Amino acid dipepetide frequency for Streptococcus phage Javan362

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.365AlaAla: 3.365 ± 0.74
0.589AlaCys: 0.589 ± 0.225
4.795AlaAsp: 4.795 ± 0.793
5.468AlaGlu: 5.468 ± 0.878
2.608AlaPhe: 2.608 ± 0.388
5.216AlaGly: 5.216 ± 0.913
0.421AlaHis: 0.421 ± 0.162
5.636AlaIle: 5.636 ± 0.656
6.982AlaLys: 6.982 ± 0.714
5.216AlaLeu: 5.216 ± 0.923
2.103AlaMet: 2.103 ± 0.404
3.702AlaAsn: 3.702 ± 0.577
1.43AlaPro: 1.43 ± 0.385
2.019AlaGln: 2.019 ± 0.335
3.197AlaArg: 3.197 ± 0.439
4.29AlaSer: 4.29 ± 0.94
4.543AlaThr: 4.543 ± 0.901
4.627AlaVal: 4.627 ± 0.793
1.01AlaTrp: 1.01 ± 0.313
3.113AlaTyr: 3.113 ± 0.51
0.0AlaXaa: 0.0 ± 0.0
Cys
0.252CysAla: 0.252 ± 0.159
0.168CysCys: 0.168 ± 0.134
0.168CysAsp: 0.168 ± 0.124
0.337CysGlu: 0.337 ± 0.18
0.589CysPhe: 0.589 ± 0.225
1.346CysGly: 1.346 ± 0.445
0.0CysHis: 0.0 ± 0.0
0.168CysIle: 0.168 ± 0.132
0.589CysLys: 0.589 ± 0.26
0.505CysLeu: 0.505 ± 0.19
0.0CysMet: 0.0 ± 0.0
0.421CysAsn: 0.421 ± 0.245
0.505CysPro: 0.505 ± 0.291
0.337CysGln: 0.337 ± 0.181
0.168CysArg: 0.168 ± 0.135
0.168CysSer: 0.168 ± 0.119
0.337CysThr: 0.337 ± 0.162
0.421CysVal: 0.421 ± 0.202
0.168CysTrp: 0.168 ± 0.111
0.337CysTyr: 0.337 ± 0.166
0.0CysXaa: 0.0 ± 0.0
Asp
3.113AspAla: 3.113 ± 0.516
0.421AspCys: 0.421 ± 0.216
3.87AspAsp: 3.87 ± 0.716
5.805AspGlu: 5.805 ± 0.71
3.533AspPhe: 3.533 ± 0.624
3.954AspGly: 3.954 ± 0.69
0.673AspHis: 0.673 ± 0.256
4.375AspIle: 4.375 ± 0.721
4.879AspLys: 4.879 ± 0.597
6.225AspLeu: 6.225 ± 0.648
1.851AspMet: 1.851 ± 0.321
2.86AspAsn: 2.86 ± 0.435
1.851AspPro: 1.851 ± 0.399
1.935AspGln: 1.935 ± 0.387
2.187AspArg: 2.187 ± 0.449
3.449AspSer: 3.449 ± 0.521
2.944AspThr: 2.944 ± 0.553
3.281AspVal: 3.281 ± 0.708
1.01AspTrp: 1.01 ± 0.277
2.44AspTyr: 2.44 ± 0.507
0.0AspXaa: 0.0 ± 0.0
Glu
7.067GluAla: 7.067 ± 0.966
0.673GluCys: 0.673 ± 0.256
3.87GluAsp: 3.87 ± 0.567
7.403GluGlu: 7.403 ± 0.93
2.608GluPhe: 2.608 ± 0.436
3.786GluGly: 3.786 ± 0.532
1.094GluHis: 1.094 ± 0.329
7.151GluIle: 7.151 ± 0.843
6.814GluLys: 6.814 ± 0.804
8.749GluLeu: 8.749 ± 0.841
1.935GluMet: 1.935 ± 0.449
3.87GluAsn: 3.87 ± 0.45
2.103GluPro: 2.103 ± 0.47
4.29GluGln: 4.29 ± 0.688
3.702GluArg: 3.702 ± 0.471
4.543GluSer: 4.543 ± 0.576
4.29GluThr: 4.29 ± 0.61
5.805GluVal: 5.805 ± 0.901
0.841GluTrp: 0.841 ± 0.289
2.44GluTyr: 2.44 ± 0.464
0.0GluXaa: 0.0 ± 0.0
Phe
2.356PheAla: 2.356 ± 0.462
0.421PheCys: 0.421 ± 0.224
3.029PheAsp: 3.029 ± 0.529
4.375PheGlu: 4.375 ± 0.7
1.767PhePhe: 1.767 ± 0.541
2.608PheGly: 2.608 ± 0.458
0.168PheHis: 0.168 ± 0.123
2.103PheIle: 2.103 ± 0.44
3.365PheLys: 3.365 ± 0.467
2.524PheLeu: 2.524 ± 0.44
1.346PheMet: 1.346 ± 0.306
1.514PheAsn: 1.514 ± 0.367
1.178PhePro: 1.178 ± 0.364
1.935PheGln: 1.935 ± 0.44
2.692PheArg: 2.692 ± 0.43
3.113PheSer: 3.113 ± 0.621
1.514PheThr: 1.514 ± 0.355
2.44PheVal: 2.44 ± 0.606
0.252PheTrp: 0.252 ± 0.14
1.683PheTyr: 1.683 ± 0.449
0.0PheXaa: 0.0 ± 0.0
Gly
4.963GlyAla: 4.963 ± 0.841
0.421GlyCys: 0.421 ± 0.241
2.524GlyAsp: 2.524 ± 0.481
4.543GlyGlu: 4.543 ± 0.593
3.113GlyPhe: 3.113 ± 0.586
3.702GlyGly: 3.702 ± 0.664
0.841GlyHis: 0.841 ± 0.309
3.87GlyIle: 3.87 ± 0.768
5.636GlyLys: 5.636 ± 0.648
5.721GlyLeu: 5.721 ± 0.905
1.514GlyMet: 1.514 ± 0.345
4.038GlyAsn: 4.038 ± 0.68
0.841GlyPro: 0.841 ± 0.287
2.019GlyGln: 2.019 ± 0.468
4.122GlyArg: 4.122 ± 0.542
4.375GlySer: 4.375 ± 0.773
3.029GlyThr: 3.029 ± 0.465
3.954GlyVal: 3.954 ± 0.522
1.178GlyTrp: 1.178 ± 0.46
3.281GlyTyr: 3.281 ± 0.603
0.0GlyXaa: 0.0 ± 0.0
His
0.925HisAla: 0.925 ± 0.279
0.252HisCys: 0.252 ± 0.152
0.841HisAsp: 0.841 ± 0.32
1.514HisGlu: 1.514 ± 0.468
0.757HisPhe: 0.757 ± 0.253
0.925HisGly: 0.925 ± 0.333
0.084HisHis: 0.084 ± 0.082
0.505HisIle: 0.505 ± 0.271
1.094HisLys: 1.094 ± 0.297
1.094HisLeu: 1.094 ± 0.306
0.084HisMet: 0.084 ± 0.071
0.673HisAsn: 0.673 ± 0.255
0.757HisPro: 0.757 ± 0.283
0.337HisGln: 0.337 ± 0.159
0.589HisArg: 0.589 ± 0.2
1.094HisSer: 1.094 ± 0.323
0.841HisThr: 0.841 ± 0.226
0.421HisVal: 0.421 ± 0.24
0.168HisTrp: 0.168 ± 0.136
0.337HisTyr: 0.337 ± 0.194
0.0HisXaa: 0.0 ± 0.0
Ile
4.795IleAla: 4.795 ± 0.713
0.421IleCys: 0.421 ± 0.185
5.132IleAsp: 5.132 ± 0.628
5.468IleGlu: 5.468 ± 0.897
1.43IlePhe: 1.43 ± 0.39
4.543IleGly: 4.543 ± 0.69
1.346IleHis: 1.346 ± 0.371
3.702IleIle: 3.702 ± 0.574
6.814IleLys: 6.814 ± 0.754
5.636IleLeu: 5.636 ± 0.873
1.01IleMet: 1.01 ± 0.32
3.029IleAsn: 3.029 ± 0.516
2.44IlePro: 2.44 ± 0.438
2.86IleGln: 2.86 ± 0.65
3.617IleArg: 3.617 ± 0.533
3.87IleSer: 3.87 ± 0.475
3.87IleThr: 3.87 ± 0.788
3.113IleVal: 3.113 ± 0.535
0.252IleTrp: 0.252 ± 0.195
1.851IleTyr: 1.851 ± 0.379
0.0IleXaa: 0.0 ± 0.0
Lys
7.571LysAla: 7.571 ± 0.969
0.168LysCys: 0.168 ± 0.139
5.132LysAsp: 5.132 ± 0.617
8.244LysGlu: 8.244 ± 0.797
3.281LysPhe: 3.281 ± 0.587
5.132LysGly: 5.132 ± 0.655
1.262LysHis: 1.262 ± 0.384
5.468LysIle: 5.468 ± 0.781
6.982LysLys: 6.982 ± 1.028
6.141LysLeu: 6.141 ± 0.596
3.113LysMet: 3.113 ± 0.473
5.132LysAsn: 5.132 ± 0.767
2.524LysPro: 2.524 ± 0.433
3.702LysGln: 3.702 ± 0.477
3.786LysArg: 3.786 ± 0.766
5.552LysSer: 5.552 ± 0.622
5.636LysThr: 5.636 ± 0.672
4.459LysVal: 4.459 ± 0.491
1.01LysTrp: 1.01 ± 0.299
2.692LysTyr: 2.692 ± 0.519
0.0LysXaa: 0.0 ± 0.0
Leu
6.814LeuAla: 6.814 ± 1.107
0.337LeuCys: 0.337 ± 0.177
6.646LeuAsp: 6.646 ± 0.753
7.151LeuGlu: 7.151 ± 0.939
2.944LeuPhe: 2.944 ± 0.595
5.889LeuGly: 5.889 ± 0.728
0.925LeuHis: 0.925 ± 0.317
4.795LeuIle: 4.795 ± 0.708
8.833LeuLys: 8.833 ± 0.992
5.216LeuLeu: 5.216 ± 0.673
1.767LeuMet: 1.767 ± 0.446
4.879LeuAsn: 4.879 ± 0.91
2.356LeuPro: 2.356 ± 0.499
3.954LeuGln: 3.954 ± 0.694
3.197LeuArg: 3.197 ± 0.457
4.963LeuSer: 4.963 ± 0.811
4.711LeuThr: 4.711 ± 0.64
4.879LeuVal: 4.879 ± 0.577
0.252LeuTrp: 0.252 ± 0.239
2.776LeuTyr: 2.776 ± 0.504
0.0LeuXaa: 0.0 ± 0.0
Met
2.524MetAla: 2.524 ± 0.444
0.0MetCys: 0.0 ± 0.0
1.683MetAsp: 1.683 ± 0.367
1.767MetGlu: 1.767 ± 0.397
1.094MetPhe: 1.094 ± 0.295
1.094MetGly: 1.094 ± 0.326
0.252MetHis: 0.252 ± 0.14
1.598MetIle: 1.598 ± 0.358
2.44MetLys: 2.44 ± 0.419
1.683MetLeu: 1.683 ± 0.368
0.421MetMet: 0.421 ± 0.158
1.514MetAsn: 1.514 ± 0.328
0.757MetPro: 0.757 ± 0.27
0.925MetGln: 0.925 ± 0.377
1.767MetArg: 1.767 ± 0.368
1.262MetSer: 1.262 ± 0.292
2.692MetThr: 2.692 ± 0.457
1.767MetVal: 1.767 ± 0.414
0.252MetTrp: 0.252 ± 0.131
0.757MetTyr: 0.757 ± 0.355
0.0MetXaa: 0.0 ± 0.0
Asn
3.197AsnAla: 3.197 ± 0.828
0.421AsnCys: 0.421 ± 0.187
2.86AsnAsp: 2.86 ± 0.529
4.29AsnGlu: 4.29 ± 0.656
2.019AsnPhe: 2.019 ± 0.344
3.449AsnGly: 3.449 ± 0.515
0.925AsnHis: 0.925 ± 0.246
3.029AsnIle: 3.029 ± 0.486
3.113AsnLys: 3.113 ± 0.53
4.375AsnLeu: 4.375 ± 0.544
1.598AsnMet: 1.598 ± 0.383
2.524AsnAsn: 2.524 ± 0.379
2.019AsnPro: 2.019 ± 0.452
4.375AsnGln: 4.375 ± 0.772
2.019AsnArg: 2.019 ± 0.382
3.87AsnSer: 3.87 ± 0.788
2.944AsnThr: 2.944 ± 0.533
3.617AsnVal: 3.617 ± 0.561
0.673AsnTrp: 0.673 ± 0.264
2.44AsnTyr: 2.44 ± 0.557
0.0AsnXaa: 0.0 ± 0.0
Pro
1.851ProAla: 1.851 ± 0.488
0.252ProCys: 0.252 ± 0.142
1.43ProAsp: 1.43 ± 0.247
2.86ProGlu: 2.86 ± 0.499
1.346ProPhe: 1.346 ± 0.28
1.43ProGly: 1.43 ± 0.332
0.252ProHis: 0.252 ± 0.14
2.524ProIle: 2.524 ± 0.415
2.019ProLys: 2.019 ± 0.504
2.356ProLeu: 2.356 ± 0.561
0.673ProMet: 0.673 ± 0.297
1.514ProAsn: 1.514 ± 0.465
0.589ProPro: 0.589 ± 0.208
0.925ProGln: 0.925 ± 0.241
1.094ProArg: 1.094 ± 0.314
1.767ProSer: 1.767 ± 0.375
1.514ProThr: 1.514 ± 0.353
2.187ProVal: 2.187 ± 0.478
0.084ProTrp: 0.084 ± 0.065
1.178ProTyr: 1.178 ± 0.367
0.0ProXaa: 0.0 ± 0.0
Gln
3.786GlnAla: 3.786 ± 0.58
0.589GlnCys: 0.589 ± 0.253
2.356GlnAsp: 2.356 ± 0.422
3.533GlnGlu: 3.533 ± 0.573
1.683GlnPhe: 1.683 ± 0.339
1.935GlnGly: 1.935 ± 0.473
0.505GlnHis: 0.505 ± 0.182
2.944GlnIle: 2.944 ± 0.462
3.87GlnLys: 3.87 ± 0.533
4.627GlnLeu: 4.627 ± 0.664
1.514GlnMet: 1.514 ± 0.405
3.197GlnAsn: 3.197 ± 0.458
1.262GlnPro: 1.262 ± 0.359
1.43GlnGln: 1.43 ± 0.369
1.683GlnArg: 1.683 ± 0.366
2.524GlnSer: 2.524 ± 0.463
3.029GlnThr: 3.029 ± 0.517
2.356GlnVal: 2.356 ± 0.469
0.673GlnTrp: 0.673 ± 0.285
0.673GlnTyr: 0.673 ± 0.198
0.0GlnXaa: 0.0 ± 0.0
Arg
2.187ArgAla: 2.187 ± 0.491
0.168ArgCys: 0.168 ± 0.121
1.851ArgAsp: 1.851 ± 0.421
4.206ArgGlu: 4.206 ± 0.675
1.767ArgPhe: 1.767 ± 0.336
2.776ArgGly: 2.776 ± 0.576
1.01ArgHis: 1.01 ± 0.271
2.944ArgIle: 2.944 ± 0.416
4.795ArgLys: 4.795 ± 1.003
3.786ArgLeu: 3.786 ± 0.563
1.514ArgMet: 1.514 ± 0.319
2.44ArgAsn: 2.44 ± 0.465
0.841ArgPro: 0.841 ± 0.298
2.944ArgGln: 2.944 ± 0.419
2.776ArgArg: 2.776 ± 0.43
2.524ArgSer: 2.524 ± 0.561
2.524ArgThr: 2.524 ± 0.509
2.608ArgVal: 2.608 ± 0.551
0.589ArgTrp: 0.589 ± 0.257
2.44ArgTyr: 2.44 ± 0.4
0.0ArgXaa: 0.0 ± 0.0
Ser
3.954SerAla: 3.954 ± 0.921
0.505SerCys: 0.505 ± 0.312
4.459SerAsp: 4.459 ± 0.787
3.786SerGlu: 3.786 ± 0.602
2.356SerPhe: 2.356 ± 0.438
3.87SerGly: 3.87 ± 0.493
0.925SerHis: 0.925 ± 0.281
4.29SerIle: 4.29 ± 0.714
4.879SerLys: 4.879 ± 0.625
5.132SerLeu: 5.132 ± 0.698
2.019SerMet: 2.019 ± 0.592
3.029SerAsn: 3.029 ± 0.562
2.103SerPro: 2.103 ± 0.476
3.113SerGln: 3.113 ± 0.634
2.524SerArg: 2.524 ± 0.455
3.702SerSer: 3.702 ± 0.611
3.029SerThr: 3.029 ± 0.592
3.702SerVal: 3.702 ± 0.591
0.589SerTrp: 0.589 ± 0.262
3.449SerTyr: 3.449 ± 0.442
0.0SerXaa: 0.0 ± 0.0
Thr
4.711ThrAla: 4.711 ± 1.204
0.084ThrCys: 0.084 ± 0.082
3.87ThrAsp: 3.87 ± 0.66
3.533ThrGlu: 3.533 ± 0.623
2.692ThrPhe: 2.692 ± 0.57
4.711ThrGly: 4.711 ± 0.657
0.925ThrHis: 0.925 ± 0.249
3.954ThrIle: 3.954 ± 0.758
4.206ThrLys: 4.206 ± 0.619
5.048ThrLeu: 5.048 ± 0.751
1.094ThrMet: 1.094 ± 0.354
3.365ThrAsn: 3.365 ± 0.575
2.019ThrPro: 2.019 ± 0.386
2.103ThrGln: 2.103 ± 0.359
2.019ThrArg: 2.019 ± 0.408
3.533ThrSer: 3.533 ± 0.528
3.281ThrThr: 3.281 ± 0.501
3.87ThrVal: 3.87 ± 0.608
0.589ThrTrp: 0.589 ± 0.234
1.683ThrTyr: 1.683 ± 0.395
0.0ThrXaa: 0.0 ± 0.0
Val
4.122ValAla: 4.122 ± 0.728
0.084ValCys: 0.084 ± 0.089
3.702ValAsp: 3.702 ± 0.486
5.468ValGlu: 5.468 ± 0.539
1.935ValPhe: 1.935 ± 0.484
3.87ValGly: 3.87 ± 0.629
0.757ValHis: 0.757 ± 0.251
3.029ValIle: 3.029 ± 0.559
5.384ValLys: 5.384 ± 0.623
5.216ValLeu: 5.216 ± 0.781
1.43ValMet: 1.43 ± 0.295
3.702ValAsn: 3.702 ± 0.451
1.178ValPro: 1.178 ± 0.353
2.356ValGln: 2.356 ± 0.366
2.776ValArg: 2.776 ± 0.604
4.038ValSer: 4.038 ± 0.611
4.543ValThr: 4.543 ± 0.56
4.038ValVal: 4.038 ± 0.6
0.421ValTrp: 0.421 ± 0.169
2.271ValTyr: 2.271 ± 0.489
0.0ValXaa: 0.0 ± 0.0
Trp
0.841TrpAla: 0.841 ± 0.227
0.084TrpCys: 0.084 ± 0.081
0.337TrpAsp: 0.337 ± 0.145
0.589TrpGlu: 0.589 ± 0.172
0.421TrpPhe: 0.421 ± 0.246
0.841TrpGly: 0.841 ± 0.304
0.0TrpHis: 0.0 ± 0.0
0.757TrpIle: 0.757 ± 0.322
1.346TrpLys: 1.346 ± 0.35
0.841TrpLeu: 0.841 ± 0.261
0.168TrpMet: 0.168 ± 0.11
0.673TrpAsn: 0.673 ± 0.279
0.084TrpPro: 0.084 ± 0.072
0.421TrpGln: 0.421 ± 0.197
0.841TrpArg: 0.841 ± 0.274
0.673TrpSer: 0.673 ± 0.27
0.252TrpThr: 0.252 ± 0.146
0.841TrpVal: 0.841 ± 0.259
0.337TrpTrp: 0.337 ± 0.187
0.673TrpTyr: 0.673 ± 0.295
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.935TyrAla: 1.935 ± 0.353
0.925TyrCys: 0.925 ± 0.268
2.103TyrAsp: 2.103 ± 0.391
2.692TyrGlu: 2.692 ± 0.382
2.44TyrPhe: 2.44 ± 0.493
2.692TyrGly: 2.692 ± 0.457
0.925TyrHis: 0.925 ± 0.274
2.356TyrIle: 2.356 ± 0.529
2.944TyrLys: 2.944 ± 0.471
3.197TyrLeu: 3.197 ± 0.49
1.01TyrMet: 1.01 ± 0.365
1.683TyrAsn: 1.683 ± 0.38
1.01TyrPro: 1.01 ± 0.314
2.187TyrGln: 2.187 ± 0.327
1.935TyrArg: 1.935 ± 0.363
2.103TyrSer: 2.103 ± 0.433
1.767TyrThr: 1.767 ± 0.48
1.935TyrVal: 1.935 ± 0.484
0.673TyrTrp: 0.673 ± 0.259
0.925TyrTyr: 0.925 ± 0.336
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (11888 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski