Amino acid dipepetide frequency for Handroanthus impetiginosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.462AlaAla: 6.462 ± 0.034	1.23AlaCys: 1.23 ± 0.012	3.067AlaAsp: 3.067 ± 0.017	4.156AlaGlu: 4.156 ± 0.024	2.793AlaPhe: 2.793 ± 0.018	3.946AlaGly: 3.946 ± 0.022	1.304AlaHis: 1.304 ± 0.011	3.908AlaIle: 3.908 ± 0.02	3.995AlaLys: 3.995 ± 0.023	6.497AlaLeu: 6.497 ± 0.029	1.772AlaMet: 1.772 ± 0.014	2.683AlaAsn: 2.683 ± 0.015	2.838AlaPro: 2.838 ± 0.021	2.085AlaGln: 2.085 ± 0.016	3.334AlaArg: 3.334 ± 0.02	5.64AlaSer: 5.64 ± 0.024	3.529AlaThr: 3.529 ± 0.018	4.736AlaVal: 4.736 ± 0.026	0.754AlaTrp: 0.754 ± 0.009	1.854AlaTyr: 1.854 ± 0.014	0.0AlaXaa: 0.0 ± 0.0
Cys	0.987CysAla: 0.987 ± 0.01	0.532CysCys: 0.532 ± 0.008	0.911CysAsp: 0.911 ± 0.009	0.922CysGlu: 0.922 ± 0.01	0.909CysPhe: 0.909 ± 0.009	1.41CysGly: 1.41 ± 0.014	0.49CysHis: 0.49 ± 0.007	1.03CysIle: 1.03 ± 0.01	1.122CysLys: 1.122 ± 0.012	1.884CysLeu: 1.884 ± 0.013	0.469CysMet: 0.469 ± 0.005	0.904CysAsn: 0.904 ± 0.011	0.961CysPro: 0.961 ± 0.012	0.605CysGln: 0.605 ± 0.009	1.085CysArg: 1.085 ± 0.011	1.803CysSer: 1.803 ± 0.015	0.844CysThr: 0.844 ± 0.009	1.049CysVal: 1.049 ± 0.01	0.249CysTrp: 0.249 ± 0.005	0.608CysTyr: 0.608 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.408AspAla: 3.408 ± 0.02	0.94AspCys: 0.94 ± 0.01	3.494AspAsp: 3.494 ± 0.023	4.091AspGlu: 4.091 ± 0.025	2.468AspPhe: 2.468 ± 0.017	3.622AspGly: 3.622 ± 0.02	1.238AspHis: 1.238 ± 0.011	3.085AspIle: 3.085 ± 0.018	2.766AspLys: 2.766 ± 0.015	5.022AspLeu: 5.022 ± 0.029	1.316AspMet: 1.316 ± 0.01	2.178AspAsn: 2.178 ± 0.016	2.618AspPro: 2.618 ± 0.016	1.734AspGln: 1.734 ± 0.013	2.314AspArg: 2.314 ± 0.018	4.082AspSer: 4.082 ± 0.024	2.103AspThr: 2.103 ± 0.016	3.536AspVal: 3.536 ± 0.019	0.723AspTrp: 0.723 ± 0.008	1.617AspTyr: 1.617 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.548GluAla: 4.548 ± 0.022	0.928GluCys: 0.928 ± 0.01	3.825GluAsp: 3.825 ± 0.022	6.049GluGlu: 6.049 ± 0.038	2.482GluPhe: 2.482 ± 0.016	3.626GluGly: 3.626 ± 0.02	1.228GluHis: 1.228 ± 0.012	3.992GluIle: 3.992 ± 0.02	5.004GluLys: 5.004 ± 0.032	6.05GluLeu: 6.05 ± 0.031	1.786GluMet: 1.786 ± 0.013	3.438GluAsn: 3.438 ± 0.02	2.117GluPro: 2.117 ± 0.014	2.123GluGln: 2.123 ± 0.016	3.328GluArg: 3.328 ± 0.023	4.494GluSer: 4.494 ± 0.023	2.961GluThr: 2.961 ± 0.018	4.13GluVal: 4.13 ± 0.025	0.731GluTrp: 0.731 ± 0.008	1.735GluTyr: 1.735 ± 0.014	0.001GluXaa: 0.001 ± 0.0
Phe	2.544PheAla: 2.544 ± 0.016	0.968PheCys: 0.968 ± 0.01	2.443PheAsp: 2.443 ± 0.015	2.324PheGlu: 2.324 ± 0.015	2.085PhePhe: 2.085 ± 0.018	3.174PheGly: 3.174 ± 0.02	1.117PheHis: 1.117 ± 0.01	2.26PheIle: 2.26 ± 0.016	2.175PheLys: 2.175 ± 0.013	4.648PheLeu: 4.648 ± 0.025	1.023PheMet: 1.023 ± 0.009	1.881PheAsn: 1.881 ± 0.014	2.157PhePro: 2.157 ± 0.013	1.556PheGln: 1.556 ± 0.013	2.06PheArg: 2.06 ± 0.015	4.259PheSer: 4.259 ± 0.021	2.073PheThr: 2.073 ± 0.016	2.738PheVal: 2.738 ± 0.018	0.576PheTrp: 0.576 ± 0.008	1.367PheTyr: 1.367 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	3.793GlyAla: 3.793 ± 0.02	1.311GlyCys: 1.311 ± 0.013	3.283GlyAsp: 3.283 ± 0.017	3.66GlyGlu: 3.66 ± 0.019	3.142GlyPhe: 3.142 ± 0.018	5.212GlyGly: 5.212 ± 0.046	1.495GlyHis: 1.495 ± 0.012	3.738GlyIle: 3.738 ± 0.019	4.113GlyLys: 4.113 ± 0.021	5.924GlyLeu: 5.924 ± 0.027	1.479GlyMet: 1.479 ± 0.011	3.252GlyAsn: 3.252 ± 0.021	2.534GlyPro: 2.534 ± 0.017	2.049GlyGln: 2.049 ± 0.015	3.561GlyArg: 3.561 ± 0.022	5.734GlySer: 5.734 ± 0.029	3.197GlyThr: 3.197 ± 0.021	4.069GlyVal: 4.069 ± 0.022	0.877GlyTrp: 0.877 ± 0.009	2.12GlyTyr: 2.12 ± 0.018	0.001GlyXaa: 0.001 ± 0.0
His	1.372HisAla: 1.372 ± 0.012	0.539HisCys: 0.539 ± 0.008	1.162HisAsp: 1.162 ± 0.011	1.287HisGlu: 1.287 ± 0.01	1.133HisPhe: 1.133 ± 0.011	1.69HisGly: 1.69 ± 0.012	0.905HisHis: 0.905 ± 0.014	1.249HisIle: 1.249 ± 0.01	1.242HisLys: 1.242 ± 0.01	2.418HisLeu: 2.418 ± 0.016	0.548HisMet: 0.548 ± 0.007	1.017HisAsn: 1.017 ± 0.012	1.342HisPro: 1.342 ± 0.012	0.965HisGln: 0.965 ± 0.009	1.38HisArg: 1.38 ± 0.011	1.864HisSer: 1.864 ± 0.014	0.937HisThr: 0.937 ± 0.009	1.481HisVal: 1.481 ± 0.012	0.315HisTrp: 0.315 ± 0.005	0.724HisTyr: 0.724 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.684IleAla: 3.684 ± 0.017	1.175IleCys: 1.175 ± 0.011	2.938IleAsp: 2.938 ± 0.017	3.263IleGlu: 3.263 ± 0.019	2.518IlePhe: 2.518 ± 0.019	3.56IleGly: 3.56 ± 0.021	1.35IleHis: 1.35 ± 0.012	3.152IleIle: 3.152 ± 0.019	3.134IleLys: 3.134 ± 0.015	5.634IleLeu: 5.634 ± 0.028	1.236IleMet: 1.236 ± 0.01	2.431IleAsn: 2.431 ± 0.016	3.218IlePro: 3.218 ± 0.025	2.002IleGln: 2.002 ± 0.013	2.696IleArg: 2.696 ± 0.016	5.192IleSer: 5.192 ± 0.025	2.713IleThr: 2.713 ± 0.017	3.528IleVal: 3.528 ± 0.02	0.726IleTrp: 0.726 ± 0.009	1.669IleTyr: 1.669 ± 0.015	0.001IleXaa: 0.001 ± 0.0
Lys	3.959LysAla: 3.959 ± 0.022	1.035LysCys: 1.035 ± 0.013	3.286LysAsp: 3.286 ± 0.02	4.644LysGlu: 4.644 ± 0.027	2.371LysPhe: 2.371 ± 0.015	3.592LysGly: 3.592 ± 0.02	1.354LysHis: 1.354 ± 0.011	3.554LysIle: 3.554 ± 0.018	4.939LysLys: 4.939 ± 0.03	6.185LysLeu: 6.185 ± 0.031	1.579LysMet: 1.579 ± 0.012	3.053LysAsn: 3.053 ± 0.019	2.803LysPro: 2.803 ± 0.018	2.236LysGln: 2.236 ± 0.015	3.576LysArg: 3.576 ± 0.019	4.698LysSer: 4.698 ± 0.022	2.839LysThr: 2.839 ± 0.017	3.798LysVal: 3.798 ± 0.021	0.848LysTrp: 0.848 ± 0.01	1.733LysTyr: 1.733 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	6.423LeuAla: 6.423 ± 0.028	1.869LeuCys: 1.869 ± 0.016	5.181LeuAsp: 5.181 ± 0.027	6.431LeuGlu: 6.431 ± 0.031	3.936LeuPhe: 3.936 ± 0.022	5.773LeuGly: 5.773 ± 0.029	2.575LeuHis: 2.575 ± 0.015	4.997LeuIle: 4.997 ± 0.021	6.259LeuLys: 6.259 ± 0.028	9.866LeuLeu: 9.866 ± 0.036	2.236LeuMet: 2.236 ± 0.014	4.195LeuAsn: 4.195 ± 0.023	5.172LeuPro: 5.172 ± 0.024	4.26LeuGln: 4.26 ± 0.022	5.453LeuArg: 5.453 ± 0.024	8.809LeuSer: 8.809 ± 0.045	4.494LeuThr: 4.494 ± 0.025	6.216LeuVal: 6.216 ± 0.026	1.133LeuTrp: 1.133 ± 0.01	2.615LeuTyr: 2.615 ± 0.016	0.001LeuXaa: 0.001 ± 0.0
Met	2.195MetAla: 2.195 ± 0.014	0.336MetCys: 0.336 ± 0.006	1.441MetAsp: 1.441 ± 0.012	1.96MetGlu: 1.96 ± 0.014	0.831MetPhe: 0.831 ± 0.009	1.619MetGly: 1.619 ± 0.012	0.543MetHis: 0.543 ± 0.006	1.304MetIle: 1.304 ± 0.013	1.733MetLys: 1.733 ± 0.013	2.196MetLeu: 2.196 ± 0.015	0.696MetMet: 0.696 ± 0.008	1.114MetAsn: 1.114 ± 0.011	1.108MetPro: 1.108 ± 0.01	0.929MetGln: 0.929 ± 0.009	1.204MetArg: 1.204 ± 0.01	1.741MetSer: 1.741 ± 0.013	1.011MetThr: 1.011 ± 0.01	1.618MetVal: 1.618 ± 0.013	0.272MetTrp: 0.272 ± 0.004	0.602MetTyr: 0.602 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.714AsnAla: 2.714 ± 0.017	0.923AsnCys: 0.923 ± 0.009	2.156AsnAsp: 2.156 ± 0.015	2.796AsnGlu: 2.796 ± 0.02	2.209AsnPhe: 2.209 ± 0.015	3.377AsnGly: 3.377 ± 0.023	1.166AsnHis: 1.166 ± 0.011	2.684AsnIle: 2.684 ± 0.015	2.544AsnLys: 2.544 ± 0.012	5.086AsnLeu: 5.086 ± 0.036	1.198AsnMet: 1.198 ± 0.01	2.526AsnAsn: 2.526 ± 0.023	2.462AsnPro: 2.462 ± 0.017	1.764AsnGln: 1.764 ± 0.014	2.103AsnArg: 2.103 ± 0.013	4.11AsnSer: 4.11 ± 0.02	1.986AsnThr: 1.986 ± 0.014	2.863AsnVal: 2.863 ± 0.016	0.604AsnTrp: 0.604 ± 0.007	1.489AsnTyr: 1.489 ± 0.011	0.001AsnXaa: 0.001 ± 0.0
Pro	3.015ProAla: 3.015 ± 0.02	0.765ProCys: 0.765 ± 0.009	2.517ProAsp: 2.517 ± 0.016	3.134ProGlu: 3.134 ± 0.018	2.102ProPhe: 2.102 ± 0.013	2.693ProGly: 2.693 ± 0.019	1.119ProHis: 1.119 ± 0.011	2.426ProIle: 2.426 ± 0.015	2.821ProLys: 2.821 ± 0.02	4.336ProLeu: 4.336 ± 0.023	0.975ProMet: 0.975 ± 0.01	2.431ProAsn: 2.431 ± 0.018	4.134ProPro: 4.134 ± 0.061	1.827ProGln: 1.827 ± 0.013	2.469ProArg: 2.469 ± 0.016	5.058ProSer: 5.058 ± 0.026	2.609ProThr: 2.609 ± 0.016	3.004ProVal: 3.004 ± 0.018	0.618ProTrp: 0.618 ± 0.008	1.379ProTyr: 1.379 ± 0.011	0.001ProXaa: 0.001 ± 0.0
Gln	2.216GlnAla: 2.216 ± 0.016	0.586GlnCys: 0.586 ± 0.008	1.65GlnAsp: 1.65 ± 0.012	2.545GlnGlu: 2.545 ± 0.019	1.373GlnPhe: 1.373 ± 0.011	2.021GlnGly: 2.021 ± 0.015	0.867GlnHis: 0.867 ± 0.011	2.109GlnIle: 2.109 ± 0.015	2.392GlnLys: 2.392 ± 0.015	3.55GlnLeu: 3.55 ± 0.023	0.972GlnMet: 0.972 ± 0.011	1.894GlnAsn: 1.894 ± 0.013	1.679GlnPro: 1.679 ± 0.016	1.892GlnGln: 1.892 ± 0.025	2.081GlnArg: 2.081 ± 0.014	2.679GlnSer: 2.679 ± 0.017	1.709GlnThr: 1.709 ± 0.014	2.228GlnVal: 2.228 ± 0.014	0.439GlnTrp: 0.439 ± 0.006	0.943GlnTyr: 0.943 ± 0.008	0.001GlnXaa: 0.001 ± 0.0
Arg	3.265ArgAla: 3.265 ± 0.02	0.978ArgCys: 0.978 ± 0.009	2.599ArgAsp: 2.599 ± 0.016	3.252ArgGlu: 3.252 ± 0.021	2.227ArgPhe: 2.227 ± 0.012	3.211ArgGly: 3.211 ± 0.019	1.289ArgHis: 1.289 ± 0.01	2.983ArgIle: 2.983 ± 0.018	3.874ArgLys: 3.874 ± 0.021	4.984ArgLeu: 4.984 ± 0.023	1.341ArgMet: 1.341 ± 0.01	2.58ArgAsn: 2.58 ± 0.017	2.331ArgPro: 2.331 ± 0.016	1.813ArgGln: 1.813 ± 0.013	3.923ArgArg: 3.923 ± 0.025	4.154ArgSer: 4.154 ± 0.026	2.456ArgThr: 2.456 ± 0.015	3.231ArgVal: 3.231 ± 0.017	0.745ArgTrp: 0.745 ± 0.009	1.464ArgTyr: 1.464 ± 0.012	0.001ArgXaa: 0.001 ± 0.0
Ser	5.266SerAla: 5.266 ± 0.023	1.766SerCys: 1.766 ± 0.014	4.37SerAsp: 4.37 ± 0.022	4.65SerGlu: 4.65 ± 0.025	4.03SerPhe: 4.03 ± 0.022	5.895SerGly: 5.895 ± 0.027	1.993SerHis: 1.993 ± 0.015	4.723SerIle: 4.723 ± 0.023	4.852SerLys: 4.852 ± 0.023	8.565SerLeu: 8.565 ± 0.041	2.067SerMet: 2.067 ± 0.014	4.154SerAsn: 4.154 ± 0.021	4.465SerPro: 4.465 ± 0.031	2.89SerGln: 2.89 ± 0.017	4.469SerArg: 4.469 ± 0.026	10.386SerSer: 10.386 ± 0.051	4.577SerThr: 4.577 ± 0.021	4.937SerVal: 4.937 ± 0.024	1.196SerTrp: 1.196 ± 0.01	2.397SerTyr: 2.397 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	3.38ThrAla: 3.38 ± 0.02	0.907ThrCys: 0.907 ± 0.01	2.184ThrAsp: 2.184 ± 0.015	2.687ThrGlu: 2.687 ± 0.017	2.123ThrPhe: 2.123 ± 0.014	3.203ThrGly: 3.203 ± 0.02	1.017ThrHis: 1.017 ± 0.009	2.871ThrIle: 2.871 ± 0.016	2.673ThrLys: 2.673 ± 0.017	4.642ThrLeu: 4.642 ± 0.02	1.146ThrMet: 1.146 ± 0.01	2.162ThrAsn: 2.162 ± 0.014	2.53ThrPro: 2.53 ± 0.018	1.479ThrGln: 1.479 ± 0.011	2.364ThrArg: 2.364 ± 0.015	4.463ThrSer: 4.463 ± 0.024	2.873ThrThr: 2.873 ± 0.02	3.146ThrVal: 3.146 ± 0.02	0.612ThrTrp: 0.612 ± 0.008	1.422ThrTyr: 1.422 ± 0.012	0.001ThrXaa: 0.001 ± 0.0
Val	4.716ValAla: 4.716 ± 0.023	1.104ValCys: 1.104 ± 0.011	3.562ValAsp: 3.562 ± 0.02	4.307ValGlu: 4.307 ± 0.024	2.74ValPhe: 2.74 ± 0.017	4.001ValGly: 4.001 ± 0.02	1.483ValHis: 1.483 ± 0.011	3.412ValIle: 3.412 ± 0.016	3.928ValLys: 3.928 ± 0.021	6.252ValLeu: 6.252 ± 0.03	1.511ValMet: 1.511 ± 0.012	2.701ValAsn: 2.701 ± 0.015	3.152ValPro: 3.152 ± 0.018	2.232ValGln: 2.232 ± 0.014	2.973ValArg: 2.973 ± 0.018	5.136ValSer: 5.136 ± 0.024	3.001ValThr: 3.001 ± 0.018	4.763ValVal: 4.763 ± 0.029	0.748ValTrp: 0.748 ± 0.009	1.971ValTyr: 1.971 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.804TrpAla: 0.804 ± 0.009	0.234TrpCys: 0.234 ± 0.005	0.721TrpAsp: 0.721 ± 0.009	0.77TrpGlu: 0.77 ± 0.009	0.542TrpPhe: 0.542 ± 0.007	0.744TrpGly: 0.744 ± 0.01	0.282TrpHis: 0.282 ± 0.005	0.773TrpIle: 0.773 ± 0.008	0.917TrpLys: 0.917 ± 0.008	1.237TrpLeu: 1.237 ± 0.013	0.336TrpMet: 0.336 ± 0.006	0.721TrpAsn: 0.721 ± 0.009	0.497TrpPro: 0.497 ± 0.007	0.429TrpGln: 0.429 ± 0.006	0.819TrpArg: 0.819 ± 0.008	0.963TrpSer: 0.963 ± 0.009	0.661TrpThr: 0.661 ± 0.008	0.778TrpVal: 0.778 ± 0.008	0.244TrpTrp: 0.244 ± 0.005	0.364TrpTyr: 0.364 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.83TyrAla: 1.83 ± 0.013	0.645TyrCys: 0.645 ± 0.008	1.568TyrAsp: 1.568 ± 0.011	1.644TyrGlu: 1.644 ± 0.013	1.415TyrPhe: 1.415 ± 0.013	2.173TyrGly: 2.173 ± 0.016	0.757TyrHis: 0.757 ± 0.009	1.572TyrIle: 1.572 ± 0.013	1.601TyrLys: 1.601 ± 0.013	2.916TyrLeu: 2.916 ± 0.018	0.767TyrMet: 0.767 ± 0.007	1.444TyrAsn: 1.444 ± 0.013	1.315TyrPro: 1.315 ± 0.013	0.955TyrGln: 0.955 ± 0.01	1.509TyrArg: 1.509 ± 0.013	2.385TyrSer: 2.385 ± 0.016	1.311TyrThr: 1.311 ± 0.013	1.844TyrVal: 1.844 ± 0.014	0.423TyrTrp: 0.423 ± 0.006	1.045TyrTyr: 1.045 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 29726 proteins (11135101 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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