Amino acid dipepetide frequency for Streptococcus phage CHPC1247

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.007AlaAla: 7.007 ± 2.799
0.28AlaCys: 0.28 ± 0.164
4.951AlaAsp: 4.951 ± 0.915
4.858AlaGlu: 4.858 ± 0.951
2.896AlaPhe: 2.896 ± 1.117
4.858AlaGly: 4.858 ± 1.418
0.841AlaHis: 0.841 ± 0.229
5.979AlaIle: 5.979 ± 1.681
5.045AlaLys: 5.045 ± 0.774
6.913AlaLeu: 6.913 ± 1.277
2.242AlaMet: 2.242 ± 1.25
4.951AlaAsn: 4.951 ± 0.867
2.055AlaPro: 2.055 ± 0.498
4.017AlaGln: 4.017 ± 0.995
3.363AlaArg: 3.363 ± 0.609
6.259AlaSer: 6.259 ± 1.744
4.017AlaThr: 4.017 ± 0.955
5.045AlaVal: 5.045 ± 1.275
0.561AlaTrp: 0.561 ± 0.194
2.242AlaTyr: 2.242 ± 0.559
0.0AlaXaa: 0.0 ± 0.0
Cys
0.374CysAla: 0.374 ± 0.193
0.0CysCys: 0.0 ± 0.0
0.467CysAsp: 0.467 ± 0.246
0.654CysGlu: 0.654 ± 0.279
0.093CysPhe: 0.093 ± 0.115
0.374CysGly: 0.374 ± 0.264
0.187CysHis: 0.187 ± 0.163
0.093CysIle: 0.093 ± 0.094
0.841CysLys: 0.841 ± 0.289
0.28CysLeu: 0.28 ± 0.234
0.093CysMet: 0.093 ± 0.108
0.093CysAsn: 0.093 ± 0.108
0.187CysPro: 0.187 ± 0.183
0.0CysGln: 0.0 ± 0.0
0.093CysArg: 0.093 ± 0.097
0.934CysSer: 0.934 ± 0.354
0.0CysThr: 0.0 ± 0.0
0.467CysVal: 0.467 ± 0.175
0.093CysTrp: 0.093 ± 0.116
0.467CysTyr: 0.467 ± 0.216
0.0CysXaa: 0.0 ± 0.0
Asp
3.55AspAla: 3.55 ± 0.568
0.841AspCys: 0.841 ± 0.354
4.111AspAsp: 4.111 ± 0.663
4.484AspGlu: 4.484 ± 0.911
2.99AspPhe: 2.99 ± 0.512
5.512AspGly: 5.512 ± 0.611
0.561AspHis: 0.561 ± 0.27
3.643AspIle: 3.643 ± 0.592
4.671AspLys: 4.671 ± 0.835
4.578AspLeu: 4.578 ± 0.678
1.495AspMet: 1.495 ± 0.447
3.924AspAsn: 3.924 ± 0.848
0.841AspPro: 0.841 ± 0.256
1.028AspGln: 1.028 ± 0.267
3.083AspArg: 3.083 ± 0.627
3.643AspSer: 3.643 ± 0.596
3.83AspThr: 3.83 ± 0.612
3.363AspVal: 3.363 ± 0.569
0.934AspTrp: 0.934 ± 0.392
2.616AspTyr: 2.616 ± 0.497
0.0AspXaa: 0.0 ± 0.0
Glu
4.951GluAla: 4.951 ± 0.807
0.093GluCys: 0.093 ± 0.103
2.896GluAsp: 2.896 ± 0.673
5.045GluGlu: 5.045 ± 1.399
2.709GluPhe: 2.709 ± 0.559
2.99GluGly: 2.99 ± 0.659
0.841GluHis: 0.841 ± 0.283
6.446GluIle: 6.446 ± 1.358
5.512GluLys: 5.512 ± 1.473
7.848GluLeu: 7.848 ± 1.509
2.429GluMet: 2.429 ± 0.698
4.578GluAsn: 4.578 ± 0.664
1.588GluPro: 1.588 ± 0.537
3.737GluGln: 3.737 ± 0.837
3.737GluArg: 3.737 ± 0.736
3.083GluSer: 3.083 ± 0.754
4.204GluThr: 4.204 ± 0.765
5.512GluVal: 5.512 ± 0.97
0.934GluTrp: 0.934 ± 0.333
3.643GluTyr: 3.643 ± 0.854
0.0GluXaa: 0.0 ± 0.0
Phe
2.242PheAla: 2.242 ± 0.498
0.187PheCys: 0.187 ± 0.159
2.99PheAsp: 2.99 ± 0.613
3.924PheGlu: 3.924 ± 0.747
1.121PhePhe: 1.121 ± 0.337
3.55PheGly: 3.55 ± 0.94
0.467PheHis: 0.467 ± 0.172
2.803PheIle: 2.803 ± 0.452
4.765PheLys: 4.765 ± 0.586
2.055PheLeu: 2.055 ± 0.447
0.654PheMet: 0.654 ± 0.315
2.803PheAsn: 2.803 ± 0.502
0.467PhePro: 0.467 ± 0.222
1.121PheGln: 1.121 ± 0.271
1.028PheArg: 1.028 ± 0.287
3.55PheSer: 3.55 ± 0.78
2.616PheThr: 2.616 ± 0.457
2.709PheVal: 2.709 ± 0.53
0.654PheTrp: 0.654 ± 0.254
1.028PheTyr: 1.028 ± 0.321
0.0PheXaa: 0.0 ± 0.0
Gly
4.765GlyAla: 4.765 ± 1.148
0.467GlyCys: 0.467 ± 0.22
2.522GlyAsp: 2.522 ± 0.401
3.363GlyGlu: 3.363 ± 0.649
2.99GlyPhe: 2.99 ± 0.465
3.176GlyGly: 3.176 ± 0.518
0.654GlyHis: 0.654 ± 0.25
6.166GlyIle: 6.166 ± 1.876
5.138GlyLys: 5.138 ± 0.893
6.54GlyLeu: 6.54 ± 1.161
1.588GlyMet: 1.588 ± 0.915
3.27GlyAsn: 3.27 ± 0.502
0.654GlyPro: 0.654 ± 0.255
2.709GlyGln: 2.709 ± 0.409
2.803GlyArg: 2.803 ± 0.538
4.017GlySer: 4.017 ± 0.933
5.045GlyThr: 5.045 ± 0.93
4.858GlyVal: 4.858 ± 0.655
0.747GlyTrp: 0.747 ± 0.249
3.363GlyTyr: 3.363 ± 0.598
0.0GlyXaa: 0.0 ± 0.0
His
0.841HisAla: 0.841 ± 0.259
0.187HisCys: 0.187 ± 0.124
0.934HisAsp: 0.934 ± 0.299
0.747HisGlu: 0.747 ± 0.32
0.654HisPhe: 0.654 ± 0.235
0.654HisGly: 0.654 ± 0.273
0.561HisHis: 0.561 ± 0.259
0.747HisIle: 0.747 ± 0.265
0.934HisLys: 0.934 ± 0.29
1.214HisLeu: 1.214 ± 0.372
0.374HisMet: 0.374 ± 0.163
0.747HisAsn: 0.747 ± 0.289
0.28HisPro: 0.28 ± 0.175
0.374HisGln: 0.374 ± 0.183
0.654HisArg: 0.654 ± 0.248
0.747HisSer: 0.747 ± 0.221
1.028HisThr: 1.028 ± 0.351
0.841HisVal: 0.841 ± 0.39
0.093HisTrp: 0.093 ± 0.108
0.561HisTyr: 0.561 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
5.325IleAla: 5.325 ± 1.168
0.561IleCys: 0.561 ± 0.252
4.671IleAsp: 4.671 ± 0.622
5.045IleGlu: 5.045 ± 1.241
1.588IlePhe: 1.588 ± 0.295
5.325IleGly: 5.325 ± 1.171
0.934IleHis: 0.934 ± 0.265
3.457IleIle: 3.457 ± 0.795
6.259IleLys: 6.259 ± 0.852
3.083IleLeu: 3.083 ± 0.416
1.868IleMet: 1.868 ± 0.365
3.176IleAsn: 3.176 ± 0.754
2.242IlePro: 2.242 ± 0.614
3.737IleGln: 3.737 ± 0.526
2.616IleArg: 2.616 ± 0.685
5.419IleSer: 5.419 ± 1.396
4.204IleThr: 4.204 ± 0.817
4.484IleVal: 4.484 ± 0.677
0.561IleTrp: 0.561 ± 0.244
2.616IleTyr: 2.616 ± 0.643
0.0IleXaa: 0.0 ± 0.0
Lys
6.726LysAla: 6.726 ± 1.017
0.28LysCys: 0.28 ± 0.183
3.924LysAsp: 3.924 ± 0.651
8.128LysGlu: 8.128 ± 1.847
2.522LysPhe: 2.522 ± 0.547
5.325LysGly: 5.325 ± 0.577
1.401LysHis: 1.401 ± 0.434
4.858LysIle: 4.858 ± 0.713
6.166LysLys: 6.166 ± 1.328
6.633LysLeu: 6.633 ± 1.15
1.682LysMet: 1.682 ± 0.457
3.27LysAsn: 3.27 ± 0.845
3.363LysPro: 3.363 ± 0.575
2.896LysGln: 2.896 ± 0.702
5.699LysArg: 5.699 ± 0.938
4.297LysSer: 4.297 ± 0.54
5.979LysThr: 5.979 ± 0.959
3.924LysVal: 3.924 ± 0.57
1.121LysTrp: 1.121 ± 0.31
3.363LysTyr: 3.363 ± 0.789
0.0LysXaa: 0.0 ± 0.0
Leu
6.726LeuAla: 6.726 ± 0.959
0.093LeuCys: 0.093 ± 0.091
5.325LeuAsp: 5.325 ± 0.913
6.446LeuGlu: 6.446 ± 1.169
2.616LeuPhe: 2.616 ± 0.437
4.858LeuGly: 4.858 ± 1.149
0.654LeuHis: 0.654 ± 0.291
4.111LeuIle: 4.111 ± 0.495
6.259LeuLys: 6.259 ± 0.92
4.765LeuLeu: 4.765 ± 0.711
2.149LeuMet: 2.149 ± 0.412
5.605LeuAsn: 5.605 ± 0.754
2.522LeuPro: 2.522 ± 0.486
2.616LeuGln: 2.616 ± 0.502
3.363LeuArg: 3.363 ± 0.875
5.419LeuSer: 5.419 ± 0.696
5.979LeuThr: 5.979 ± 0.946
4.858LeuVal: 4.858 ± 0.535
0.467LeuTrp: 0.467 ± 0.282
3.176LeuTyr: 3.176 ± 0.704
0.0LeuXaa: 0.0 ± 0.0
Met
2.522MetAla: 2.522 ± 1.0
0.0MetCys: 0.0 ± 0.0
1.401MetAsp: 1.401 ± 0.372
1.308MetGlu: 1.308 ± 0.398
1.028MetPhe: 1.028 ± 0.263
1.308MetGly: 1.308 ± 0.469
0.0MetHis: 0.0 ± 0.0
1.028MetIle: 1.028 ± 0.339
2.242MetLys: 2.242 ± 0.518
1.775MetLeu: 1.775 ± 0.38
1.121MetMet: 1.121 ± 0.554
1.214MetAsn: 1.214 ± 0.387
0.467MetPro: 0.467 ± 0.208
1.214MetGln: 1.214 ± 0.538
0.934MetArg: 0.934 ± 0.305
2.429MetSer: 2.429 ± 0.587
1.775MetThr: 1.775 ± 0.39
1.962MetVal: 1.962 ± 0.591
0.0MetTrp: 0.0 ± 0.0
0.747MetTyr: 0.747 ± 0.295
0.0MetXaa: 0.0 ± 0.0
Asn
4.017AsnAla: 4.017 ± 0.654
0.28AsnCys: 0.28 ± 0.166
3.363AsnAsp: 3.363 ± 0.552
3.643AsnGlu: 3.643 ± 0.858
2.99AsnPhe: 2.99 ± 0.568
5.325AsnGly: 5.325 ± 0.947
1.121AsnHis: 1.121 ± 0.452
3.176AsnIle: 3.176 ± 0.646
4.297AsnLys: 4.297 ± 0.767
4.671AsnLeu: 4.671 ± 0.879
1.028AsnMet: 1.028 ± 0.272
2.896AsnAsn: 2.896 ± 0.679
2.896AsnPro: 2.896 ± 0.485
1.775AsnGln: 1.775 ± 0.501
2.055AsnArg: 2.055 ± 0.605
3.83AsnSer: 3.83 ± 0.67
2.616AsnThr: 2.616 ± 0.475
2.616AsnVal: 2.616 ± 0.444
1.214AsnTrp: 1.214 ± 0.39
1.962AsnTyr: 1.962 ± 0.483
0.0AsnXaa: 0.0 ± 0.0
Pro
1.775ProAla: 1.775 ± 0.375
0.28ProCys: 0.28 ± 0.197
1.868ProAsp: 1.868 ± 0.552
1.682ProGlu: 1.682 ± 0.463
0.934ProPhe: 0.934 ± 0.274
0.934ProGly: 0.934 ± 0.306
0.561ProHis: 0.561 ± 0.172
1.682ProIle: 1.682 ± 0.391
2.896ProLys: 2.896 ± 0.512
1.868ProLeu: 1.868 ± 0.395
0.187ProMet: 0.187 ± 0.134
1.962ProAsn: 1.962 ± 0.415
1.028ProPro: 1.028 ± 0.223
1.682ProGln: 1.682 ± 0.403
1.121ProArg: 1.121 ± 0.379
2.242ProSer: 2.242 ± 0.499
1.121ProThr: 1.121 ± 0.437
1.682ProVal: 1.682 ± 0.393
0.28ProTrp: 0.28 ± 0.141
1.121ProTyr: 1.121 ± 0.423
0.0ProXaa: 0.0 ± 0.0
Gln
4.858GlnAla: 4.858 ± 0.938
0.28GlnCys: 0.28 ± 0.149
2.055GlnAsp: 2.055 ± 0.466
2.99GlnGlu: 2.99 ± 0.704
2.149GlnPhe: 2.149 ± 0.489
1.775GlnGly: 1.775 ± 0.66
0.561GlnHis: 0.561 ± 0.24
2.055GlnIle: 2.055 ± 0.47
2.616GlnLys: 2.616 ± 0.681
3.643GlnLeu: 3.643 ± 0.519
1.308GlnMet: 1.308 ± 0.334
1.962GlnAsn: 1.962 ± 0.369
0.934GlnPro: 0.934 ± 0.369
1.775GlnGln: 1.775 ± 0.519
1.495GlnArg: 1.495 ± 0.434
3.083GlnSer: 3.083 ± 0.615
2.896GlnThr: 2.896 ± 0.457
2.522GlnVal: 2.522 ± 0.398
0.374GlnTrp: 0.374 ± 0.169
1.214GlnTyr: 1.214 ± 0.402
0.0GlnXaa: 0.0 ± 0.0
Arg
4.204ArgAla: 4.204 ± 0.573
0.467ArgCys: 0.467 ± 0.268
2.336ArgAsp: 2.336 ± 0.454
3.083ArgGlu: 3.083 ± 0.693
1.868ArgPhe: 1.868 ± 0.4
2.616ArgGly: 2.616 ± 0.457
0.374ArgHis: 0.374 ± 0.162
2.803ArgIle: 2.803 ± 0.601
3.176ArgLys: 3.176 ± 0.815
4.951ArgLeu: 4.951 ± 0.661
1.214ArgMet: 1.214 ± 0.34
1.775ArgAsn: 1.775 ± 0.457
1.028ArgPro: 1.028 ± 0.329
1.868ArgGln: 1.868 ± 0.472
1.868ArgArg: 1.868 ± 0.42
2.616ArgSer: 2.616 ± 0.401
1.682ArgThr: 1.682 ± 0.462
2.616ArgVal: 2.616 ± 0.594
0.467ArgTrp: 0.467 ± 0.22
2.336ArgTyr: 2.336 ± 0.565
0.0ArgXaa: 0.0 ± 0.0
Ser
6.633SerAla: 6.633 ± 2.619
0.374SerCys: 0.374 ± 0.196
4.671SerAsp: 4.671 ± 0.742
4.297SerGlu: 4.297 ± 0.793
2.803SerPhe: 2.803 ± 0.481
4.484SerGly: 4.484 ± 0.726
0.934SerHis: 0.934 ± 0.408
5.792SerIle: 5.792 ± 1.026
5.232SerLys: 5.232 ± 0.761
4.765SerLeu: 4.765 ± 0.83
1.588SerMet: 1.588 ± 0.276
3.643SerAsn: 3.643 ± 0.613
1.775SerPro: 1.775 ± 0.386
3.27SerGln: 3.27 ± 1.112
2.429SerArg: 2.429 ± 0.44
3.55SerSer: 3.55 ± 1.145
4.391SerThr: 4.391 ± 0.87
5.512SerVal: 5.512 ± 0.743
0.561SerTrp: 0.561 ± 0.205
1.775SerTyr: 1.775 ± 0.393
0.0SerXaa: 0.0 ± 0.0
Thr
4.765ThrAla: 4.765 ± 1.747
0.28ThrCys: 0.28 ± 0.179
3.083ThrAsp: 3.083 ± 0.581
4.297ThrGlu: 4.297 ± 0.684
3.643ThrPhe: 3.643 ± 0.662
4.111ThrGly: 4.111 ± 0.922
1.401ThrHis: 1.401 ± 0.341
5.045ThrIle: 5.045 ± 0.674
6.54ThrLys: 6.54 ± 0.803
5.325ThrLeu: 5.325 ± 0.637
1.401ThrMet: 1.401 ± 0.933
2.803ThrAsn: 2.803 ± 0.451
1.588ThrPro: 1.588 ± 0.436
2.709ThrGln: 2.709 ± 0.5
2.149ThrArg: 2.149 ± 0.385
3.643ThrSer: 3.643 ± 0.777
3.363ThrThr: 3.363 ± 0.631
5.045ThrVal: 5.045 ± 0.723
0.187ThrTrp: 0.187 ± 0.159
1.868ThrTyr: 1.868 ± 0.555
0.0ThrXaa: 0.0 ± 0.0
Val
4.111ValAla: 4.111 ± 1.124
0.374ValCys: 0.374 ± 0.203
4.484ValAsp: 4.484 ± 0.729
5.419ValGlu: 5.419 ± 1.027
2.616ValPhe: 2.616 ± 0.434
3.737ValGly: 3.737 ± 0.587
0.561ValHis: 0.561 ± 0.245
4.578ValIle: 4.578 ± 0.659
5.232ValLys: 5.232 ± 0.519
3.643ValLeu: 3.643 ± 0.65
1.214ValMet: 1.214 ± 0.314
4.858ValAsn: 4.858 ± 0.885
1.495ValPro: 1.495 ± 0.351
2.336ValGln: 2.336 ± 0.538
2.149ValArg: 2.149 ± 0.42
5.792ValSer: 5.792 ± 0.745
5.512ValThr: 5.512 ± 0.671
4.297ValVal: 4.297 ± 0.65
0.841ValTrp: 0.841 ± 0.295
2.336ValTyr: 2.336 ± 0.507
0.0ValXaa: 0.0 ± 0.0
Trp
0.467TrpAla: 0.467 ± 0.198
0.093TrpCys: 0.093 ± 0.096
0.467TrpAsp: 0.467 ± 0.231
1.028TrpGlu: 1.028 ± 0.313
0.467TrpPhe: 0.467 ± 0.275
0.934TrpGly: 0.934 ± 0.32
0.187TrpHis: 0.187 ± 0.114
0.467TrpIle: 0.467 ± 0.263
0.561TrpLys: 0.561 ± 0.207
0.934TrpLeu: 0.934 ± 0.285
0.187TrpMet: 0.187 ± 0.134
0.561TrpAsn: 0.561 ± 0.258
0.187TrpPro: 0.187 ± 0.123
0.374TrpGln: 0.374 ± 0.174
0.374TrpArg: 0.374 ± 0.203
1.214TrpSer: 1.214 ± 0.481
0.374TrpThr: 0.374 ± 0.229
1.121TrpVal: 1.121 ± 0.29
0.561TrpTrp: 0.561 ± 0.248
0.374TrpTyr: 0.374 ± 0.166
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.522TyrAla: 2.522 ± 0.448
0.374TyrCys: 0.374 ± 0.16
3.176TyrAsp: 3.176 ± 0.856
2.336TyrGlu: 2.336 ± 0.588
2.055TyrPhe: 2.055 ± 0.52
2.99TyrGly: 2.99 ± 0.664
0.374TyrHis: 0.374 ± 0.198
2.242TyrIle: 2.242 ± 0.639
3.27TyrLys: 3.27 ± 0.627
2.522TyrLeu: 2.522 ± 0.567
0.561TyrMet: 0.561 ± 0.206
1.682TyrAsn: 1.682 ± 0.447
1.308TyrPro: 1.308 ± 0.398
1.308TyrGln: 1.308 ± 0.357
2.336TyrArg: 2.336 ± 0.644
2.709TyrSer: 2.709 ± 0.625
2.616TyrThr: 2.616 ± 0.718
2.149TyrVal: 2.149 ± 0.441
0.28TyrTrp: 0.28 ± 0.124
1.775TyrTyr: 1.775 ± 0.625
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (10705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski