Amino acid dipepetide frequency for Rhodovulum steppense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.181AlaAla: 21.181 ± 0.22	1.224AlaCys: 1.224 ± 0.034	7.528AlaAsp: 7.528 ± 0.103	9.707AlaGlu: 9.707 ± 0.117	4.385AlaPhe: 4.385 ± 0.068	12.24AlaGly: 12.24 ± 0.13	2.655AlaHis: 2.655 ± 0.057	6.134AlaIle: 6.134 ± 0.081	2.751AlaLys: 2.751 ± 0.065	16.367AlaLeu: 16.367 ± 0.145	4.07AlaMet: 4.07 ± 0.056	2.347AlaAsn: 2.347 ± 0.046	7.168AlaPro: 7.168 ± 0.115	4.345AlaGln: 4.345 ± 0.055	12.123AlaArg: 12.123 ± 0.125	5.16AlaSer: 5.16 ± 0.073	6.225AlaThr: 6.225 ± 0.076	9.034AlaVal: 9.034 ± 0.092	1.61AlaTrp: 1.61 ± 0.042	2.385AlaTyr: 2.385 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.186CysAla: 1.186 ± 0.038	0.115CysCys: 0.115 ± 0.011	0.585CysAsp: 0.585 ± 0.021	0.463CysGlu: 0.463 ± 0.021	0.284CysPhe: 0.284 ± 0.017	0.894CysGly: 0.894 ± 0.029	0.258CysHis: 0.258 ± 0.02	0.383CysIle: 0.383 ± 0.019	0.171CysLys: 0.171 ± 0.012	0.842CysLeu: 0.842 ± 0.03	0.147CysMet: 0.147 ± 0.013	0.183CysAsn: 0.183 ± 0.015	0.599CysPro: 0.599 ± 0.026	0.219CysGln: 0.219 ± 0.014	0.734CysArg: 0.734 ± 0.033	0.388CysSer: 0.388 ± 0.019	0.443CysThr: 0.443 ± 0.02	0.597CysVal: 0.597 ± 0.028	0.136CysTrp: 0.136 ± 0.011	0.204CysTyr: 0.204 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.319AspAla: 7.319 ± 0.081	0.519AspCys: 0.519 ± 0.024	2.917AspAsp: 2.917 ± 0.068	3.555AspGlu: 3.555 ± 0.062	2.228AspPhe: 2.228 ± 0.05	5.163AspGly: 5.163 ± 0.077	1.253AspHis: 1.253 ± 0.035	2.805AspIle: 2.805 ± 0.055	1.289AspLys: 1.289 ± 0.036	6.72AspLeu: 6.72 ± 0.092	1.505AspMet: 1.505 ± 0.036	1.027AspAsn: 1.027 ± 0.036	4.215AspPro: 4.215 ± 0.067	1.555AspGln: 1.555 ± 0.035	5.15AspArg: 5.15 ± 0.068	2.129AspSer: 2.129 ± 0.043	2.445AspThr: 2.445 ± 0.047	3.558AspVal: 3.558 ± 0.059	1.255AspTrp: 1.255 ± 0.036	1.385AspTyr: 1.385 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	9.106GluAla: 9.106 ± 0.142	0.373GluCys: 0.373 ± 0.015	3.253GluAsp: 3.253 ± 0.056	3.275GluGlu: 3.275 ± 0.085	1.726GluPhe: 1.726 ± 0.042	5.251GluGly: 5.251 ± 0.085	1.045GluHis: 1.045 ± 0.033	3.786GluIle: 3.786 ± 0.06	1.74GluLys: 1.74 ± 0.048	5.014GluLeu: 5.014 ± 0.069	1.722GluMet: 1.722 ± 0.042	1.429GluAsn: 1.429 ± 0.038	2.803GluPro: 2.803 ± 0.085	1.723GluGln: 1.723 ± 0.046	5.166GluArg: 5.166 ± 0.085	2.046GluSer: 2.046 ± 0.042	4.001GluThr: 4.001 ± 0.066	4.29GluVal: 4.29 ± 0.072	0.65GluTrp: 0.65 ± 0.022	0.896GluTyr: 0.896 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.597PheAla: 4.597 ± 0.062	0.398PheCys: 0.398 ± 0.019	2.661PheAsp: 2.661 ± 0.052	2.124PheGlu: 2.124 ± 0.048	1.359PhePhe: 1.359 ± 0.044	3.546PheGly: 3.546 ± 0.065	0.768PheHis: 0.768 ± 0.027	1.342PheIle: 1.342 ± 0.035	0.654PheLys: 0.654 ± 0.024	3.636PheLeu: 3.636 ± 0.061	0.727PheMet: 0.727 ± 0.026	0.839PheAsn: 0.839 ± 0.028	1.609PhePro: 1.609 ± 0.037	0.967PheGln: 0.967 ± 0.031	2.526PheArg: 2.526 ± 0.048	1.807PheSer: 1.807 ± 0.04	1.932PheThr: 1.932 ± 0.045	2.569PheVal: 2.569 ± 0.052	0.529PheTrp: 0.529 ± 0.024	0.807PheTyr: 0.807 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	11.387GlyAla: 11.387 ± 0.128	0.92GlyCys: 0.92 ± 0.031	4.414GlyAsp: 4.414 ± 0.055	4.931GlyGlu: 4.931 ± 0.068	3.766GlyPhe: 3.766 ± 0.063	7.821GlyGly: 7.821 ± 0.112	2.003GlyHis: 2.003 ± 0.04	4.413GlyIle: 4.413 ± 0.06	2.637GlyLys: 2.637 ± 0.052	10.333GlyLeu: 10.333 ± 0.126	2.64GlyMet: 2.64 ± 0.047	1.772GlyAsn: 1.772 ± 0.049	4.32GlyPro: 4.32 ± 0.061	3.187GlyGln: 3.187 ± 0.052	7.314GlyArg: 7.314 ± 0.088	3.859GlySer: 3.859 ± 0.066	4.555GlyThr: 4.555 ± 0.077	6.417GlyVal: 6.417 ± 0.092	1.597GlyTrp: 1.597 ± 0.04	2.126GlyTyr: 2.126 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.588HisAla: 2.588 ± 0.054	0.214HisCys: 0.214 ± 0.012	1.295HisAsp: 1.295 ± 0.034	1.069HisGlu: 1.069 ± 0.032	0.785HisPhe: 0.785 ± 0.032	2.002HisGly: 2.002 ± 0.046	0.507HisHis: 0.507 ± 0.025	0.778HisIle: 0.778 ± 0.028	0.407HisLys: 0.407 ± 0.017	2.108HisLeu: 2.108 ± 0.045	0.481HisMet: 0.481 ± 0.022	0.375HisAsn: 0.375 ± 0.018	1.453HisPro: 1.453 ± 0.042	0.522HisGln: 0.522 ± 0.022	1.576HisArg: 1.576 ± 0.042	0.783HisSer: 0.783 ± 0.028	0.725HisThr: 0.725 ± 0.024	1.623HisVal: 1.623 ± 0.043	0.359HisTrp: 0.359 ± 0.018	0.536HisTyr: 0.536 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.324IleAla: 7.324 ± 0.082	0.563IleCys: 0.563 ± 0.024	3.259IleAsp: 3.259 ± 0.058	3.632IleGlu: 3.632 ± 0.055	1.492IlePhe: 1.492 ± 0.041	4.726IleGly: 4.726 ± 0.076	0.939IleHis: 0.939 ± 0.029	1.528IleIle: 1.528 ± 0.037	0.994IleLys: 0.994 ± 0.033	4.689IleLeu: 4.689 ± 0.069	0.842IleMet: 0.842 ± 0.031	1.02IleAsn: 1.02 ± 0.032	2.238IlePro: 2.238 ± 0.041	0.961IleGln: 0.961 ± 0.031	3.653IleArg: 3.653 ± 0.063	2.311IleSer: 2.311 ± 0.052	2.387IleThr: 2.387 ± 0.048	3.73IleVal: 3.73 ± 0.059	0.605IleTrp: 0.605 ± 0.023	0.968IleTyr: 0.968 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.279LysAla: 3.279 ± 0.072	0.153LysCys: 0.153 ± 0.011	1.298LysAsp: 1.298 ± 0.04	1.147LysGlu: 1.147 ± 0.037	0.679LysPhe: 0.679 ± 0.025	2.228LysGly: 2.228 ± 0.054	0.44LysHis: 0.44 ± 0.021	1.136LysIle: 1.136 ± 0.032	0.849LysLys: 0.849 ± 0.039	2.298LysLeu: 2.298 ± 0.052	0.61LysMet: 0.61 ± 0.028	0.547LysAsn: 0.547 ± 0.025	1.519LysPro: 1.519 ± 0.047	0.633LysGln: 0.633 ± 0.025	1.972LysArg: 1.972 ± 0.043	1.348LysSer: 1.348 ± 0.037	1.497LysThr: 1.497 ± 0.041	1.846LysVal: 1.846 ± 0.046	0.294LysTrp: 0.294 ± 0.018	0.485LysTyr: 0.485 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	16.075LeuAla: 16.075 ± 0.155	0.978LeuCys: 0.978 ± 0.034	6.623LeuAsp: 6.623 ± 0.092	5.091LeuGlu: 5.091 ± 0.071	3.607LeuPhe: 3.607 ± 0.06	9.231LeuGly: 9.231 ± 0.107	2.014LeuHis: 2.014 ± 0.052	5.103LeuIle: 5.103 ± 0.07	2.774LeuLys: 2.774 ± 0.053	8.997LeuLeu: 8.997 ± 0.11	2.635LeuMet: 2.635 ± 0.053	2.217LeuAsn: 2.217 ± 0.042	6.125LeuPro: 6.125 ± 0.089	2.345LeuGln: 2.345 ± 0.052	8.147LeuArg: 8.147 ± 0.101	6.077LeuSer: 6.077 ± 0.079	5.757LeuThr: 5.757 ± 0.075	7.575LeuVal: 7.575 ± 0.097	1.382LeuTrp: 1.382 ± 0.036	1.847LeuTyr: 1.847 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.755MetAla: 3.755 ± 0.063	0.162MetCys: 0.162 ± 0.012	1.302MetAsp: 1.302 ± 0.031	1.274MetGlu: 1.274 ± 0.037	0.713MetPhe: 0.713 ± 0.032	2.278MetGly: 2.278 ± 0.045	0.403MetHis: 0.403 ± 0.018	1.349MetIle: 1.349 ± 0.04	0.821MetLys: 0.821 ± 0.03	2.59MetLeu: 2.59 ± 0.046	0.657MetMet: 0.657 ± 0.023	0.686MetAsn: 0.686 ± 0.024	1.559MetPro: 1.559 ± 0.033	0.846MetGln: 0.846 ± 0.028	2.097MetArg: 2.097 ± 0.038	1.469MetSer: 1.469 ± 0.036	1.902MetThr: 1.902 ± 0.041	1.8MetVal: 1.8 ± 0.041	0.199MetTrp: 0.199 ± 0.013	0.256MetTyr: 0.256 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.846AsnAla: 2.846 ± 0.052	0.206AsnCys: 0.206 ± 0.015	1.071AsnAsp: 1.071 ± 0.029	0.954AsnGlu: 0.954 ± 0.032	0.706AsnPhe: 0.706 ± 0.029	1.969AsnGly: 1.969 ± 0.041	0.405AsnHis: 0.405 ± 0.02	1.035AsnIle: 1.035 ± 0.033	0.442AsnLys: 0.442 ± 0.024	2.1AsnLeu: 2.1 ± 0.048	0.521AsnMet: 0.521 ± 0.021	0.466AsnAsn: 0.466 ± 0.022	1.7AsnPro: 1.7 ± 0.041	0.535AsnGln: 0.535 ± 0.022	1.763AsnArg: 1.763 ± 0.047	0.866AsnSer: 0.866 ± 0.028	1.02AsnThr: 1.02 ± 0.031	1.619AsnVal: 1.619 ± 0.036	0.353AsnTrp: 0.353 ± 0.019	0.474AsnTyr: 0.474 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.181ProAla: 7.181 ± 0.103	0.436ProCys: 0.436 ± 0.019	4.232ProAsp: 4.232 ± 0.064	4.494ProGlu: 4.494 ± 0.082	2.025ProPhe: 2.025 ± 0.04	5.952ProGly: 5.952 ± 0.081	1.083ProHis: 1.083 ± 0.032	2.076ProIle: 2.076 ± 0.037	1.239ProLys: 1.239 ± 0.041	5.124ProLeu: 5.124 ± 0.079	1.353ProMet: 1.353 ± 0.04	1.098ProAsn: 1.098 ± 0.035	3.095ProPro: 3.095 ± 0.075	1.523ProGln: 1.523 ± 0.037	3.723ProArg: 3.723 ± 0.066	2.272ProSer: 2.272 ± 0.047	2.416ProThr: 2.416 ± 0.049	4.724ProVal: 4.724 ± 0.075	0.716ProTrp: 0.716 ± 0.025	1.035ProTyr: 1.035 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.003GlnAla: 4.003 ± 0.066	0.185GlnCys: 0.185 ± 0.014	1.463GlnAsp: 1.463 ± 0.04	1.383GlnGlu: 1.383 ± 0.041	0.896GlnPhe: 0.896 ± 0.027	2.628GlnGly: 2.628 ± 0.047	0.498GlnHis: 0.498 ± 0.021	1.756GlnIle: 1.756 ± 0.041	0.839GlnLys: 0.839 ± 0.028	2.404GlnLeu: 2.404 ± 0.052	0.903GlnMet: 0.903 ± 0.032	0.718GlnAsn: 0.718 ± 0.027	1.585GlnPro: 1.585 ± 0.038	0.892GlnGln: 0.892 ± 0.035	2.19GlnArg: 2.19 ± 0.044	1.356GlnSer: 1.356 ± 0.038	1.576GlnThr: 1.576 ± 0.037	2.291GlnVal: 2.291 ± 0.046	0.301GlnTrp: 0.301 ± 0.014	0.476GlnTyr: 0.476 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	10.981ArgAla: 10.981 ± 0.101	0.54ArgCys: 0.54 ± 0.021	4.66ArgAsp: 4.66 ± 0.071	4.455ArgGlu: 4.455 ± 0.078	3.117ArgPhe: 3.117 ± 0.062	5.734ArgGly: 5.734 ± 0.082	1.778ArgHis: 1.778 ± 0.047	4.438ArgIle: 4.438 ± 0.069	2.115ArgLys: 2.115 ± 0.051	9.424ArgLeu: 9.424 ± 0.12	2.315ArgMet: 2.315 ± 0.049	1.729ArgAsn: 1.729 ± 0.04	4.551ArgPro: 4.551 ± 0.059	2.388ArgGln: 2.388 ± 0.047	6.561ArgArg: 6.561 ± 0.102	3.309ArgSer: 3.309 ± 0.054	3.374ArgThr: 3.374 ± 0.056	5.606ArgVal: 5.606 ± 0.072	1.064ArgTrp: 1.064 ± 0.035	1.564ArgTyr: 1.564 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.557SerAla: 5.557 ± 0.071	0.422SerCys: 0.422 ± 0.02	2.652SerAsp: 2.652 ± 0.043	2.472SerGlu: 2.472 ± 0.052	1.906SerPhe: 1.906 ± 0.04	4.899SerGly: 4.899 ± 0.072	0.961SerHis: 0.961 ± 0.032	1.98SerIle: 1.98 ± 0.049	1.02SerLys: 1.02 ± 0.033	4.331SerLeu: 4.331 ± 0.064	1.102SerMet: 1.102 ± 0.036	0.989SerAsn: 0.989 ± 0.03	2.53SerPro: 2.53 ± 0.051	1.248SerGln: 1.248 ± 0.034	3.272SerArg: 3.272 ± 0.065	2.019SerSer: 2.019 ± 0.045	2.112SerThr: 2.112 ± 0.045	3.464SerVal: 3.464 ± 0.051	0.594SerTrp: 0.594 ± 0.023	1.059SerTyr: 1.059 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.381ThrAla: 6.381 ± 0.089	0.472ThrCys: 0.472 ± 0.021	2.912ThrAsp: 2.912 ± 0.056	2.933ThrGlu: 2.933 ± 0.06	1.62ThrPhe: 1.62 ± 0.04	5.5ThrGly: 5.5 ± 0.079	1.061ThrHis: 1.061 ± 0.03	2.416ThrIle: 2.416 ± 0.05	0.969ThrLys: 0.969 ± 0.03	5.945ThrLeu: 5.945 ± 0.077	1.136ThrMet: 1.136 ± 0.028	1.074ThrAsn: 1.074 ± 0.034	3.291ThrPro: 3.291 ± 0.057	1.275ThrGln: 1.275 ± 0.037	4.042ThrArg: 4.042 ± 0.069	2.142ThrSer: 2.142 ± 0.044	2.445ThrThr: 2.445 ± 0.051	3.837ThrVal: 3.837 ± 0.059	0.633ThrTrp: 0.633 ± 0.025	1.052ThrTyr: 1.052 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.899ValAla: 9.899 ± 0.094	0.603ValCys: 0.603 ± 0.025	3.802ValAsp: 3.802 ± 0.057	4.611ValGlu: 4.611 ± 0.072	2.807ValPhe: 2.807 ± 0.053	5.39ValGly: 5.39 ± 0.073	1.337ValHis: 1.337 ± 0.036	3.995ValIle: 3.995 ± 0.068	1.688ValLys: 1.688 ± 0.046	7.922ValLeu: 7.922 ± 0.111	1.973ValMet: 1.973 ± 0.043	1.743ValAsn: 1.743 ± 0.043	3.756ValPro: 3.756 ± 0.065	2.001ValGln: 2.001 ± 0.042	4.836ValArg: 4.836 ± 0.067	3.595ValSer: 3.595 ± 0.061	4.606ValThr: 4.606 ± 0.063	5.559ValVal: 5.559 ± 0.085	0.939ValTrp: 0.939 ± 0.032	1.358ValTyr: 1.358 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.544TrpAla: 1.544 ± 0.044	0.138TrpCys: 0.138 ± 0.011	0.724TrpAsp: 0.724 ± 0.03	0.608TrpGlu: 0.608 ± 0.027	0.53TrpPhe: 0.53 ± 0.021	1.004TrpGly: 1.004 ± 0.031	0.319TrpHis: 0.319 ± 0.015	0.672TrpIle: 0.672 ± 0.026	0.421TrpLys: 0.421 ± 0.02	1.682TrpLeu: 1.682 ± 0.047	0.347TrpMet: 0.347 ± 0.016	0.326TrpAsn: 0.326 ± 0.016	0.744TrpPro: 0.744 ± 0.027	0.63TrpGln: 0.63 ± 0.022	1.212TrpArg: 1.212 ± 0.036	0.717TrpSer: 0.717 ± 0.025	0.768TrpThr: 0.768 ± 0.028	0.88TrpVal: 0.88 ± 0.033	0.218TrpTrp: 0.218 ± 0.015	0.248TrpTyr: 0.248 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.453TyrAla: 2.453 ± 0.046	0.213TyrCys: 0.213 ± 0.014	1.341TyrAsp: 1.341 ± 0.037	1.117TyrGlu: 1.117 ± 0.033	0.762TyrPhe: 0.762 ± 0.03	1.957TyrGly: 1.957 ± 0.045	0.456TyrHis: 0.456 ± 0.021	0.736TyrIle: 0.736 ± 0.027	0.435TyrLys: 0.435 ± 0.021	2.077TyrLeu: 2.077 ± 0.047	0.428TyrMet: 0.428 ± 0.02	0.464TyrAsn: 0.464 ± 0.023	0.937TyrPro: 0.937 ± 0.027	0.548TyrGln: 0.548 ± 0.023	1.649TyrArg: 1.649 ± 0.041	0.935TyrSer: 0.935 ± 0.029	0.95TyrThr: 0.95 ± 0.029	1.405TyrVal: 1.405 ± 0.035	0.299TyrTrp: 0.299 ± 0.016	0.484TyrTyr: 0.484 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3581 proteins (1093594 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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