Amino acid dipepetide frequency for Mycobacterium phage Yunkel11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.727AlaAla: 21.727 ± 1.888
1.424AlaCys: 1.424 ± 0.336
8.437AlaAsp: 8.437 ± 0.718
9.545AlaGlu: 9.545 ± 1.103
2.9AlaPhe: 2.9 ± 0.527
9.018AlaGly: 9.018 ± 1.113
3.164AlaHis: 3.164 ± 0.436
6.328AlaIle: 6.328 ± 0.614
3.48AlaLys: 3.48 ± 0.456
11.391AlaLeu: 11.391 ± 0.854
3.217AlaMet: 3.217 ± 0.408
3.164AlaAsn: 3.164 ± 0.5
6.855AlaPro: 6.855 ± 0.567
4.535AlaGln: 4.535 ± 0.554
8.543AlaArg: 8.543 ± 0.796
5.59AlaSer: 5.59 ± 0.765
6.434AlaThr: 6.434 ± 0.777
10.125AlaVal: 10.125 ± 0.665
2.479AlaTrp: 2.479 ± 0.286
2.689AlaTyr: 2.689 ± 0.494
0.0AlaXaa: 0.0 ± 0.0
Cys
1.107CysAla: 1.107 ± 0.238
0.158CysCys: 0.158 ± 0.081
0.58CysAsp: 0.58 ± 0.256
0.58CysGlu: 0.58 ± 0.208
0.264CysPhe: 0.264 ± 0.127
1.687CysGly: 1.687 ± 0.376
0.105CysHis: 0.105 ± 0.071
0.422CysIle: 0.422 ± 0.141
0.264CysLys: 0.264 ± 0.111
0.738CysLeu: 0.738 ± 0.217
0.053CysMet: 0.053 ± 0.058
0.158CysAsn: 0.158 ± 0.085
1.107CysPro: 1.107 ± 0.322
0.264CysGln: 0.264 ± 0.114
0.949CysArg: 0.949 ± 0.263
0.738CysSer: 0.738 ± 0.232
0.686CysThr: 0.686 ± 0.222
0.686CysVal: 0.686 ± 0.205
0.527CysTrp: 0.527 ± 0.151
0.105CysTyr: 0.105 ± 0.065
0.0CysXaa: 0.0 ± 0.0
Asp
7.91AspAla: 7.91 ± 0.811
0.844AspCys: 0.844 ± 0.236
5.959AspAsp: 5.959 ± 0.894
5.59AspGlu: 5.59 ± 0.776
1.318AspPhe: 1.318 ± 0.218
7.066AspGly: 7.066 ± 0.585
0.896AspHis: 0.896 ± 0.204
1.635AspIle: 1.635 ± 0.379
2.268AspLys: 2.268 ± 0.372
5.959AspLeu: 5.959 ± 0.745
1.793AspMet: 1.793 ± 0.319
1.687AspAsn: 1.687 ± 0.246
4.166AspPro: 4.166 ± 0.487
2.32AspGln: 2.32 ± 0.34
4.588AspArg: 4.588 ± 0.572
2.057AspSer: 2.057 ± 0.251
3.006AspThr: 3.006 ± 0.424
3.691AspVal: 3.691 ± 0.371
1.213AspTrp: 1.213 ± 0.247
1.424AspTyr: 1.424 ± 0.272
0.0AspXaa: 0.0 ± 0.0
Glu
8.174GluAla: 8.174 ± 1.062
0.844GluCys: 0.844 ± 0.211
2.109GluAsp: 2.109 ± 0.395
1.16GluGlu: 1.16 ± 0.281
2.268GluPhe: 2.268 ± 0.351
4.377GluGly: 4.377 ± 0.495
1.846GluHis: 1.846 ± 0.343
2.637GluIle: 2.637 ± 0.29
1.371GluLys: 1.371 ± 0.375
5.854GluLeu: 5.854 ± 0.655
1.318GluMet: 1.318 ± 0.283
1.16GluAsn: 1.16 ± 0.256
2.795GluPro: 2.795 ± 0.435
2.373GluGln: 2.373 ± 0.347
5.221GluArg: 5.221 ± 0.555
2.426GluSer: 2.426 ± 0.327
3.006GluThr: 3.006 ± 0.353
5.273GluVal: 5.273 ± 0.73
0.738GluTrp: 0.738 ± 0.229
2.057GluTyr: 2.057 ± 0.355
0.0GluXaa: 0.0 ± 0.0
Phe
3.164PheAla: 3.164 ± 0.468
0.264PheCys: 0.264 ± 0.126
3.059PheAsp: 3.059 ± 0.407
1.371PheGlu: 1.371 ± 0.258
0.633PhePhe: 0.633 ± 0.2
2.848PheGly: 2.848 ± 0.379
0.369PheHis: 0.369 ± 0.154
1.266PheIle: 1.266 ± 0.198
1.107PheLys: 1.107 ± 0.213
1.687PheLeu: 1.687 ± 0.314
0.686PheMet: 0.686 ± 0.207
1.266PheAsn: 1.266 ± 0.282
1.16PhePro: 1.16 ± 0.214
0.633PheGln: 0.633 ± 0.194
1.582PheArg: 1.582 ± 0.322
1.16PheSer: 1.16 ± 0.309
1.582PheThr: 1.582 ± 0.244
2.215PheVal: 2.215 ± 0.335
0.369PheTrp: 0.369 ± 0.129
0.369PheTyr: 0.369 ± 0.191
0.0PheXaa: 0.0 ± 0.0
Gly
11.285GlyAla: 11.285 ± 0.966
1.16GlyCys: 1.16 ± 0.294
5.115GlyAsp: 5.115 ± 0.634
4.588GlyGlu: 4.588 ± 0.522
2.215GlyPhe: 2.215 ± 0.414
10.02GlyGly: 10.02 ± 1.566
1.793GlyHis: 1.793 ± 0.32
2.848GlyIle: 2.848 ± 0.524
3.744GlyLys: 3.744 ± 0.442
6.803GlyLeu: 6.803 ± 0.623
1.898GlyMet: 1.898 ± 0.31
3.27GlyAsn: 3.27 ± 0.412
3.691GlyPro: 3.691 ± 0.566
1.74GlyGln: 1.74 ± 0.305
5.906GlyArg: 5.906 ± 0.515
6.328GlySer: 6.328 ± 0.64
5.326GlyThr: 5.326 ± 0.546
7.225GlyVal: 7.225 ± 0.798
2.742GlyTrp: 2.742 ± 0.366
2.373GlyTyr: 2.373 ± 0.468
0.0GlyXaa: 0.0 ± 0.0
His
2.373HisAla: 2.373 ± 0.35
0.316HisCys: 0.316 ± 0.127
1.635HisAsp: 1.635 ± 0.334
1.371HisGlu: 1.371 ± 0.333
0.527HisPhe: 0.527 ± 0.185
2.479HisGly: 2.479 ± 0.43
0.475HisHis: 0.475 ± 0.152
0.791HisIle: 0.791 ± 0.216
0.475HisLys: 0.475 ± 0.16
1.846HisLeu: 1.846 ± 0.291
0.422HisMet: 0.422 ± 0.146
0.738HisAsn: 0.738 ± 0.186
1.529HisPro: 1.529 ± 0.3
0.264HisGln: 0.264 ± 0.136
1.793HisArg: 1.793 ± 0.301
0.738HisSer: 0.738 ± 0.186
1.477HisThr: 1.477 ± 0.244
1.687HisVal: 1.687 ± 0.335
0.686HisTrp: 0.686 ± 0.221
0.686HisTyr: 0.686 ± 0.2
0.0HisXaa: 0.0 ± 0.0
Ile
6.539IleAla: 6.539 ± 0.611
0.158IleCys: 0.158 ± 0.093
3.322IleAsp: 3.322 ± 0.524
2.9IleGlu: 2.9 ± 0.492
0.58IlePhe: 0.58 ± 0.155
4.324IleGly: 4.324 ± 0.775
0.475IleHis: 0.475 ± 0.171
0.844IleIle: 0.844 ± 0.251
1.687IleLys: 1.687 ± 0.288
2.953IleLeu: 2.953 ± 0.366
0.316IleMet: 0.316 ± 0.128
1.318IleAsn: 1.318 ± 0.241
2.057IlePro: 2.057 ± 0.422
1.002IleGln: 1.002 ± 0.218
2.426IleArg: 2.426 ± 0.398
1.951IleSer: 1.951 ± 0.297
2.479IleThr: 2.479 ± 0.306
3.639IleVal: 3.639 ± 0.471
0.527IleTrp: 0.527 ± 0.168
0.369IleTyr: 0.369 ± 0.129
0.0IleXaa: 0.0 ± 0.0
Lys
3.902LysAla: 3.902 ± 0.474
0.369LysCys: 0.369 ± 0.145
1.107LysAsp: 1.107 ± 0.215
0.475LysGlu: 0.475 ± 0.107
1.213LysPhe: 1.213 ± 0.26
3.006LysGly: 3.006 ± 0.494
0.686LysHis: 0.686 ± 0.214
1.687LysIle: 1.687 ± 0.341
0.844LysLys: 0.844 ± 0.22
3.322LysLeu: 3.322 ± 0.306
1.318LysMet: 1.318 ± 0.294
0.422LysAsn: 0.422 ± 0.159
2.531LysPro: 2.531 ± 0.424
0.633LysGln: 0.633 ± 0.165
3.059LysArg: 3.059 ± 0.491
1.107LysSer: 1.107 ± 0.246
2.004LysThr: 2.004 ± 0.357
3.059LysVal: 3.059 ± 0.39
0.316LysTrp: 0.316 ± 0.109
1.055LysTyr: 1.055 ± 0.304
0.0LysXaa: 0.0 ± 0.0
Leu
12.92LeuAla: 12.92 ± 0.871
0.844LeuCys: 0.844 ± 0.222
7.91LeuAsp: 7.91 ± 0.609
2.373LeuGlu: 2.373 ± 0.369
1.846LeuPhe: 1.846 ± 0.285
6.539LeuGly: 6.539 ± 0.72
2.268LeuHis: 2.268 ± 0.405
3.797LeuIle: 3.797 ± 0.531
2.162LeuLys: 2.162 ± 0.282
5.379LeuLeu: 5.379 ± 0.59
1.635LeuMet: 1.635 ± 0.259
2.268LeuAsn: 2.268 ± 0.344
4.166LeuPro: 4.166 ± 0.613
2.268LeuGln: 2.268 ± 0.373
6.012LeuArg: 6.012 ± 0.636
5.326LeuSer: 5.326 ± 0.416
5.01LeuThr: 5.01 ± 0.518
5.906LeuVal: 5.906 ± 0.583
1.371LeuTrp: 1.371 ± 0.275
1.529LeuTyr: 1.529 ± 0.313
0.0LeuXaa: 0.0 ± 0.0
Met
2.689MetAla: 2.689 ± 0.412
0.053MetCys: 0.053 ± 0.05
0.896MetAsp: 0.896 ± 0.189
0.738MetGlu: 0.738 ± 0.187
1.002MetPhe: 1.002 ± 0.212
1.477MetGly: 1.477 ± 0.311
0.633MetHis: 0.633 ± 0.173
1.002MetIle: 1.002 ± 0.219
0.475MetLys: 0.475 ± 0.152
1.477MetLeu: 1.477 ± 0.295
0.738MetMet: 0.738 ± 0.211
0.844MetAsn: 0.844 ± 0.204
1.266MetPro: 1.266 ± 0.251
0.633MetGln: 0.633 ± 0.166
1.371MetArg: 1.371 ± 0.274
2.531MetSer: 2.531 ± 0.327
2.004MetThr: 2.004 ± 0.328
1.793MetVal: 1.793 ± 0.367
0.422MetTrp: 0.422 ± 0.135
0.422MetTyr: 0.422 ± 0.154
0.0MetXaa: 0.0 ± 0.0
Asn
3.639AsnAla: 3.639 ± 0.494
0.369AsnCys: 0.369 ± 0.14
1.529AsnAsp: 1.529 ± 0.285
1.266AsnGlu: 1.266 ± 0.253
0.949AsnPhe: 0.949 ± 0.335
3.744AsnGly: 3.744 ± 0.451
0.58AsnHis: 0.58 ± 0.14
1.002AsnIle: 1.002 ± 0.233
0.844AsnLys: 0.844 ± 0.195
2.32AsnLeu: 2.32 ± 0.381
0.475AsnMet: 0.475 ± 0.135
0.633AsnAsn: 0.633 ± 0.218
2.373AsnPro: 2.373 ± 0.347
0.633AsnGln: 0.633 ± 0.159
1.424AsnArg: 1.424 ± 0.259
1.055AsnSer: 1.055 ± 0.221
1.635AsnThr: 1.635 ± 0.268
2.373AsnVal: 2.373 ± 0.413
0.475AsnTrp: 0.475 ± 0.157
0.369AsnTyr: 0.369 ± 0.11
0.0AsnXaa: 0.0 ± 0.0
Pro
8.121ProAla: 8.121 ± 0.586
0.527ProCys: 0.527 ± 0.156
3.111ProAsp: 3.111 ± 0.456
4.166ProGlu: 4.166 ± 0.554
1.635ProPhe: 1.635 ± 0.295
5.484ProGly: 5.484 ± 0.521
1.16ProHis: 1.16 ± 0.356
1.898ProIle: 1.898 ± 0.28
2.162ProLys: 2.162 ± 0.414
3.955ProLeu: 3.955 ± 0.501
1.266ProMet: 1.266 ± 0.226
1.424ProAsn: 1.424 ± 0.343
3.111ProPro: 3.111 ± 0.461
1.951ProGln: 1.951 ± 0.377
3.006ProArg: 3.006 ± 0.436
2.848ProSer: 2.848 ± 0.421
2.742ProThr: 2.742 ± 0.415
4.746ProVal: 4.746 ± 0.461
1.213ProTrp: 1.213 ± 0.21
1.371ProTyr: 1.371 ± 0.246
0.0ProXaa: 0.0 ± 0.0
Gln
3.797GlnAla: 3.797 ± 0.54
0.369GlnCys: 0.369 ± 0.161
1.055GlnAsp: 1.055 ± 0.233
1.477GlnGlu: 1.477 ± 0.273
0.844GlnPhe: 0.844 ± 0.222
2.268GlnGly: 2.268 ± 0.281
0.896GlnHis: 0.896 ± 0.186
1.687GlnIle: 1.687 ± 0.253
0.686GlnLys: 0.686 ± 0.201
2.057GlnLeu: 2.057 ± 0.351
1.16GlnMet: 1.16 ± 0.234
0.686GlnAsn: 0.686 ± 0.266
2.004GlnPro: 2.004 ± 0.244
1.529GlnGln: 1.529 ± 0.351
3.006GlnArg: 3.006 ± 0.388
0.738GlnSer: 0.738 ± 0.163
1.846GlnThr: 1.846 ± 0.309
3.428GlnVal: 3.428 ± 0.456
0.738GlnTrp: 0.738 ± 0.209
1.002GlnTyr: 1.002 ± 0.203
0.0GlnXaa: 0.0 ± 0.0
Arg
7.066ArgAla: 7.066 ± 0.773
0.791ArgCys: 0.791 ± 0.275
4.324ArgAsp: 4.324 ± 0.463
5.115ArgGlu: 5.115 ± 0.62
2.109ArgPhe: 2.109 ± 0.363
5.379ArgGly: 5.379 ± 0.54
2.004ArgHis: 2.004 ± 0.314
2.742ArgIle: 2.742 ± 0.413
2.953ArgLys: 2.953 ± 0.509
6.17ArgLeu: 6.17 ± 0.761
2.162ArgMet: 2.162 ± 0.306
2.109ArgAsn: 2.109 ± 0.351
3.586ArgPro: 3.586 ± 0.549
3.164ArgGln: 3.164 ± 0.396
5.801ArgArg: 5.801 ± 0.657
3.006ArgSer: 3.006 ± 0.432
3.797ArgThr: 3.797 ± 0.447
5.168ArgVal: 5.168 ± 0.55
2.057ArgTrp: 2.057 ± 0.321
2.215ArgTyr: 2.215 ± 0.413
0.0ArgXaa: 0.0 ± 0.0
Ser
6.539SerAla: 6.539 ± 0.802
0.316SerCys: 0.316 ± 0.133
2.531SerAsp: 2.531 ± 0.359
2.531SerGlu: 2.531 ± 0.367
1.529SerPhe: 1.529 ± 0.257
4.482SerGly: 4.482 ± 0.613
1.318SerHis: 1.318 ± 0.378
1.846SerIle: 1.846 ± 0.39
1.16SerLys: 1.16 ± 0.265
4.377SerLeu: 4.377 ± 0.432
1.318SerMet: 1.318 ± 0.234
1.213SerAsn: 1.213 ± 0.241
3.428SerPro: 3.428 ± 0.35
1.371SerGln: 1.371 ± 0.213
3.006SerArg: 3.006 ± 0.467
3.322SerSer: 3.322 ± 0.439
3.217SerThr: 3.217 ± 0.319
3.586SerVal: 3.586 ± 0.419
1.318SerTrp: 1.318 ± 0.291
1.266SerTyr: 1.266 ± 0.241
0.0SerXaa: 0.0 ± 0.0
Thr
6.592ThrAla: 6.592 ± 0.82
0.738ThrCys: 0.738 ± 0.215
3.375ThrAsp: 3.375 ± 0.508
3.691ThrGlu: 3.691 ± 0.411
2.004ThrPhe: 2.004 ± 0.274
5.326ThrGly: 5.326 ± 0.639
1.055ThrHis: 1.055 ± 0.286
3.428ThrIle: 3.428 ± 0.463
2.162ThrLys: 2.162 ± 0.33
4.219ThrLeu: 4.219 ± 0.489
0.527ThrMet: 0.527 ± 0.145
1.318ThrAsn: 1.318 ± 0.286
3.533ThrPro: 3.533 ± 0.441
1.424ThrGln: 1.424 ± 0.31
4.008ThrArg: 4.008 ± 0.611
3.164ThrSer: 3.164 ± 0.403
3.217ThrThr: 3.217 ± 0.448
4.852ThrVal: 4.852 ± 0.383
1.16ThrTrp: 1.16 ± 0.213
1.793ThrTyr: 1.793 ± 0.326
0.0ThrXaa: 0.0 ± 0.0
Val
9.281ValAla: 9.281 ± 0.853
1.055ValCys: 1.055 ± 0.247
6.645ValAsp: 6.645 ± 0.659
5.643ValGlu: 5.643 ± 0.738
1.898ValPhe: 1.898 ± 0.31
6.803ValGly: 6.803 ± 0.77
1.846ValHis: 1.846 ± 0.399
2.742ValIle: 2.742 ± 0.376
3.006ValLys: 3.006 ± 0.346
6.117ValLeu: 6.117 ± 0.599
1.424ValMet: 1.424 ± 0.247
2.479ValAsn: 2.479 ± 0.38
4.904ValPro: 4.904 ± 0.564
2.215ValGln: 2.215 ± 0.391
5.484ValArg: 5.484 ± 0.535
3.375ValSer: 3.375 ± 0.387
5.115ValThr: 5.115 ± 0.503
6.645ValVal: 6.645 ± 0.767
2.479ValTrp: 2.479 ± 0.359
1.635ValTyr: 1.635 ± 0.267
0.0ValXaa: 0.0 ± 0.0
Trp
1.635TrpAla: 1.635 ± 0.29
0.264TrpCys: 0.264 ± 0.111
0.896TrpAsp: 0.896 ± 0.25
0.844TrpGlu: 0.844 ± 0.173
0.369TrpPhe: 0.369 ± 0.14
1.529TrpGly: 1.529 ± 0.253
0.422TrpHis: 0.422 ± 0.131
0.791TrpIle: 0.791 ± 0.164
0.475TrpLys: 0.475 ± 0.159
3.059TrpLeu: 3.059 ± 0.374
0.211TrpMet: 0.211 ± 0.111
0.844TrpAsn: 0.844 ± 0.21
0.896TrpPro: 0.896 ± 0.193
1.477TrpGln: 1.477 ± 0.269
2.584TrpArg: 2.584 ± 0.392
0.791TrpSer: 0.791 ± 0.209
1.16TrpThr: 1.16 ± 0.229
2.426TrpVal: 2.426 ± 0.34
0.633TrpTrp: 0.633 ± 0.174
0.633TrpTyr: 0.633 ± 0.163
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.584TyrAla: 2.584 ± 0.309
0.316TyrCys: 0.316 ± 0.121
1.793TyrAsp: 1.793 ± 0.291
1.582TyrGlu: 1.582 ± 0.244
0.686TyrPhe: 0.686 ± 0.152
2.215TyrGly: 2.215 ± 0.394
0.316TyrHis: 0.316 ± 0.125
0.475TyrIle: 0.475 ± 0.145
0.791TyrLys: 0.791 ± 0.216
1.846TyrLeu: 1.846 ± 0.314
0.475TyrMet: 0.475 ± 0.142
0.686TyrAsn: 0.686 ± 0.145
0.738TyrPro: 0.738 ± 0.207
0.844TyrGln: 0.844 ± 0.22
2.004TyrArg: 2.004 ± 0.357
1.424TyrSer: 1.424 ± 0.261
1.846TyrThr: 1.846 ± 0.324
2.268TyrVal: 2.268 ± 0.402
0.475TyrTrp: 0.475 ± 0.196
0.316TyrTyr: 0.316 ± 0.125
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 100 proteins (18964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski