Amino acid dipepetide frequency for Pan troglodytes (Chimpanzee)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.85AlaAla: 6.85 ± 0.033	1.387AlaCys: 1.387 ± 0.011	2.903AlaAsp: 2.903 ± 0.012	4.802AlaGlu: 4.802 ± 0.02	2.637AlaPhe: 2.637 ± 0.012	4.772AlaGly: 4.772 ± 0.02	1.558AlaHis: 1.558 ± 0.009	2.778AlaIle: 2.778 ± 0.013	3.454AlaLys: 3.454 ± 0.018	7.076AlaLeu: 7.076 ± 0.024	1.495AlaMet: 1.495 ± 0.008	2.014AlaAsn: 2.014 ± 0.009	4.187AlaPro: 4.187 ± 0.021	3.267AlaGln: 3.267 ± 0.018	3.658AlaArg: 3.658 ± 0.014	5.718AlaSer: 5.718 ± 0.02	3.616AlaThr: 3.616 ± 0.014	4.661AlaVal: 4.661 ± 0.015	0.815AlaTrp: 0.815 ± 0.005	1.519AlaTyr: 1.519 ± 0.009	0.0AlaXaa: 0.0 ± 0.0
Cys	1.241CysAla: 1.241 ± 0.009	0.668CysCys: 0.668 ± 0.009	1.015CysAsp: 1.015 ± 0.01	1.323CysGlu: 1.323 ± 0.013	0.846CysPhe: 0.846 ± 0.006	1.783CysGly: 1.783 ± 0.017	0.675CysHis: 0.675 ± 0.006	0.949CysIle: 0.949 ± 0.008	1.174CysLys: 1.174 ± 0.009	2.191CysLeu: 2.191 ± 0.014	0.422CysMet: 0.422 ± 0.005	0.821CysAsn: 0.821 ± 0.008	1.388CysPro: 1.388 ± 0.012	1.08CysGln: 1.08 ± 0.009	1.31CysArg: 1.31 ± 0.009	2.007CysSer: 2.007 ± 0.012	1.088CysThr: 1.088 ± 0.009	1.292CysVal: 1.292 ± 0.01	0.303CysTrp: 0.303 ± 0.004	0.571CysTyr: 0.571 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	2.883AspAla: 2.883 ± 0.014	1.056AspCys: 1.056 ± 0.009	2.629AspAsp: 2.629 ± 0.015	3.455AspGlu: 3.455 ± 0.015	2.105AspPhe: 2.105 ± 0.01	3.333AspGly: 3.333 ± 0.018	1.138AspHis: 1.138 ± 0.007	2.603AspIle: 2.603 ± 0.013	2.552AspLys: 2.552 ± 0.013	4.98AspLeu: 4.98 ± 0.017	1.118AspMet: 1.118 ± 0.008	1.687AspAsn: 1.687 ± 0.009	2.887AspPro: 2.887 ± 0.013	1.824AspGln: 1.824 ± 0.01	2.424AspArg: 2.424 ± 0.011	4.174AspSer: 4.174 ± 0.018	2.459AspThr: 2.459 ± 0.011	3.074AspVal: 3.074 ± 0.013	0.616AspTrp: 0.616 ± 0.006	1.493AspTyr: 1.493 ± 0.009	0.0AspXaa: 0.0 ± 0.0
Glu	5.29GluAla: 5.29 ± 0.022	1.494GluCys: 1.494 ± 0.017	4.48GluAsp: 4.48 ± 0.015	8.053GluGlu: 8.053 ± 0.038	2.045GluPhe: 2.045 ± 0.009	4.191GluGly: 4.191 ± 0.016	1.526GluHis: 1.526 ± 0.01	3.2GluIle: 3.2 ± 0.016	5.512GluLys: 5.512 ± 0.025	6.498GluLeu: 6.498 ± 0.025	1.697GluMet: 1.697 ± 0.009	3.214GluAsn: 3.214 ± 0.016	3.246GluPro: 3.246 ± 0.018	3.159GluGln: 3.159 ± 0.015	4.009GluArg: 4.009 ± 0.016	4.386GluSer: 4.386 ± 0.017	3.425GluThr: 3.425 ± 0.014	4.169GluVal: 4.169 ± 0.02	0.71GluTrp: 0.71 ± 0.005	1.609GluTyr: 1.609 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	1.947PheAla: 1.947 ± 0.01	0.927PheCys: 0.927 ± 0.007	1.66PheAsp: 1.66 ± 0.011	2.011PheGlu: 2.011 ± 0.009	1.575PhePhe: 1.575 ± 0.011	2.188PheGly: 2.188 ± 0.012	1.051PheHis: 1.051 ± 0.006	1.816PheIle: 1.816 ± 0.012	1.813PheLys: 1.813 ± 0.009	4.034PheLeu: 4.034 ± 0.018	0.771PheMet: 0.771 ± 0.006	1.346PheAsn: 1.346 ± 0.009	2.009PhePro: 2.009 ± 0.01	1.815PheGln: 1.815 ± 0.009	1.959PheArg: 1.959 ± 0.011	3.407PheSer: 3.407 ± 0.015	2.043PheThr: 2.043 ± 0.011	2.115PheVal: 2.115 ± 0.011	0.496PheTrp: 0.496 ± 0.005	1.158PheTyr: 1.158 ± 0.007	0.0PheXaa: 0.0 ± 0.0
Gly	4.511GlyAla: 4.511 ± 0.023	1.287GlyCys: 1.287 ± 0.01	3.144GlyAsp: 3.144 ± 0.016	4.204GlyGlu: 4.204 ± 0.02	2.405GlyPhe: 2.405 ± 0.014	5.111GlyGly: 5.111 ± 0.031	1.7GlyHis: 1.7 ± 0.011	2.757GlyIle: 2.757 ± 0.013	3.88GlyLys: 3.88 ± 0.016	5.859GlyLeu: 5.859 ± 0.025	1.312GlyMet: 1.312 ± 0.008	2.38GlyAsn: 2.38 ± 0.013	4.287GlyPro: 4.287 ± 0.034	2.793GlyGln: 2.793 ± 0.014	3.779GlyArg: 3.779 ± 0.016	5.797GlySer: 5.797 ± 0.022	3.564GlyThr: 3.564 ± 0.015	3.539GlyVal: 3.539 ± 0.018	0.802GlyTrp: 0.802 ± 0.008	1.741GlyTyr: 1.741 ± 0.011	0.0GlyXaa: 0.0 ± 0.0
His	1.324HisAla: 1.324 ± 0.008	0.743HisCys: 0.743 ± 0.007	0.893HisAsp: 0.893 ± 0.006	1.343HisGlu: 1.343 ± 0.008	1.083HisPhe: 1.083 ± 0.007	1.556HisGly: 1.556 ± 0.012	0.92HisHis: 0.92 ± 0.009	1.25HisIle: 1.25 ± 0.009	1.301HisLys: 1.301 ± 0.008	2.955HisLeu: 2.955 ± 0.012	0.594HisMet: 0.594 ± 0.005	0.876HisAsn: 0.876 ± 0.007	1.684HisPro: 1.684 ± 0.01	1.364HisGln: 1.364 ± 0.01	1.6HisArg: 1.6 ± 0.01	2.329HisSer: 2.329 ± 0.01	1.578HisThr: 1.578 ± 0.012	1.472HisVal: 1.472 ± 0.009	0.349HisTrp: 0.349 ± 0.004	0.806HisTyr: 0.806 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	2.565IleAla: 2.565 ± 0.011	1.086IleCys: 1.086 ± 0.008	2.015IleAsp: 2.015 ± 0.012	2.601IleGlu: 2.601 ± 0.015	1.885IlePhe: 1.885 ± 0.012	2.201IleGly: 2.201 ± 0.012	1.408IleHis: 1.408 ± 0.011	2.408IleIle: 2.408 ± 0.013	2.658IleLys: 2.658 ± 0.015	4.57IleLeu: 4.57 ± 0.018	0.997IleMet: 0.997 ± 0.008	1.867IleAsn: 1.867 ± 0.01	2.615IlePro: 2.615 ± 0.011	2.325IleGln: 2.325 ± 0.011	2.367IleArg: 2.367 ± 0.011	3.722IleSer: 3.722 ± 0.015	2.59IleThr: 2.59 ± 0.017	2.488IleVal: 2.488 ± 0.014	0.516IleTrp: 0.516 ± 0.005	1.38IleTyr: 1.38 ± 0.008	0.0IleXaa: 0.0 ± 0.0
Lys	4.07LysAla: 4.07 ± 0.018	1.198LysCys: 1.198 ± 0.011	3.171LysAsp: 3.171 ± 0.016	5.176LysGlu: 5.176 ± 0.023	1.733LysPhe: 1.733 ± 0.011	3.263LysGly: 3.263 ± 0.019	1.424LysHis: 1.424 ± 0.011	2.844LysIle: 2.844 ± 0.013	4.75LysLys: 4.75 ± 0.025	5.195LysLeu: 5.195 ± 0.021	1.467LysMet: 1.467 ± 0.009	2.418LysAsn: 2.418 ± 0.013	3.171LysPro: 3.171 ± 0.019	2.637LysGln: 2.637 ± 0.012	3.319LysArg: 3.319 ± 0.014	3.922LysSer: 3.922 ± 0.018	3.135LysThr: 3.135 ± 0.015	3.477LysVal: 3.477 ± 0.019	0.62LysTrp: 0.62 ± 0.006	1.585LysTyr: 1.585 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	6.716LeuAla: 6.716 ± 0.022	2.188LeuCys: 2.188 ± 0.013	4.683LeuAsp: 4.683 ± 0.016	7.239LeuGlu: 7.239 ± 0.026	3.357LeuPhe: 3.357 ± 0.017	5.859LeuGly: 5.859 ± 0.025	2.736LeuHis: 2.736 ± 0.013	3.879LeuIle: 3.879 ± 0.016	5.832LeuLys: 5.832 ± 0.023	10.763LeuLeu: 10.763 ± 0.036	2.017LeuMet: 2.017 ± 0.011	3.495LeuAsn: 3.495 ± 0.014	6.016LeuPro: 6.016 ± 0.026	5.843LeuGln: 5.843 ± 0.024	5.878LeuArg: 5.878 ± 0.023	7.916LeuSer: 7.916 ± 0.022	5.071LeuThr: 5.071 ± 0.016	5.442LeuVal: 5.442 ± 0.018	1.144LeuTrp: 1.144 ± 0.008	2.535LeuTyr: 2.535 ± 0.013	0.0LeuXaa: 0.0 ± 0.0
Met	1.931MetAla: 1.931 ± 0.008	0.403MetCys: 0.403 ± 0.004	1.256MetAsp: 1.256 ± 0.007	1.892MetGlu: 1.892 ± 0.01	0.723MetPhe: 0.723 ± 0.005	1.32MetGly: 1.32 ± 0.009	0.472MetHis: 0.472 ± 0.004	0.843MetIle: 0.843 ± 0.006	1.457MetLys: 1.457 ± 0.008	1.966MetLeu: 1.966 ± 0.009	0.567MetMet: 0.567 ± 0.006	0.914MetAsn: 0.914 ± 0.007	1.103MetPro: 1.103 ± 0.01	0.931MetGln: 0.931 ± 0.007	1.049MetArg: 1.049 ± 0.007	1.563MetSer: 1.563 ± 0.009	1.133MetThr: 1.133 ± 0.007	1.387MetVal: 1.387 ± 0.007	0.246MetTrp: 0.246 ± 0.003	0.563MetTyr: 0.563 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.065AsnAla: 2.065 ± 0.01	0.836AsnCys: 0.836 ± 0.007	1.545AsnAsp: 1.545 ± 0.009	2.26AsnGlu: 2.26 ± 0.012	1.473AsnPhe: 1.473 ± 0.009	2.465AsnGly: 2.465 ± 0.014	0.967AsnHis: 0.967 ± 0.006	2.147AsnIle: 2.147 ± 0.012	2.234AsnLys: 2.234 ± 0.012	3.771AsnLeu: 3.771 ± 0.015	0.912AsnMet: 0.912 ± 0.007	1.541AsnAsn: 1.541 ± 0.009	2.171AsnPro: 2.171 ± 0.012	1.663AsnGln: 1.663 ± 0.009	1.84AsnArg: 1.84 ± 0.01	3.146AsnSer: 3.146 ± 0.015	1.957AsnThr: 1.957 ± 0.01	2.192AsnVal: 2.192 ± 0.011	0.454AsnTrp: 0.454 ± 0.004	1.132AsnTyr: 1.132 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	4.872ProAla: 4.872 ± 0.024	1.162ProCys: 1.162 ± 0.011	2.781ProAsp: 2.781 ± 0.014	4.455ProGlu: 4.455 ± 0.018	1.911ProPhe: 1.911 ± 0.01	5.308ProGly: 5.308 ± 0.047	1.466ProHis: 1.466 ± 0.009	1.907ProIle: 1.907 ± 0.011	2.776ProLys: 2.776 ± 0.018	5.22ProLeu: 5.22 ± 0.02	1.058ProMet: 1.058 ± 0.009	1.814ProAsn: 1.814 ± 0.01	6.115ProPro: 6.115 ± 0.043	2.855ProGln: 2.855 ± 0.017	3.367ProArg: 3.367 ± 0.016	5.703ProSer: 5.703 ± 0.023	3.121ProThr: 3.121 ± 0.016	3.796ProVal: 3.796 ± 0.018	0.705ProTrp: 0.705 ± 0.006	1.55ProTyr: 1.55 ± 0.012	0.001ProXaa: 0.001 ± 0.0
Gln	3.575GlnAla: 3.575 ± 0.019	0.955GlnCys: 0.955 ± 0.008	2.346GlnAsp: 2.346 ± 0.011	3.972GlnGlu: 3.972 ± 0.017	1.379GlnPhe: 1.379 ± 0.007	2.866GlnGly: 2.866 ± 0.015	1.311GlnHis: 1.311 ± 0.009	2.0GlnIle: 2.0 ± 0.009	2.988GlnLys: 2.988 ± 0.016	4.762GlnLeu: 4.762 ± 0.022	1.126GlnMet: 1.126 ± 0.008	1.869GlnAsn: 1.869 ± 0.009	2.842GlnPro: 2.842 ± 0.017	3.142GlnGln: 3.142 ± 0.027	2.988GlnArg: 2.988 ± 0.015	3.139GlnSer: 3.139 ± 0.016	2.28GlnThr: 2.28 ± 0.012	2.817GlnVal: 2.817 ± 0.013	0.553GlnTrp: 0.553 ± 0.005	1.155GlnTyr: 1.155 ± 0.007	0.0GlnXaa: 0.0 ± 0.0
Arg	3.833ArgAla: 3.833 ± 0.015	1.239ArgCys: 1.239 ± 0.012	2.762ArgAsp: 2.762 ± 0.011	3.994ArgGlu: 3.994 ± 0.017	1.836ArgPhe: 1.836 ± 0.008	3.656ArgGly: 3.656 ± 0.018	1.557ArgHis: 1.557 ± 0.01	2.449ArgIle: 2.449 ± 0.011	3.677ArgLys: 3.677 ± 0.015	5.396ArgLeu: 5.396 ± 0.019	1.201ArgMet: 1.201 ± 0.007	2.153ArgAsn: 2.153 ± 0.01	3.233ArgPro: 3.233 ± 0.016	2.641ArgGln: 2.641 ± 0.015	4.326ArgArg: 4.326 ± 0.021	4.26ArgSer: 4.26 ± 0.021	2.821ArgThr: 2.821 ± 0.013	3.143ArgVal: 3.143 ± 0.014	0.714ArgTrp: 0.714 ± 0.005	1.436ArgTyr: 1.436 ± 0.008	0.0ArgXaa: 0.0 ± 0.0
Ser	5.292SerAla: 5.292 ± 0.017	1.867SerCys: 1.867 ± 0.013	3.879SerAsp: 3.879 ± 0.02	5.195SerGlu: 5.195 ± 0.021	3.044SerPhe: 3.044 ± 0.013	5.611SerGly: 5.611 ± 0.021	2.145SerHis: 2.145 ± 0.01	3.215SerIle: 3.215 ± 0.014	4.077SerLys: 4.077 ± 0.019	8.169SerLeu: 8.169 ± 0.024	1.613SerMet: 1.613 ± 0.01	2.728SerAsn: 2.728 ± 0.013	5.981SerPro: 5.981 ± 0.03	3.893SerGln: 3.893 ± 0.016	4.575SerArg: 4.575 ± 0.019	9.325SerSer: 9.325 ± 0.041	4.431SerThr: 4.431 ± 0.02	4.809SerVal: 4.809 ± 0.015	1.105SerTrp: 1.105 ± 0.008	2.085SerTyr: 2.085 ± 0.011	0.001SerXaa: 0.001 ± 0.0
Thr	3.769ThrAla: 3.769 ± 0.016	1.297ThrCys: 1.297 ± 0.012	2.451ThrAsp: 2.451 ± 0.011	3.534ThrGlu: 3.534 ± 0.015	2.076ThrPhe: 2.076 ± 0.01	3.582ThrGly: 3.582 ± 0.017	1.338ThrHis: 1.338 ± 0.009	2.398ThrIle: 2.398 ± 0.012	2.673ThrLys: 2.673 ± 0.015	5.284ThrLeu: 5.284 ± 0.014	1.114ThrMet: 1.114 ± 0.007	1.748ThrAsn: 1.748 ± 0.009	3.592ThrPro: 3.592 ± 0.021	2.298ThrGln: 2.298 ± 0.011	2.476ThrArg: 2.476 ± 0.01	4.602ThrSer: 4.602 ± 0.023	3.039ThrThr: 3.039 ± 0.023	3.822ThrVal: 3.822 ± 0.021	0.708ThrTrp: 0.708 ± 0.007	1.428ThrTyr: 1.428 ± 0.009	0.0ThrXaa: 0.0 ± 0.0
Val	4.243ValAla: 4.243 ± 0.016	1.427ValCys: 1.427 ± 0.011	2.941ValAsp: 2.941 ± 0.015	3.849ValGlu: 3.849 ± 0.017	2.375ValPhe: 2.375 ± 0.011	3.377ValGly: 3.377 ± 0.015	1.561ValHis: 1.561 ± 0.009	2.891ValIle: 2.891 ± 0.014	3.395ValLys: 3.395 ± 0.017	6.072ValLeu: 6.072 ± 0.018	1.312ValMet: 1.312 ± 0.007	2.251ValAsn: 2.251 ± 0.013	3.583ValPro: 3.583 ± 0.015	2.724ValGln: 2.724 ± 0.012	3.019ValArg: 3.019 ± 0.014	4.836ValSer: 4.836 ± 0.017	3.749ValThr: 3.749 ± 0.023	3.928ValVal: 3.928 ± 0.017	0.717ValTrp: 0.717 ± 0.006	1.616ValTyr: 1.616 ± 0.009	0.0ValXaa: 0.0 ± 0.0
Trp	0.803TrpAla: 0.803 ± 0.007	0.253TrpCys: 0.253 ± 0.004	0.649TrpAsp: 0.649 ± 0.007	0.826TrpGlu: 0.826 ± 0.006	0.444TrpPhe: 0.444 ± 0.004	0.736TrpGly: 0.736 ± 0.008	0.312TrpHis: 0.312 ± 0.004	0.547TrpIle: 0.547 ± 0.004	0.818TrpLys: 0.818 ± 0.006	1.225TrpLeu: 1.225 ± 0.008	0.325TrpMet: 0.325 ± 0.003	0.541TrpAsn: 0.541 ± 0.005	0.55TrpPro: 0.55 ± 0.005	0.543TrpGln: 0.543 ± 0.005	0.748TrpArg: 0.748 ± 0.007	0.9TrpSer: 0.9 ± 0.008	0.678TrpThr: 0.678 ± 0.007	0.694TrpVal: 0.694 ± 0.005	0.205TrpTrp: 0.205 ± 0.002	0.339TrpTyr: 0.339 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.388TyrAla: 1.388 ± 0.008	0.674TyrCys: 0.674 ± 0.006	1.29TyrAsp: 1.29 ± 0.008	1.729TyrGlu: 1.729 ± 0.011	1.205TyrPhe: 1.205 ± 0.008	1.675TyrGly: 1.675 ± 0.01	0.754TyrHis: 0.754 ± 0.005	1.383TyrIle: 1.383 ± 0.009	1.553TyrLys: 1.553 ± 0.019	2.624TyrLeu: 2.624 ± 0.012	0.599TyrMet: 0.599 ± 0.004	1.094TyrAsn: 1.094 ± 0.009	1.283TyrPro: 1.283 ± 0.009	1.267TyrGln: 1.267 ± 0.008	1.634TyrArg: 1.634 ± 0.01	2.19TyrSer: 2.19 ± 0.012	1.451TyrThr: 1.451 ± 0.009	1.548TyrVal: 1.548 ± 0.008	0.359TyrTrp: 0.359 ± 0.005	0.936TyrTyr: 0.936 ± 0.006	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.075XaaXaa: 0.075 ± 0.013

Statistics based on 48793 proteins (26098445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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