.202 ± 0.09
2.574ValGln: 2.574 ± 0.097
3.247ValArg: 3.247 ± 0.105
5.626ValSer: 5.626 ± 0.145
3.603ValThr: 3.603 ± 0.113
5.898ValVal: 5.898 ± 0.137
0.62ValTrp: 0.62 ± 0.04
2.589ValTyr: 2.589 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.412TrpAla: 0.412 ± 0.032
0.136TrpCys: 0.136 ± 0.021
0.351TrpAsp: 0.351 ± 0.03
0.417TrpGlu: 0.417 ± 0.032
0.353TrpPhe: 0.353 ± 0.03
0.438TrpGly: 0.438 ± 0.033
0.223TrpHis: 0.223 ± 0.021
0.545TrpIle: 0.545 ± 0.044
0.517TrpLys: 0.517 ± 0.039
1.014TrpLeu: 1.014 ± 0.061
0.228TrpMet: 0.228 ± 0.029
0.499TrpAsn: 0.499 ± 0.034
0.197TrpPro: 0.197 ± 0.024
0.341TrpGln: 0.341 ± 0.028
0.494TrpArg: 0.494 ± 0.036
0.981TrpSer: 0.981 ± 0.103
0.389TrpThr: 0.389 ± 0.036
0.63TrpVal: 0.63 ± 0.069
0.125TrpTrp: 0.125 ± 0.018
0.446TrpTyr: 0.446 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.054TyrAla: 2.054 ± 0.075
0.563TyrCys: 0.563 ± 0.037
2.128TyrAsp: 2.128 ± 0.078
1.959TyrGlu: 1.959 ± 0.064
1.536TyrPhe: 1.536 ± 0.066
2.633TyrGly: 2.633 ± 0.098
0.886TyrHis: 0.886 ± 0.047
2.73TyrIle: 2.73 ± 0.087
2.343TyrLys: 2.343 ± 0.09
3.401TyrLeu: 3.401 ± 0.115
0.853TyrMet: 0.853 ± 0.047
1.718TyrAsn: 1.718 ± 0.072
1.052TyrPro: 1.052 ± 0.048
1.511TyrGln: 1.511 ± 0.066
1.798TyrArg: 1.798 ± 0.084
2.517TyrSer: 2.517 ± 0.09
1.905TyrThr: 1.905 ± 0.074
2.507TyrVal: 2.507 ± 0.091
0.389TyrTrp: 0.389 ± 0.033
1.383TyrTyr: 1.383 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1129 proteins (390504 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski