Amino acid dipepetide frequency for Rheinheimera sp. A13L

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.366AlaAla: 10.366 ± 0.125
0.995AlaCys: 0.995 ± 0.026
5.781AlaAsp: 5.781 ± 0.079
6.794AlaGlu: 6.794 ± 0.078
3.645AlaPhe: 3.645 ± 0.051
6.958AlaGly: 6.958 ± 0.078
1.581AlaHis: 1.581 ± 0.035
5.401AlaIle: 5.401 ± 0.063
4.78AlaLys: 4.78 ± 0.068
11.805AlaLeu: 11.805 ± 0.133
2.438AlaMet: 2.438 ± 0.047
3.182AlaAsn: 3.182 ± 0.052
3.171AlaPro: 3.171 ± 0.056
4.652AlaGln: 4.652 ± 0.076
3.872AlaArg: 3.872 ± 0.061
5.691AlaSer: 5.691 ± 0.075
4.79AlaThr: 4.79 ± 0.077
7.367AlaVal: 7.367 ± 0.086
0.966AlaTrp: 0.966 ± 0.028
2.603AlaTyr: 2.603 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.86CysAla: 0.86 ± 0.028
0.2CysCys: 0.2 ± 0.012
0.502CysAsp: 0.502 ± 0.019
0.468CysGlu: 0.468 ± 0.018
0.475CysPhe: 0.475 ± 0.019
0.8CysGly: 0.8 ± 0.026
0.278CysHis: 0.278 ± 0.016
0.532CysIle: 0.532 ± 0.021
0.38CysLys: 0.38 ± 0.018
1.035CysLeu: 1.035 ± 0.03
0.183CysMet: 0.183 ± 0.013
0.312CysAsn: 0.312 ± 0.016
0.427CysPro: 0.427 ± 0.017
0.551CysGln: 0.551 ± 0.024
0.494CysArg: 0.494 ± 0.023
0.755CysSer: 0.755 ± 0.027
0.469CysThr: 0.469 ± 0.02
0.545CysVal: 0.545 ± 0.021
0.173CysTrp: 0.173 ± 0.012
0.401CysTyr: 0.401 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.603AspAla: 4.603 ± 0.067
0.515AspCys: 0.515 ± 0.023
2.556AspAsp: 2.556 ± 0.047
3.134AspGlu: 3.134 ± 0.059
2.592AspPhe: 2.592 ± 0.046
3.487AspGly: 3.487 ± 0.059
1.088AspHis: 1.088 ± 0.031
3.304AspIle: 3.304 ± 0.048
2.882AspLys: 2.882 ± 0.05
6.005AspLeu: 6.005 ± 0.078
1.283AspMet: 1.283 ± 0.035
1.987AspAsn: 1.987 ± 0.044
2.232AspPro: 2.232 ± 0.038
2.698AspGln: 2.698 ± 0.053
2.043AspArg: 2.043 ± 0.042
3.105AspSer: 3.105 ± 0.047
2.45AspThr: 2.45 ± 0.05
3.288AspVal: 3.288 ± 0.047
0.969AspTrp: 0.969 ± 0.03
2.011AspTyr: 2.011 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
4.964GluAla: 4.964 ± 0.072
0.327GluCys: 0.327 ± 0.014
2.303GluAsp: 2.303 ± 0.041
2.603GluGlu: 2.603 ± 0.057
2.35GluPhe: 2.35 ± 0.041
2.908GluGly: 2.908 ± 0.052
1.569GluHis: 1.569 ± 0.034
2.903GluIle: 2.903 ± 0.059
2.93GluLys: 2.93 ± 0.051
7.985GluLeu: 7.985 ± 0.089
1.345GluMet: 1.345 ± 0.032
1.875GluAsn: 1.875 ± 0.04
2.108GluPro: 2.108 ± 0.044
5.264GluGln: 5.264 ± 0.075
2.934GluArg: 2.934 ± 0.047
2.691GluSer: 2.691 ± 0.052
2.709GluThr: 2.709 ± 0.047
3.716GluVal: 3.716 ± 0.064
0.671GluTrp: 0.671 ± 0.02
1.351GluTyr: 1.351 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.046PheAla: 4.046 ± 0.058
0.584PheCys: 0.584 ± 0.021
2.593PheAsp: 2.593 ± 0.049
2.288PheGlu: 2.288 ± 0.043
1.755PhePhe: 1.755 ± 0.041
3.076PheGly: 3.076 ± 0.056
0.796PheHis: 0.796 ± 0.025
2.452PheIle: 2.452 ± 0.048
1.799PheLys: 1.799 ± 0.041
3.515PheLeu: 3.515 ± 0.059
0.946PheMet: 0.946 ± 0.026
1.847PheAsn: 1.847 ± 0.04
1.44PhePro: 1.44 ± 0.031
1.457PheGln: 1.457 ± 0.032
1.741PheArg: 1.741 ± 0.039
3.665PheSer: 3.665 ± 0.06
2.172PheThr: 2.172 ± 0.051
2.887PheVal: 2.887 ± 0.05
0.646PheTrp: 0.646 ± 0.023
1.571PheTyr: 1.571 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.392GlyAla: 5.392 ± 0.072
0.782GlyCys: 0.782 ± 0.028
3.269GlyAsp: 3.269 ± 0.057
3.569GlyGlu: 3.569 ± 0.05
3.315GlyPhe: 3.315 ± 0.057
4.363GlyGly: 4.363 ± 0.081
1.551GlyHis: 1.551 ± 0.033
3.978GlyIle: 3.978 ± 0.06
3.653GlyLys: 3.653 ± 0.059
7.26GlyLeu: 7.26 ± 0.075
1.687GlyMet: 1.687 ± 0.042
2.232GlyAsn: 2.232 ± 0.048
1.861GlyPro: 1.861 ± 0.037
3.427GlyGln: 3.427 ± 0.056
3.165GlyArg: 3.165 ± 0.053
4.308GlySer: 4.308 ± 0.071
3.47GlyThr: 3.47 ± 0.073
4.753GlyVal: 4.753 ± 0.067
1.066GlyTrp: 1.066 ± 0.033
2.58GlyTyr: 2.58 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.6HisAla: 1.6 ± 0.035
0.323HisCys: 0.323 ± 0.017
0.926HisAsp: 0.926 ± 0.025
0.934HisGlu: 0.934 ± 0.026
1.084HisPhe: 1.084 ± 0.028
1.5HisGly: 1.5 ± 0.039
0.737HisHis: 0.737 ± 0.029
1.239HisIle: 1.239 ± 0.031
1.177HisLys: 1.177 ± 0.032
2.539HisLeu: 2.539 ± 0.05
0.473HisMet: 0.473 ± 0.019
0.838HisAsn: 0.838 ± 0.029
1.17HisPro: 1.17 ± 0.029
1.724HisGln: 1.724 ± 0.035
0.924HisArg: 0.924 ± 0.025
1.609HisSer: 1.609 ± 0.038
0.862HisThr: 0.862 ± 0.024
1.024HisVal: 1.024 ± 0.032
0.49HisTrp: 0.49 ± 0.02
0.897HisTyr: 0.897 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.686IleAla: 5.686 ± 0.067
0.622IleCys: 0.622 ± 0.023
3.176IleAsp: 3.176 ± 0.058
3.634IleGlu: 3.634 ± 0.054
1.85IlePhe: 1.85 ± 0.043
3.797IleGly: 3.797 ± 0.052
1.054IleHis: 1.054 ± 0.027
2.413IleIle: 2.413 ± 0.054
2.857IleLys: 2.857 ± 0.05
4.527IleLeu: 4.527 ± 0.081
0.943IleMet: 0.943 ± 0.026
2.315IleAsn: 2.315 ± 0.044
2.208IlePro: 2.208 ± 0.043
2.498IleGln: 2.498 ± 0.047
2.746IleArg: 2.746 ± 0.046
4.225IleSer: 4.225 ± 0.063
2.861IleThr: 2.861 ± 0.056
3.244IleVal: 3.244 ± 0.048
0.647IleTrp: 0.647 ± 0.023
1.461IleTyr: 1.461 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
5.749LysAla: 5.749 ± 0.073
0.213LysCys: 0.213 ± 0.013
2.619LysAsp: 2.619 ± 0.05
2.626LysGlu: 2.626 ± 0.05
1.482LysPhe: 1.482 ± 0.031
2.924LysGly: 2.924 ± 0.051
1.035LysHis: 1.035 ± 0.03
2.369LysIle: 2.369 ± 0.039
2.53LysLys: 2.53 ± 0.055
5.387LysLeu: 5.387 ± 0.07
1.092LysMet: 1.092 ± 0.032
1.882LysAsn: 1.882 ± 0.039
2.269LysPro: 2.269 ± 0.05
3.17LysGln: 3.17 ± 0.056
2.281LysArg: 2.281 ± 0.052
2.614LysSer: 2.614 ± 0.051
2.976LysThr: 2.976 ± 0.05
3.82LysVal: 3.82 ± 0.055
0.401LysTrp: 0.401 ± 0.017
1.118LysTyr: 1.118 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
12.046LeuAla: 12.046 ± 0.126
1.344LeuCys: 1.344 ± 0.034
5.947LeuAsp: 5.947 ± 0.076
5.808LeuGlu: 5.808 ± 0.078
4.529LeuPhe: 4.529 ± 0.076
6.924LeuGly: 6.924 ± 0.09
2.442LeuHis: 2.442 ± 0.048
5.855LeuIle: 5.855 ± 0.077
5.861LeuLys: 5.861 ± 0.084
14.141LeuLeu: 14.141 ± 0.187
2.948LeuMet: 2.948 ± 0.046
4.545LeuAsn: 4.545 ± 0.067
5.639LeuPro: 5.639 ± 0.071
6.649LeuGln: 6.649 ± 0.107
4.754LeuArg: 4.754 ± 0.066
8.545LeuSer: 8.545 ± 0.088
6.791LeuThr: 6.791 ± 0.084
8.174LeuVal: 8.174 ± 0.097
1.683LeuTrp: 1.683 ± 0.042
3.197LeuTyr: 3.197 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.581MetAla: 2.581 ± 0.045
0.125MetCys: 0.125 ± 0.01
1.121MetAsp: 1.121 ± 0.028
1.044MetGlu: 1.044 ± 0.028
0.759MetPhe: 0.759 ± 0.024
1.381MetGly: 1.381 ± 0.038
0.446MetHis: 0.446 ± 0.019
1.034MetIle: 1.034 ± 0.031
1.245MetLys: 1.245 ± 0.032
2.901MetLeu: 2.901 ± 0.048
0.595MetMet: 0.595 ± 0.023
0.883MetAsn: 0.883 ± 0.029
1.222MetPro: 1.222 ± 0.032
1.524MetGln: 1.524 ± 0.036
1.033MetArg: 1.033 ± 0.034
1.639MetSer: 1.639 ± 0.039
1.407MetThr: 1.407 ± 0.033
1.543MetVal: 1.543 ± 0.037
0.209MetTrp: 0.209 ± 0.014
0.487MetTyr: 0.487 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.211AsnAla: 3.211 ± 0.06
0.356AsnCys: 0.356 ± 0.016
1.796AsnAsp: 1.796 ± 0.034
1.9AsnGlu: 1.9 ± 0.041
1.483AsnPhe: 1.483 ± 0.036
2.462AsnGly: 2.462 ± 0.053
0.808AsnHis: 0.808 ± 0.024
1.935AsnIle: 1.935 ± 0.043
1.924AsnLys: 1.924 ± 0.038
3.665AsnLeu: 3.665 ± 0.051
0.8AsnMet: 0.8 ± 0.022
1.553AsnAsn: 1.553 ± 0.04
1.982AsnPro: 1.982 ± 0.038
2.098AsnGln: 2.098 ± 0.041
1.793AsnArg: 1.793 ± 0.036
2.594AsnSer: 2.594 ± 0.05
2.069AsnThr: 2.069 ± 0.043
2.017AsnVal: 2.017 ± 0.045
0.65AsnTrp: 0.65 ± 0.024
1.354AsnTyr: 1.354 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
4.548ProAla: 4.548 ± 0.067
0.358ProCys: 0.358 ± 0.019
2.863ProAsp: 2.863 ± 0.047
3.408ProGlu: 3.408 ± 0.049
1.683ProPhe: 1.683 ± 0.034
2.808ProGly: 2.808 ± 0.048
0.814ProHis: 0.814 ± 0.027
1.635ProIle: 1.635 ± 0.042
1.776ProLys: 1.776 ± 0.041
4.727ProLeu: 4.727 ± 0.065
0.91ProMet: 0.91 ± 0.026
1.369ProAsn: 1.369 ± 0.034
1.113ProPro: 1.113 ± 0.035
2.101ProGln: 2.101 ± 0.041
1.376ProArg: 1.376 ± 0.035
2.069ProSer: 2.069 ± 0.04
1.879ProThr: 1.879 ± 0.039
3.783ProVal: 3.783 ± 0.059
0.558ProTrp: 0.558 ± 0.02
1.24ProTyr: 1.24 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
5.502GlnAla: 5.502 ± 0.073
0.39GlnCys: 0.39 ± 0.016
2.401GlnAsp: 2.401 ± 0.04
2.131GlnGlu: 2.131 ± 0.048
2.138GlnPhe: 2.138 ± 0.047
3.678GlnGly: 3.678 ± 0.061
1.949GlnHis: 1.949 ± 0.043
3.029GlnIle: 3.029 ± 0.043
2.707GlnLys: 2.707 ± 0.051
8.989GlnLeu: 8.989 ± 0.156
1.342GlnMet: 1.342 ± 0.033
2.06GlnAsn: 2.06 ± 0.04
2.431GlnPro: 2.431 ± 0.045
7.573GlnGln: 7.573 ± 0.17
2.861GlnArg: 2.861 ± 0.048
3.846GlnSer: 3.846 ± 0.067
2.412GlnThr: 2.412 ± 0.05
3.704GlnVal: 3.704 ± 0.053
0.9GlnTrp: 0.9 ± 0.026
1.502GlnTyr: 1.502 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.452ArgAla: 3.452 ± 0.049
0.423ArgCys: 0.423 ± 0.018
2.291ArgAsp: 2.291 ± 0.046
2.367ArgGlu: 2.367 ± 0.049
2.271ArgPhe: 2.271 ± 0.048
2.453ArgGly: 2.453 ± 0.046
1.154ArgHis: 1.154 ± 0.03
2.806ArgIle: 2.806 ± 0.046
1.997ArgLys: 1.997 ± 0.043
5.516ArgLeu: 5.516 ± 0.068
1.055ArgMet: 1.055 ± 0.026
1.603ArgAsn: 1.603 ± 0.035
1.647ArgPro: 1.647 ± 0.039
3.01ArgGln: 3.01 ± 0.053
2.211ArgArg: 2.211 ± 0.05
2.769ArgSer: 2.769 ± 0.045
2.132ArgThr: 2.132 ± 0.044
2.87ArgVal: 2.87 ± 0.05
0.696ArgTrp: 0.696 ± 0.022
1.831ArgTyr: 1.831 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.292SerAla: 6.292 ± 0.079
0.725SerCys: 0.725 ± 0.027
3.38SerAsp: 3.38 ± 0.055
3.507SerGlu: 3.507 ± 0.056
3.131SerPhe: 3.131 ± 0.054
5.103SerGly: 5.103 ± 0.071
1.438SerHis: 1.438 ± 0.038
3.335SerIle: 3.335 ± 0.052
2.82SerLys: 2.82 ± 0.051
7.369SerLeu: 7.369 ± 0.09
1.532SerMet: 1.532 ± 0.036
2.201SerAsn: 2.201 ± 0.043
2.557SerPro: 2.557 ± 0.053
3.123SerGln: 3.123 ± 0.052
3.12SerArg: 3.12 ± 0.049
4.708SerSer: 4.708 ± 0.07
3.265SerThr: 3.265 ± 0.054
4.635SerVal: 4.635 ± 0.06
1.112SerTrp: 1.112 ± 0.03
2.399SerTyr: 2.399 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
5.588ThrAla: 5.588 ± 0.11
0.323ThrCys: 0.323 ± 0.017
3.112ThrAsp: 3.112 ± 0.053
3.7ThrGlu: 3.7 ± 0.059
1.727ThrPhe: 1.727 ± 0.045
4.227ThrGly: 4.227 ± 0.07
0.955ThrHis: 0.955 ± 0.027
2.524ThrIle: 2.524 ± 0.054
2.149ThrLys: 2.149 ± 0.043
5.939ThrLeu: 5.939 ± 0.068
0.995ThrMet: 0.995 ± 0.029
1.708ThrAsn: 1.708 ± 0.049
2.635ThrPro: 2.635 ± 0.057
2.492ThrGln: 2.492 ± 0.045
1.77ThrArg: 1.77 ± 0.041
3.131ThrSer: 3.131 ± 0.05
2.798ThrThr: 2.798 ± 0.055
3.895ThrVal: 3.895 ± 0.064
0.432ThrTrp: 0.432 ± 0.025
1.329ThrTyr: 1.329 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
6.914ValAla: 6.914 ± 0.079
0.692ValCys: 0.692 ± 0.025
3.526ValAsp: 3.526 ± 0.048
3.833ValGlu: 3.833 ± 0.057
2.897ValPhe: 2.897 ± 0.053
3.999ValGly: 3.999 ± 0.062
1.236ValHis: 1.236 ± 0.031
4.004ValIle: 4.004 ± 0.06
3.369ValLys: 3.369 ± 0.055
8.471ValLeu: 8.471 ± 0.102
1.727ValMet: 1.727 ± 0.036
2.583ValAsn: 2.583 ± 0.045
2.834ValPro: 2.834 ± 0.045
3.357ValGln: 3.357 ± 0.057
2.982ValArg: 2.982 ± 0.045
4.73ValSer: 4.73 ± 0.073
4.015ValThr: 4.015 ± 0.072
5.22ValVal: 5.22 ± 0.08
0.886ValTrp: 0.886 ± 0.027
1.772ValTyr: 1.772 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.949TrpAla: 0.949 ± 0.031
0.17TrpCys: 0.17 ± 0.01
0.57TrpAsp: 0.57 ± 0.019
0.401TrpGlu: 0.401 ± 0.018
0.739TrpPhe: 0.739 ± 0.024
0.725TrpGly: 0.725 ± 0.026
0.404TrpHis: 0.404 ± 0.017
0.599TrpIle: 0.599 ± 0.021
0.37TrpLys: 0.37 ± 0.018
2.313TrpLeu: 2.313 ± 0.049
0.322TrpMet: 0.322 ± 0.017
0.429TrpAsn: 0.429 ± 0.017
0.65TrpPro: 0.65 ± 0.022
1.492TrpGln: 1.492 ± 0.041
0.792TrpArg: 0.792 ± 0.023
0.871TrpSer: 0.871 ± 0.026
0.623TrpThr: 0.623 ± 0.028
0.813TrpVal: 0.813 ± 0.025
0.264TrpTrp: 0.264 ± 0.016
0.432TrpTyr: 0.432 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.485TyrAla: 2.485 ± 0.043
0.375TyrCys: 0.375 ± 0.019
1.504TyrAsp: 1.504 ± 0.042
1.357TyrGlu: 1.357 ± 0.038
1.372TyrPhe: 1.372 ± 0.033
2.107TyrGly: 2.107 ± 0.044
0.734TyrHis: 0.734 ± 0.024
1.418TyrIle: 1.418 ± 0.038
1.35TyrLys: 1.35 ± 0.031
3.73TyrLeu: 3.73 ± 0.059
0.564TyrMet: 0.564 ± 0.02
1.043TyrAsn: 1.043 ± 0.032
1.424TyrPro: 1.424 ± 0.034
2.685TyrGln: 2.685 ± 0.054
1.662TyrArg: 1.662 ± 0.037
2.187TyrSer: 2.187 ± 0.047
1.279TyrThr: 1.279 ± 0.039
1.748TyrVal: 1.748 ± 0.037
0.512TyrTrp: 0.512 ± 0.024
0.98TyrTyr: 0.98 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3941 proteins (1348315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski