Amino acid dipepetide frequency for Streptomyces sp. PAN_FS17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.321AlaAla: 20.321 ± 0.143	1.057AlaCys: 1.057 ± 0.023	8.351AlaAsp: 8.351 ± 0.064	8.764AlaGlu: 8.764 ± 0.084	3.487AlaPhe: 3.487 ± 0.041	12.797AlaGly: 12.797 ± 0.098	2.868AlaHis: 2.868 ± 0.041	3.471AlaIle: 3.471 ± 0.039	2.82AlaLys: 2.82 ± 0.046	14.496AlaLeu: 14.496 ± 0.116	2.436AlaMet: 2.436 ± 0.03	1.959AlaAsn: 1.959 ± 0.03	6.818AlaPro: 6.818 ± 0.062	3.797AlaGln: 3.797 ± 0.046	10.086AlaArg: 10.086 ± 0.082	6.036AlaSer: 6.036 ± 0.042	7.037AlaThr: 7.037 ± 0.062	12.183AlaVal: 12.183 ± 0.093	1.874AlaTrp: 1.874 ± 0.027	2.75AlaTyr: 2.75 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.059CysAla: 1.059 ± 0.023	0.106CysCys: 0.106 ± 0.008	0.473CysAsp: 0.473 ± 0.013	0.417CysGlu: 0.417 ± 0.011	0.213CysPhe: 0.213 ± 0.008	0.937CysGly: 0.937 ± 0.021	0.184CysHis: 0.184 ± 0.008	0.157CysIle: 0.157 ± 0.007	0.121CysLys: 0.121 ± 0.007	0.767CysLeu: 0.767 ± 0.018	0.126CysMet: 0.126 ± 0.007	0.138CysAsn: 0.138 ± 0.008	0.471CysPro: 0.471 ± 0.011	0.163CysGln: 0.163 ± 0.008	0.614CysArg: 0.614 ± 0.015	0.426CysSer: 0.426 ± 0.012	0.5CysThr: 0.5 ± 0.014	0.658CysVal: 0.658 ± 0.015	0.125CysTrp: 0.125 ± 0.007	0.145CysTyr: 0.145 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.736AspAla: 7.736 ± 0.062	0.436AspCys: 0.436 ± 0.014	3.792AspAsp: 3.792 ± 0.039	4.02AspGlu: 4.02 ± 0.046	1.695AspPhe: 1.695 ± 0.025	6.527AspGly: 6.527 ± 0.046	1.441AspHis: 1.441 ± 0.022	1.939AspIle: 1.939 ± 0.032	1.284AspLys: 1.284 ± 0.029	6.269AspLeu: 6.269 ± 0.051	0.843AspMet: 0.843 ± 0.019	1.022AspAsn: 1.022 ± 0.022	4.425AspPro: 4.425 ± 0.046	1.524AspGln: 1.524 ± 0.027	5.009AspArg: 5.009 ± 0.05	2.73AspSer: 2.73 ± 0.033	3.302AspThr: 3.302 ± 0.038	4.87AspVal: 4.87 ± 0.041	1.11AspTrp: 1.11 ± 0.02	1.126AspTyr: 1.126 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.406GluAla: 7.406 ± 0.065	0.382GluCys: 0.382 ± 0.01	2.884GluAsp: 2.884 ± 0.037	3.563GluGlu: 3.563 ± 0.042	1.543GluPhe: 1.543 ± 0.025	4.364GluGly: 4.364 ± 0.041	1.547GluHis: 1.547 ± 0.025	2.205GluIle: 2.205 ± 0.031	1.437GluLys: 1.437 ± 0.029	6.897GluLeu: 6.897 ± 0.059	0.879GluMet: 0.879 ± 0.018	1.07GluAsn: 1.07 ± 0.022	3.54GluPro: 3.54 ± 0.04	2.293GluGln: 2.293 ± 0.035	5.525GluArg: 5.525 ± 0.055	2.667GluSer: 2.667 ± 0.028	2.957GluThr: 2.957 ± 0.034	4.51GluVal: 4.51 ± 0.04	0.79GluTrp: 0.79 ± 0.016	1.122GluTyr: 1.122 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.657PheAla: 3.657 ± 0.04	0.257PheCys: 0.257 ± 0.008	1.937PheAsp: 1.937 ± 0.026	1.473PheGlu: 1.473 ± 0.022	0.863PhePhe: 0.863 ± 0.019	3.002PheGly: 3.002 ± 0.034	0.618PheHis: 0.618 ± 0.017	0.705PheIle: 0.705 ± 0.016	0.539PheLys: 0.539 ± 0.015	2.608PheLeu: 2.608 ± 0.034	0.432PheMet: 0.432 ± 0.013	0.564PheAsn: 0.564 ± 0.014	1.381PhePro: 1.381 ± 0.024	0.71PheGln: 0.71 ± 0.015	1.855PheArg: 1.855 ± 0.024	1.449PheSer: 1.449 ± 0.023	1.983PheThr: 1.983 ± 0.029	2.322PheVal: 2.322 ± 0.031	0.44PheTrp: 0.44 ± 0.014	0.574PheTyr: 0.574 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.84GlyAla: 10.84 ± 0.076	0.812GlyCys: 0.812 ± 0.016	5.329GlyAsp: 5.329 ± 0.045	5.129GlyGlu: 5.129 ± 0.047	2.9GlyPhe: 2.9 ± 0.037	8.64GlyGly: 8.64 ± 0.073	2.351GlyHis: 2.351 ± 0.034	3.505GlyIle: 3.505 ± 0.036	2.401GlyLys: 2.401 ± 0.036	9.332GlyLeu: 9.332 ± 0.064	2.059GlyMet: 2.059 ± 0.026	1.825GlyAsn: 1.825 ± 0.032	5.06GlyPro: 5.06 ± 0.047	2.666GlyGln: 2.666 ± 0.032	7.662GlyArg: 7.662 ± 0.056	5.452GlySer: 5.452 ± 0.043	6.55GlyThr: 6.55 ± 0.058	7.548GlyVal: 7.548 ± 0.066	1.718GlyTrp: 1.718 ± 0.027	2.263GlyTyr: 2.263 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.656HisAla: 2.656 ± 0.028	0.215HisCys: 0.215 ± 0.008	1.411HisAsp: 1.411 ± 0.024	1.259HisGlu: 1.259 ± 0.021	0.629HisPhe: 0.629 ± 0.014	2.381HisGly: 2.381 ± 0.034	0.668HisHis: 0.668 ± 0.016	0.713HisIle: 0.713 ± 0.017	0.359HisLys: 0.359 ± 0.012	2.437HisLeu: 2.437 ± 0.032	0.35HisMet: 0.35 ± 0.011	0.394HisAsn: 0.394 ± 0.011	1.823HisPro: 1.823 ± 0.034	0.614HisGln: 0.614 ± 0.014	2.113HisArg: 2.113 ± 0.035	1.054HisSer: 1.054 ± 0.02	1.388HisThr: 1.388 ± 0.02	1.754HisVal: 1.754 ± 0.024	0.377HisTrp: 0.377 ± 0.011	0.489HisTyr: 0.489 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.775IleAla: 4.775 ± 0.047	0.291IleCys: 0.291 ± 0.01	2.269IleAsp: 2.269 ± 0.029	1.978IleGlu: 1.978 ± 0.03	0.705IlePhe: 0.705 ± 0.018	3.589IleGly: 3.589 ± 0.041	0.636IleHis: 0.636 ± 0.016	0.853IleIle: 0.853 ± 0.02	0.725IleLys: 0.725 ± 0.018	2.415IleLeu: 2.415 ± 0.033	0.446IleMet: 0.446 ± 0.014	0.682IleAsn: 0.682 ± 0.014	1.794IlePro: 1.794 ± 0.026	0.747IleGln: 0.747 ± 0.014	2.295IleArg: 2.295 ± 0.029	1.68IleSer: 1.68 ± 0.024	2.241IleThr: 2.241 ± 0.032	2.722IleVal: 2.722 ± 0.036	0.383IleTrp: 0.383 ± 0.011	0.539IleTyr: 0.539 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.925LysAla: 2.925 ± 0.039	0.123LysCys: 0.123 ± 0.007	1.422LysAsp: 1.422 ± 0.027	1.229LysGlu: 1.229 ± 0.023	0.464LysPhe: 0.464 ± 0.014	1.886LysGly: 1.886 ± 0.029	0.406LysHis: 0.406 ± 0.013	0.817LysIle: 0.817 ± 0.02	0.851LysLys: 0.851 ± 0.025	2.001LysLeu: 2.001 ± 0.031	0.389LysMet: 0.389 ± 0.01	0.501LysAsn: 0.501 ± 0.015	1.377LysPro: 1.377 ± 0.036	0.713LysGln: 0.713 ± 0.018	1.403LysArg: 1.403 ± 0.025	1.216LysSer: 1.216 ± 0.025	1.235LysThr: 1.235 ± 0.026	1.955LysVal: 1.955 ± 0.033	0.297LysTrp: 0.297 ± 0.011	0.491LysTyr: 0.491 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.93LeuAla: 14.93 ± 0.099	0.848LeuCys: 0.848 ± 0.016	6.765LeuAsp: 6.765 ± 0.055	4.754LeuGlu: 4.754 ± 0.047	2.664LeuPhe: 2.664 ± 0.035	9.267LeuGly: 9.267 ± 0.07	2.336LeuHis: 2.336 ± 0.037	3.349LeuIle: 3.349 ± 0.044	2.129LeuLys: 2.129 ± 0.035	11.368LeuLeu: 11.368 ± 0.09	1.7LeuMet: 1.7 ± 0.026	1.762LeuAsn: 1.762 ± 0.029	6.434LeuPro: 6.434 ± 0.055	2.18LeuGln: 2.18 ± 0.032	8.598LeuArg: 8.598 ± 0.066	5.306LeuSer: 5.306 ± 0.043	6.992LeuThr: 6.992 ± 0.05	8.723LeuVal: 8.723 ± 0.068	1.328LeuTrp: 1.328 ± 0.025	1.892LeuTyr: 1.892 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.276MetAla: 2.276 ± 0.028	0.137MetCys: 0.137 ± 0.007	0.902MetAsp: 0.902 ± 0.021	0.753MetGlu: 0.753 ± 0.015	0.446MetPhe: 0.446 ± 0.014	1.357MetGly: 1.357 ± 0.022	0.378MetHis: 0.378 ± 0.01	0.658MetIle: 0.658 ± 0.017	0.417MetLys: 0.417 ± 0.013	1.678MetLeu: 1.678 ± 0.026	0.296MetMet: 0.296 ± 0.011	0.455MetAsn: 0.455 ± 0.013	1.124MetPro: 1.124 ± 0.02	0.463MetGln: 0.463 ± 0.013	1.416MetArg: 1.416 ± 0.022	1.338MetSer: 1.338 ± 0.019	1.596MetThr: 1.596 ± 0.024	1.278MetVal: 1.278 ± 0.024	0.24MetTrp: 0.24 ± 0.008	0.33MetTyr: 0.33 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.252AsnAla: 2.252 ± 0.033	0.171AsnCys: 0.171 ± 0.008	1.006AsnAsp: 1.006 ± 0.02	0.842AsnGlu: 0.842 ± 0.018	0.495AsnPhe: 0.495 ± 0.014	1.985AsnGly: 1.985 ± 0.036	0.413AsnHis: 0.413 ± 0.014	0.656AsnIle: 0.656 ± 0.016	0.406AsnLys: 0.406 ± 0.014	1.677AsnLeu: 1.677 ± 0.028	0.3AsnMet: 0.3 ± 0.011	0.476AsnAsn: 0.476 ± 0.016	1.396AsnPro: 1.396 ± 0.025	0.54AsnGln: 0.54 ± 0.015	1.302AsnArg: 1.302 ± 0.021	1.026AsnSer: 1.026 ± 0.023	1.165AsnThr: 1.165 ± 0.022	1.401AsnVal: 1.401 ± 0.022	0.314AsnTrp: 0.314 ± 0.012	0.435AsnTyr: 0.435 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.319ProAla: 8.319 ± 0.077	0.325ProCys: 0.325 ± 0.012	4.633ProAsp: 4.633 ± 0.047	4.403ProGlu: 4.403 ± 0.046	1.538ProPhe: 1.538 ± 0.021	6.364ProGly: 6.364 ± 0.053	1.403ProHis: 1.403 ± 0.023	1.325ProIle: 1.325 ± 0.021	1.216ProLys: 1.216 ± 0.022	5.377ProLeu: 5.377 ± 0.05	1.014ProMet: 1.014 ± 0.02	0.972ProAsn: 0.972 ± 0.019	3.416ProPro: 3.416 ± 0.047	1.799ProGln: 1.799 ± 0.034	3.853ProArg: 3.853 ± 0.042	3.243ProSer: 3.243 ± 0.038	3.392ProThr: 3.392 ± 0.038	5.362ProVal: 5.362 ± 0.047	0.919ProTrp: 0.919 ± 0.018	1.439ProTyr: 1.439 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.66GlnAla: 3.66 ± 0.045	0.17GlnCys: 0.17 ± 0.007	1.503GlnAsp: 1.503 ± 0.026	1.497GlnGlu: 1.497 ± 0.027	0.691GlnPhe: 0.691 ± 0.017	2.402GlnGly: 2.402 ± 0.032	0.656GlnHis: 0.656 ± 0.015	1.06GlnIle: 1.06 ± 0.021	0.611GlnLys: 0.611 ± 0.014	3.021GlnLeu: 3.021 ± 0.032	0.504GlnMet: 0.504 ± 0.014	0.527GlnAsn: 0.527 ± 0.015	1.733GlnPro: 1.733 ± 0.032	1.275GlnGln: 1.275 ± 0.031	2.321GlnArg: 2.321 ± 0.028	1.322GlnSer: 1.322 ± 0.022	1.326GlnThr: 1.326 ± 0.023	2.405GlnVal: 2.405 ± 0.031	0.481GlnTrp: 0.481 ± 0.012	0.63GlnTyr: 0.63 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.615ArgAla: 9.615 ± 0.083	0.568ArgCys: 0.568 ± 0.014	4.247ArgAsp: 4.247 ± 0.047	4.786ArgGlu: 4.786 ± 0.044	2.339ArgPhe: 2.339 ± 0.029	5.728ArgGly: 5.728 ± 0.05	2.193ArgHis: 2.193 ± 0.033	3.244ArgIle: 3.244 ± 0.035	1.631ArgLys: 1.631 ± 0.027	8.894ArgLeu: 8.894 ± 0.068	1.747ArgMet: 1.747 ± 0.026	1.338ArgAsn: 1.338 ± 0.023	4.954ArgPro: 4.954 ± 0.054	2.326ArgGln: 2.326 ± 0.033	7.697ArgArg: 7.697 ± 0.066	4.038ArgSer: 4.038 ± 0.036	5.508ArgThr: 5.508 ± 0.041	5.85ArgVal: 5.85 ± 0.049	1.361ArgTrp: 1.361 ± 0.023	1.773ArgTyr: 1.773 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.911SerAla: 6.911 ± 0.06	0.411SerCys: 0.411 ± 0.012	2.887SerAsp: 2.887 ± 0.034	2.537SerGlu: 2.537 ± 0.036	1.482SerPhe: 1.482 ± 0.024	6.092SerGly: 6.092 ± 0.06	1.029SerHis: 1.029 ± 0.022	1.473SerIle: 1.473 ± 0.022	1.055SerLys: 1.055 ± 0.022	4.874SerLeu: 4.874 ± 0.042	1.074SerMet: 1.074 ± 0.02	0.965SerAsn: 0.965 ± 0.018	3.186SerPro: 3.186 ± 0.036	1.264SerGln: 1.264 ± 0.024	3.714SerArg: 3.714 ± 0.039	2.971SerSer: 2.971 ± 0.045	3.093SerThr: 3.093 ± 0.034	4.358SerVal: 4.358 ± 0.039	0.905SerTrp: 0.905 ± 0.018	1.289SerTyr: 1.289 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.935ThrAla: 8.935 ± 0.067	0.435ThrCys: 0.435 ± 0.014	3.858ThrAsp: 3.858 ± 0.041	3.366ThrGlu: 3.366 ± 0.035	1.644ThrPhe: 1.644 ± 0.023	6.815ThrGly: 6.815 ± 0.06	1.25ThrHis: 1.25 ± 0.022	1.694ThrIle: 1.694 ± 0.028	1.21ThrLys: 1.21 ± 0.024	5.788ThrLeu: 5.788 ± 0.047	0.937ThrMet: 0.937 ± 0.02	1.034ThrAsn: 1.034 ± 0.019	4.292ThrPro: 4.292 ± 0.051	1.401ThrGln: 1.401 ± 0.024	3.962ThrArg: 3.962 ± 0.035	3.272ThrSer: 3.272 ± 0.036	3.928ThrThr: 3.928 ± 0.05	6.052ThrVal: 6.052 ± 0.05	0.923ThrTrp: 0.923 ± 0.019	1.427ThrTyr: 1.427 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.673ValAla: 10.673 ± 0.073	0.74ValCys: 0.74 ± 0.018	4.978ValAsp: 4.978 ± 0.045	4.78ValGlu: 4.78 ± 0.046	2.412ValPhe: 2.412 ± 0.032	6.471ValGly: 6.471 ± 0.052	1.957ValHis: 1.957 ± 0.028	2.874ValIle: 2.874 ± 0.037	1.734ValLys: 1.734 ± 0.033	9.498ValLeu: 9.498 ± 0.077	1.44ValMet: 1.44 ± 0.025	1.702ValAsn: 1.702 ± 0.026	5.219ValPro: 5.219 ± 0.048	2.09ValGln: 2.09 ± 0.027	7.221ValArg: 7.221 ± 0.051	4.386ValSer: 4.386 ± 0.041	5.759ValThr: 5.759 ± 0.053	8.001ValVal: 8.001 ± 0.074	1.182ValTrp: 1.182 ± 0.019	1.562ValTyr: 1.562 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.7TrpAla: 1.7 ± 0.027	0.145TrpCys: 0.145 ± 0.007	0.847TrpAsp: 0.847 ± 0.018	0.739TrpGlu: 0.739 ± 0.016	0.507TrpPhe: 0.507 ± 0.014	1.1TrpGly: 1.1 ± 0.022	0.38TrpHis: 0.38 ± 0.012	0.556TrpIle: 0.556 ± 0.014	0.352TrpLys: 0.352 ± 0.012	1.811TrpLeu: 1.811 ± 0.029	0.305TrpMet: 0.305 ± 0.01	0.443TrpAsn: 0.443 ± 0.014	0.798TrpPro: 0.798 ± 0.018	0.652TrpGln: 0.652 ± 0.016	1.357TrpArg: 1.357 ± 0.022	0.995TrpSer: 0.995 ± 0.02	1.058TrpThr: 1.058 ± 0.02	0.999TrpVal: 0.999 ± 0.021	0.354TrpTrp: 0.354 ± 0.012	0.384TrpTyr: 0.384 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.765TyrAla: 2.765 ± 0.031	0.17TyrCys: 0.17 ± 0.007	1.608TyrAsp: 1.608 ± 0.028	1.288TyrGlu: 1.288 ± 0.024	0.653TyrPhe: 0.653 ± 0.015	2.34TyrGly: 2.34 ± 0.033	0.371TyrHis: 0.371 ± 0.012	0.507TyrIle: 0.507 ± 0.013	0.405TyrLys: 0.405 ± 0.014	2.111TyrLeu: 2.111 ± 0.031	0.259TyrMet: 0.259 ± 0.01	0.43TyrAsn: 0.43 ± 0.015	1.069TyrPro: 1.069 ± 0.022	0.582TyrGln: 0.582 ± 0.015	1.837TyrArg: 1.837 ± 0.029	0.964TyrSer: 0.964 ± 0.019	1.212TyrThr: 1.212 ± 0.022	1.725TyrVal: 1.725 ± 0.026	0.363TyrTrp: 0.363 ± 0.012	0.466TyrTyr: 0.466 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8901 proteins (3045133 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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