Amino acid dipepetide frequency for Ferak virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.467AlaAla: 2.467 ± 1.957
0.74AlaCys: 0.74 ± 0.436
2.96AlaAsp: 2.96 ± 1.029
2.467AlaGlu: 2.467 ± 0.896
2.22AlaPhe: 2.22 ± 2.597
2.22AlaGly: 2.22 ± 0.781
0.493AlaHis: 0.493 ± 0.291
3.947AlaIle: 3.947 ± 1.162
4.193AlaLys: 4.193 ± 1.005
2.22AlaLeu: 2.22 ± 1.041
3.207AlaMet: 3.207 ± 1.251
3.947AlaAsn: 3.947 ± 1.067
0.987AlaPro: 0.987 ± 0.395
1.48AlaGln: 1.48 ± 0.394
1.233AlaArg: 1.233 ± 0.569
3.947AlaSer: 3.947 ± 0.621
1.973AlaThr: 1.973 ± 1.501
3.453AlaVal: 3.453 ± 0.374
0.0AlaTrp: 0.0 ± 0.0
1.48AlaTyr: 1.48 ± 0.327
0.0AlaXaa: 0.0 ± 0.0
Cys
0.987CysAla: 0.987 ± 0.53
1.233CysCys: 1.233 ± 0.661
0.987CysAsp: 0.987 ± 0.563
0.987CysGlu: 0.987 ± 0.313
0.493CysPhe: 0.493 ± 0.157
0.74CysGly: 0.74 ± 0.208
0.247CysHis: 0.247 ± 0.145
1.727CysIle: 1.727 ± 0.412
2.22CysLys: 2.22 ± 1.049
1.973CysLeu: 1.973 ± 0.574
0.74CysMet: 0.74 ± 0.469
0.493CysAsn: 0.493 ± 0.157
0.247CysPro: 0.247 ± 0.145
0.0CysGln: 0.0 ± 0.0
0.493CysArg: 0.493 ± 0.505
2.467CysSer: 2.467 ± 0.831
1.233CysThr: 1.233 ± 1.069
2.713CysVal: 2.713 ± 0.879
0.0CysTrp: 0.0 ± 0.0
0.987CysTyr: 0.987 ± 0.323
0.0CysXaa: 0.0 ± 0.0
Asp
1.973AspAla: 1.973 ± 0.569
0.493AspCys: 0.493 ± 0.437
4.44AspAsp: 4.44 ± 1.373
5.18AspGlu: 5.18 ± 1.402
4.44AspPhe: 4.44 ± 1.298
2.467AspGly: 2.467 ± 1.56
0.987AspHis: 0.987 ± 0.313
7.153AspIle: 7.153 ± 1.138
6.907AspLys: 6.907 ± 0.915
4.687AspLeu: 4.687 ± 1.158
2.22AspMet: 2.22 ± 0.777
5.673AspAsn: 5.673 ± 1.661
1.48AspPro: 1.48 ± 0.595
1.727AspGln: 1.727 ± 1.017
2.467AspArg: 2.467 ± 0.678
4.193AspSer: 4.193 ± 1.477
2.22AspThr: 2.22 ± 1.097
3.453AspVal: 3.453 ± 1.049
1.48AspTrp: 1.48 ± 0.417
3.453AspTyr: 3.453 ± 1.438
0.0AspXaa: 0.0 ± 0.0
Glu
3.7GluAla: 3.7 ± 1.154
0.493GluCys: 0.493 ± 0.291
4.193GluAsp: 4.193 ± 0.748
5.673GluGlu: 5.673 ± 2.239
1.727GluPhe: 1.727 ± 0.736
2.96GluGly: 2.96 ± 0.834
1.233GluHis: 1.233 ± 0.78
4.44GluIle: 4.44 ± 1.216
5.18GluLys: 5.18 ± 1.961
5.92GluLeu: 5.92 ± 2.148
3.7GluMet: 3.7 ± 0.77
3.207GluAsn: 3.207 ± 1.444
0.74GluPro: 0.74 ± 0.208
2.22GluGln: 2.22 ± 1.308
1.727GluArg: 1.727 ± 0.467
3.947GluSer: 3.947 ± 0.621
2.22GluThr: 2.22 ± 0.625
5.92GluVal: 5.92 ± 0.857
0.493GluTrp: 0.493 ± 0.157
2.22GluTyr: 2.22 ± 0.625
0.0GluXaa: 0.0 ± 0.0
Phe
1.973PheAla: 1.973 ± 1.038
1.233PheCys: 1.233 ± 0.726
2.96PheAsp: 2.96 ± 0.564
1.48PheGlu: 1.48 ± 0.417
2.22PhePhe: 2.22 ± 1.054
1.48PheGly: 1.48 ± 0.549
0.493PheHis: 0.493 ± 0.291
3.7PheIle: 3.7 ± 1.108
3.453PheLys: 3.453 ± 1.181
5.427PheLeu: 5.427 ± 2.16
0.74PheMet: 0.74 ± 0.208
5.673PheAsn: 5.673 ± 1.082
0.74PhePro: 0.74 ± 0.436
1.233PheGln: 1.233 ± 0.592
1.727PheArg: 1.727 ± 0.288
4.44PheSer: 4.44 ± 0.509
2.96PheThr: 2.96 ± 0.564
1.727PheVal: 1.727 ± 0.412
0.493PheTrp: 0.493 ± 0.437
1.233PheTyr: 1.233 ± 0.367
0.0PheXaa: 0.0 ± 0.0
Gly
1.48GlyAla: 1.48 ± 0.595
0.0GlyCys: 0.0 ± 0.0
3.453GlyAsp: 3.453 ± 1.049
1.973GlyGlu: 1.973 ± 0.569
1.973GlyPhe: 1.973 ± 0.752
1.727GlyGly: 1.727 ± 0.705
0.493GlyHis: 0.493 ± 0.437
3.7GlyIle: 3.7 ± 0.782
4.687GlyLys: 4.687 ± 1.796
3.947GlyLeu: 3.947 ± 0.935
1.973GlyMet: 1.973 ± 0.719
1.973GlyAsn: 1.973 ± 0.626
0.987GlyPro: 0.987 ± 0.313
1.973GlyGln: 1.973 ± 0.54
1.233GlyArg: 1.233 ± 0.456
4.933GlySer: 4.933 ± 1.093
2.713GlyThr: 2.713 ± 1.509
1.973GlyVal: 1.973 ± 0.791
0.987GlyTrp: 0.987 ± 0.581
2.713GlyTyr: 2.713 ± 1.477
0.0GlyXaa: 0.0 ± 0.0
His
0.74HisAla: 0.74 ± 0.208
0.74HisCys: 0.74 ± 0.485
0.987HisAsp: 0.987 ± 0.313
0.493HisGlu: 0.493 ± 0.291
0.493HisPhe: 0.493 ± 0.157
0.74HisGly: 0.74 ± 0.208
0.247HisHis: 0.247 ± 0.145
0.74HisIle: 0.74 ± 0.436
1.48HisLys: 1.48 ± 0.47
1.233HisLeu: 1.233 ± 0.498
0.74HisMet: 0.74 ± 0.208
0.247HisAsn: 0.247 ± 0.219
0.247HisPro: 0.247 ± 0.145
0.493HisGln: 0.493 ± 0.157
0.74HisArg: 0.74 ± 0.436
0.987HisSer: 0.987 ± 0.313
0.493HisThr: 0.493 ± 0.157
0.247HisVal: 0.247 ± 0.219
0.0HisTrp: 0.0 ± 0.0
1.48HisTyr: 1.48 ± 0.417
0.0HisXaa: 0.0 ± 0.0
Ile
4.193IleAla: 4.193 ± 0.428
1.727IleCys: 1.727 ± 0.811
5.673IleAsp: 5.673 ± 1.335
3.947IleGlu: 3.947 ± 1.04
3.207IlePhe: 3.207 ± 0.732
4.193IleGly: 4.193 ± 1.901
1.48IleHis: 1.48 ± 0.394
4.44IleIle: 4.44 ± 1.093
8.633IleLys: 8.633 ± 1.699
5.427IleLeu: 5.427 ± 1.923
1.48IleMet: 1.48 ± 0.346
5.18IleAsn: 5.18 ± 0.535
3.207IlePro: 3.207 ± 0.91
1.48IleGln: 1.48 ± 0.417
4.44IleArg: 4.44 ± 1.774
6.413IleSer: 6.413 ± 1.897
4.933IleThr: 4.933 ± 0.782
4.687IleVal: 4.687 ± 0.709
0.493IleTrp: 0.493 ± 0.157
2.96IleTyr: 2.96 ± 1.067
0.0IleXaa: 0.0 ± 0.0
Lys
3.7LysAla: 3.7 ± 2.242
2.22LysCys: 2.22 ± 1.093
4.933LysAsp: 4.933 ± 1.355
7.4LysGlu: 7.4 ± 1.526
4.193LysPhe: 4.193 ± 1.25
3.7LysGly: 3.7 ± 0.606
1.233LysHis: 1.233 ± 0.339
6.167LysIle: 6.167 ± 0.944
6.66LysLys: 6.66 ± 1.301
8.633LysLeu: 8.633 ± 1.278
2.713LysMet: 2.713 ± 0.641
5.427LysAsn: 5.427 ± 0.712
3.7LysPro: 3.7 ± 0.895
1.973LysGln: 1.973 ± 0.647
3.207LysArg: 3.207 ± 0.632
6.413LysSer: 6.413 ± 1.315
5.673LysThr: 5.673 ± 0.539
4.44LysVal: 4.44 ± 0.611
0.987LysTrp: 0.987 ± 0.323
4.687LysTyr: 4.687 ± 1.134
0.0LysXaa: 0.0 ± 0.0
Leu
4.193LeuAla: 4.193 ± 2.313
2.22LeuCys: 2.22 ± 0.625
6.907LeuAsp: 6.907 ± 1.53
4.687LeuGlu: 4.687 ± 0.536
5.18LeuPhe: 5.18 ± 1.235
2.467LeuGly: 2.467 ± 0.912
0.987LeuHis: 0.987 ± 0.581
5.92LeuIle: 5.92 ± 1.171
4.44LeuLys: 4.44 ± 1.409
6.167LeuLeu: 6.167 ± 2.519
4.933LeuMet: 4.933 ± 0.782
5.92LeuAsn: 5.92 ± 1.258
1.48LeuPro: 1.48 ± 0.591
1.48LeuGln: 1.48 ± 0.595
3.453LeuArg: 3.453 ± 0.519
7.153LeuSer: 7.153 ± 0.547
7.4LeuThr: 7.4 ± 3.614
4.687LeuVal: 4.687 ± 1.221
0.247LeuTrp: 0.247 ± 0.562
3.7LeuTyr: 3.7 ± 0.96
0.0LeuXaa: 0.0 ± 0.0
Met
1.727MetAla: 1.727 ± 1.49
0.247MetCys: 0.247 ± 0.145
1.727MetAsp: 1.727 ± 0.467
2.467MetGlu: 2.467 ± 0.896
1.48MetPhe: 1.48 ± 0.394
0.493MetGly: 0.493 ± 0.291
0.0MetHis: 0.0 ± 0.0
2.96MetIle: 2.96 ± 0.661
4.44MetLys: 4.44 ± 0.84
4.44MetLeu: 4.44 ± 1.055
1.48MetMet: 1.48 ± 0.872
1.973MetAsn: 1.973 ± 1.41
1.48MetPro: 1.48 ± 0.417
1.233MetGln: 1.233 ± 0.456
1.233MetArg: 1.233 ± 0.367
5.427MetSer: 5.427 ± 0.719
2.22MetThr: 2.22 ± 2.046
2.96MetVal: 2.96 ± 0.768
0.247MetTrp: 0.247 ± 0.219
1.233MetTyr: 1.233 ± 0.456
0.0MetXaa: 0.0 ± 0.0
Asn
1.727AsnAla: 1.727 ± 0.701
0.74AsnCys: 0.74 ± 0.682
4.193AsnAsp: 4.193 ± 0.97
4.193AsnGlu: 4.193 ± 1.254
2.713AsnPhe: 2.713 ± 1.014
2.467AsnGly: 2.467 ± 0.783
0.247AsnHis: 0.247 ± 0.145
7.153AsnIle: 7.153 ± 1.059
6.66AsnLys: 6.66 ± 0.698
6.907AsnLeu: 6.907 ± 1.995
3.947AsnMet: 3.947 ± 0.859
3.947AsnAsn: 3.947 ± 1.601
2.713AsnPro: 2.713 ± 1.05
2.467AsnGln: 2.467 ± 0.836
2.22AsnArg: 2.22 ± 1.189
4.44AsnSer: 4.44 ± 1.984
2.96AsnThr: 2.96 ± 1.246
3.207AsnVal: 3.207 ± 1.735
0.247AsnTrp: 0.247 ± 0.219
3.7AsnTyr: 3.7 ± 1.1
0.0AsnXaa: 0.0 ± 0.0
Pro
0.493ProAla: 0.493 ± 0.571
0.247ProCys: 0.247 ± 0.219
1.727ProAsp: 1.727 ± 0.63
2.22ProGlu: 2.22 ± 0.777
1.727ProPhe: 1.727 ± 0.542
1.48ProGly: 1.48 ± 0.595
0.74ProHis: 0.74 ± 0.436
2.713ProIle: 2.713 ± 0.66
2.22ProLys: 2.22 ± 0.625
2.96ProLeu: 2.96 ± 0.376
0.74ProMet: 0.74 ± 0.351
1.727ProAsn: 1.727 ± 0.701
0.247ProPro: 0.247 ± 0.145
0.987ProGln: 0.987 ± 0.313
0.493ProArg: 0.493 ± 0.157
1.973ProSer: 1.973 ± 0.878
1.973ProThr: 1.973 ± 0.326
0.247ProVal: 0.247 ± 0.219
0.0ProTrp: 0.0 ± 0.0
0.493ProTyr: 0.493 ± 0.291
0.0ProXaa: 0.0 ± 0.0
Gln
1.48GlnAla: 1.48 ± 0.872
0.74GlnCys: 0.74 ± 0.208
1.973GlnAsp: 1.973 ± 1.162
1.233GlnGlu: 1.233 ± 0.339
1.48GlnPhe: 1.48 ± 0.872
0.987GlnGly: 0.987 ± 0.647
0.247GlnHis: 0.247 ± 0.145
1.973GlnIle: 1.973 ± 0.569
2.467GlnLys: 2.467 ± 0.678
3.7GlnLeu: 3.7 ± 1.031
0.74GlnMet: 0.74 ± 0.436
1.48GlnAsn: 1.48 ± 0.94
0.987GlnPro: 0.987 ± 0.564
0.74GlnGln: 0.74 ± 0.436
0.987GlnArg: 0.987 ± 0.581
1.233GlnSer: 1.233 ± 0.569
1.233GlnThr: 1.233 ± 1.045
1.233GlnVal: 1.233 ± 0.456
0.493GlnTrp: 0.493 ± 0.157
1.48GlnTyr: 1.48 ± 0.703
0.0GlnXaa: 0.0 ± 0.0
Arg
1.48ArgAla: 1.48 ± 0.872
1.233ArgCys: 1.233 ± 0.685
2.713ArgAsp: 2.713 ± 0.659
3.7ArgGlu: 3.7 ± 0.797
2.467ArgPhe: 2.467 ± 0.903
2.96ArgGly: 2.96 ± 0.506
0.247ArgHis: 0.247 ± 0.145
2.96ArgIle: 2.96 ± 0.648
2.713ArgLys: 2.713 ± 0.66
1.973ArgLeu: 1.973 ± 0.569
1.233ArgMet: 1.233 ± 0.367
2.96ArgAsn: 2.96 ± 1.401
0.74ArgPro: 0.74 ± 0.208
0.987ArgGln: 0.987 ± 0.508
2.467ArgArg: 2.467 ± 0.912
3.947ArgSer: 3.947 ± 0.742
1.727ArgThr: 1.727 ± 1.142
2.22ArgVal: 2.22 ± 1.809
0.0ArgTrp: 0.0 ± 0.0
1.973ArgTyr: 1.973 ± 0.647
0.0ArgXaa: 0.0 ± 0.0
Ser
4.193SerAla: 4.193 ± 2.748
1.973SerCys: 1.973 ± 1.119
5.673SerAsp: 5.673 ± 0.691
4.687SerGlu: 4.687 ± 1.689
3.453SerPhe: 3.453 ± 1.104
5.673SerGly: 5.673 ± 0.418
1.727SerHis: 1.727 ± 0.485
5.673SerIle: 5.673 ± 1.248
5.92SerLys: 5.92 ± 0.931
6.413SerLeu: 6.413 ± 0.955
2.96SerMet: 2.96 ± 0.789
6.413SerAsn: 6.413 ± 1.943
1.48SerPro: 1.48 ± 0.997
2.713SerGln: 2.713 ± 0.945
5.18SerArg: 5.18 ± 1.253
6.66SerSer: 6.66 ± 1.134
5.92SerThr: 5.92 ± 1.842
3.7SerVal: 3.7 ± 0.59
0.74SerTrp: 0.74 ± 0.469
2.713SerTyr: 2.713 ± 0.356
0.0SerXaa: 0.0 ± 0.0
Thr
2.467ThrAla: 2.467 ± 0.311
1.973ThrCys: 1.973 ± 0.752
3.453ThrAsp: 3.453 ± 1.717
3.453ThrGlu: 3.453 ± 1.431
1.727ThrPhe: 1.727 ± 0.578
2.22ThrGly: 2.22 ± 0.474
0.74ThrHis: 0.74 ± 0.351
5.92ThrIle: 5.92 ± 2.775
6.167ThrLys: 6.167 ± 0.646
4.193ThrLeu: 4.193 ± 2.095
1.233ThrMet: 1.233 ± 0.415
2.22ThrAsn: 2.22 ± 0.625
1.727ThrPro: 1.727 ± 0.417
1.233ThrGln: 1.233 ± 0.456
3.207ThrArg: 3.207 ± 0.824
4.193ThrSer: 4.193 ± 3.447
4.44ThrThr: 4.44 ± 0.916
3.947ThrVal: 3.947 ± 1.218
0.74ThrTrp: 0.74 ± 0.485
1.973ThrTyr: 1.973 ± 1.493
0.0ThrXaa: 0.0 ± 0.0
Val
3.7ValAla: 3.7 ± 0.59
0.0ValCys: 0.0 ± 0.0
4.933ValAsp: 4.933 ± 1.976
3.7ValGlu: 3.7 ± 0.788
1.727ValPhe: 1.727 ± 1.005
4.933ValGly: 4.933 ± 0.562
0.493ValHis: 0.493 ± 0.157
2.96ValIle: 2.96 ± 0.741
4.193ValLys: 4.193 ± 0.48
3.453ValLeu: 3.453 ± 0.921
2.467ValMet: 2.467 ± 0.624
5.18ValAsn: 5.18 ± 1.235
0.493ValPro: 0.493 ± 0.505
0.74ValGln: 0.74 ± 0.436
2.96ValArg: 2.96 ± 1.401
6.413ValSer: 6.413 ± 2.12
3.7ValThr: 3.7 ± 1.012
4.193ValVal: 4.193 ± 3.365
0.74ValTrp: 0.74 ± 0.656
1.727ValTyr: 1.727 ± 0.914
0.0ValXaa: 0.0 ± 0.0
Trp
1.233TrpAla: 1.233 ± 0.979
0.493TrpCys: 0.493 ± 0.437
0.493TrpAsp: 0.493 ± 0.437
0.0TrpGlu: 0.0 ± 0.0
0.493TrpPhe: 0.493 ± 0.157
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.493TrpIle: 0.493 ± 0.157
0.987TrpLys: 0.987 ± 0.564
0.987TrpLeu: 0.987 ± 0.323
0.0TrpMet: 0.0 ± 0.0
0.247TrpAsn: 0.247 ± 0.145
0.74TrpPro: 0.74 ± 0.469
0.74TrpGln: 0.74 ± 0.656
0.0TrpArg: 0.0 ± 0.0
0.493TrpSer: 0.493 ± 0.437
0.493TrpThr: 0.493 ± 0.291
0.493TrpVal: 0.493 ± 0.291
0.0TrpTrp: 0.0 ± 0.0
0.493TrpTyr: 0.493 ± 0.291
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.727TyrAla: 1.727 ± 0.722
2.22TyrCys: 2.22 ± 1.097
2.713TyrAsp: 2.713 ± 0.957
1.973TyrGlu: 1.973 ± 0.626
1.973TyrPhe: 1.973 ± 0.626
0.987TyrGly: 0.987 ± 0.53
1.233TyrHis: 1.233 ± 0.498
3.453TyrIle: 3.453 ± 0.857
4.44TyrLys: 4.44 ± 1.409
2.96TyrLeu: 2.96 ± 0.397
1.973TyrMet: 1.973 ± 0.872
2.96TyrAsn: 2.96 ± 0.661
0.987TyrPro: 0.987 ± 0.323
0.987TyrGln: 0.987 ± 0.794
1.233TyrArg: 1.233 ± 0.498
4.193TyrSer: 4.193 ± 1.027
0.74TyrThr: 0.74 ± 0.208
3.453TyrVal: 3.453 ± 0.484
0.493TyrTrp: 0.493 ± 0.437
1.973TyrTyr: 1.973 ± 0.574
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (4055 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski