Amino acid dipepetide frequency for Eufriesea mexicana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.813AlaAla: 4.813 ± 0.078	1.162AlaCys: 1.162 ± 0.021	2.74AlaAsp: 2.74 ± 0.035	3.899AlaGlu: 3.899 ± 0.045	2.051AlaPhe: 2.051 ± 0.03	3.443AlaGly: 3.443 ± 0.045	1.324AlaHis: 1.324 ± 0.02	3.476AlaIle: 3.476 ± 0.033	3.569AlaLys: 3.569 ± 0.075	5.509AlaLeu: 5.509 ± 0.059	1.458AlaMet: 1.458 ± 0.022	2.725AlaAsn: 2.725 ± 0.037	2.591AlaPro: 2.591 ± 0.04	2.232AlaGln: 2.232 ± 0.03	3.387AlaArg: 3.387 ± 0.04	4.674AlaSer: 4.674 ± 0.041	3.826AlaThr: 3.826 ± 0.037	3.884AlaVal: 3.884 ± 0.043	0.629AlaTrp: 0.629 ± 0.016	1.632AlaTyr: 1.632 ± 0.026	0.002AlaXaa: 0.002 ± 0.001
Cys	1.051CysAla: 1.051 ± 0.021	0.47CysCys: 0.47 ± 0.015	1.098CysAsp: 1.098 ± 0.025	1.178CysGlu: 1.178 ± 0.034	0.711CysPhe: 0.711 ± 0.016	1.261CysGly: 1.261 ± 0.028	0.531CysHis: 0.531 ± 0.015	1.221CysIle: 1.221 ± 0.026	1.205CysLys: 1.205 ± 0.023	1.812CysLeu: 1.812 ± 0.028	0.436CysMet: 0.436 ± 0.012	1.05CysAsn: 1.05 ± 0.025	1.022CysPro: 1.022 ± 0.027	0.791CysGln: 0.791 ± 0.021	1.197CysArg: 1.197 ± 0.026	1.66CysSer: 1.66 ± 0.031	1.189CysThr: 1.189 ± 0.026	1.182CysVal: 1.182 ± 0.029	0.249CysTrp: 0.249 ± 0.009	0.617CysTyr: 0.617 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	2.89AspAla: 2.89 ± 0.04	0.982AspCys: 0.982 ± 0.026	3.346AspAsp: 3.346 ± 0.044	4.183AspGlu: 4.183 ± 0.051	2.0AspPhe: 2.0 ± 0.027	2.973AspGly: 2.973 ± 0.036	1.126AspHis: 1.126 ± 0.019	3.628AspIle: 3.628 ± 0.036	3.269AspLys: 3.269 ± 0.054	4.661AspLeu: 4.661 ± 0.041	1.147AspMet: 1.147 ± 0.019	2.59AspAsn: 2.59 ± 0.034	2.441AspPro: 2.441 ± 0.031	1.737AspGln: 1.737 ± 0.023	2.829AspArg: 2.829 ± 0.043	4.312AspSer: 4.312 ± 0.041	3.061AspThr: 3.061 ± 0.035	3.402AspVal: 3.402 ± 0.035	0.633AspTrp: 0.633 ± 0.014	1.727AspTyr: 1.727 ± 0.023	0.001AspXaa: 0.001 ± 0.0
Glu	4.07GluAla: 4.07 ± 0.051	1.266GluCys: 1.266 ± 0.033	4.275GluAsp: 4.275 ± 0.05	6.921GluGlu: 6.921 ± 0.143	2.134GluPhe: 2.134 ± 0.027	3.197GluGly: 3.197 ± 0.043	1.466GluHis: 1.466 ± 0.021	4.274GluIle: 4.274 ± 0.048	5.583GluLys: 5.583 ± 0.075	5.906GluLeu: 5.906 ± 0.062	1.601GluMet: 1.601 ± 0.024	4.172GluAsn: 4.172 ± 0.047	2.554GluPro: 2.554 ± 0.038	2.85GluGln: 2.85 ± 0.038	4.035GluArg: 4.035 ± 0.051	4.859GluSer: 4.859 ± 0.055	4.083GluThr: 4.083 ± 0.043	3.895GluVal: 3.895 ± 0.076	0.699GluTrp: 0.699 ± 0.015	1.993GluTyr: 1.993 ± 0.023	0.001GluXaa: 0.001 ± 0.0
Phe	2.029PheAla: 2.029 ± 0.026	0.81PheCys: 0.81 ± 0.016	1.943PheAsp: 1.943 ± 0.028	2.114PheGlu: 2.114 ± 0.031	1.448PhePhe: 1.448 ± 0.023	2.234PheGly: 2.234 ± 0.032	0.996PheHis: 0.996 ± 0.02	2.08PheIle: 2.08 ± 0.031	1.965PheLys: 1.965 ± 0.024	3.402PheLeu: 3.402 ± 0.04	0.744PheMet: 0.744 ± 0.017	1.733PheAsn: 1.733 ± 0.024	1.636PhePro: 1.636 ± 0.022	1.421PheGln: 1.421 ± 0.02	1.873PheArg: 1.873 ± 0.029	2.878PheSer: 2.878 ± 0.035	2.067PheThr: 2.067 ± 0.025	2.237PheVal: 2.237 ± 0.027	0.393PheTrp: 0.393 ± 0.012	1.196PheTyr: 1.196 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	2.994GlyAla: 2.994 ± 0.043	1.076GlyCys: 1.076 ± 0.027	2.71GlyAsp: 2.71 ± 0.032	3.385GlyGlu: 3.385 ± 0.043	2.06GlyPhe: 2.06 ± 0.034	4.1GlyGly: 4.1 ± 0.064	1.401GlyHis: 1.401 ± 0.024	3.302GlyIle: 3.302 ± 0.04	3.766GlyLys: 3.766 ± 0.047	4.509GlyLeu: 4.509 ± 0.042	1.153GlyMet: 1.153 ± 0.021	2.827GlyAsn: 2.827 ± 0.035	2.493GlyPro: 2.493 ± 0.054	2.061GlyGln: 2.061 ± 0.029	3.213GlyArg: 3.213 ± 0.038	4.836GlySer: 4.836 ± 0.053	3.513GlyThr: 3.513 ± 0.084	3.267GlyVal: 3.267 ± 0.04	0.662GlyTrp: 0.662 ± 0.016	1.949GlyTyr: 1.949 ± 0.056	0.001GlyXaa: 0.001 ± 0.001
His	1.352HisAla: 1.352 ± 0.025	0.577HisCys: 0.577 ± 0.014	1.118HisAsp: 1.118 ± 0.021	1.414HisGlu: 1.414 ± 0.021	0.926HisPhe: 0.926 ± 0.016	1.495HisGly: 1.495 ± 0.021	0.965HisHis: 0.965 ± 0.03	1.371HisIle: 1.371 ± 0.024	1.296HisLys: 1.296 ± 0.02	2.298HisLeu: 2.298 ± 0.029	0.558HisMet: 0.558 ± 0.015	1.091HisAsn: 1.091 ± 0.025	1.512HisPro: 1.512 ± 0.051	1.075HisGln: 1.075 ± 0.023	1.538HisArg: 1.538 ± 0.028	1.944HisSer: 1.944 ± 0.029	1.538HisThr: 1.538 ± 0.054	1.498HisVal: 1.498 ± 0.021	0.298HisTrp: 0.298 ± 0.009	0.81HisTyr: 0.81 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.629IleAla: 3.629 ± 0.036	1.254IleCys: 1.254 ± 0.024	3.274IleAsp: 3.274 ± 0.039	4.062IleGlu: 4.062 ± 0.046	2.3IlePhe: 2.3 ± 0.033	3.045IleGly: 3.045 ± 0.033	1.625IleHis: 1.625 ± 0.095	3.69IleIle: 3.69 ± 0.048	3.785IleLys: 3.785 ± 0.045	5.644IleLeu: 5.644 ± 0.064	1.223IleMet: 1.223 ± 0.023	3.061IleAsn: 3.061 ± 0.041	3.101IlePro: 3.101 ± 0.035	2.419IleGln: 2.419 ± 0.035	2.98IleArg: 2.98 ± 0.034	4.704IleSer: 4.704 ± 0.045	3.485IleThr: 3.485 ± 0.039	3.71IleVal: 3.71 ± 0.036	0.589IleTrp: 0.589 ± 0.016	1.902IleTyr: 1.902 ± 0.026	0.001IleXaa: 0.001 ± 0.0
Lys	3.415LysAla: 3.415 ± 0.047	1.209LysCys: 1.209 ± 0.025	3.704LysAsp: 3.704 ± 0.07	5.325LysGlu: 5.325 ± 0.076	2.2LysPhe: 2.2 ± 0.03	2.865LysGly: 2.865 ± 0.031	1.595LysHis: 1.595 ± 0.03	4.102LysIle: 4.102 ± 0.05	5.468LysLys: 5.468 ± 0.095	5.94LysLeu: 5.94 ± 0.049	1.516LysMet: 1.516 ± 0.022	3.451LysAsn: 3.451 ± 0.042	2.908LysPro: 2.908 ± 0.076	2.783LysGln: 2.783 ± 0.036	3.938LysArg: 3.938 ± 0.041	4.781LysSer: 4.781 ± 0.053	3.661LysThr: 3.661 ± 0.039	3.686LysVal: 3.686 ± 0.051	0.683LysTrp: 0.683 ± 0.014	2.15LysTyr: 2.15 ± 0.03	0.001LysXaa: 0.001 ± 0.001
Leu	5.628LeuAla: 5.628 ± 0.054	1.827LeuCys: 1.827 ± 0.029	4.672LeuAsp: 4.672 ± 0.038	6.368LeuGlu: 6.368 ± 0.065	3.083LeuPhe: 3.083 ± 0.038	4.506LeuGly: 4.506 ± 0.046	2.383LeuHis: 2.383 ± 0.033	4.8LeuIle: 4.8 ± 0.056	6.011LeuLys: 6.011 ± 0.064	8.627LeuLeu: 8.627 ± 0.088	1.916LeuMet: 1.916 ± 0.025	4.422LeuAsn: 4.422 ± 0.046	4.611LeuPro: 4.611 ± 0.048	4.407LeuGln: 4.407 ± 0.047	5.235LeuArg: 5.235 ± 0.054	7.257LeuSer: 7.257 ± 0.057	5.071LeuThr: 5.071 ± 0.043	4.951LeuVal: 4.951 ± 0.047	0.979LeuTrp: 0.979 ± 0.02	2.707LeuTyr: 2.707 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	1.512MetAla: 1.512 ± 0.022	0.417MetCys: 0.417 ± 0.011	1.28MetAsp: 1.28 ± 0.022	1.731MetGlu: 1.731 ± 0.026	0.803MetPhe: 0.803 ± 0.015	1.076MetGly: 1.076 ± 0.022	0.514MetHis: 0.514 ± 0.013	1.204MetIle: 1.204 ± 0.019	1.599MetLys: 1.599 ± 0.02	1.946MetLeu: 1.946 ± 0.029	0.568MetMet: 0.568 ± 0.021	1.111MetAsn: 1.111 ± 0.019	1.022MetPro: 1.022 ± 0.018	1.017MetGln: 1.017 ± 0.019	1.121MetArg: 1.121 ± 0.02	1.713MetSer: 1.713 ± 0.024	1.264MetThr: 1.264 ± 0.021	1.247MetVal: 1.247 ± 0.022	0.235MetTrp: 0.235 ± 0.009	0.69MetTyr: 0.69 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.87AsnAla: 2.87 ± 0.036	0.969AsnCys: 0.969 ± 0.021	2.755AsnAsp: 2.755 ± 0.035	3.627AsnGlu: 3.627 ± 0.043	1.897AsnPhe: 1.897 ± 0.025	3.025AsnGly: 3.025 ± 0.052	1.159AsnHis: 1.159 ± 0.019	3.636AsnIle: 3.636 ± 0.048	3.352AsnLys: 3.352 ± 0.047	4.515AsnLeu: 4.515 ± 0.036	1.18AsnMet: 1.18 ± 0.019	3.24AsnAsn: 3.24 ± 0.045	2.28AsnPro: 2.28 ± 0.028	1.881AsnGln: 1.881 ± 0.031	2.482AsnArg: 2.482 ± 0.026	4.18AsnSer: 4.18 ± 0.041	3.035AsnThr: 3.035 ± 0.041	3.445AsnVal: 3.445 ± 0.035	0.523AsnTrp: 0.523 ± 0.014	1.64AsnTyr: 1.64 ± 0.025	0.001AsnXaa: 0.001 ± 0.0
Pro	2.972ProAla: 2.972 ± 0.041	0.871ProCys: 0.871 ± 0.024	2.393ProAsp: 2.393 ± 0.027	3.195ProGlu: 3.195 ± 0.046	1.664ProPhe: 1.664 ± 0.024	3.098ProGly: 3.098 ± 0.163	1.187ProHis: 1.187 ± 0.024	2.691ProIle: 2.691 ± 0.032	2.759ProLys: 2.759 ± 0.048	4.148ProLeu: 4.148 ± 0.042	0.992ProMet: 0.992 ± 0.019	2.259ProAsn: 2.259 ± 0.033	4.263ProPro: 4.263 ± 0.097	2.063ProGln: 2.063 ± 0.035	2.973ProArg: 2.973 ± 0.042	4.311ProSer: 4.311 ± 0.054	3.19ProThr: 3.19 ± 0.039	3.258ProVal: 3.258 ± 0.045	0.53ProTrp: 0.53 ± 0.013	1.538ProTyr: 1.538 ± 0.038	0.001ProXaa: 0.001 ± 0.0
Gln	2.35GlnAla: 2.35 ± 0.034	0.8GlnCys: 0.8 ± 0.02	1.946GlnAsp: 1.946 ± 0.026	3.056GlnGlu: 3.056 ± 0.041	1.344GlnPhe: 1.344 ± 0.021	1.896GlnGly: 1.896 ± 0.029	1.177GlnHis: 1.177 ± 0.025	2.313GlnIle: 2.313 ± 0.035	2.623GlnLys: 2.623 ± 0.042	3.916GlnLeu: 3.916 ± 0.041	0.939GlnMet: 0.939 ± 0.02	2.385GlnAsn: 2.385 ± 0.035	2.098GlnPro: 2.098 ± 0.041	3.313GlnGln: 3.313 ± 0.113	2.574GlnArg: 2.574 ± 0.034	3.106GlnSer: 3.106 ± 0.037	2.4GlnThr: 2.4 ± 0.031	2.288GlnVal: 2.288 ± 0.031	0.455GlnTrp: 0.455 ± 0.011	1.265GlnTyr: 1.265 ± 0.021	0.001GlnXaa: 0.001 ± 0.0
Arg	3.107ArgAla: 3.107 ± 0.034	1.177ArgCys: 1.177 ± 0.027	3.036ArgAsp: 3.036 ± 0.045	3.791ArgGlu: 3.791 ± 0.05	1.962ArgPhe: 1.962 ± 0.025	3.183ArgGly: 3.183 ± 0.045	1.554ArgHis: 1.554 ± 0.026	3.208ArgIle: 3.208 ± 0.031	4.095ArgLys: 4.095 ± 0.046	5.109ArgLeu: 5.109 ± 0.05	1.197ArgMet: 1.197 ± 0.017	3.007ArgAsn: 3.007 ± 0.036	2.617ArgPro: 2.617 ± 0.034	2.338ArgGln: 2.338 ± 0.033	4.465ArgArg: 4.465 ± 0.058	4.599ArgSer: 4.599 ± 0.057	3.019ArgThr: 3.019 ± 0.033	3.218ArgVal: 3.218 ± 0.037	0.628ArgTrp: 0.628 ± 0.013	1.772ArgTyr: 1.772 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	4.385SerAla: 4.385 ± 0.045	1.555SerCys: 1.555 ± 0.028	4.171SerAsp: 4.171 ± 0.043	4.954SerGlu: 4.954 ± 0.045	2.778SerPhe: 2.778 ± 0.031	4.824SerGly: 4.824 ± 0.055	1.798SerHis: 1.798 ± 0.031	4.637SerIle: 4.637 ± 0.043	4.857SerLys: 4.857 ± 0.055	7.072SerLeu: 7.072 ± 0.057	1.796SerMet: 1.796 ± 0.026	4.389SerAsn: 4.389 ± 0.044	4.487SerPro: 4.487 ± 0.063	3.324SerGln: 3.324 ± 0.039	4.579SerArg: 4.579 ± 0.059	8.803SerSer: 8.803 ± 0.108	5.552SerThr: 5.552 ± 0.061	4.925SerVal: 4.925 ± 0.041	0.895SerTrp: 0.895 ± 0.017	2.243SerTyr: 2.243 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	3.704ThrAla: 3.704 ± 0.039	1.212ThrCys: 1.212 ± 0.032	2.976ThrAsp: 2.976 ± 0.035	3.945ThrGlu: 3.945 ± 0.062	2.086ThrPhe: 2.086 ± 0.028	3.58ThrGly: 3.58 ± 0.039	1.268ThrHis: 1.268 ± 0.025	3.647ThrIle: 3.647 ± 0.035	3.694ThrLys: 3.694 ± 0.042	5.325ThrLeu: 5.325 ± 0.047	1.38ThrMet: 1.38 ± 0.022	2.995ThrAsn: 2.995 ± 0.035	3.468ThrPro: 3.468 ± 0.084	2.224ThrGln: 2.224 ± 0.028	3.101ThrArg: 3.101 ± 0.032	5.346ThrSer: 5.346 ± 0.05	4.512ThrThr: 4.512 ± 0.081	4.013ThrVal: 4.013 ± 0.049	0.672ThrTrp: 0.672 ± 0.016	1.755ThrTyr: 1.755 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	3.964ValAla: 3.964 ± 0.043	1.355ValCys: 1.355 ± 0.032	3.241ValAsp: 3.241 ± 0.038	4.108ValGlu: 4.108 ± 0.078	2.066ValPhe: 2.066 ± 0.031	3.113ValGly: 3.113 ± 0.035	1.497ValHis: 1.497 ± 0.025	3.623ValIle: 3.623 ± 0.035	3.786ValLys: 3.786 ± 0.049	5.273ValLeu: 5.273 ± 0.054	1.299ValMet: 1.299 ± 0.021	2.901ValAsn: 2.901 ± 0.039	3.297ValPro: 3.297 ± 0.041	2.565ValGln: 2.565 ± 0.032	3.098ValArg: 3.098 ± 0.031	4.865ValSer: 4.865 ± 0.041	4.055ValThr: 4.055 ± 0.071	3.843ValVal: 3.843 ± 0.042	0.695ValTrp: 0.695 ± 0.017	1.786ValTyr: 1.786 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.585TrpAla: 0.585 ± 0.017	0.229TrpCys: 0.229 ± 0.009	0.601TrpAsp: 0.601 ± 0.016	0.662TrpGlu: 0.662 ± 0.016	0.434TrpPhe: 0.434 ± 0.012	0.554TrpGly: 0.554 ± 0.018	0.29TrpHis: 0.29 ± 0.01	0.688TrpIle: 0.688 ± 0.015	0.798TrpLys: 0.798 ± 0.023	1.099TrpLeu: 1.099 ± 0.021	0.28TrpMet: 0.28 ± 0.009	0.627TrpAsn: 0.627 ± 0.014	0.431TrpPro: 0.431 ± 0.011	0.47TrpGln: 0.47 ± 0.011	0.706TrpArg: 0.706 ± 0.015	0.857TrpSer: 0.857 ± 0.019	0.612TrpThr: 0.612 ± 0.014	0.558TrpVal: 0.558 ± 0.014	0.181TrpTrp: 0.181 ± 0.008	0.361TrpTyr: 0.361 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.707TyrAla: 1.707 ± 0.027	0.711TyrCys: 0.711 ± 0.015	1.657TyrAsp: 1.657 ± 0.026	1.913TyrGlu: 1.913 ± 0.026	1.254TyrPhe: 1.254 ± 0.022	1.809TyrGly: 1.809 ± 0.032	0.821TyrHis: 0.821 ± 0.016	1.89TyrIle: 1.89 ± 0.057	1.898TyrLys: 1.898 ± 0.025	2.75TyrLeu: 2.75 ± 0.036	0.687TyrMet: 0.687 ± 0.013	1.655TyrAsn: 1.655 ± 0.028	1.523TyrPro: 1.523 ± 0.042	1.272TyrGln: 1.272 ± 0.021	1.758TyrArg: 1.758 ± 0.027	2.337TyrSer: 2.337 ± 0.032	1.771TyrThr: 1.771 ± 0.027	1.923TyrVal: 1.923 ± 0.028	0.394TyrTrp: 0.394 ± 0.011	1.171TyrTyr: 1.171 ± 0.022	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.059XaaXaa: 0.059 ± 0.02

Statistics based on 7068 proteins (3581618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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