Amino acid dipepetide frequency for Peptoniphilus duerdenii ATCC BAA-1640

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.411AlaAla: 3.411 ± 0.107	0.548AlaCys: 0.548 ± 0.036	2.918AlaAsp: 2.918 ± 0.099	3.68AlaGlu: 3.68 ± 0.094	2.417AlaPhe: 2.417 ± 0.073	3.797AlaGly: 3.797 ± 0.091	0.839AlaHis: 0.839 ± 0.034	5.482AlaIle: 5.482 ± 0.104	5.309AlaLys: 5.309 ± 0.128	5.506AlaLeu: 5.506 ± 0.114	1.701AlaMet: 1.701 ± 0.067	2.716AlaAsn: 2.716 ± 0.073	1.454AlaPro: 1.454 ± 0.059	1.307AlaGln: 1.307 ± 0.058	2.267AlaArg: 2.267 ± 0.062	3.414AlaSer: 3.414 ± 0.077	3.105AlaThr: 3.105 ± 0.091	3.766AlaVal: 3.766 ± 0.106	0.305AlaTrp: 0.305 ± 0.024	2.049AlaTyr: 2.049 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.47CysAla: 0.47 ± 0.028	0.12CysCys: 0.12 ± 0.015	0.607CysAsp: 0.607 ± 0.036	0.628CysGlu: 0.628 ± 0.038	0.328CysPhe: 0.328 ± 0.022	0.89CysGly: 0.89 ± 0.048	0.195CysHis: 0.195 ± 0.017	0.658CysIle: 0.658 ± 0.036	0.603CysLys: 0.603 ± 0.035	0.643CysLeu: 0.643 ± 0.03	0.192CysMet: 0.192 ± 0.017	0.37CysAsn: 0.37 ± 0.025	0.375CysPro: 0.375 ± 0.034	0.192CysGln: 0.192 ± 0.02	0.241CysArg: 0.241 ± 0.018	0.541CysSer: 0.541 ± 0.03	0.349CysThr: 0.349 ± 0.029	0.464CysVal: 0.464 ± 0.027	0.057CysTrp: 0.057 ± 0.009	0.347CysTyr: 0.347 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.15AspAla: 3.15 ± 0.081	0.462AspCys: 0.462 ± 0.033	3.328AspAsp: 3.328 ± 0.099	5.844AspGlu: 5.844 ± 0.103	3.469AspPhe: 3.469 ± 0.086	4.246AspGly: 4.246 ± 0.138	0.792AspHis: 0.792 ± 0.034	5.503AspIle: 5.503 ± 0.108	5.76AspLys: 5.76 ± 0.152	6.131AspLeu: 6.131 ± 0.11	1.611AspMet: 1.611 ± 0.057	2.897AspAsn: 2.897 ± 0.065	1.789AspPro: 1.789 ± 0.074	1.103AspGln: 1.103 ± 0.04	2.474AspArg: 2.474 ± 0.072	3.427AspSer: 3.427 ± 0.08	2.601AspThr: 2.601 ± 0.075	3.747AspVal: 3.747 ± 0.081	0.364AspTrp: 0.364 ± 0.028	2.95AspTyr: 2.95 ± 0.077	0.0AspXaa: 0.0 ± 0.0
Glu	4.411GluAla: 4.411 ± 0.104	0.43GluCys: 0.43 ± 0.03	5.383GluAsp: 5.383 ± 0.111	7.988GluGlu: 7.988 ± 0.175	3.472GluPhe: 3.472 ± 0.081	4.301GluGly: 4.301 ± 0.092	0.981GluHis: 0.981 ± 0.042	7.938GluIle: 7.938 ± 0.127	8.426GluLys: 8.426 ± 0.142	6.936GluLeu: 6.936 ± 0.116	2.228GluMet: 2.228 ± 0.07	5.915GluAsn: 5.915 ± 0.119	1.553GluPro: 1.553 ± 0.055	1.459GluGln: 1.459 ± 0.049	3.062GluArg: 3.062 ± 0.082	3.868GluSer: 3.868 ± 0.087	3.306GluThr: 3.306 ± 0.086	5.471GluVal: 5.471 ± 0.105	0.415GluTrp: 0.415 ± 0.024	3.265GluTyr: 3.265 ± 0.079	0.0GluXaa: 0.0 ± 0.0
Phe	2.543PheAla: 2.543 ± 0.067	0.401PheCys: 0.401 ± 0.027	2.966PheAsp: 2.966 ± 0.077	3.343PheGlu: 3.343 ± 0.082	2.062PhePhe: 2.062 ± 0.066	2.928PheGly: 2.928 ± 0.075	0.553PheHis: 0.553 ± 0.033	4.336PheIle: 4.336 ± 0.09	4.178PheLys: 4.178 ± 0.082	4.354PheLeu: 4.354 ± 0.11	1.204PheMet: 1.204 ± 0.048	2.454PheAsn: 2.454 ± 0.072	1.147PhePro: 1.147 ± 0.045	0.989PheGln: 0.989 ± 0.039	1.533PheArg: 1.533 ± 0.051	3.175PheSer: 3.175 ± 0.087	2.507PheThr: 2.507 ± 0.073	3.146PheVal: 3.146 ± 0.094	0.278PheTrp: 0.278 ± 0.023	2.089PheTyr: 2.089 ± 0.064	0.0PheXaa: 0.0 ± 0.0
Gly	4.012GlyAla: 4.012 ± 0.102	0.659GlyCys: 0.659 ± 0.038	3.369GlyAsp: 3.369 ± 0.078	4.608GlyGlu: 4.608 ± 0.099	3.184GlyPhe: 3.184 ± 0.068	4.22GlyGly: 4.22 ± 0.115	1.029GlyHis: 1.029 ± 0.043	5.992GlyIle: 5.992 ± 0.114	5.755GlyLys: 5.755 ± 0.142	5.713GlyLeu: 5.713 ± 0.114	1.813GlyMet: 1.813 ± 0.058	3.01GlyAsn: 3.01 ± 0.094	1.328GlyPro: 1.328 ± 0.048	1.519GlyGln: 1.519 ± 0.054	2.6GlyArg: 2.6 ± 0.069	3.884GlySer: 3.884 ± 0.089	3.432GlyThr: 3.432 ± 0.093	4.346GlyVal: 4.346 ± 0.104	0.46GlyTrp: 0.46 ± 0.033	3.099GlyTyr: 3.099 ± 0.093	0.0GlyXaa: 0.0 ± 0.0
His	0.733HisAla: 0.733 ± 0.041	0.149HisCys: 0.149 ± 0.016	0.821HisAsp: 0.821 ± 0.036	0.947HisGlu: 0.947 ± 0.043	0.638HisPhe: 0.638 ± 0.031	1.074HisGly: 1.074 ± 0.047	0.313HisHis: 0.313 ± 0.029	1.165HisIle: 1.165 ± 0.05	0.945HisLys: 0.945 ± 0.039	1.289HisLeu: 1.289 ± 0.048	0.355HisMet: 0.355 ± 0.027	0.628HisAsn: 0.628 ± 0.036	0.583HisPro: 0.583 ± 0.035	0.313HisGln: 0.313 ± 0.023	0.62HisArg: 0.62 ± 0.031	0.818HisSer: 0.818 ± 0.045	0.703HisThr: 0.703 ± 0.032	0.733HisVal: 0.733 ± 0.032	0.103HisTrp: 0.103 ± 0.013	0.577HisTyr: 0.577 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.445IleAla: 5.445 ± 0.123	0.816IleCys: 0.816 ± 0.042	5.905IleAsp: 5.905 ± 0.11	7.437IleGlu: 7.437 ± 0.14	4.437IlePhe: 4.437 ± 0.108	5.65IleGly: 5.65 ± 0.105	1.103IleHis: 1.103 ± 0.047	7.762IleIle: 7.762 ± 0.158	7.936IleLys: 7.936 ± 0.13	8.972IleLeu: 8.972 ± 0.164	2.147IleMet: 2.147 ± 0.065	4.81IleAsn: 4.81 ± 0.091	3.037IlePro: 3.037 ± 0.084	1.632IleGln: 1.632 ± 0.056	3.133IleArg: 3.133 ± 0.072	6.511IleSer: 6.511 ± 0.148	4.383IleThr: 4.383 ± 0.087	5.847IleVal: 5.847 ± 0.113	0.48IleTrp: 0.48 ± 0.035	3.516IleTyr: 3.516 ± 0.082	0.0IleXaa: 0.0 ± 0.0
Lys	4.617LysAla: 4.617 ± 0.135	0.522LysCys: 0.522 ± 0.033	6.923LysAsp: 6.923 ± 0.146	8.928LysGlu: 8.928 ± 0.151	3.58LysPhe: 3.58 ± 0.08	4.622LysGly: 4.622 ± 0.095	1.018LysHis: 1.018 ± 0.041	8.364LysIle: 8.364 ± 0.125	8.435LysLys: 8.435 ± 0.162	7.518LysLeu: 7.518 ± 0.115	2.532LysMet: 2.532 ± 0.056	6.647LysAsn: 6.647 ± 0.123	2.215LysPro: 2.215 ± 0.086	1.727LysGln: 1.727 ± 0.066	3.467LysArg: 3.467 ± 0.085	5.776LysSer: 5.776 ± 0.129	4.815LysThr: 4.815 ± 0.105	5.711LysVal: 5.711 ± 0.131	0.502LysTrp: 0.502 ± 0.036	3.974LysTyr: 3.974 ± 0.091	0.0LysXaa: 0.0 ± 0.0
Leu	5.267LeuAla: 5.267 ± 0.106	0.74LeuCys: 0.74 ± 0.036	5.815LeuAsp: 5.815 ± 0.098	7.309LeuGlu: 7.309 ± 0.121	3.873LeuPhe: 3.873 ± 0.097	5.983LeuGly: 5.983 ± 0.124	1.016LeuHis: 1.016 ± 0.047	7.666LeuIle: 7.666 ± 0.141	9.262LeuLys: 9.262 ± 0.14	7.731LeuLeu: 7.731 ± 0.157	2.359LeuMet: 2.359 ± 0.068	5.603LeuAsn: 5.603 ± 0.114	2.848LeuPro: 2.848 ± 0.076	1.986LeuGln: 1.986 ± 0.06	3.517LeuArg: 3.517 ± 0.096	6.652LeuSer: 6.652 ± 0.121	4.606LeuThr: 4.606 ± 0.098	5.714LeuVal: 5.714 ± 0.112	0.467LeuTrp: 0.467 ± 0.03	3.052LeuTyr: 3.052 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	1.863MetAla: 1.863 ± 0.068	0.192MetCys: 0.192 ± 0.018	1.827MetAsp: 1.827 ± 0.051	2.087MetGlu: 2.087 ± 0.063	0.994MetPhe: 0.994 ± 0.04	1.853MetGly: 1.853 ± 0.065	0.281MetHis: 0.281 ± 0.023	2.33MetIle: 2.33 ± 0.068	2.824MetLys: 2.824 ± 0.078	2.076MetLeu: 2.076 ± 0.07	0.745MetMet: 0.745 ± 0.041	1.496MetAsn: 1.496 ± 0.049	0.826MetPro: 0.826 ± 0.038	0.517MetGln: 0.517 ± 0.028	1.013MetArg: 1.013 ± 0.035	1.612MetSer: 1.612 ± 0.055	1.383MetThr: 1.383 ± 0.05	1.769MetVal: 1.769 ± 0.06	0.17MetTrp: 0.17 ± 0.018	0.83MetTyr: 0.83 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	2.541AsnAla: 2.541 ± 0.069	0.473AsnCys: 0.473 ± 0.031	2.504AsnAsp: 2.504 ± 0.075	3.848AsnGlu: 3.848 ± 0.078	2.811AsnPhe: 2.811 ± 0.068	3.327AsnGly: 3.327 ± 0.081	0.797AsnHis: 0.797 ± 0.034	6.075AsnIle: 6.075 ± 0.106	5.143AsnLys: 5.143 ± 0.107	6.096AsnLeu: 6.096 ± 0.12	1.515AsnMet: 1.515 ± 0.048	2.973AsnAsn: 2.973 ± 0.095	2.22AsnPro: 2.22 ± 0.072	1.349AsnGln: 1.349 ± 0.051	2.43AsnArg: 2.43 ± 0.07	3.391AsnSer: 3.391 ± 0.089	2.595AsnThr: 2.595 ± 0.066	3.231AsnVal: 3.231 ± 0.066	0.37AsnTrp: 0.37 ± 0.025	2.491AsnTyr: 2.491 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.527ProAla: 1.527 ± 0.067	0.218ProCys: 0.218 ± 0.021	1.575ProAsp: 1.575 ± 0.065	2.483ProGlu: 2.483 ± 0.074	1.372ProPhe: 1.372 ± 0.046	1.903ProGly: 1.903 ± 0.075	0.493ProHis: 0.493 ± 0.035	2.646ProIle: 2.646 ± 0.067	2.488ProLys: 2.488 ± 0.075	2.22ProLeu: 2.22 ± 0.066	0.808ProMet: 0.808 ± 0.04	1.501ProAsn: 1.501 ± 0.06	0.651ProPro: 0.651 ± 0.035	0.806ProGln: 0.806 ± 0.041	0.953ProArg: 0.953 ± 0.041	1.8ProSer: 1.8 ± 0.06	1.656ProThr: 1.656 ± 0.07	2.06ProVal: 2.06 ± 0.058	0.174ProTrp: 0.174 ± 0.017	1.255ProTyr: 1.255 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	1.335GlnAla: 1.335 ± 0.049	0.113GlnCys: 0.113 ± 0.015	1.281GlnAsp: 1.281 ± 0.045	1.677GlnGlu: 1.677 ± 0.063	0.848GlnPhe: 0.848 ± 0.039	1.512GlnGly: 1.512 ± 0.054	0.223GlnHis: 0.223 ± 0.019	1.939GlnIle: 1.939 ± 0.062	2.039GlnLys: 2.039 ± 0.06	1.494GlnLeu: 1.494 ± 0.059	0.658GlnMet: 0.658 ± 0.035	1.488GlnAsn: 1.488 ± 0.051	0.475GlnPro: 0.475 ± 0.038	0.444GlnGln: 0.444 ± 0.029	0.987GlnArg: 0.987 ± 0.046	1.166GlnSer: 1.166 ± 0.044	1.034GlnThr: 1.034 ± 0.052	1.617GlnVal: 1.617 ± 0.055	0.16GlnTrp: 0.16 ± 0.016	0.766GlnTyr: 0.766 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.155ArgAla: 2.155 ± 0.066	0.375ArgCys: 0.375 ± 0.026	2.632ArgAsp: 2.632 ± 0.068	3.567ArgGlu: 3.567 ± 0.083	1.708ArgPhe: 1.708 ± 0.055	2.348ArgGly: 2.348 ± 0.073	0.588ArgHis: 0.588 ± 0.028	3.445ArgIle: 3.445 ± 0.08	3.293ArgLys: 3.293 ± 0.082	3.307ArgLeu: 3.307 ± 0.08	1.097ArgMet: 1.097 ± 0.042	2.175ArgAsn: 2.175 ± 0.07	1.137ArgPro: 1.137 ± 0.045	1.01ArgGln: 1.01 ± 0.041	1.81ArgArg: 1.81 ± 0.054	2.074ArgSer: 2.074 ± 0.062	1.709ArgThr: 1.709 ± 0.049	2.315ArgVal: 2.315 ± 0.06	0.228ArgTrp: 0.228 ± 0.019	1.593ArgTyr: 1.593 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	3.162SerAla: 3.162 ± 0.07	0.53SerCys: 0.53 ± 0.034	3.454SerAsp: 3.454 ± 0.082	4.223SerGlu: 4.223 ± 0.091	3.183SerPhe: 3.183 ± 0.082	4.262SerGly: 4.262 ± 0.099	0.969SerHis: 0.969 ± 0.041	5.884SerIle: 5.884 ± 0.11	5.634SerLys: 5.634 ± 0.112	6.243SerLeu: 6.243 ± 0.122	1.667SerMet: 1.667 ± 0.051	3.123SerAsn: 3.123 ± 0.082	1.637SerPro: 1.637 ± 0.049	1.536SerGln: 1.536 ± 0.06	2.351SerArg: 2.351 ± 0.068	3.858SerSer: 3.858 ± 0.1	3.173SerThr: 3.173 ± 0.078	3.764SerVal: 3.764 ± 0.088	0.469SerTrp: 0.469 ± 0.028	2.932SerTyr: 2.932 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	2.991ThrAla: 2.991 ± 0.101	0.451ThrCys: 0.451 ± 0.025	2.987ThrAsp: 2.987 ± 0.091	3.382ThrGlu: 3.382 ± 0.083	2.414ThrPhe: 2.414 ± 0.072	3.634ThrGly: 3.634 ± 0.09	0.803ThrHis: 0.803 ± 0.033	4.651ThrIle: 4.651 ± 0.095	4.125ThrLys: 4.125 ± 0.095	4.559ThrLeu: 4.559 ± 0.091	1.276ThrMet: 1.276 ± 0.05	2.377ThrAsn: 2.377 ± 0.069	1.787ThrPro: 1.787 ± 0.075	0.997ThrGln: 0.997 ± 0.046	1.839ThrArg: 1.839 ± 0.054	3.125ThrSer: 3.125 ± 0.077	2.785ThrThr: 2.785 ± 0.088	3.514ThrVal: 3.514 ± 0.103	0.351ThrTrp: 0.351 ± 0.027	1.918ThrTyr: 1.918 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	3.976ValAla: 3.976 ± 0.102	0.585ValCys: 0.585 ± 0.032	4.302ValAsp: 4.302 ± 0.081	5.204ValGlu: 5.204 ± 0.118	3.015ValPhe: 3.015 ± 0.07	4.383ValGly: 4.383 ± 0.108	0.858ValHis: 0.858 ± 0.042	5.16ValIle: 5.16 ± 0.099	5.375ValLys: 5.375 ± 0.089	6.146ValLeu: 6.146 ± 0.123	1.57ValMet: 1.57 ± 0.058	3.309ValAsn: 3.309 ± 0.073	2.178ValPro: 2.178 ± 0.065	1.267ValGln: 1.267 ± 0.047	2.302ValArg: 2.302 ± 0.054	4.102ValSer: 4.102 ± 0.084	3.414ValThr: 3.414 ± 0.124	4.714ValVal: 4.714 ± 0.105	0.339ValTrp: 0.339 ± 0.021	2.444ValTyr: 2.444 ± 0.072	0.0ValXaa: 0.0 ± 0.0
Trp	0.376TrpAla: 0.376 ± 0.028	0.057TrpCys: 0.057 ± 0.011	0.428TrpAsp: 0.428 ± 0.027	0.383TrpGlu: 0.383 ± 0.028	0.216TrpPhe: 0.216 ± 0.021	0.444TrpGly: 0.444 ± 0.027	0.11TrpHis: 0.11 ± 0.014	0.543TrpIle: 0.543 ± 0.034	0.502TrpLys: 0.502 ± 0.028	0.402TrpLeu: 0.402 ± 0.023	0.215TrpMet: 0.215 ± 0.021	0.414TrpAsn: 0.414 ± 0.029	0.124TrpPro: 0.124 ± 0.015	0.191TrpGln: 0.191 ± 0.019	0.25TrpArg: 0.25 ± 0.018	0.367TrpSer: 0.367 ± 0.025	0.367TrpThr: 0.367 ± 0.025	0.331TrpVal: 0.331 ± 0.024	0.048TrpTrp: 0.048 ± 0.008	0.252TrpTyr: 0.252 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.005TyrAla: 2.005 ± 0.058	0.431TyrCys: 0.431 ± 0.028	2.619TyrAsp: 2.619 ± 0.075	3.238TyrGlu: 3.238 ± 0.073	2.165TyrPhe: 2.165 ± 0.061	2.654TyrGly: 2.654 ± 0.069	0.549TyrHis: 0.549 ± 0.032	3.419TyrIle: 3.419 ± 0.075	3.863TyrLys: 3.863 ± 0.097	4.13TyrLeu: 4.13 ± 0.098	0.994TyrMet: 0.994 ± 0.04	2.278TyrAsn: 2.278 ± 0.063	1.226TyrPro: 1.226 ± 0.047	0.913TyrGln: 0.913 ± 0.043	1.717TyrArg: 1.717 ± 0.062	2.495TyrSer: 2.495 ± 0.067	2.041TyrThr: 2.041 ± 0.067	2.383TyrVal: 2.383 ± 0.073	0.281TyrTrp: 0.281 ± 0.021	1.881TyrTyr: 1.881 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1987 proteins (618953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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