Amino acid dipepetide frequency for Ramularia collo-cygni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.734AlaAla: 9.734 ± 0.067	1.12AlaCys: 1.12 ± 0.017	4.471AlaAsp: 4.471 ± 0.033	5.541AlaGlu: 5.541 ± 0.043	3.226AlaPhe: 3.226 ± 0.025	6.223AlaGly: 6.223 ± 0.042	1.837AlaHis: 1.837 ± 0.018	4.309AlaIle: 4.309 ± 0.032	4.439AlaLys: 4.439 ± 0.039	7.815AlaLeu: 7.815 ± 0.046	2.151AlaMet: 2.151 ± 0.021	3.107AlaAsn: 3.107 ± 0.028	4.99AlaPro: 4.99 ± 0.048	3.565AlaGln: 3.565 ± 0.033	5.153AlaArg: 5.153 ± 0.038	7.554AlaSer: 7.554 ± 0.046	5.474AlaThr: 5.474 ± 0.034	5.616AlaVal: 5.616 ± 0.036	1.219AlaTrp: 1.219 ± 0.019	2.216AlaTyr: 2.216 ± 0.02	0.132AlaXaa: 0.132 ± 0.005
Cys	0.968CysAla: 0.968 ± 0.015	0.246CysCys: 0.246 ± 0.009	0.674CysAsp: 0.674 ± 0.012	0.639CysGlu: 0.639 ± 0.012	0.529CysPhe: 0.529 ± 0.01	0.969CysGly: 0.969 ± 0.016	0.327CysHis: 0.327 ± 0.009	0.679CysIle: 0.679 ± 0.012	0.548CysLys: 0.548 ± 0.011	1.176CysLeu: 1.176 ± 0.017	0.277CysMet: 0.277 ± 0.008	0.431CysAsn: 0.431 ± 0.01	0.636CysPro: 0.636 ± 0.014	0.436CysGln: 0.436 ± 0.01	0.749CysArg: 0.749 ± 0.012	0.922CysSer: 0.922 ± 0.017	0.711CysThr: 0.711 ± 0.012	0.792CysVal: 0.792 ± 0.013	0.19CysTrp: 0.19 ± 0.006	0.367CysTyr: 0.367 ± 0.008	0.023CysXaa: 0.023 ± 0.002
Asp	5.142AspAla: 5.142 ± 0.038	0.654AspCys: 0.654 ± 0.012	4.539AspAsp: 4.539 ± 0.052	4.647AspGlu: 4.647 ± 0.041	2.27AspPhe: 2.27 ± 0.021	4.392AspGly: 4.392 ± 0.035	1.268AspHis: 1.268 ± 0.015	2.818AspIle: 2.818 ± 0.025	2.227AspLys: 2.227 ± 0.023	5.088AspLeu: 5.088 ± 0.035	1.392AspMet: 1.392 ± 0.016	1.773AspAsn: 1.773 ± 0.017	3.138AspPro: 3.138 ± 0.025	1.921AspGln: 1.921 ± 0.018	3.028AspArg: 3.028 ± 0.028	4.138AspSer: 4.138 ± 0.029	2.864AspThr: 2.864 ± 0.023	3.946AspVal: 3.946 ± 0.028	0.91AspTrp: 0.91 ± 0.011	1.544AspTyr: 1.544 ± 0.02	0.086AspXaa: 0.086 ± 0.004
Glu	5.593GluAla: 5.593 ± 0.045	0.683GluCys: 0.683 ± 0.013	4.561GluAsp: 4.561 ± 0.042	5.619GluGlu: 5.619 ± 0.053	1.882GluPhe: 1.882 ± 0.018	4.038GluGly: 4.038 ± 0.032	1.515GluHis: 1.515 ± 0.019	2.998GluIle: 2.998 ± 0.027	3.678GluLys: 3.678 ± 0.035	5.208GluLeu: 5.208 ± 0.039	1.594GluMet: 1.594 ± 0.02	2.185GluAsn: 2.185 ± 0.02	2.64GluPro: 2.64 ± 0.032	2.751GluGln: 2.751 ± 0.027	4.167GluArg: 4.167 ± 0.03	4.268GluSer: 4.268 ± 0.035	3.375GluThr: 3.375 ± 0.028	3.716GluVal: 3.716 ± 0.031	0.9GluTrp: 0.9 ± 0.013	1.636GluTyr: 1.636 ± 0.017	0.086GluXaa: 0.086 ± 0.004
Phe	3.221PheAla: 3.221 ± 0.026	0.541PheCys: 0.541 ± 0.011	2.262PheAsp: 2.262 ± 0.02	2.183PheGlu: 2.183 ± 0.02	1.502PhePhe: 1.502 ± 0.018	2.853PheGly: 2.853 ± 0.032	0.9PheHis: 0.9 ± 0.015	1.612PheIle: 1.612 ± 0.019	1.475PheLys: 1.475 ± 0.016	3.196PheLeu: 3.196 ± 0.028	0.753PheMet: 0.753 ± 0.013	1.372PheAsn: 1.372 ± 0.016	1.823PhePro: 1.823 ± 0.019	1.346PheGln: 1.346 ± 0.016	1.84PheArg: 1.84 ± 0.018	2.764PheSer: 2.764 ± 0.022	2.116PheThr: 2.116 ± 0.022	2.283PheVal: 2.283 ± 0.022	0.618PheTrp: 0.618 ± 0.012	1.007PheTyr: 1.007 ± 0.015	0.067PheXaa: 0.067 ± 0.003
Gly	5.412GlyAla: 5.412 ± 0.036	0.888GlyCys: 0.888 ± 0.016	3.872GlyAsp: 3.872 ± 0.029	4.067GlyGlu: 4.067 ± 0.035	2.725GlyPhe: 2.725 ± 0.027	6.445GlyGly: 6.445 ± 0.066	1.67GlyHis: 1.67 ± 0.019	3.453GlyIle: 3.453 ± 0.029	3.686GlyLys: 3.686 ± 0.033	5.91GlyLeu: 5.91 ± 0.035	1.892GlyMet: 1.892 ± 0.022	2.652GlyAsn: 2.652 ± 0.028	3.168GlyPro: 3.168 ± 0.03	2.594GlyGln: 2.594 ± 0.024	4.244GlyArg: 4.244 ± 0.033	5.806GlySer: 5.806 ± 0.046	3.913GlyThr: 3.913 ± 0.028	4.482GlyVal: 4.482 ± 0.036	1.126GlyTrp: 1.126 ± 0.016	2.08GlyTyr: 2.08 ± 0.027	0.101GlyXaa: 0.101 ± 0.004
His	2.085HisAla: 2.085 ± 0.02	0.337HisCys: 0.337 ± 0.007	1.37HisAsp: 1.37 ± 0.014	1.372HisGlu: 1.372 ± 0.015	0.933HisPhe: 0.933 ± 0.012	1.744HisGly: 1.744 ± 0.02	0.886HisHis: 0.886 ± 0.015	1.167HisIle: 1.167 ± 0.017	0.924HisLys: 0.924 ± 0.013	2.196HisLeu: 2.196 ± 0.022	0.497HisMet: 0.497 ± 0.01	0.847HisAsn: 0.847 ± 0.014	1.604HisPro: 1.604 ± 0.017	1.059HisGln: 1.059 ± 0.015	1.528HisArg: 1.528 ± 0.016	1.873HisSer: 1.873 ± 0.023	1.31HisThr: 1.31 ± 0.016	1.489HisVal: 1.489 ± 0.016	0.337HisTrp: 0.337 ± 0.009	0.653HisTyr: 0.653 ± 0.011	0.037HisXaa: 0.037 ± 0.003
Ile	4.326IleAla: 4.326 ± 0.03	0.725IleCys: 0.725 ± 0.014	2.811IleAsp: 2.811 ± 0.022	2.799IleGlu: 2.799 ± 0.026	1.828IlePhe: 1.828 ± 0.018	3.147IleGly: 3.147 ± 0.028	1.128IleHis: 1.128 ± 0.015	2.265IleIle: 2.265 ± 0.025	2.095IleLys: 2.095 ± 0.021	4.144IleLeu: 4.144 ± 0.037	0.979IleMet: 0.979 ± 0.013	1.748IleAsn: 1.748 ± 0.018	2.913IlePro: 2.913 ± 0.023	1.76IleGln: 1.76 ± 0.021	2.626IleArg: 2.626 ± 0.022	3.725IleSer: 3.725 ± 0.034	2.796IleThr: 2.796 ± 0.025	3.083IleVal: 3.083 ± 0.029	0.674IleTrp: 0.674 ± 0.011	1.303IleTyr: 1.303 ± 0.018	0.069IleXaa: 0.069 ± 0.004
Lys	4.5LysAla: 4.5 ± 0.038	0.5LysCys: 0.5 ± 0.011	2.876LysAsp: 2.876 ± 0.028	3.368LysGlu: 3.368 ± 0.033	1.43LysPhe: 1.43 ± 0.017	3.022LysGly: 3.022 ± 0.027	1.175LysHis: 1.175 ± 0.015	2.224LysIle: 2.224 ± 0.024	3.423LysLys: 3.423 ± 0.053	4.053LysLeu: 4.053 ± 0.032	1.101LysMet: 1.101 ± 0.014	1.667LysAsn: 1.667 ± 0.02	2.662LysPro: 2.662 ± 0.029	1.988LysGln: 1.988 ± 0.024	3.515LysArg: 3.515 ± 0.027	3.569LysSer: 3.569 ± 0.033	2.848LysThr: 2.848 ± 0.022	2.889LysVal: 2.889 ± 0.024	0.675LysTrp: 0.675 ± 0.012	1.267LysTyr: 1.267 ± 0.016	0.06LysXaa: 0.06 ± 0.003
Leu	7.87LeuAla: 7.87 ± 0.042	1.152LeuCys: 1.152 ± 0.017	5.02LeuAsp: 5.02 ± 0.035	5.485LeuGlu: 5.485 ± 0.043	3.049LeuPhe: 3.049 ± 0.031	5.68LeuGly: 5.68 ± 0.036	2.235LeuHis: 2.235 ± 0.021	3.685LeuIle: 3.685 ± 0.031	4.112LeuLys: 4.112 ± 0.035	7.974LeuLeu: 7.974 ± 0.055	1.759LeuMet: 1.759 ± 0.02	2.979LeuAsn: 2.979 ± 0.024	5.479LeuPro: 5.479 ± 0.039	3.935LeuGln: 3.935 ± 0.031	5.667LeuArg: 5.667 ± 0.038	6.805LeuSer: 6.805 ± 0.037	4.657LeuThr: 4.657 ± 0.034	5.031LeuVal: 5.031 ± 0.034	1.121LeuTrp: 1.121 ± 0.017	2.192LeuTyr: 2.192 ± 0.022	0.133LeuXaa: 0.133 ± 0.005
Met	2.323MetAla: 2.323 ± 0.023	0.256MetCys: 0.256 ± 0.007	1.33MetAsp: 1.33 ± 0.016	1.398MetGlu: 1.398 ± 0.017	0.774MetPhe: 0.774 ± 0.013	1.516MetGly: 1.516 ± 0.021	0.546MetHis: 0.546 ± 0.011	0.989MetIle: 0.989 ± 0.014	1.043MetLys: 1.043 ± 0.013	1.982MetLeu: 1.982 ± 0.02	0.623MetMet: 0.623 ± 0.013	0.834MetAsn: 0.834 ± 0.013	1.422MetPro: 1.422 ± 0.019	1.018MetGln: 1.018 ± 0.015	1.373MetArg: 1.373 ± 0.016	2.004MetSer: 2.004 ± 0.02	1.294MetThr: 1.294 ± 0.017	1.303MetVal: 1.303 ± 0.016	0.269MetTrp: 0.269 ± 0.008	0.543MetTyr: 0.543 ± 0.01	0.041MetXaa: 0.041 ± 0.003
Asn	3.377AsnAla: 3.377 ± 0.025	0.42AsnCys: 0.42 ± 0.01	2.034AsnAsp: 2.034 ± 0.02	1.981AsnGlu: 1.981 ± 0.022	1.355AsnPhe: 1.355 ± 0.016	3.169AsnGly: 3.169 ± 0.033	0.848AsnHis: 0.848 ± 0.013	1.908AsnIle: 1.908 ± 0.021	1.521AsnLys: 1.521 ± 0.016	3.057AsnLeu: 3.057 ± 0.027	0.847AsnMet: 0.847 ± 0.015	1.521AsnAsn: 1.521 ± 0.024	2.238AsnPro: 2.238 ± 0.023	1.252AsnGln: 1.252 ± 0.016	1.845AsnArg: 1.845 ± 0.02	2.692AsnSer: 2.692 ± 0.026	2.207AsnThr: 2.207 ± 0.02	2.399AsnVal: 2.399 ± 0.022	0.505AsnTrp: 0.505 ± 0.01	0.981AsnTyr: 0.981 ± 0.015	0.056AsnXaa: 0.056 ± 0.003
Pro	5.475ProAla: 5.475 ± 0.043	0.49ProCys: 0.49 ± 0.012	3.032ProAsp: 3.032 ± 0.023	3.636ProGlu: 3.636 ± 0.028	1.935ProPhe: 1.935 ± 0.022	3.831ProGly: 3.831 ± 0.028	1.325ProHis: 1.325 ± 0.018	2.469ProIle: 2.469 ± 0.022	2.629ProLys: 2.629 ± 0.024	4.451ProLeu: 4.451 ± 0.033	1.108ProMet: 1.108 ± 0.016	2.106ProAsn: 2.106 ± 0.021	5.064ProPro: 5.064 ± 0.068	2.556ProGln: 2.556 ± 0.031	3.285ProArg: 3.285 ± 0.031	5.78ProSer: 5.78 ± 0.044	4.069ProThr: 4.069 ± 0.036	3.383ProVal: 3.383 ± 0.031	0.701ProTrp: 0.701 ± 0.011	1.413ProTyr: 1.413 ± 0.019	0.085ProXaa: 0.085 ± 0.004
Gln	3.708GlnAla: 3.708 ± 0.031	0.452GlnCys: 0.452 ± 0.011	2.243GlnAsp: 2.243 ± 0.019	2.432GlnGlu: 2.432 ± 0.026	1.216GlnPhe: 1.216 ± 0.016	2.453GlnGly: 2.453 ± 0.024	1.297GlnHis: 1.297 ± 0.018	1.836GlnIle: 1.836 ± 0.023	1.975GlnLys: 1.975 ± 0.019	3.418GlnLeu: 3.418 ± 0.028	0.964GlnMet: 0.964 ± 0.016	1.546GlnAsn: 1.546 ± 0.02	2.535GlnPro: 2.535 ± 0.027	2.913GlnGln: 2.913 ± 0.052	2.86GlnArg: 2.86 ± 0.028	3.312GlnSer: 3.312 ± 0.031	2.39GlnThr: 2.39 ± 0.021	2.158GlnVal: 2.158 ± 0.022	0.582GlnTrp: 0.582 ± 0.012	1.218GlnTyr: 1.218 ± 0.017	0.061GlnXaa: 0.061 ± 0.004
Arg	4.888ArgAla: 4.888 ± 0.033	0.714ArgCys: 0.714 ± 0.013	3.401ArgAsp: 3.401 ± 0.029	3.979ArgGlu: 3.979 ± 0.037	2.038ArgPhe: 2.038 ± 0.022	3.785ArgGly: 3.785 ± 0.035	1.533ArgHis: 1.533 ± 0.017	2.817ArgIle: 2.817 ± 0.021	3.63ArgLys: 3.63 ± 0.029	5.196ArgLeu: 5.196 ± 0.036	1.456ArgMet: 1.456 ± 0.016	2.316ArgAsn: 2.316 ± 0.021	3.444ArgPro: 3.444 ± 0.032	2.731ArgGln: 2.731 ± 0.024	5.021ArgArg: 5.021 ± 0.043	4.886ArgSer: 4.886 ± 0.042	3.361ArgThr: 3.361 ± 0.027	3.314ArgVal: 3.314 ± 0.027	0.893ArgTrp: 0.893 ± 0.013	1.57ArgTyr: 1.57 ± 0.019	0.092ArgXaa: 0.092 ± 0.004
Ser	6.93SerAla: 6.93 ± 0.043	0.879SerCys: 0.879 ± 0.016	4.18SerAsp: 4.18 ± 0.028	4.215SerGlu: 4.215 ± 0.035	2.859SerPhe: 2.859 ± 0.025	5.678SerGly: 5.678 ± 0.037	1.975SerHis: 1.975 ± 0.02	3.87SerIle: 3.87 ± 0.026	3.85SerLys: 3.85 ± 0.032	6.782SerLeu: 6.782 ± 0.037	1.841SerMet: 1.841 ± 0.021	3.103SerAsn: 3.103 ± 0.028	5.273SerPro: 5.273 ± 0.05	3.321SerGln: 3.321 ± 0.03	4.954SerArg: 4.954 ± 0.041	8.689SerSer: 8.689 ± 0.073	5.805SerThr: 5.805 ± 0.048	4.419SerVal: 4.419 ± 0.032	1.064SerTrp: 1.064 ± 0.015	2.008SerTyr: 2.008 ± 0.021	0.121SerXaa: 0.121 ± 0.005
Thr	5.507ThrAla: 5.507 ± 0.035	0.776ThrCys: 0.776 ± 0.015	2.762ThrAsp: 2.762 ± 0.024	3.026ThrGlu: 3.026 ± 0.026	2.239ThrPhe: 2.239 ± 0.02	4.128ThrGly: 4.128 ± 0.032	1.287ThrHis: 1.287 ± 0.018	3.059ThrIle: 3.059 ± 0.026	2.655ThrLys: 2.655 ± 0.023	5.149ThrLeu: 5.149 ± 0.038	1.263ThrMet: 1.263 ± 0.013	2.11ThrAsn: 2.11 ± 0.022	4.297ThrPro: 4.297 ± 0.036	2.129ThrGln: 2.129 ± 0.021	3.137ThrArg: 3.137 ± 0.027	5.524ThrSer: 5.524 ± 0.044	4.618ThrThr: 4.618 ± 0.068	3.554ThrVal: 3.554 ± 0.03	0.823ThrTrp: 0.823 ± 0.012	1.579ThrTyr: 1.579 ± 0.016	0.092ThrXaa: 0.092 ± 0.004
Val	5.401ValAla: 5.401 ± 0.035	0.835ValCys: 0.835 ± 0.013	3.762ValAsp: 3.762 ± 0.03	4.22ValGlu: 4.22 ± 0.031	2.282ValPhe: 2.282 ± 0.024	4.098ValGly: 4.098 ± 0.03	1.397ValHis: 1.397 ± 0.017	2.672ValIle: 2.672 ± 0.024	3.015ValLys: 3.015 ± 0.028	5.403ValLeu: 5.403 ± 0.037	1.363ValMet: 1.363 ± 0.016	2.139ValAsn: 2.139 ± 0.022	3.421ValPro: 3.421 ± 0.025	2.481ValGln: 2.481 ± 0.022	3.489ValArg: 3.489 ± 0.028	4.376ValSer: 4.376 ± 0.032	3.313ValThr: 3.313 ± 0.026	4.325ValVal: 4.325 ± 0.034	0.852ValTrp: 0.852 ± 0.012	1.633ValTyr: 1.633 ± 0.019	0.096ValXaa: 0.096 ± 0.005
Trp	1.08TrpAla: 1.08 ± 0.017	0.195TrpCys: 0.195 ± 0.006	0.853TrpAsp: 0.853 ± 0.015	0.834TrpGlu: 0.834 ± 0.012	0.519TrpPhe: 0.519 ± 0.01	0.822TrpGly: 0.822 ± 0.014	0.345TrpHis: 0.345 ± 0.009	0.738TrpIle: 0.738 ± 0.015	0.788TrpLys: 0.788 ± 0.012	1.29TrpLeu: 1.29 ± 0.018	0.385TrpMet: 0.385 ± 0.008	0.628TrpAsn: 0.628 ± 0.012	0.597TrpPro: 0.597 ± 0.01	0.623TrpGln: 0.623 ± 0.011	0.964TrpArg: 0.964 ± 0.013	1.07TrpSer: 1.07 ± 0.014	0.921TrpThr: 0.921 ± 0.015	0.793TrpVal: 0.793 ± 0.013	0.262TrpTrp: 0.262 ± 0.009	0.419TrpTyr: 0.419 ± 0.009	0.026TrpXaa: 0.026 ± 0.002
Tyr	2.222TyrAla: 2.222 ± 0.021	0.407TyrCys: 0.407 ± 0.01	1.647TyrAsp: 1.647 ± 0.019	1.556TyrGlu: 1.556 ± 0.018	1.102TyrPhe: 1.102 ± 0.015	2.083TyrGly: 2.083 ± 0.026	0.714TyrHis: 0.714 ± 0.012	1.3TyrIle: 1.3 ± 0.018	1.018TyrLys: 1.018 ± 0.015	2.41TyrLeu: 2.41 ± 0.028	0.597TyrMet: 0.597 ± 0.011	1.083TyrAsn: 1.083 ± 0.018	1.388TyrPro: 1.388 ± 0.019	1.119TyrGln: 1.119 ± 0.016	1.531TyrArg: 1.531 ± 0.018	1.945TyrSer: 1.945 ± 0.022	1.574TyrThr: 1.574 ± 0.018	1.515TyrVal: 1.515 ± 0.018	0.408TyrTrp: 0.408 ± 0.008	0.857TyrTyr: 0.857 ± 0.014	0.048TyrXaa: 0.048 ± 0.003
Xaa	0.129XaaAla: 0.129 ± 0.004	0.018XaaCys: 0.018 ± 0.002	0.084XaaAsp: 0.084 ± 0.004	0.095XaaGlu: 0.095 ± 0.004	0.043XaaPhe: 0.043 ± 0.003	0.108XaaGly: 0.108 ± 0.004	0.04XaaHis: 0.04 ± 0.003	0.074XaaIle: 0.074 ± 0.004	0.085XaaLys: 0.085 ± 0.004	0.122XaaLeu: 0.122 ± 0.005	0.04XaaMet: 0.04 ± 0.003	0.064XaaAsn: 0.064 ± 0.003	0.091XaaPro: 0.091 ± 0.004	0.07XaaGln: 0.07 ± 0.004	0.092XaaArg: 0.092 ± 0.004	0.114XaaSer: 0.114 ± 0.005	0.096XaaThr: 0.096 ± 0.005	0.085XaaVal: 0.085 ± 0.004	0.022XaaTrp: 0.022 ± 0.002	0.038XaaTyr: 0.038 ± 0.002	0.151XaaXaa: 0.151 ± 0.041

Statistics based on 11621 proteins (5390580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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