Amino acid dipepetide frequency for Rose spring dwarf-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.661AlaAla: 5.661 ± 0.881
0.0AlaCys: 0.0 ± 0.0
3.235AlaAsp: 3.235 ± 0.971
2.022AlaGlu: 2.022 ± 0.689
2.426AlaPhe: 2.426 ± 0.521
4.852AlaGly: 4.852 ± 3.052
0.809AlaHis: 0.809 ± 0.305
2.426AlaIle: 2.426 ± 1.057
3.235AlaLys: 3.235 ± 0.316
4.448AlaLeu: 4.448 ± 1.166
2.426AlaMet: 2.426 ± 1.076
0.809AlaAsn: 0.809 ± 0.305
4.044AlaPro: 4.044 ± 1.633
3.235AlaGln: 3.235 ± 0.841
9.3AlaArg: 9.3 ± 1.442
5.257AlaSer: 5.257 ± 1.435
4.448AlaThr: 4.448 ± 1.071
3.235AlaVal: 3.235 ± 1.245
0.404AlaTrp: 0.404 ± 0.294
1.213AlaTyr: 1.213 ± 0.529
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.617CysAsp: 1.617 ± 0.765
2.022CysGlu: 2.022 ± 0.674
0.404CysPhe: 0.404 ± 0.282
1.213CysGly: 1.213 ± 0.481
1.213CysHis: 1.213 ± 0.317
1.213CysIle: 1.213 ± 0.538
2.022CysLys: 2.022 ± 0.61
1.617CysLeu: 1.617 ± 0.809
0.809CysMet: 0.809 ± 0.408
0.404CysAsn: 0.404 ± 0.294
0.404CysPro: 0.404 ± 0.294
1.213CysGln: 1.213 ± 0.562
0.404CysArg: 0.404 ± 0.294
0.809CysSer: 0.809 ± 0.598
0.809CysThr: 0.809 ± 0.598
0.809CysVal: 0.809 ± 0.727
0.809CysTrp: 0.809 ± 0.598
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.257AspAla: 5.257 ± 0.596
1.213AspCys: 1.213 ± 0.538
3.639AspAsp: 3.639 ± 0.586
5.661AspGlu: 5.661 ± 1.267
4.044AspPhe: 4.044 ± 1.423
2.426AspGly: 2.426 ± 0.479
0.404AspHis: 0.404 ± 0.282
4.044AspIle: 4.044 ± 0.938
4.044AspLys: 4.044 ± 0.849
2.022AspLeu: 2.022 ± 0.413
0.809AspMet: 0.809 ± 0.408
3.639AspAsn: 3.639 ± 0.72
4.448AspPro: 4.448 ± 0.938
1.617AspGln: 1.617 ± 0.61
0.404AspArg: 0.404 ± 0.294
2.831AspSer: 2.831 ± 0.831
3.235AspThr: 3.235 ± 1.042
3.235AspVal: 3.235 ± 0.587
0.809AspTrp: 0.809 ± 0.565
0.809AspTyr: 0.809 ± 0.598
0.0AspXaa: 0.0 ± 0.0
Glu
4.852GluAla: 4.852 ± 1.048
0.404GluCys: 0.404 ± 0.282
6.066GluAsp: 6.066 ± 0.902
4.044GluGlu: 4.044 ± 1.274
4.044GluPhe: 4.044 ± 0.417
2.831GluGly: 2.831 ± 0.541
0.404GluHis: 0.404 ± 0.294
0.809GluIle: 0.809 ± 0.305
3.235GluLys: 3.235 ± 1.109
5.257GluLeu: 5.257 ± 2.17
0.809GluMet: 0.809 ± 0.715
0.404GluAsn: 0.404 ± 0.282
3.235GluPro: 3.235 ± 1.124
2.022GluGln: 2.022 ± 0.669
4.852GluArg: 4.852 ± 1.162
3.235GluSer: 3.235 ± 1.067
1.617GluThr: 1.617 ± 0.529
10.109GluVal: 10.109 ± 3.505
0.404GluTrp: 0.404 ± 0.587
2.426GluTyr: 2.426 ± 0.634
0.404GluXaa: 0.404 ± 0.282
Phe
1.617PheAla: 1.617 ± 0.619
1.617PheCys: 1.617 ± 0.765
3.235PheAsp: 3.235 ± 0.822
3.639PheGlu: 3.639 ± 1.614
1.213PhePhe: 1.213 ± 0.763
2.831PheGly: 2.831 ± 0.599
3.235PheHis: 3.235 ± 0.581
1.213PheIle: 1.213 ± 0.317
2.022PheLys: 2.022 ± 1.245
5.661PheLeu: 5.661 ± 1.342
0.809PheMet: 0.809 ± 0.964
2.426PheAsn: 2.426 ± 0.735
1.213PhePro: 1.213 ± 0.509
2.022PheGln: 2.022 ± 0.434
1.213PheArg: 1.213 ± 0.882
3.235PheSer: 3.235 ± 0.906
3.639PheThr: 3.639 ± 0.943
3.235PheVal: 3.235 ± 0.645
1.213PheTrp: 1.213 ± 0.538
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
3.639GlyAla: 3.639 ± 1.081
0.809GlyCys: 0.809 ± 0.623
1.213GlyAsp: 1.213 ± 0.882
2.426GlyGlu: 2.426 ± 0.634
1.213GlyPhe: 1.213 ± 0.529
3.235GlyGly: 3.235 ± 1.441
1.617GlyHis: 1.617 ± 0.765
1.617GlyIle: 1.617 ± 0.528
5.661GlyLys: 5.661 ± 0.63
3.639GlyLeu: 3.639 ± 1.685
0.0GlyMet: 0.0 ± 0.0
1.617GlyAsn: 1.617 ± 0.528
4.044GlyPro: 4.044 ± 1.496
3.235GlyGln: 3.235 ± 1.763
4.448GlyArg: 4.448 ± 1.447
4.044GlySer: 4.044 ± 1.793
1.617GlyThr: 1.617 ± 0.983
5.257GlyVal: 5.257 ± 1.599
0.809GlyTrp: 0.809 ± 0.598
2.831GlyTyr: 2.831 ± 1.156
0.0GlyXaa: 0.0 ± 0.0
His
1.617HisAla: 1.617 ± 0.527
0.404HisCys: 0.404 ± 0.282
0.809HisAsp: 0.809 ± 0.408
1.617HisGlu: 1.617 ± 0.614
0.809HisPhe: 0.809 ± 0.596
0.404HisGly: 0.404 ± 0.282
0.809HisHis: 0.809 ± 0.587
0.404HisIle: 0.404 ± 0.282
0.809HisLys: 0.809 ± 0.623
1.213HisLeu: 1.213 ± 0.725
0.404HisMet: 0.404 ± 0.282
0.404HisAsn: 0.404 ± 0.294
1.617HisPro: 1.617 ± 0.686
1.213HisGln: 1.213 ± 0.867
1.617HisArg: 1.617 ± 0.647
4.448HisSer: 4.448 ± 1.658
0.404HisThr: 0.404 ± 0.282
1.617HisVal: 1.617 ± 0.387
0.809HisTrp: 0.809 ± 0.598
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.235IleAla: 3.235 ± 0.67
1.213IleCys: 1.213 ± 0.529
2.426IleAsp: 2.426 ± 1.076
4.044IleGlu: 4.044 ± 0.92
3.235IlePhe: 3.235 ± 0.773
0.404IleGly: 0.404 ± 0.294
0.404IleHis: 0.404 ± 0.53
1.617IleIle: 1.617 ± 0.61
1.213IleLys: 1.213 ± 0.538
4.044IleLeu: 4.044 ± 1.212
1.213IleMet: 1.213 ± 0.866
2.426IleAsn: 2.426 ± 0.521
1.213IlePro: 1.213 ± 0.618
0.404IleGln: 0.404 ± 0.282
3.639IleArg: 3.639 ± 0.637
3.639IleSer: 3.639 ± 0.62
4.448IleThr: 4.448 ± 1.909
4.044IleVal: 4.044 ± 1.355
0.0IleTrp: 0.0 ± 0.0
1.213IleTyr: 1.213 ± 0.317
0.0IleXaa: 0.0 ± 0.0
Lys
2.831LysAla: 2.831 ± 1.072
1.617LysCys: 1.617 ± 0.527
4.044LysAsp: 4.044 ± 0.388
0.809LysGlu: 0.809 ± 0.408
5.257LysPhe: 5.257 ± 0.933
1.617LysGly: 1.617 ± 1.018
2.426LysHis: 2.426 ± 0.617
5.257LysIle: 5.257 ± 0.628
3.235LysLys: 3.235 ± 1.067
3.639LysLeu: 3.639 ± 0.667
1.617LysMet: 1.617 ± 0.765
2.831LysAsn: 2.831 ± 0.97
2.022LysPro: 2.022 ± 0.61
1.213LysGln: 1.213 ± 0.618
4.448LysArg: 4.448 ± 1.3
5.257LysSer: 5.257 ± 1.736
3.639LysThr: 3.639 ± 0.943
2.831LysVal: 2.831 ± 0.801
0.809LysTrp: 0.809 ± 0.588
1.213LysTyr: 1.213 ± 0.763
0.0LysXaa: 0.0 ± 0.0
Leu
3.235LeuAla: 3.235 ± 0.914
3.235LeuCys: 3.235 ± 1.418
2.022LeuAsp: 2.022 ± 0.99
4.044LeuGlu: 4.044 ± 1.221
2.426LeuPhe: 2.426 ± 0.721
2.831LeuGly: 2.831 ± 1.323
1.617LeuHis: 1.617 ± 1.161
1.617LeuIle: 1.617 ± 0.765
8.896LeuLys: 8.896 ± 1.233
6.874LeuLeu: 6.874 ± 1.265
2.426LeuMet: 2.426 ± 1.076
5.661LeuAsn: 5.661 ± 0.647
6.47LeuPro: 6.47 ± 1.542
3.235LeuGln: 3.235 ± 0.611
6.874LeuArg: 6.874 ± 1.752
2.831LeuSer: 2.831 ± 0.899
3.235LeuThr: 3.235 ± 1.127
5.661LeuVal: 5.661 ± 2.198
0.809LeuTrp: 0.809 ± 0.408
2.022LeuTyr: 2.022 ± 0.706
0.0LeuXaa: 0.0 ± 0.0
Met
1.617MetAla: 1.617 ± 0.614
0.404MetCys: 0.404 ± 0.294
3.639MetAsp: 3.639 ± 1.578
1.617MetGlu: 1.617 ± 0.387
0.404MetPhe: 0.404 ± 0.294
0.809MetGly: 0.809 ± 0.588
1.213MetHis: 1.213 ± 0.538
0.0MetIle: 0.0 ± 0.0
1.213MetLys: 1.213 ± 0.538
2.426MetLeu: 2.426 ± 0.794
0.0MetMet: 0.0 ± 0.0
0.404MetAsn: 0.404 ± 0.587
0.0MetPro: 0.0 ± 0.0
1.213MetGln: 1.213 ± 0.618
1.213MetArg: 1.213 ± 0.72
3.639MetSer: 3.639 ± 0.988
1.213MetThr: 1.213 ± 0.538
2.022MetVal: 2.022 ± 0.908
0.0MetTrp: 0.0 ± 0.0
0.404MetTyr: 0.404 ± 0.577
0.0MetXaa: 0.0 ± 0.0
Asn
2.022AsnAla: 2.022 ± 0.61
0.809AsnCys: 0.809 ± 0.408
1.617AsnAsp: 1.617 ± 0.765
0.809AsnGlu: 0.809 ± 0.588
0.0AsnPhe: 0.0 ± 0.0
4.852AsnGly: 4.852 ± 1.63
0.0AsnHis: 0.0 ± 0.0
1.213AsnIle: 1.213 ± 0.538
2.426AsnLys: 2.426 ± 0.453
5.257AsnLeu: 5.257 ± 1.116
0.404AsnMet: 0.404 ± 0.669
3.639AsnAsn: 3.639 ± 1.684
1.617AsnPro: 1.617 ± 0.859
1.617AsnGln: 1.617 ± 0.921
1.617AsnArg: 1.617 ± 0.647
4.852AsnSer: 4.852 ± 0.888
1.617AsnThr: 1.617 ± 0.387
3.235AsnVal: 3.235 ± 1.376
0.404AsnTrp: 0.404 ± 0.282
0.809AsnTyr: 0.809 ± 0.305
0.0AsnXaa: 0.0 ± 0.0
Pro
5.257ProAla: 5.257 ± 1.512
0.809ProCys: 0.809 ± 0.408
4.852ProAsp: 4.852 ± 0.97
3.639ProGlu: 3.639 ± 1.048
2.831ProPhe: 2.831 ± 0.97
3.639ProGly: 3.639 ± 2.241
1.213ProHis: 1.213 ± 0.618
4.044ProIle: 4.044 ± 1.423
2.831ProLys: 2.831 ± 0.711
4.448ProLeu: 4.448 ± 1.672
0.809ProMet: 0.809 ± 0.623
1.213ProAsn: 1.213 ± 0.481
4.044ProPro: 4.044 ± 1.917
1.617ProGln: 1.617 ± 0.669
5.661ProArg: 5.661 ± 1.079
6.066ProSer: 6.066 ± 2.03
4.044ProThr: 4.044 ± 1.793
8.492ProVal: 8.492 ± 1.438
0.809ProTrp: 0.809 ± 0.408
0.404ProTyr: 0.404 ± 0.282
0.0ProXaa: 0.0 ± 0.0
Gln
4.044GlnAla: 4.044 ± 1.785
1.213GlnCys: 1.213 ± 0.481
2.022GlnAsp: 2.022 ± 0.908
1.617GlnGlu: 1.617 ± 0.529
4.044GlnPhe: 4.044 ± 1.546
2.426GlnGly: 2.426 ± 0.44
0.809GlnHis: 0.809 ± 0.587
1.617GlnIle: 1.617 ± 0.765
1.213GlnLys: 1.213 ± 0.631
4.044GlnLeu: 4.044 ± 2.139
0.0GlnMet: 0.0 ± 0.0
0.404GlnAsn: 0.404 ± 0.587
4.448GlnPro: 4.448 ± 1.357
3.235GlnGln: 3.235 ± 1.308
2.426GlnArg: 2.426 ± 1.076
2.426GlnSer: 2.426 ± 1.042
4.044GlnThr: 4.044 ± 2.101
2.022GlnVal: 2.022 ± 0.706
0.404GlnTrp: 0.404 ± 0.587
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
4.044ArgAla: 4.044 ± 0.77
2.022ArgCys: 2.022 ± 0.434
2.831ArgAsp: 2.831 ± 1.085
6.874ArgGlu: 6.874 ± 1.41
2.426ArgPhe: 2.426 ± 0.479
3.639ArgGly: 3.639 ± 1.46
0.404ArgHis: 0.404 ± 0.294
3.235ArgIle: 3.235 ± 1.226
1.617ArgLys: 1.617 ± 0.799
6.874ArgLeu: 6.874 ± 1.321
4.448ArgMet: 4.448 ± 1.04
3.235ArgAsn: 3.235 ± 1.763
6.47ArgPro: 6.47 ± 1.375
3.235ArgGln: 3.235 ± 1.44
10.514ArgArg: 10.514 ± 3.539
7.683ArgSer: 7.683 ± 1.197
1.617ArgThr: 1.617 ± 0.645
4.852ArgVal: 4.852 ± 1.429
1.213ArgTrp: 1.213 ± 0.763
2.022ArgTyr: 2.022 ± 0.61
0.0ArgXaa: 0.0 ± 0.0
Ser
4.044SerAla: 4.044 ± 0.902
0.809SerCys: 0.809 ± 0.598
2.426SerAsp: 2.426 ± 1.488
3.639SerGlu: 3.639 ± 0.749
4.044SerPhe: 4.044 ± 0.611
6.47SerGly: 6.47 ± 1.191
2.022SerHis: 2.022 ± 0.731
3.639SerIle: 3.639 ± 0.732
2.022SerLys: 2.022 ± 0.61
4.044SerLeu: 4.044 ± 1.582
2.831SerMet: 2.831 ± 1.637
2.022SerAsn: 2.022 ± 1.106
6.874SerPro: 6.874 ± 1.187
5.257SerGln: 5.257 ± 1.675
9.3SerArg: 9.3 ± 2.675
9.3SerSer: 9.3 ± 2.608
4.044SerThr: 4.044 ± 2.263
5.257SerVal: 5.257 ± 0.611
2.426SerTrp: 2.426 ± 1.279
4.448SerTyr: 4.448 ± 1.159
0.0SerXaa: 0.0 ± 0.0
Thr
4.044ThrAla: 4.044 ± 0.575
0.404ThrCys: 0.404 ± 0.76
2.426ThrAsp: 2.426 ± 0.746
1.617ThrGlu: 1.617 ± 0.44
1.213ThrPhe: 1.213 ± 0.538
2.426ThrGly: 2.426 ± 0.453
1.213ThrHis: 1.213 ± 0.481
4.044ThrIle: 4.044 ± 1.182
1.617ThrLys: 1.617 ± 1.084
2.831ThrLeu: 2.831 ± 0.845
1.617ThrMet: 1.617 ± 0.387
1.617ThrAsn: 1.617 ± 1.0
4.448ThrPro: 4.448 ± 1.831
2.426ThrGln: 2.426 ± 1.079
3.639ThrArg: 3.639 ± 1.076
7.279ThrSer: 7.279 ± 2.556
3.235ThrThr: 3.235 ± 1.765
3.235ThrVal: 3.235 ± 0.821
1.213ThrTrp: 1.213 ± 0.317
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
5.257ValAla: 5.257 ± 0.933
0.404ValCys: 0.404 ± 0.282
6.066ValAsp: 6.066 ± 1.601
8.492ValGlu: 8.492 ± 1.642
3.235ValPhe: 3.235 ± 1.035
3.639ValGly: 3.639 ± 0.932
0.809ValHis: 0.809 ± 0.408
2.831ValIle: 2.831 ± 0.994
7.279ValLys: 7.279 ± 1.104
4.044ValLeu: 4.044 ± 1.197
0.0ValMet: 0.0 ± 0.0
3.235ValAsn: 3.235 ± 1.415
7.683ValPro: 7.683 ± 0.735
2.426ValGln: 2.426 ± 1.178
6.47ValArg: 6.47 ± 0.806
4.852ValSer: 4.852 ± 1.106
2.022ValThr: 2.022 ± 0.61
8.087ValVal: 8.087 ± 2.831
0.0ValTrp: 0.0 ± 0.0
4.044ValTyr: 4.044 ± 1.144
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.213TrpGlu: 1.213 ± 0.763
1.213TrpPhe: 1.213 ± 0.481
0.404TrpGly: 0.404 ± 0.294
0.0TrpHis: 0.0 ± 0.0
1.213TrpIle: 1.213 ± 0.317
0.809TrpLys: 0.809 ± 0.305
2.426TrpLeu: 2.426 ± 0.651
0.0TrpMet: 0.0 ± 0.0
0.404TrpAsn: 0.404 ± 0.282
2.022TrpPro: 2.022 ± 0.617
0.404TrpGln: 0.404 ± 0.294
0.0TrpArg: 0.0 ± 0.0
0.809TrpSer: 0.809 ± 0.596
1.213TrpThr: 1.213 ± 0.763
0.809TrpVal: 0.809 ± 0.408
0.0TrpTrp: 0.0 ± 0.0
0.404TrpTyr: 0.404 ± 0.282
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.213TyrAla: 1.213 ± 0.763
0.404TyrCys: 0.404 ± 0.294
0.404TyrAsp: 0.404 ± 0.294
1.617TyrGlu: 1.617 ± 0.765
1.213TyrPhe: 1.213 ± 0.882
2.022TyrGly: 2.022 ± 0.61
0.809TyrHis: 0.809 ± 0.803
2.022TyrIle: 2.022 ± 0.434
1.213TyrLys: 1.213 ± 0.481
1.213TyrLeu: 1.213 ± 0.481
1.617TyrMet: 1.617 ± 0.685
2.022TyrAsn: 2.022 ± 0.791
0.404TyrPro: 0.404 ± 0.294
1.617TyrGln: 1.617 ± 0.387
0.809TyrArg: 0.809 ± 0.588
2.426TyrSer: 2.426 ± 0.634
0.404TyrThr: 0.404 ± 0.282
2.831TyrVal: 2.831 ± 0.644
0.0TyrTrp: 0.0 ± 0.0
1.213TyrTyr: 1.213 ± 0.763
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.404XaaArg: 0.404 ± 0.282
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2474 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski