Amino acid dipepetide frequency for Burkholderiaceae bacterium PBA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.517AlaAla: 17.517 ± 0.186	1.444AlaCys: 1.444 ± 0.037	6.689AlaAsp: 6.689 ± 0.085	6.877AlaGlu: 6.877 ± 0.085	3.925AlaPhe: 3.925 ± 0.065	10.808AlaGly: 10.808 ± 0.124	2.774AlaHis: 2.774 ± 0.059	5.582AlaIle: 5.582 ± 0.081	3.472AlaLys: 3.472 ± 0.082	14.076AlaLeu: 14.076 ± 0.146	3.662AlaMet: 3.662 ± 0.048	2.993AlaAsn: 2.993 ± 0.057	6.162AlaPro: 6.162 ± 0.105	5.406AlaGln: 5.406 ± 0.075	9.203AlaArg: 9.203 ± 0.102	6.64AlaSer: 6.64 ± 0.082	6.552AlaThr: 6.552 ± 0.086	8.701AlaVal: 8.701 ± 0.084	1.767AlaTrp: 1.767 ± 0.046	2.618AlaTyr: 2.618 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.213CysAla: 1.213 ± 0.036	0.123CysCys: 0.123 ± 0.011	0.565CysAsp: 0.565 ± 0.022	0.537CysGlu: 0.537 ± 0.023	0.318CysPhe: 0.318 ± 0.018	1.03CysGly: 1.03 ± 0.036	0.318CysHis: 0.318 ± 0.018	0.429CysIle: 0.429 ± 0.021	0.232CysLys: 0.232 ± 0.015	0.906CysLeu: 0.906 ± 0.026	0.217CysMet: 0.217 ± 0.015	0.25CysAsn: 0.25 ± 0.015	0.539CysPro: 0.539 ± 0.024	0.276CysGln: 0.276 ± 0.014	0.628CysArg: 0.628 ± 0.023	0.507CysSer: 0.507 ± 0.022	0.569CysThr: 0.569 ± 0.024	0.731CysVal: 0.731 ± 0.026	0.132CysTrp: 0.132 ± 0.011	0.215CysTyr: 0.215 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.41AspAla: 7.41 ± 0.094	0.479AspCys: 0.479 ± 0.02	2.937AspAsp: 2.937 ± 0.053	3.015AspGlu: 3.015 ± 0.06	1.945AspPhe: 1.945 ± 0.043	4.591AspGly: 4.591 ± 0.075	1.186AspHis: 1.186 ± 0.037	2.83AspIle: 2.83 ± 0.05	1.761AspLys: 1.761 ± 0.042	5.204AspLeu: 5.204 ± 0.071	1.418AspMet: 1.418 ± 0.036	1.321AspAsn: 1.321 ± 0.035	2.982AspPro: 2.982 ± 0.054	1.57AspGln: 1.57 ± 0.034	3.387AspArg: 3.387 ± 0.059	2.229AspSer: 2.229 ± 0.044	2.985AspThr: 2.985 ± 0.06	4.11AspVal: 4.11 ± 0.064	0.889AspTrp: 0.889 ± 0.027	1.422AspTyr: 1.422 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.106GluAla: 7.106 ± 0.099	0.448GluCys: 0.448 ± 0.021	2.326GluAsp: 2.326 ± 0.052	2.678GluGlu: 2.678 ± 0.062	1.714GluPhe: 1.714 ± 0.04	3.557GluGly: 3.557 ± 0.069	1.413GluHis: 1.413 ± 0.035	2.986GluIle: 2.986 ± 0.06	1.818GluLys: 1.818 ± 0.048	5.445GluLeu: 5.445 ± 0.074	1.346GluMet: 1.346 ± 0.037	1.343GluAsn: 1.343 ± 0.035	2.377GluPro: 2.377 ± 0.044	2.768GluGln: 2.768 ± 0.054	4.739GluArg: 4.739 ± 0.08	2.481GluSer: 2.481 ± 0.052	2.928GluThr: 2.928 ± 0.053	3.8GluVal: 3.8 ± 0.062	0.709GluTrp: 0.709 ± 0.026	1.196GluTyr: 1.196 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.06PheAla: 4.06 ± 0.076	0.397PheCys: 0.397 ± 0.018	2.397PheAsp: 2.397 ± 0.049	1.962PheGlu: 1.962 ± 0.047	1.313PhePhe: 1.313 ± 0.043	3.312PheGly: 3.312 ± 0.06	0.753PheHis: 0.753 ± 0.029	1.581PheIle: 1.581 ± 0.04	1.003PheLys: 1.003 ± 0.029	2.915PheLeu: 2.915 ± 0.058	0.793PheMet: 0.793 ± 0.027	1.083PheAsn: 1.083 ± 0.031	1.516PhePro: 1.516 ± 0.041	1.03PheGln: 1.03 ± 0.027	2.195PheArg: 2.195 ± 0.043	2.066PheSer: 2.066 ± 0.044	1.821PheThr: 1.821 ± 0.04	2.575PheVal: 2.575 ± 0.05	0.444PheTrp: 0.444 ± 0.021	0.926PheTyr: 0.926 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.8GlyAla: 8.8 ± 0.109	0.854GlyCys: 0.854 ± 0.027	4.044GlyAsp: 4.044 ± 0.077	4.346GlyGlu: 4.346 ± 0.062	2.996GlyPhe: 2.996 ± 0.061	6.925GlyGly: 6.925 ± 0.108	1.888GlyHis: 1.888 ± 0.046	4.453GlyIle: 4.453 ± 0.066	3.469GlyLys: 3.469 ± 0.073	8.219GlyLeu: 8.219 ± 0.091	2.618GlyMet: 2.618 ± 0.049	2.527GlyAsn: 2.527 ± 0.085	2.914GlyPro: 2.914 ± 0.055	3.145GlyGln: 3.145 ± 0.056	5.319GlyArg: 5.319 ± 0.074	4.356GlySer: 4.356 ± 0.063	4.861GlyThr: 4.861 ± 0.102	6.423GlyVal: 6.423 ± 0.084	1.32GlyTrp: 1.32 ± 0.039	2.434GlyTyr: 2.434 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	3.345HisAla: 3.345 ± 0.065	0.282HisCys: 0.282 ± 0.015	1.308HisAsp: 1.308 ± 0.037	1.093HisGlu: 1.093 ± 0.034	0.857HisPhe: 0.857 ± 0.031	2.295HisGly: 2.295 ± 0.052	0.64HisHis: 0.64 ± 0.029	1.044HisIle: 1.044 ± 0.031	0.545HisLys: 0.545 ± 0.023	2.356HisLeu: 2.356 ± 0.046	0.536HisMet: 0.536 ± 0.025	0.534HisAsn: 0.534 ± 0.022	1.519HisPro: 1.519 ± 0.043	0.756HisGln: 0.756 ± 0.029	1.528HisArg: 1.528 ± 0.039	0.991HisSer: 0.991 ± 0.03	1.123HisThr: 1.123 ± 0.034	1.72HisVal: 1.72 ± 0.039	0.396HisTrp: 0.396 ± 0.018	0.672HisTyr: 0.672 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.549IleAla: 6.549 ± 0.08	0.47IleCys: 0.47 ± 0.025	3.256IleAsp: 3.256 ± 0.05	3.193IleGlu: 3.193 ± 0.061	1.394IlePhe: 1.394 ± 0.038	4.409IleGly: 4.409 ± 0.07	0.947IleHis: 0.947 ± 0.033	2.027IleIle: 2.027 ± 0.05	1.478IleLys: 1.478 ± 0.04	3.904IleLeu: 3.904 ± 0.066	0.934IleMet: 0.934 ± 0.028	1.43IleAsn: 1.43 ± 0.042	2.36IlePro: 2.36 ± 0.048	1.434IleGln: 1.434 ± 0.037	3.138IleArg: 3.138 ± 0.058	2.412IleSer: 2.412 ± 0.048	2.526IleThr: 2.526 ± 0.051	3.988IleVal: 3.988 ± 0.056	0.507IleTrp: 0.507 ± 0.022	0.982IleTyr: 0.982 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.596LysAla: 3.596 ± 0.078	0.182LysCys: 0.182 ± 0.014	1.531LysAsp: 1.531 ± 0.05	1.535LysGlu: 1.535 ± 0.046	0.887LysPhe: 0.887 ± 0.03	2.266LysGly: 2.266 ± 0.053	0.665LysHis: 0.665 ± 0.024	1.496LysIle: 1.496 ± 0.043	1.244LysLys: 1.244 ± 0.042	3.292LysLeu: 3.292 ± 0.058	0.78LysMet: 0.78 ± 0.028	0.888LysAsn: 0.888 ± 0.033	1.988LysPro: 1.988 ± 0.042	1.263LysGln: 1.263 ± 0.039	2.435LysArg: 2.435 ± 0.05	1.664LysSer: 1.664 ± 0.047	1.861LysThr: 1.861 ± 0.048	2.328LysVal: 2.328 ± 0.061	0.344LysTrp: 0.344 ± 0.019	0.73LysTyr: 0.73 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.234LeuAla: 14.234 ± 0.156	1.052LeuCys: 1.052 ± 0.032	5.987LeuAsp: 5.987 ± 0.079	5.382LeuGlu: 5.382 ± 0.086	3.475LeuPhe: 3.475 ± 0.065	8.244LeuGly: 8.244 ± 0.101	2.438LeuHis: 2.438 ± 0.05	4.423LeuIle: 4.423 ± 0.071	3.209LeuLys: 3.209 ± 0.065	10.829LeuLeu: 10.829 ± 0.147	2.462LeuMet: 2.462 ± 0.053	2.764LeuAsn: 2.764 ± 0.059	6.055LeuPro: 6.055 ± 0.082	4.085LeuGln: 4.085 ± 0.066	7.634LeuArg: 7.634 ± 0.088	5.874LeuSer: 5.874 ± 0.069	5.743LeuThr: 5.743 ± 0.076	7.185LeuVal: 7.185 ± 0.094	1.223LeuTrp: 1.223 ± 0.043	2.122LeuTyr: 2.122 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.011MetAla: 3.011 ± 0.052	0.203MetCys: 0.203 ± 0.013	1.084MetAsp: 1.084 ± 0.029	1.175MetGlu: 1.175 ± 0.036	0.787MetPhe: 0.787 ± 0.027	1.823MetGly: 1.823 ± 0.048	0.634MetHis: 0.634 ± 0.023	1.095MetIle: 1.095 ± 0.033	0.975MetLys: 0.975 ± 0.031	3.055MetLeu: 3.055 ± 0.057	0.68MetMet: 0.68 ± 0.025	0.776MetAsn: 0.776 ± 0.029	1.683MetPro: 1.683 ± 0.041	1.227MetGln: 1.227 ± 0.032	2.013MetArg: 2.013 ± 0.038	1.662MetSer: 1.662 ± 0.04	1.785MetThr: 1.785 ± 0.04	1.738MetVal: 1.738 ± 0.043	0.242MetTrp: 0.242 ± 0.015	0.404MetTyr: 0.404 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.212AsnAla: 3.212 ± 0.059	0.291AsnCys: 0.291 ± 0.017	1.46AsnAsp: 1.46 ± 0.048	1.211AsnGlu: 1.211 ± 0.035	0.891AsnPhe: 0.891 ± 0.028	2.424AsnGly: 2.424 ± 0.069	0.529AsnHis: 0.529 ± 0.021	1.416AsnIle: 1.416 ± 0.038	0.809AsnLys: 0.809 ± 0.031	2.792AsnLeu: 2.792 ± 0.054	0.639AsnMet: 0.639 ± 0.025	0.827AsnAsn: 0.827 ± 0.036	1.788AsnPro: 1.788 ± 0.043	0.928AsnGln: 0.928 ± 0.032	1.844AsnArg: 1.844 ± 0.042	1.182AsnSer: 1.182 ± 0.042	1.523AsnThr: 1.523 ± 0.043	2.101AsnVal: 2.101 ± 0.057	0.38AsnTrp: 0.38 ± 0.018	0.655AsnTyr: 0.655 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.618ProAla: 7.618 ± 0.1	0.38ProCys: 0.38 ± 0.018	3.388ProAsp: 3.388 ± 0.056	3.398ProGlu: 3.398 ± 0.062	1.818ProPhe: 1.818 ± 0.038	4.518ProGly: 4.518 ± 0.075	1.275ProHis: 1.275 ± 0.033	1.927ProIle: 1.927 ± 0.045	1.318ProLys: 1.318 ± 0.041	5.228ProLeu: 5.228 ± 0.085	1.21ProMet: 1.21 ± 0.036	1.338ProAsn: 1.338 ± 0.042	2.641ProPro: 2.641 ± 0.07	2.003ProGln: 2.003 ± 0.042	3.048ProArg: 3.048 ± 0.057	2.629ProSer: 2.629 ± 0.049	2.513ProThr: 2.513 ± 0.047	4.611ProVal: 4.611 ± 0.066	0.659ProTrp: 0.659 ± 0.025	1.243ProTyr: 1.243 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.494GlnAla: 5.494 ± 0.068	0.344GlnCys: 0.344 ± 0.021	1.669GlnAsp: 1.669 ± 0.038	1.792GlnGlu: 1.792 ± 0.046	1.238GlnPhe: 1.238 ± 0.034	2.826GlnGly: 2.826 ± 0.05	1.015GlnHis: 1.015 ± 0.035	1.994GlnIle: 1.994 ± 0.049	1.129GlnLys: 1.129 ± 0.032	4.007GlnLeu: 4.007 ± 0.064	1.043GlnMet: 1.043 ± 0.03	0.926GlnAsn: 0.926 ± 0.029	2.323GlnPro: 2.323 ± 0.047	1.926GlnGln: 1.926 ± 0.052	3.296GlnArg: 3.296 ± 0.06	1.984GlnSer: 1.984 ± 0.043	1.917GlnThr: 1.917 ± 0.04	2.806GlnVal: 2.806 ± 0.049	0.591GlnTrp: 0.591 ± 0.024	0.868GlnTyr: 0.868 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.065ArgAla: 8.065 ± 0.086	0.597ArgCys: 0.597 ± 0.023	3.888ArgAsp: 3.888 ± 0.061	4.207ArgGlu: 4.207 ± 0.068	2.765ArgPhe: 2.765 ± 0.05	4.742ArgGly: 4.742 ± 0.07	2.023ArgHis: 2.023 ± 0.05	3.793ArgIle: 3.793 ± 0.058	2.334ArgLys: 2.334 ± 0.048	7.803ArgLeu: 7.803 ± 0.101	2.204ArgMet: 2.204 ± 0.041	2.031ArgAsn: 2.031 ± 0.044	3.307ArgPro: 3.307 ± 0.052	3.256ArgGln: 3.256 ± 0.055	5.154ArgArg: 5.154 ± 0.084	3.372ArgSer: 3.372 ± 0.061	3.74ArgThr: 3.74 ± 0.059	4.998ArgVal: 4.998 ± 0.078	1.039ArgTrp: 1.039 ± 0.036	1.999ArgTyr: 1.999 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.281SerAla: 6.281 ± 0.086	0.468SerCys: 0.468 ± 0.021	2.628SerAsp: 2.628 ± 0.059	2.467SerGlu: 2.467 ± 0.051	1.903SerPhe: 1.903 ± 0.043	5.128SerGly: 5.128 ± 0.084	1.216SerHis: 1.216 ± 0.034	2.467SerIle: 2.467 ± 0.049	1.533SerLys: 1.533 ± 0.039	5.276SerLeu: 5.276 ± 0.075	1.418SerMet: 1.418 ± 0.039	1.416SerAsn: 1.416 ± 0.043	2.774SerPro: 2.774 ± 0.053	1.811SerGln: 1.811 ± 0.042	3.543SerArg: 3.543 ± 0.06	2.891SerSer: 2.891 ± 0.064	2.857SerThr: 2.857 ± 0.055	3.799SerVal: 3.799 ± 0.075	0.675SerTrp: 0.675 ± 0.027	1.217SerTyr: 1.217 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.381ThrAla: 6.381 ± 0.08	0.467ThrCys: 0.467 ± 0.021	2.661ThrAsp: 2.661 ± 0.056	2.511ThrGlu: 2.511 ± 0.056	1.937ThrPhe: 1.937 ± 0.039	4.891ThrGly: 4.891 ± 0.102	1.276ThrHis: 1.276 ± 0.032	2.468ThrIle: 2.468 ± 0.057	1.195ThrLys: 1.195 ± 0.04	6.785ThrLeu: 6.785 ± 0.084	1.244ThrMet: 1.244 ± 0.034	1.284ThrAsn: 1.284 ± 0.043	3.777ThrPro: 3.777 ± 0.064	1.94ThrGln: 1.94 ± 0.041	3.659ThrArg: 3.659 ± 0.056	2.723ThrSer: 2.723 ± 0.059	2.961ThrThr: 2.961 ± 0.066	4.586ThrVal: 4.586 ± 0.079	0.687ThrTrp: 0.687 ± 0.024	1.207ThrTyr: 1.207 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.088ValAla: 9.088 ± 0.106	0.783ValCys: 0.783 ± 0.027	3.924ValAsp: 3.924 ± 0.064	4.062ValGlu: 4.062 ± 0.065	2.553ValPhe: 2.553 ± 0.048	5.18ValGly: 5.18 ± 0.076	1.618ValHis: 1.618 ± 0.039	3.722ValIle: 3.722 ± 0.066	2.333ValLys: 2.333 ± 0.057	7.837ValLeu: 7.837 ± 0.094	1.989ValMet: 1.989 ± 0.047	2.163ValAsn: 2.163 ± 0.054	4.229ValPro: 4.229 ± 0.055	2.709ValGln: 2.709 ± 0.047	5.45ValArg: 5.45 ± 0.075	4.295ValSer: 4.295 ± 0.071	4.442ValThr: 4.442 ± 0.066	5.954ValVal: 5.954 ± 0.085	0.931ValTrp: 0.931 ± 0.03	1.466ValTyr: 1.466 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.15TrpAla: 1.15 ± 0.034	0.185TrpCys: 0.185 ± 0.013	0.585TrpAsp: 0.585 ± 0.025	0.572TrpGlu: 0.572 ± 0.024	0.538TrpPhe: 0.538 ± 0.021	0.821TrpGly: 0.821 ± 0.031	0.426TrpHis: 0.426 ± 0.02	0.671TrpIle: 0.671 ± 0.025	0.421TrpLys: 0.421 ± 0.016	1.992TrpLeu: 1.992 ± 0.053	0.43TrpMet: 0.43 ± 0.021	0.42TrpAsn: 0.42 ± 0.018	0.631TrpPro: 0.631 ± 0.025	0.77TrpGln: 0.77 ± 0.027	1.147TrpArg: 1.147 ± 0.039	0.691TrpSer: 0.691 ± 0.025	0.64TrpThr: 0.64 ± 0.024	0.877TrpVal: 0.877 ± 0.03	0.252TrpTrp: 0.252 ± 0.015	0.316TrpTyr: 0.316 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.739TyrAla: 2.739 ± 0.049	0.286TyrCys: 0.286 ± 0.016	1.341TyrAsp: 1.341 ± 0.034	1.165TyrGlu: 1.165 ± 0.031	0.891TyrPhe: 0.891 ± 0.029	2.121TyrGly: 2.121 ± 0.04	0.508TyrHis: 0.508 ± 0.021	0.934TyrIle: 0.934 ± 0.03	0.698TyrLys: 0.698 ± 0.023	2.501TyrLeu: 2.501 ± 0.049	0.427TyrMet: 0.427 ± 0.02	0.588TyrAsn: 0.588 ± 0.021	1.195TyrPro: 1.195 ± 0.03	0.886TyrGln: 0.886 ± 0.028	1.954TyrArg: 1.954 ± 0.041	1.119TyrSer: 1.119 ± 0.034	1.294TyrThr: 1.294 ± 0.039	1.696TyrVal: 1.696 ± 0.037	0.35TyrTrp: 0.35 ± 0.017	0.643TyrTyr: 0.643 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3449 proteins (1125142 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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