Amino acid dipepetide frequency for Tomato infectious chlorosis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.74AlaAla: 1.74 ± 0.49
0.145AlaCys: 0.145 ± 0.194
2.899AlaAsp: 2.899 ± 0.482
1.305AlaGlu: 1.305 ± 0.282
1.45AlaPhe: 1.45 ± 0.492
1.74AlaGly: 1.74 ± 0.473
0.0AlaHis: 0.0 ± 0.0
3.044AlaIle: 3.044 ± 0.28
3.044AlaLys: 3.044 ± 0.814
5.364AlaLeu: 5.364 ± 0.887
1.305AlaMet: 1.305 ± 0.386
2.175AlaAsn: 2.175 ± 0.515
0.87AlaPro: 0.87 ± 0.368
1.305AlaGln: 1.305 ± 0.196
2.175AlaArg: 2.175 ± 0.681
1.885AlaSer: 1.885 ± 0.313
2.32AlaThr: 2.32 ± 0.791
3.044AlaVal: 3.044 ± 0.81
0.29AlaTrp: 0.29 ± 0.114
3.044AlaTyr: 3.044 ± 0.58
0.0AlaXaa: 0.0 ± 0.0
Cys
0.87CysAla: 0.87 ± 0.154
0.435CysCys: 0.435 ± 0.13
1.305CysAsp: 1.305 ± 0.247
2.03CysGlu: 2.03 ± 0.285
0.435CysPhe: 0.435 ± 0.209
1.015CysGly: 1.015 ± 0.268
0.145CysHis: 0.145 ± 0.192
1.305CysIle: 1.305 ± 0.251
0.725CysLys: 0.725 ± 0.287
2.175CysLeu: 2.175 ± 0.456
0.145CysMet: 0.145 ± 0.19
1.015CysAsn: 1.015 ± 0.316
0.58CysPro: 0.58 ± 0.272
0.725CysGln: 0.725 ± 0.34
0.87CysArg: 0.87 ± 0.319
1.16CysSer: 1.16 ± 0.193
0.58CysThr: 0.58 ± 0.217
1.45CysVal: 1.45 ± 0.389
0.29CysTrp: 0.29 ± 0.114
1.45CysTyr: 1.45 ± 0.482
0.0CysXaa: 0.0 ± 0.0
Asp
3.044AspAla: 3.044 ± 0.649
1.45AspCys: 1.45 ± 0.336
4.929AspAsp: 4.929 ± 1.186
3.044AspGlu: 3.044 ± 0.469
3.624AspPhe: 3.624 ± 0.702
2.609AspGly: 2.609 ± 0.443
1.305AspHis: 1.305 ± 0.421
4.349AspIle: 4.349 ± 0.667
6.959AspLys: 6.959 ± 1.521
5.654AspLeu: 5.654 ± 0.685
0.87AspMet: 0.87 ± 0.315
2.899AspAsn: 2.899 ± 0.798
1.16AspPro: 1.16 ± 0.194
1.595AspGln: 1.595 ± 0.382
2.754AspArg: 2.754 ± 0.7
4.204AspSer: 4.204 ± 0.518
3.479AspThr: 3.479 ± 0.578
6.959AspVal: 6.959 ± 0.576
0.58AspTrp: 0.58 ± 0.148
4.494AspTyr: 4.494 ± 0.77
0.0AspXaa: 0.0 ± 0.0
Glu
1.885GluAla: 1.885 ± 0.605
1.015GluCys: 1.015 ± 0.622
4.349GluAsp: 4.349 ± 0.54
3.769GluGlu: 3.769 ± 0.59
1.885GluPhe: 1.885 ± 0.343
3.044GluGly: 3.044 ± 0.423
1.16GluHis: 1.16 ± 0.336
4.204GluIle: 4.204 ± 0.665
4.929GluLys: 4.929 ± 0.771
6.959GluLeu: 6.959 ± 0.715
1.305GluMet: 1.305 ± 0.293
3.044GluAsn: 3.044 ± 0.695
0.87GluPro: 0.87 ± 0.346
1.015GluGln: 1.015 ± 0.268
2.03GluArg: 2.03 ± 0.374
3.334GluSer: 3.334 ± 0.523
2.32GluThr: 2.32 ± 0.37
4.204GluVal: 4.204 ± 0.259
1.74GluTrp: 1.74 ± 0.676
2.175GluTyr: 2.175 ± 0.316
0.0GluXaa: 0.0 ± 0.0
Phe
1.45PheAla: 1.45 ± 0.574
0.58PheCys: 0.58 ± 0.259
4.349PheAsp: 4.349 ± 0.385
3.044PheGlu: 3.044 ± 0.388
2.899PhePhe: 2.899 ± 0.661
2.03PheGly: 2.03 ± 0.681
0.29PheHis: 0.29 ± 0.114
1.74PheIle: 1.74 ± 0.349
4.929PheLys: 4.929 ± 0.688
5.219PheLeu: 5.219 ± 0.436
1.885PheMet: 1.885 ± 0.462
4.204PheAsn: 4.204 ± 0.497
1.305PhePro: 1.305 ± 0.283
1.885PheGln: 1.885 ± 0.5
1.595PheArg: 1.595 ± 0.38
5.219PheSer: 5.219 ± 0.747
3.189PheThr: 3.189 ± 0.494
2.03PheVal: 2.03 ± 0.367
0.145PheTrp: 0.145 ± 0.165
2.03PheTyr: 2.03 ± 0.473
0.0PheXaa: 0.0 ± 0.0
Gly
3.334GlyAla: 3.334 ± 0.81
1.595GlyCys: 1.595 ± 0.373
3.044GlyAsp: 3.044 ± 0.227
3.044GlyGlu: 3.044 ± 0.537
2.175GlyPhe: 2.175 ± 0.471
3.189GlyGly: 3.189 ± 0.693
1.45GlyHis: 1.45 ± 0.601
2.464GlyIle: 2.464 ± 0.363
5.364GlyLys: 5.364 ± 0.577
3.479GlyLeu: 3.479 ± 0.415
0.725GlyMet: 0.725 ± 0.369
4.059GlyAsn: 4.059 ± 0.595
0.29GlyPro: 0.29 ± 0.294
0.58GlyGln: 0.58 ± 0.228
2.609GlyArg: 2.609 ± 0.38
3.479GlySer: 3.479 ± 0.593
1.305GlyThr: 1.305 ± 0.463
4.784GlyVal: 4.784 ± 0.395
0.435GlyTrp: 0.435 ± 0.13
1.74GlyTyr: 1.74 ± 0.191
0.0GlyXaa: 0.0 ± 0.0
His
0.58HisAla: 0.58 ± 0.206
0.435HisCys: 0.435 ± 0.209
1.16HisAsp: 1.16 ± 0.292
0.87HisGlu: 0.87 ± 0.197
2.03HisPhe: 2.03 ± 0.404
1.16HisGly: 1.16 ± 0.41
0.725HisHis: 0.725 ± 0.215
0.725HisIle: 0.725 ± 0.236
1.16HisLys: 1.16 ± 0.33
1.45HisLeu: 1.45 ± 0.285
1.305HisMet: 1.305 ± 0.277
1.015HisAsn: 1.015 ± 0.261
1.595HisPro: 1.595 ± 0.329
0.58HisGln: 0.58 ± 0.228
1.45HisArg: 1.45 ± 0.379
2.32HisSer: 2.32 ± 0.285
1.16HisThr: 1.16 ± 0.395
1.16HisVal: 1.16 ± 0.456
0.0HisTrp: 0.0 ± 0.0
1.015HisTyr: 1.015 ± 0.269
0.0HisXaa: 0.0 ± 0.0
Ile
1.885IleAla: 1.885 ± 0.427
1.015IleCys: 1.015 ± 0.16
4.204IleAsp: 4.204 ± 0.581
6.524IleGlu: 6.524 ± 0.79
1.45IlePhe: 1.45 ± 0.315
3.189IleGly: 3.189 ± 1.325
0.87IleHis: 0.87 ± 0.315
3.914IleIle: 3.914 ± 1.119
5.364IleLys: 5.364 ± 0.737
6.379IleLeu: 6.379 ± 0.729
2.175IleMet: 2.175 ± 0.283
4.494IleAsn: 4.494 ± 0.768
3.189IlePro: 3.189 ± 0.356
1.595IleGln: 1.595 ± 0.461
2.899IleArg: 2.899 ± 0.377
4.494IleSer: 4.494 ± 1.4
2.754IleThr: 2.754 ± 0.474
3.914IleVal: 3.914 ± 0.505
0.725IleTrp: 0.725 ± 0.255
1.45IleTyr: 1.45 ± 0.602
0.0IleXaa: 0.0 ± 0.0
Lys
3.334LysAla: 3.334 ± 0.626
1.16LysCys: 1.16 ± 0.349
3.769LysAsp: 3.769 ± 0.635
4.059LysGlu: 4.059 ± 0.391
3.189LysPhe: 3.189 ± 0.566
3.189LysGly: 3.189 ± 0.48
2.03LysHis: 2.03 ± 0.373
4.059LysIle: 4.059 ± 0.475
4.349LysLys: 4.349 ± 0.586
10.583LysLeu: 10.583 ± 0.849
2.609LysMet: 2.609 ± 0.604
5.799LysAsn: 5.799 ± 0.835
3.479LysPro: 3.479 ± 0.47
3.044LysGln: 3.044 ± 0.609
4.639LysArg: 4.639 ± 0.632
7.248LysSer: 7.248 ± 1.164
6.234LysThr: 6.234 ± 1.026
4.204LysVal: 4.204 ± 0.531
0.435LysTrp: 0.435 ± 0.166
3.769LysTyr: 3.769 ± 0.981
0.0LysXaa: 0.0 ± 0.0
Leu
4.929LeuAla: 4.929 ± 0.662
1.595LeuCys: 1.595 ± 0.741
5.944LeuAsp: 5.944 ± 0.787
4.639LeuGlu: 4.639 ± 0.612
4.349LeuPhe: 4.349 ± 0.775
3.479LeuGly: 3.479 ± 0.458
2.899LeuHis: 2.899 ± 0.65
6.089LeuIle: 6.089 ± 1.073
9.713LeuLys: 9.713 ± 0.4
6.379LeuLeu: 6.379 ± 0.679
3.334LeuMet: 3.334 ± 0.487
5.074LeuAsn: 5.074 ± 1.162
3.479LeuPro: 3.479 ± 0.54
2.175LeuGln: 2.175 ± 0.26
6.814LeuArg: 6.814 ± 0.985
10.003LeuSer: 10.003 ± 1.364
4.204LeuThr: 4.204 ± 1.034
6.089LeuVal: 6.089 ± 0.661
0.58LeuTrp: 0.58 ± 0.28
3.769LeuTyr: 3.769 ± 0.593
0.0LeuXaa: 0.0 ± 0.0
Met
1.015MetAla: 1.015 ± 0.359
0.29MetCys: 0.29 ± 0.114
1.74MetAsp: 1.74 ± 0.379
1.595MetGlu: 1.595 ± 0.382
2.03MetPhe: 2.03 ± 0.171
1.16MetGly: 1.16 ± 0.456
0.0MetHis: 0.0 ± 0.0
1.45MetIle: 1.45 ± 0.464
2.464MetLys: 2.464 ± 0.678
3.044MetLeu: 3.044 ± 0.416
1.015MetMet: 1.015 ± 0.266
1.885MetAsn: 1.885 ± 0.48
0.435MetPro: 0.435 ± 0.312
0.145MetGln: 0.145 ± 0.158
1.74MetArg: 1.74 ± 0.194
4.204MetSer: 4.204 ± 0.74
2.464MetThr: 2.464 ± 0.355
2.754MetVal: 2.754 ± 0.467
0.0MetTrp: 0.0 ± 0.0
1.305MetTyr: 1.305 ± 0.291
0.0MetXaa: 0.0 ± 0.0
Asn
2.609AsnAla: 2.609 ± 0.423
0.29AsnCys: 0.29 ± 0.296
4.204AsnAsp: 4.204 ± 0.414
2.464AsnGlu: 2.464 ± 0.271
2.03AsnPhe: 2.03 ± 0.378
3.624AsnGly: 3.624 ± 0.717
1.45AsnHis: 1.45 ± 0.237
4.639AsnIle: 4.639 ± 0.601
6.524AsnLys: 6.524 ± 0.944
6.524AsnLeu: 6.524 ± 1.744
2.754AsnMet: 2.754 ± 0.434
6.524AsnAsn: 6.524 ± 0.856
2.175AsnPro: 2.175 ± 0.709
2.464AsnGln: 2.464 ± 0.561
2.464AsnArg: 2.464 ± 0.454
6.524AsnSer: 6.524 ± 0.948
4.929AsnThr: 4.929 ± 0.886
5.219AsnVal: 5.219 ± 0.561
0.0AsnTrp: 0.0 ± 0.0
2.32AsnTyr: 2.32 ± 0.448
0.0AsnXaa: 0.0 ± 0.0
Pro
1.305ProAla: 1.305 ± 0.298
0.725ProCys: 0.725 ± 0.205
2.175ProAsp: 2.175 ± 0.486
1.305ProGlu: 1.305 ± 0.345
1.595ProPhe: 1.595 ± 0.225
1.885ProGly: 1.885 ± 0.605
0.435ProHis: 0.435 ± 0.357
0.87ProIle: 0.87 ± 0.217
1.45ProLys: 1.45 ± 0.306
3.189ProLeu: 3.189 ± 0.775
1.305ProMet: 1.305 ± 0.353
2.175ProAsn: 2.175 ± 0.214
1.305ProPro: 1.305 ± 0.329
0.435ProGln: 0.435 ± 0.13
1.595ProArg: 1.595 ± 0.303
3.044ProSer: 3.044 ± 0.166
0.87ProThr: 0.87 ± 0.255
2.609ProVal: 2.609 ± 0.374
0.145ProTrp: 0.145 ± 0.162
1.74ProTyr: 1.74 ± 0.319
0.0ProXaa: 0.0 ± 0.0
Gln
0.435GlnAla: 0.435 ± 0.143
0.87GlnCys: 0.87 ± 0.342
1.305GlnAsp: 1.305 ± 0.26
0.58GlnGlu: 0.58 ± 0.28
0.87GlnPhe: 0.87 ± 0.158
1.305GlnGly: 1.305 ± 0.291
0.725GlnHis: 0.725 ± 0.288
2.32GlnIle: 2.32 ± 0.267
1.885GlnLys: 1.885 ± 0.361
3.914GlnLeu: 3.914 ± 0.779
0.0GlnMet: 0.0 ± 0.0
1.015GlnAsn: 1.015 ± 0.16
0.29GlnPro: 0.29 ± 0.114
0.725GlnGln: 0.725 ± 0.268
0.435GlnArg: 0.435 ± 0.245
2.464GlnSer: 2.464 ± 0.311
1.45GlnThr: 1.45 ± 0.339
2.03GlnVal: 2.03 ± 0.304
0.29GlnTrp: 0.29 ± 0.114
1.16GlnTyr: 1.16 ± 0.207
0.0GlnXaa: 0.0 ± 0.0
Arg
1.74ArgAla: 1.74 ± 0.204
0.725ArgCys: 0.725 ± 0.255
2.899ArgAsp: 2.899 ± 0.329
2.754ArgGlu: 2.754 ± 0.685
1.74ArgPhe: 1.74 ± 0.462
2.32ArgGly: 2.32 ± 0.744
1.45ArgHis: 1.45 ± 0.464
2.175ArgIle: 2.175 ± 0.632
4.784ArgLys: 4.784 ± 0.518
3.769ArgLeu: 3.769 ± 0.406
2.32ArgMet: 2.32 ± 0.349
2.32ArgAsn: 2.32 ± 0.312
1.305ArgPro: 1.305 ± 0.309
0.87ArgGln: 0.87 ± 0.287
1.595ArgArg: 1.595 ± 0.336
3.914ArgSer: 3.914 ± 0.54
3.189ArgThr: 3.189 ± 0.6
4.204ArgVal: 4.204 ± 0.614
0.87ArgTrp: 0.87 ± 0.295
1.74ArgTyr: 1.74 ± 0.365
0.0ArgXaa: 0.0 ± 0.0
Ser
2.03SerAla: 2.03 ± 0.455
1.74SerCys: 1.74 ± 0.502
6.089SerAsp: 6.089 ± 0.931
5.654SerGlu: 5.654 ± 0.711
6.669SerPhe: 6.669 ± 0.965
4.929SerGly: 4.929 ± 0.843
1.595SerHis: 1.595 ± 0.344
5.509SerIle: 5.509 ± 0.876
6.524SerLys: 6.524 ± 0.623
6.524SerLeu: 6.524 ± 1.561
1.885SerMet: 1.885 ± 0.251
7.104SerAsn: 7.104 ± 0.907
1.74SerPro: 1.74 ± 0.38
1.74SerGln: 1.74 ± 0.354
3.769SerArg: 3.769 ± 1.49
6.524SerSer: 6.524 ± 0.873
4.204SerThr: 4.204 ± 1.082
4.784SerVal: 4.784 ± 1.071
0.29SerTrp: 0.29 ± 0.234
2.899SerTyr: 2.899 ± 0.463
0.0SerXaa: 0.0 ± 0.0
Thr
1.16ThrAla: 1.16 ± 0.185
0.87ThrCys: 0.87 ± 0.274
2.03ThrAsp: 2.03 ± 0.415
2.175ThrGlu: 2.175 ± 0.895
4.059ThrPhe: 4.059 ± 0.438
3.334ThrGly: 3.334 ± 0.423
2.32ThrHis: 2.32 ± 0.484
3.479ThrIle: 3.479 ± 0.595
4.349ThrLys: 4.349 ± 0.564
6.524ThrLeu: 6.524 ± 0.728
1.305ThrMet: 1.305 ± 0.215
3.189ThrAsn: 3.189 ± 0.481
0.725ThrPro: 0.725 ± 0.284
0.87ThrGln: 0.87 ± 0.287
1.45ThrArg: 1.45 ± 0.288
3.479ThrSer: 3.479 ± 1.279
2.609ThrThr: 2.609 ± 0.514
3.769ThrVal: 3.769 ± 0.782
0.435ThrTrp: 0.435 ± 0.237
3.624ThrTyr: 3.624 ± 0.829
0.0ThrXaa: 0.0 ± 0.0
Val
3.914ValAla: 3.914 ± 0.692
2.32ValCys: 2.32 ± 0.744
6.669ValAsp: 6.669 ± 0.501
3.479ValGlu: 3.479 ± 0.561
3.624ValPhe: 3.624 ± 0.376
3.189ValGly: 3.189 ± 0.502
1.595ValHis: 1.595 ± 0.193
4.929ValIle: 4.929 ± 0.739
4.059ValLys: 4.059 ± 0.821
4.494ValLeu: 4.494 ± 0.816
1.305ValMet: 1.305 ± 0.405
8.553ValAsn: 8.553 ± 0.79
2.175ValPro: 2.175 ± 0.302
1.305ValGln: 1.305 ± 0.496
3.624ValArg: 3.624 ± 0.41
5.654ValSer: 5.654 ± 0.469
2.899ValThr: 2.899 ± 0.323
6.234ValVal: 6.234 ± 1.802
0.0ValTrp: 0.0 ± 0.0
2.754ValTyr: 2.754 ± 0.398
0.0ValXaa: 0.0 ± 0.0
Trp
0.725TrpAla: 0.725 ± 0.236
0.0TrpCys: 0.0 ± 0.0
0.145TrpAsp: 0.145 ± 0.165
0.145TrpGlu: 0.145 ± 0.169
0.58TrpPhe: 0.58 ± 0.228
1.16TrpGly: 1.16 ± 0.456
0.0TrpHis: 0.0 ± 0.0
0.435TrpIle: 0.435 ± 0.13
0.725TrpLys: 0.725 ± 0.284
0.725TrpLeu: 0.725 ± 0.212
0.725TrpMet: 0.725 ± 0.296
0.29TrpAsn: 0.29 ± 0.114
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.58TrpArg: 0.58 ± 0.208
0.29TrpSer: 0.29 ± 0.216
0.29TrpThr: 0.29 ± 0.177
0.145TrpVal: 0.145 ± 0.194
0.0TrpTrp: 0.0 ± 0.0
0.58TrpTyr: 0.58 ± 0.154
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.16TyrAla: 1.16 ± 0.578
1.45TyrCys: 1.45 ± 0.274
2.754TyrAsp: 2.754 ± 0.291
2.754TyrGlu: 2.754 ± 0.514
3.334TyrPhe: 3.334 ± 0.612
1.595TyrGly: 1.595 ± 0.316
1.45TyrHis: 1.45 ± 0.348
4.784TyrIle: 4.784 ± 0.784
1.885TyrLys: 1.885 ± 0.701
3.189TyrLeu: 3.189 ± 0.865
2.32TyrMet: 2.32 ± 0.634
2.899TyrAsn: 2.899 ± 0.497
3.189TyrPro: 3.189 ± 0.996
1.015TyrGln: 1.015 ± 0.266
1.595TyrArg: 1.595 ± 0.418
2.754TyrSer: 2.754 ± 1.282
1.45TyrThr: 1.45 ± 0.303
3.189TyrVal: 3.189 ± 0.419
0.29TyrTrp: 0.29 ± 0.114
2.03TyrTyr: 2.03 ± 0.514
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (6899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski