Amino acid dipepetide frequency for Sphingobium sp. (strain NBRC 103272 / SYK-6)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.437AlaAla: 18.437 ± 0.179	1.175AlaCys: 1.175 ± 0.036	7.415AlaAsp: 7.415 ± 0.093	7.218AlaGlu: 7.218 ± 0.082	4.301AlaPhe: 4.301 ± 0.065	11.732AlaGly: 11.732 ± 0.138	2.486AlaHis: 2.486 ± 0.051	6.782AlaIle: 6.782 ± 0.071	3.19AlaLys: 3.19 ± 0.058	14.595AlaLeu: 14.595 ± 0.136	4.096AlaMet: 4.096 ± 0.059	2.982AlaAsn: 2.982 ± 0.052	6.735AlaPro: 6.735 ± 0.086	4.977AlaGln: 4.977 ± 0.075	10.664AlaArg: 10.664 ± 0.115	6.848AlaSer: 6.848 ± 0.088	6.348AlaThr: 6.348 ± 0.089	8.302AlaVal: 8.302 ± 0.086	1.583AlaTrp: 1.583 ± 0.038	2.662AlaTyr: 2.662 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.114CysAla: 1.114 ± 0.032	0.107CysCys: 0.107 ± 0.01	0.477CysAsp: 0.477 ± 0.018	0.422CysGlu: 0.422 ± 0.018	0.337CysPhe: 0.337 ± 0.015	0.858CysGly: 0.858 ± 0.03	0.224CysHis: 0.224 ± 0.015	0.382CysIle: 0.382 ± 0.017	0.164CysLys: 0.164 ± 0.011	0.801CysLeu: 0.801 ± 0.023	0.177CysMet: 0.177 ± 0.012	0.191CysAsn: 0.191 ± 0.012	0.451CysPro: 0.451 ± 0.018	0.199CysGln: 0.199 ± 0.012	0.628CysArg: 0.628 ± 0.025	0.432CysSer: 0.432 ± 0.016	0.391CysThr: 0.391 ± 0.019	0.543CysVal: 0.543 ± 0.02	0.114CysTrp: 0.114 ± 0.01	0.19CysTyr: 0.19 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.413AspAla: 7.413 ± 0.092	0.473AspCys: 0.473 ± 0.021	3.133AspAsp: 3.133 ± 0.055	3.475AspGlu: 3.475 ± 0.057	2.136AspPhe: 2.136 ± 0.047	5.531AspGly: 5.531 ± 0.081	1.376AspHis: 1.376 ± 0.039	3.001AspIle: 3.001 ± 0.051	1.505AspLys: 1.505 ± 0.037	5.868AspLeu: 5.868 ± 0.068	1.589AspMet: 1.589 ± 0.039	1.317AspAsn: 1.317 ± 0.038	3.791AspPro: 3.791 ± 0.055	1.82AspGln: 1.82 ± 0.039	4.858AspArg: 4.858 ± 0.061	2.209AspSer: 2.209 ± 0.047	2.264AspThr: 2.264 ± 0.044	4.077AspVal: 4.077 ± 0.063	1.153AspTrp: 1.153 ± 0.032	1.654AspTyr: 1.654 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.819GluAla: 7.819 ± 0.094	0.328GluCys: 0.328 ± 0.018	2.893GluAsp: 2.893 ± 0.053	3.047GluGlu: 3.047 ± 0.059	1.331GluPhe: 1.331 ± 0.032	4.739GluGly: 4.739 ± 0.064	1.067GluHis: 1.067 ± 0.03	2.96GluIle: 2.96 ± 0.051	1.855GluLys: 1.855 ± 0.037	4.704GluLeu: 4.704 ± 0.067	1.442GluMet: 1.442 ± 0.034	1.34GluAsn: 1.34 ± 0.034	2.661GluPro: 2.661 ± 0.05	2.083GluGln: 2.083 ± 0.046	5.153GluArg: 5.153 ± 0.073	2.412GluSer: 2.412 ± 0.043	3.332GluThr: 3.332 ± 0.058	3.176GluVal: 3.176 ± 0.052	0.709GluTrp: 0.709 ± 0.021	0.862GluTyr: 0.862 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.563PheAla: 4.563 ± 0.063	0.317PheCys: 0.317 ± 0.015	2.535PheAsp: 2.535 ± 0.046	2.0PheGlu: 2.0 ± 0.049	1.278PhePhe: 1.278 ± 0.036	3.572PheGly: 3.572 ± 0.05	0.731PheHis: 0.731 ± 0.021	1.6PheIle: 1.6 ± 0.035	0.731PheLys: 0.731 ± 0.025	3.172PheLeu: 3.172 ± 0.062	0.815PheMet: 0.815 ± 0.027	1.032PheAsn: 1.032 ± 0.033	1.593PhePro: 1.593 ± 0.034	0.905PheGln: 0.905 ± 0.027	2.369PheArg: 2.369 ± 0.045	2.14PheSer: 2.14 ± 0.037	2.027PheThr: 2.027 ± 0.044	2.539PheVal: 2.539 ± 0.048	0.528PheTrp: 0.528 ± 0.02	0.895PheTyr: 0.895 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.285GlyAla: 10.285 ± 0.12	0.836GlyCys: 0.836 ± 0.023	4.711GlyAsp: 4.711 ± 0.069	5.062GlyGlu: 5.062 ± 0.06	3.587GlyPhe: 3.587 ± 0.057	8.113GlyGly: 8.113 ± 0.126	1.947GlyHis: 1.947 ± 0.047	4.49GlyIle: 4.49 ± 0.055	3.176GlyLys: 3.176 ± 0.055	9.046GlyLeu: 9.046 ± 0.09	2.485GlyMet: 2.485 ± 0.048	2.308GlyAsn: 2.308 ± 0.056	4.02GlyPro: 4.02 ± 0.061	3.064GlyGln: 3.064 ± 0.05	6.817GlyArg: 6.817 ± 0.077	4.942GlySer: 4.942 ± 0.105	5.005GlyThr: 5.005 ± 0.139	6.046GlyVal: 6.046 ± 0.076	1.651GlyTrp: 1.651 ± 0.036	2.367GlyTyr: 2.367 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.465HisAla: 2.465 ± 0.049	0.241HisCys: 0.241 ± 0.015	1.191HisAsp: 1.191 ± 0.034	1.086HisGlu: 1.086 ± 0.03	0.816HisPhe: 0.816 ± 0.025	2.122HisGly: 2.122 ± 0.048	0.555HisHis: 0.555 ± 0.025	0.951HisIle: 0.951 ± 0.03	0.436HisLys: 0.436 ± 0.019	1.926HisLeu: 1.926 ± 0.039	0.499HisMet: 0.499 ± 0.02	0.408HisAsn: 0.408 ± 0.018	1.311HisPro: 1.311 ± 0.038	0.532HisGln: 0.532 ± 0.02	1.477HisArg: 1.477 ± 0.034	0.956HisSer: 0.956 ± 0.03	0.626HisThr: 0.626 ± 0.024	1.649HisVal: 1.649 ± 0.034	0.401HisTrp: 0.401 ± 0.018	0.615HisTyr: 0.615 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.661IleAla: 7.661 ± 0.084	0.42IleCys: 0.42 ± 0.02	3.878IleAsp: 3.878 ± 0.059	3.549IleGlu: 3.549 ± 0.051	1.641IlePhe: 1.641 ± 0.033	5.034IleGly: 5.034 ± 0.067	0.92IleHis: 0.92 ± 0.029	2.217IleIle: 2.217 ± 0.042	1.071IleLys: 1.071 ± 0.031	4.115IleLeu: 4.115 ± 0.058	1.017IleMet: 1.017 ± 0.032	1.334IleAsn: 1.334 ± 0.033	2.27IlePro: 2.27 ± 0.04	1.179IleGln: 1.179 ± 0.028	3.331IleArg: 3.331 ± 0.058	2.717IleSer: 2.717 ± 0.051	2.485IleThr: 2.485 ± 0.053	4.07IleVal: 4.07 ± 0.061	0.579IleTrp: 0.579 ± 0.021	1.061IleTyr: 1.061 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.842LysAla: 3.842 ± 0.07	0.114LysCys: 0.114 ± 0.009	1.422LysAsp: 1.422 ± 0.041	1.127LysGlu: 1.127 ± 0.034	0.679LysPhe: 0.679 ± 0.024	2.345LysGly: 2.345 ± 0.048	0.478LysHis: 0.478 ± 0.017	1.274LysIle: 1.274 ± 0.031	0.866LysLys: 0.866 ± 0.031	2.73LysLeu: 2.73 ± 0.048	0.646LysMet: 0.646 ± 0.025	0.582LysAsn: 0.582 ± 0.023	1.739LysPro: 1.739 ± 0.039	0.729LysGln: 0.729 ± 0.029	1.996LysArg: 1.996 ± 0.042	1.372LysSer: 1.372 ± 0.036	1.46LysThr: 1.46 ± 0.039	1.913LysVal: 1.913 ± 0.047	0.365LysTrp: 0.365 ± 0.018	0.507LysTyr: 0.507 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.726LeuAla: 14.726 ± 0.142	0.922LeuCys: 0.922 ± 0.026	6.193LeuAsp: 6.193 ± 0.076	4.709LeuGlu: 4.709 ± 0.068	3.76LeuPhe: 3.76 ± 0.061	8.584LeuGly: 8.584 ± 0.092	1.838LeuHis: 1.838 ± 0.041	4.841LeuIle: 4.841 ± 0.071	2.553LeuLys: 2.553 ± 0.052	10.189LeuLeu: 10.189 ± 0.12	2.251LeuMet: 2.251 ± 0.042	2.357LeuAsn: 2.357 ± 0.049	5.859LeuPro: 5.859 ± 0.065	2.488LeuGln: 2.488 ± 0.042	7.49LeuArg: 7.49 ± 0.088	6.125LeuSer: 6.125 ± 0.076	5.371LeuThr: 5.371 ± 0.072	7.343LeuVal: 7.343 ± 0.08	1.266LeuTrp: 1.266 ± 0.033	1.927LeuTyr: 1.927 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.544MetAla: 3.544 ± 0.058	0.145MetCys: 0.145 ± 0.009	1.203MetAsp: 1.203 ± 0.029	1.091MetGlu: 1.091 ± 0.029	0.722MetPhe: 0.722 ± 0.023	1.863MetGly: 1.863 ± 0.046	0.455MetHis: 0.455 ± 0.02	1.426MetIle: 1.426 ± 0.036	0.926MetLys: 0.926 ± 0.031	2.739MetLeu: 2.739 ± 0.053	0.745MetMet: 0.745 ± 0.024	0.713MetAsn: 0.713 ± 0.022	1.625MetPro: 1.625 ± 0.034	0.737MetGln: 0.737 ± 0.024	1.966MetArg: 1.966 ± 0.041	1.581MetSer: 1.581 ± 0.039	1.785MetThr: 1.785 ± 0.032	1.645MetVal: 1.645 ± 0.036	0.249MetTrp: 0.249 ± 0.016	0.258MetTyr: 0.258 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.181AsnAla: 3.181 ± 0.056	0.219AsnCys: 0.219 ± 0.015	1.371AsnAsp: 1.371 ± 0.032	1.118AsnGlu: 1.118 ± 0.031	0.923AsnPhe: 0.923 ± 0.03	2.432AsnGly: 2.432 ± 0.058	0.463AsnHis: 0.463 ± 0.022	1.314AsnIle: 1.314 ± 0.039	0.574AsnLys: 0.574 ± 0.025	2.393AsnLeu: 2.393 ± 0.043	0.559AsnMet: 0.559 ± 0.024	0.655AsnAsn: 0.655 ± 0.027	1.707AsnPro: 1.707 ± 0.036	0.732AsnGln: 0.732 ± 0.025	1.824AsnArg: 1.824 ± 0.039	1.219AsnSer: 1.219 ± 0.043	0.999AsnThr: 0.999 ± 0.032	1.831AsnVal: 1.831 ± 0.039	0.415AsnTrp: 0.415 ± 0.018	0.685AsnTyr: 0.685 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.585ProAla: 7.585 ± 0.091	0.382ProCys: 0.382 ± 0.015	4.06ProAsp: 4.06 ± 0.062	3.59ProGlu: 3.59 ± 0.061	2.02ProPhe: 2.02 ± 0.044	5.195ProGly: 5.195 ± 0.07	1.082ProHis: 1.082 ± 0.03	2.38ProIle: 2.38 ± 0.044	1.135ProLys: 1.135 ± 0.035	5.163ProLeu: 5.163 ± 0.07	1.258ProMet: 1.258 ± 0.035	1.212ProAsn: 1.212 ± 0.032	3.173ProPro: 3.173 ± 0.069	1.698ProGln: 1.698 ± 0.043	3.383ProArg: 3.383 ± 0.057	2.789ProSer: 2.789 ± 0.049	2.535ProThr: 2.535 ± 0.047	4.581ProVal: 4.581 ± 0.074	0.727ProTrp: 0.727 ± 0.024	1.144ProTyr: 1.144 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.531GlnAla: 4.531 ± 0.067	0.253GlnCys: 0.253 ± 0.013	1.544GlnAsp: 1.544 ± 0.033	1.355GlnGlu: 1.355 ± 0.034	1.078GlnPhe: 1.078 ± 0.028	2.63GlnGly: 2.63 ± 0.045	0.62GlnHis: 0.62 ± 0.021	1.778GlnIle: 1.778 ± 0.04	0.822GlnLys: 0.822 ± 0.023	3.037GlnLeu: 3.037 ± 0.044	0.805GlnMet: 0.805 ± 0.021	0.737GlnAsn: 0.737 ± 0.025	1.908GlnPro: 1.908 ± 0.044	1.177GlnGln: 1.177 ± 0.032	2.523GlnArg: 2.523 ± 0.044	1.778GlnSer: 1.778 ± 0.039	1.581GlnThr: 1.581 ± 0.038	2.129GlnVal: 2.129 ± 0.045	0.463GlnTrp: 0.463 ± 0.018	0.61GlnTyr: 0.61 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.538ArgAla: 9.538 ± 0.099	0.583ArgCys: 0.583 ± 0.022	4.387ArgAsp: 4.387 ± 0.061	4.182ArgGlu: 4.182 ± 0.067	3.253ArgPhe: 3.253 ± 0.056	5.35ArgGly: 5.35 ± 0.074	1.813ArgHis: 1.813 ± 0.04	4.369ArgIle: 4.369 ± 0.06	2.131ArgLys: 2.131 ± 0.042	8.703ArgLeu: 8.703 ± 0.095	2.011ArgMet: 2.011 ± 0.041	1.884ArgAsn: 1.884 ± 0.041	4.069ArgPro: 4.069 ± 0.062	2.672ArgGln: 2.672 ± 0.048	6.252ArgArg: 6.252 ± 0.083	3.884ArgSer: 3.884 ± 0.065	3.788ArgThr: 3.788 ± 0.051	4.68ArgVal: 4.68 ± 0.061	1.247ArgTrp: 1.247 ± 0.035	1.957ArgTyr: 1.957 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.681SerAla: 6.681 ± 0.086	0.425SerCys: 0.425 ± 0.02	2.959SerAsp: 2.959 ± 0.053	2.556SerGlu: 2.556 ± 0.044	2.329SerPhe: 2.329 ± 0.049	5.747SerGly: 5.747 ± 0.115	1.011SerHis: 1.011 ± 0.029	2.624SerIle: 2.624 ± 0.045	1.176SerLys: 1.176 ± 0.033	5.471SerLeu: 5.471 ± 0.069	1.3SerMet: 1.3 ± 0.036	1.362SerAsn: 1.362 ± 0.04	2.921SerPro: 2.921 ± 0.051	1.514SerGln: 1.514 ± 0.034	3.882SerArg: 3.882 ± 0.056	2.822SerSer: 2.822 ± 0.057	2.571SerThr: 2.571 ± 0.053	3.604SerVal: 3.604 ± 0.062	0.818SerTrp: 0.818 ± 0.027	1.372SerTyr: 1.372 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.143ThrAla: 6.143 ± 0.072	0.374ThrCys: 0.374 ± 0.018	2.815ThrAsp: 2.815 ± 0.052	2.234ThrGlu: 2.234 ± 0.041	1.714ThrPhe: 1.714 ± 0.034	5.601ThrGly: 5.601 ± 0.102	0.914ThrHis: 0.914 ± 0.022	2.963ThrIle: 2.963 ± 0.054	1.019ThrLys: 1.019 ± 0.029	5.79ThrLeu: 5.79 ± 0.086	1.221ThrMet: 1.221 ± 0.03	1.277ThrAsn: 1.277 ± 0.033	3.481ThrPro: 3.481 ± 0.051	1.473ThrGln: 1.473 ± 0.032	3.495ThrArg: 3.495 ± 0.055	2.677ThrSer: 2.677 ± 0.056	2.553ThrThr: 2.553 ± 0.052	3.949ThrVal: 3.949 ± 0.064	0.61ThrTrp: 0.61 ± 0.025	1.12ThrTyr: 1.12 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.976ValAla: 8.976 ± 0.098	0.526ValCys: 0.526 ± 0.022	4.261ValAsp: 4.261 ± 0.055	4.271ValGlu: 4.271 ± 0.059	2.088ValPhe: 2.088 ± 0.046	5.419ValGly: 5.419 ± 0.088	1.385ValHis: 1.385 ± 0.033	3.705ValIle: 3.705 ± 0.059	1.88ValLys: 1.88 ± 0.046	6.485ValLeu: 6.485 ± 0.077	1.67ValMet: 1.67 ± 0.041	1.914ValAsn: 1.914 ± 0.047	3.978ValPro: 3.978 ± 0.061	2.031ValGln: 2.031 ± 0.039	5.294ValArg: 5.294 ± 0.067	4.101ValSer: 4.101 ± 0.059	4.389ValThr: 4.389 ± 0.071	4.858ValVal: 4.858 ± 0.077	0.824ValTrp: 0.824 ± 0.028	1.323ValTyr: 1.323 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.439TrpAla: 1.439 ± 0.04	0.131TrpCys: 0.131 ± 0.011	0.721TrpAsp: 0.721 ± 0.027	0.595TrpGlu: 0.595 ± 0.02	0.51TrpPhe: 0.51 ± 0.019	0.93TrpGly: 0.93 ± 0.025	0.376TrpHis: 0.376 ± 0.019	0.662TrpIle: 0.662 ± 0.025	0.452TrpLys: 0.452 ± 0.019	1.748TrpLeu: 1.748 ± 0.037	0.38TrpMet: 0.38 ± 0.017	0.405TrpAsn: 0.405 ± 0.016	0.741TrpPro: 0.741 ± 0.024	0.636TrpGln: 0.636 ± 0.023	1.428TrpArg: 1.428 ± 0.033	0.965TrpSer: 0.965 ± 0.028	0.896TrpThr: 0.896 ± 0.026	0.775TrpVal: 0.775 ± 0.023	0.246TrpTrp: 0.246 ± 0.015	0.267TrpTyr: 0.267 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.584TyrAla: 2.584 ± 0.043	0.232TyrCys: 0.232 ± 0.014	1.475TyrAsp: 1.475 ± 0.039	1.227TyrGlu: 1.227 ± 0.028	0.838TyrPhe: 0.838 ± 0.028	2.162TyrGly: 2.162 ± 0.046	0.523TyrHis: 0.523 ± 0.022	0.83TyrIle: 0.83 ± 0.024	0.522TyrLys: 0.522 ± 0.022	2.114TyrLeu: 2.114 ± 0.046	0.45TyrMet: 0.45 ± 0.017	0.603TyrAsn: 0.603 ± 0.022	1.062TyrPro: 1.062 ± 0.031	0.713TyrGln: 0.713 ± 0.024	1.928TyrArg: 1.928 ± 0.039	1.176TyrSer: 1.176 ± 0.032	1.017TyrThr: 1.017 ± 0.032	1.666TyrVal: 1.666 ± 0.032	0.356TyrTrp: 0.356 ± 0.018	0.658TyrTyr: 0.658 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4050 proteins (1285391 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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