Amino acid dipepetide frequency for Clostridium sp. CAG:302

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.962AlaAla: 1.962 ± 0.089
0.338AlaCys: 0.338 ± 0.026
1.907AlaAsp: 1.907 ± 0.081
2.097AlaGlu: 2.097 ± 0.083
1.665AlaPhe: 1.665 ± 0.066
2.369AlaGly: 2.369 ± 0.093
0.528AlaHis: 0.528 ± 0.044
4.144AlaIle: 4.144 ± 0.114
3.746AlaLys: 3.746 ± 0.125
3.735AlaLeu: 3.735 ± 0.124
1.077AlaMet: 1.077 ± 0.054
2.344AlaAsn: 2.344 ± 0.087
0.912AlaPro: 0.912 ± 0.05
0.704AlaGln: 0.704 ± 0.042
1.616AlaArg: 1.616 ± 0.073
3.02AlaSer: 3.02 ± 0.097
2.306AlaThr: 2.306 ± 0.083
2.619AlaVal: 2.619 ± 0.097
0.264AlaTrp: 0.264 ± 0.027
2.003AlaTyr: 2.003 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.357CysAla: 0.357 ± 0.033
0.157CysCys: 0.157 ± 0.025
0.66CysAsp: 0.66 ± 0.043
0.539CysGlu: 0.539 ± 0.035
0.434CysPhe: 0.434 ± 0.034
0.808CysGly: 0.808 ± 0.054
0.214CysHis: 0.214 ± 0.026
0.893CysIle: 0.893 ± 0.051
0.915CysLys: 0.915 ± 0.052
0.811CysLeu: 0.811 ± 0.047
0.19CysMet: 0.19 ± 0.023
0.794CysAsn: 0.794 ± 0.05
0.393CysPro: 0.393 ± 0.041
0.19CysGln: 0.19 ± 0.024
0.289CysArg: 0.289 ± 0.029
0.764CysSer: 0.764 ± 0.059
0.662CysThr: 0.662 ± 0.055
0.429CysVal: 0.429 ± 0.036
0.049CysTrp: 0.049 ± 0.013
0.541CysTyr: 0.541 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
2.13AspAla: 2.13 ± 0.079
0.456AspCys: 0.456 ± 0.032
3.51AspAsp: 3.51 ± 0.113
4.23AspGlu: 4.23 ± 0.116
2.627AspPhe: 2.627 ± 0.081
3.268AspGly: 3.268 ± 0.1
0.478AspHis: 0.478 ± 0.037
7.53AspIle: 7.53 ± 0.162
7.126AspLys: 7.126 ± 0.16
4.895AspLeu: 4.895 ± 0.136
1.498AspMet: 1.498 ± 0.068
5.936AspAsn: 5.936 ± 0.159
1.08AspPro: 1.08 ± 0.066
0.544AspGln: 0.544 ± 0.041
1.921AspArg: 1.921 ± 0.077
3.806AspSer: 3.806 ± 0.111
3.875AspThr: 3.875 ± 0.105
3.378AspVal: 3.378 ± 0.101
0.289AspTrp: 0.289 ± 0.028
4.018AspTyr: 4.018 ± 0.101
0.0AspXaa: 0.0 ± 0.0
Glu
3.062GluAla: 3.062 ± 0.106
0.599GluCys: 0.599 ± 0.041
4.562GluAsp: 4.562 ± 0.125
7.42GluGlu: 7.42 ± 0.165
2.506GluPhe: 2.506 ± 0.099
3.18GluGly: 3.18 ± 0.098
0.673GluHis: 0.673 ± 0.04
6.725GluIle: 6.725 ± 0.153
7.31GluLys: 7.31 ± 0.162
7.071GluLeu: 7.071 ± 0.156
1.767GluMet: 1.767 ± 0.061
4.743GluAsn: 4.743 ± 0.133
1.3GluPro: 1.3 ± 0.07
1.204GluGln: 1.204 ± 0.065
2.506GluArg: 2.506 ± 0.087
3.16GluSer: 3.16 ± 0.099
3.13GluThr: 3.13 ± 0.106
5.068GluVal: 5.068 ± 0.133
0.382GluTrp: 0.382 ± 0.033
4.438GluTyr: 4.438 ± 0.134
0.0GluXaa: 0.0 ± 0.0
Phe
1.726PheAla: 1.726 ± 0.084
0.442PheCys: 0.442 ± 0.037
3.059PheAsp: 3.059 ± 0.088
2.289PheGlu: 2.289 ± 0.085
1.715PhePhe: 1.715 ± 0.076
2.259PheGly: 2.259 ± 0.085
0.459PheHis: 0.459 ± 0.035
4.576PheIle: 4.576 ± 0.144
3.603PheLys: 3.603 ± 0.102
3.575PheLeu: 3.575 ± 0.106
0.846PheMet: 0.846 ± 0.047
3.463PheAsn: 3.463 ± 0.098
0.921PhePro: 0.921 ± 0.051
0.627PheGln: 0.627 ± 0.043
1.212PheArg: 1.212 ± 0.061
2.853PheSer: 2.853 ± 0.102
2.473PheThr: 2.473 ± 0.075
2.405PheVal: 2.405 ± 0.099
0.203PheTrp: 0.203 ± 0.025
2.113PheTyr: 2.113 ± 0.082
0.0PheXaa: 0.0 ± 0.0
Gly
2.515GlyAla: 2.515 ± 0.108
0.676GlyCys: 0.676 ± 0.052
2.765GlyAsp: 2.765 ± 0.094
3.235GlyGlu: 3.235 ± 0.105
2.039GlyPhe: 2.039 ± 0.086
3.226GlyGly: 3.226 ± 0.134
0.863GlyHis: 0.863 ± 0.053
5.76GlyIle: 5.76 ± 0.135
5.01GlyLys: 5.01 ± 0.118
4.191GlyLeu: 4.191 ± 0.104
1.316GlyMet: 1.316 ± 0.067
3.691GlyAsn: 3.691 ± 0.114
0.965GlyPro: 0.965 ± 0.083
0.888GlyGln: 0.888 ± 0.047
1.72GlyArg: 1.72 ± 0.082
3.455GlySer: 3.455 ± 0.096
3.815GlyThr: 3.815 ± 0.143
3.449GlyVal: 3.449 ± 0.102
0.289GlyTrp: 0.289 ± 0.032
3.259GlyTyr: 3.259 ± 0.105
0.0GlyXaa: 0.0 ± 0.0
His
0.53HisAla: 0.53 ± 0.042
0.113HisCys: 0.113 ± 0.02
0.638HisAsp: 0.638 ± 0.043
0.695HisGlu: 0.695 ± 0.047
0.552HisPhe: 0.552 ± 0.04
0.706HisGly: 0.706 ± 0.048
0.269HisHis: 0.269 ± 0.031
1.138HisIle: 1.138 ± 0.063
0.959HisLys: 0.959 ± 0.054
1.058HisLeu: 1.058 ± 0.057
0.242HisMet: 0.242 ± 0.026
0.951HisAsn: 0.951 ± 0.055
0.577HisPro: 0.577 ± 0.048
0.291HisGln: 0.291 ± 0.027
0.401HisArg: 0.401 ± 0.036
0.772HisSer: 0.772 ± 0.046
0.572HisThr: 0.572 ± 0.046
0.536HisVal: 0.536 ± 0.042
0.052HisTrp: 0.052 ± 0.013
0.632HisTyr: 0.632 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
4.122IleAla: 4.122 ± 0.13
1.055IleCys: 1.055 ± 0.059
7.286IleAsp: 7.286 ± 0.151
6.846IleGlu: 6.846 ± 0.151
4.328IlePhe: 4.328 ± 0.134
5.103IleGly: 5.103 ± 0.132
1.061IleHis: 1.061 ± 0.059
11.411IleIle: 11.411 ± 0.292
10.597IleLys: 10.597 ± 0.191
9.809IleLeu: 9.809 ± 0.239
2.276IleMet: 2.276 ± 0.092
8.759IleAsn: 8.759 ± 0.174
3.103IlePro: 3.103 ± 0.088
1.253IleGln: 1.253 ± 0.06
2.985IleArg: 2.985 ± 0.096
7.239IleSer: 7.239 ± 0.164
6.035IleThr: 6.035 ± 0.147
6.247IleVal: 6.247 ± 0.153
0.44IleTrp: 0.44 ± 0.034
5.175IleTyr: 5.175 ± 0.124
0.0IleXaa: 0.0 ± 0.0
Lys
3.193LysAla: 3.193 ± 0.104
0.899LysCys: 0.899 ± 0.058
7.42LysAsp: 7.42 ± 0.149
10.875LysGlu: 10.875 ± 0.202
2.916LysPhe: 2.916 ± 0.089
4.219LysGly: 4.219 ± 0.114
0.987LysHis: 0.987 ± 0.054
9.995LysIle: 9.995 ± 0.179
10.765LysLys: 10.765 ± 0.227
8.388LysLeu: 8.388 ± 0.152
2.888LysMet: 2.888 ± 0.085
7.849LysAsn: 7.849 ± 0.165
1.803LysPro: 1.803 ± 0.066
1.891LysGln: 1.891 ± 0.071
3.232LysArg: 3.232 ± 0.097
4.581LysSer: 4.581 ± 0.103
4.507LysThr: 4.507 ± 0.13
6.436LysVal: 6.436 ± 0.151
0.473LysTrp: 0.473 ± 0.032
6.23LysTyr: 6.23 ± 0.16
0.0LysXaa: 0.0 ± 0.0
Leu
3.806LeuAla: 3.806 ± 0.116
1.02LeuCys: 1.02 ± 0.058
5.873LeuAsp: 5.873 ± 0.151
6.252LeuGlu: 6.252 ± 0.15
4.219LeuPhe: 4.219 ± 0.151
5.057LeuGly: 5.057 ± 0.136
0.973LeuHis: 0.973 ± 0.055
8.709LeuIle: 8.709 ± 0.203
8.041LeuLys: 8.041 ± 0.174
8.602LeuLeu: 8.602 ± 0.211
1.817LeuMet: 1.817 ± 0.072
6.651LeuAsn: 6.651 ± 0.139
2.482LeuPro: 2.482 ± 0.091
1.314LeuGln: 1.314 ± 0.059
2.556LeuArg: 2.556 ± 0.097
7.096LeuSer: 7.096 ± 0.128
5.158LeuThr: 5.158 ± 0.12
5.502LeuVal: 5.502 ± 0.117
0.495LeuTrp: 0.495 ± 0.037
4.21LeuTyr: 4.21 ± 0.118
0.0LeuXaa: 0.0 ± 0.0
Met
1.209MetAla: 1.209 ± 0.058
0.247MetCys: 0.247 ± 0.027
1.217MetAsp: 1.217 ± 0.056
1.608MetGlu: 1.608 ± 0.069
1.259MetPhe: 1.259 ± 0.088
1.316MetGly: 1.316 ± 0.066
0.297MetHis: 0.297 ± 0.03
2.3MetIle: 2.3 ± 0.08
2.776MetLys: 2.776 ± 0.079
2.025MetLeu: 2.025 ± 0.078
0.602MetMet: 0.602 ± 0.047
1.91MetAsn: 1.91 ± 0.076
0.742MetPro: 0.742 ± 0.044
0.459MetGln: 0.459 ± 0.039
0.668MetArg: 0.668 ± 0.041
1.413MetSer: 1.413 ± 0.069
1.22MetThr: 1.22 ± 0.057
1.344MetVal: 1.344 ± 0.06
0.157MetTrp: 0.157 ± 0.021
1.072MetTyr: 1.072 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
2.355AsnAla: 2.355 ± 0.085
0.717AsnCys: 0.717 ± 0.049
4.862AsnAsp: 4.862 ± 0.131
4.903AsnGlu: 4.903 ± 0.121
2.759AsnPhe: 2.759 ± 0.094
4.059AsnGly: 4.059 ± 0.124
0.863AsnHis: 0.863 ± 0.049
9.718AsnIle: 9.718 ± 0.226
9.058AsnLys: 9.058 ± 0.198
6.104AsnLeu: 6.104 ± 0.128
1.905AsnMet: 1.905 ± 0.088
8.338AsnAsn: 8.338 ± 0.236
1.932AsnPro: 1.932 ± 0.077
1.195AsnGln: 1.195 ± 0.062
2.196AsnArg: 2.196 ± 0.074
4.713AsnSer: 4.713 ± 0.113
4.617AsnThr: 4.617 ± 0.135
3.955AsnVal: 3.955 ± 0.108
0.349AsnTrp: 0.349 ± 0.03
4.961AsnTyr: 4.961 ± 0.135
0.0AsnXaa: 0.0 ± 0.0
Pro
0.83ProAla: 0.83 ± 0.052
0.275ProCys: 0.275 ± 0.031
1.314ProAsp: 1.314 ± 0.06
1.759ProGlu: 1.759 ± 0.072
1.231ProPhe: 1.231 ± 0.054
1.212ProGly: 1.212 ± 0.057
0.338ProHis: 0.338 ± 0.032
2.27ProIle: 2.27 ± 0.083
2.097ProLys: 2.097 ± 0.085
2.124ProLeu: 2.124 ± 0.074
0.605ProMet: 0.605 ± 0.045
1.852ProAsn: 1.852 ± 0.071
0.393ProPro: 0.393 ± 0.032
0.396ProGln: 0.396 ± 0.041
0.786ProArg: 0.786 ± 0.05
1.929ProSer: 1.929 ± 0.072
1.44ProThr: 1.44 ± 0.071
1.635ProVal: 1.635 ± 0.07
0.17ProTrp: 0.17 ± 0.022
1.352ProTyr: 1.352 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
0.745GlnAla: 0.745 ± 0.056
0.146GlnCys: 0.146 ± 0.023
0.926GlnAsp: 0.926 ± 0.049
1.206GlnGlu: 1.206 ± 0.065
0.552GlnPhe: 0.552 ± 0.04
0.973GlnGly: 0.973 ± 0.064
0.151GlnHis: 0.151 ± 0.022
1.742GlnIle: 1.742 ± 0.067
1.682GlnLys: 1.682 ± 0.081
1.27GlnLeu: 1.27 ± 0.059
0.467GlnMet: 0.467 ± 0.038
1.267GlnAsn: 1.267 ± 0.071
0.305GlnPro: 0.305 ± 0.027
0.291GlnGln: 0.291 ± 0.031
0.72GlnArg: 0.72 ± 0.051
0.893GlnSer: 0.893 ± 0.05
0.951GlnThr: 0.951 ± 0.055
0.959GlnVal: 0.959 ± 0.051
0.088GlnTrp: 0.088 ± 0.014
0.671GlnTyr: 0.671 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
1.187ArgAla: 1.187 ± 0.065
0.388ArgCys: 0.388 ± 0.034
1.861ArgAsp: 1.861 ± 0.077
2.649ArgGlu: 2.649 ± 0.092
1.171ArgPhe: 1.171 ± 0.056
1.707ArgGly: 1.707 ± 0.068
0.448ArgHis: 0.448 ± 0.037
3.122ArgIle: 3.122 ± 0.11
3.188ArgLys: 3.188 ± 0.106
2.746ArgLeu: 2.746 ± 0.094
0.995ArgMet: 0.995 ± 0.052
2.298ArgAsn: 2.298 ± 0.08
0.712ArgPro: 0.712 ± 0.043
0.649ArgGln: 0.649 ± 0.041
1.322ArgArg: 1.322 ± 0.06
1.525ArgSer: 1.525 ± 0.063
1.514ArgThr: 1.514 ± 0.067
2.166ArgVal: 2.166 ± 0.078
0.206ArgTrp: 0.206 ± 0.023
1.748ArgTyr: 1.748 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
2.281SerAla: 2.281 ± 0.089
0.629SerCys: 0.629 ± 0.042
3.848SerAsp: 3.848 ± 0.101
3.757SerGlu: 3.757 ± 0.11
3.095SerPhe: 3.095 ± 0.09
3.743SerGly: 3.743 ± 0.098
0.811SerHis: 0.811 ± 0.05
6.467SerIle: 6.467 ± 0.155
6.293SerLys: 6.293 ± 0.141
6.206SerLeu: 6.206 ± 0.152
1.539SerMet: 1.539 ± 0.076
5.271SerAsn: 5.271 ± 0.158
1.278SerPro: 1.278 ± 0.06
1.066SerGln: 1.066 ± 0.058
2.034SerArg: 2.034 ± 0.071
4.988SerSer: 4.988 ± 0.152
3.867SerThr: 3.867 ± 0.108
3.534SerVal: 3.534 ± 0.12
0.33SerTrp: 0.33 ± 0.032
3.521SerTyr: 3.521 ± 0.101
0.0SerXaa: 0.0 ± 0.0
Thr
2.583ThrAla: 2.583 ± 0.105
0.561ThrCys: 0.561 ± 0.042
3.342ThrAsp: 3.342 ± 0.121
3.35ThrGlu: 3.35 ± 0.115
2.476ThrPhe: 2.476 ± 0.096
3.534ThrGly: 3.534 ± 0.114
0.66ThrHis: 0.66 ± 0.046
6.206ThrIle: 6.206 ± 0.15
5.359ThrLys: 5.359 ± 0.144
5.178ThrLeu: 5.178 ± 0.123
1.237ThrMet: 1.237 ± 0.06
4.114ThrAsn: 4.114 ± 0.113
1.781ThrPro: 1.781 ± 0.078
0.745ThrGln: 0.745 ± 0.052
1.712ThrArg: 1.712 ± 0.071
4.312ThrSer: 4.312 ± 0.145
3.54ThrThr: 3.54 ± 0.126
3.018ThrVal: 3.018 ± 0.12
0.363ThrTrp: 0.363 ± 0.03
2.839ThrTyr: 2.839 ± 0.096
0.0ThrXaa: 0.0 ± 0.0
Val
2.509ValAla: 2.509 ± 0.083
0.731ValCys: 0.731 ± 0.048
3.424ValAsp: 3.424 ± 0.1
3.353ValGlu: 3.353 ± 0.115
2.421ValPhe: 2.421 ± 0.085
3.246ValGly: 3.246 ± 0.1
0.72ValHis: 0.72 ± 0.047
6.544ValIle: 6.544 ± 0.13
5.444ValLys: 5.444 ± 0.136
5.944ValLeu: 5.944 ± 0.131
1.308ValMet: 1.308 ± 0.055
4.125ValAsn: 4.125 ± 0.113
1.863ValPro: 1.863 ± 0.07
0.868ValGln: 0.868 ± 0.053
1.932ValArg: 1.932 ± 0.089
4.334ValSer: 4.334 ± 0.118
3.828ValThr: 3.828 ± 0.115
4.076ValVal: 4.076 ± 0.115
0.33ValTrp: 0.33 ± 0.029
2.886ValTyr: 2.886 ± 0.085
0.0ValXaa: 0.0 ± 0.0
Trp
0.19TrpAla: 0.19 ± 0.024
0.104TrpCys: 0.104 ± 0.018
0.322TrpAsp: 0.322 ± 0.034
0.313TrpGlu: 0.313 ± 0.029
0.236TrpPhe: 0.236 ± 0.027
0.264TrpGly: 0.264 ± 0.025
0.08TrpHis: 0.08 ± 0.013
0.473TrpIle: 0.473 ± 0.038
0.368TrpLys: 0.368 ± 0.036
0.503TrpLeu: 0.503 ± 0.04
0.137TrpMet: 0.137 ± 0.018
0.442TrpAsn: 0.442 ± 0.036
0.121TrpPro: 0.121 ± 0.019
0.124TrpGln: 0.124 ± 0.019
0.181TrpArg: 0.181 ± 0.019
0.316TrpSer: 0.316 ± 0.033
0.247TrpThr: 0.247 ± 0.028
0.247TrpVal: 0.247 ± 0.028
0.058TrpTrp: 0.058 ± 0.014
0.473TrpTyr: 0.473 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.064TyrAla: 2.064 ± 0.075
0.536TyrCys: 0.536 ± 0.04
3.801TyrAsp: 3.801 ± 0.103
3.433TyrGlu: 3.433 ± 0.094
2.616TyrPhe: 2.616 ± 0.096
2.877TyrGly: 2.877 ± 0.095
0.813TyrHis: 0.813 ± 0.048
5.409TyrIle: 5.409 ± 0.135
5.208TyrLys: 5.208 ± 0.128
5.598TyrLeu: 5.598 ± 0.151
1.127TyrMet: 1.127 ± 0.061
4.76TyrAsn: 4.76 ± 0.141
1.347TyrPro: 1.347 ± 0.066
1.308TyrGln: 1.308 ± 0.066
1.61TyrArg: 1.61 ± 0.069
3.386TyrSer: 3.386 ± 0.11
3.149TyrThr: 3.149 ± 0.096
2.886TyrVal: 2.886 ± 0.091
0.214TyrTrp: 0.214 ± 0.022
3.303TyrTyr: 3.303 ± 0.114
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1248 proteins (363869 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski