Amino acid dipepetide frequency for Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.527AlaAla: 7.527 ± 0.1	0.927AlaCys: 0.927 ± 0.028	4.852AlaAsp: 4.852 ± 0.067	5.421AlaGlu: 5.421 ± 0.072	3.696AlaPhe: 3.696 ± 0.06	5.626AlaGly: 5.626 ± 0.07	1.548AlaHis: 1.548 ± 0.038	6.144AlaIle: 6.144 ± 0.079	5.416AlaLys: 5.416 ± 0.082	9.349AlaLeu: 9.349 ± 0.092	2.436AlaMet: 2.436 ± 0.047	4.117AlaAsn: 4.117 ± 0.061	2.804AlaPro: 2.804 ± 0.055	3.642AlaGln: 3.642 ± 0.06	3.375AlaArg: 3.375 ± 0.053	5.902AlaSer: 5.902 ± 0.07	4.416AlaThr: 4.416 ± 0.069	5.836AlaVal: 5.836 ± 0.077	0.848AlaTrp: 0.848 ± 0.029	2.393AlaTyr: 2.393 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.811CysAla: 0.811 ± 0.027	0.139CysCys: 0.139 ± 0.012	0.572CysAsp: 0.572 ± 0.022	0.587CysGlu: 0.587 ± 0.026	0.473CysPhe: 0.473 ± 0.021	0.721CysGly: 0.721 ± 0.027	0.276CysHis: 0.276 ± 0.015	0.675CysIle: 0.675 ± 0.027	0.47CysLys: 0.47 ± 0.023	0.892CysLeu: 0.892 ± 0.028	0.225CysMet: 0.225 ± 0.013	0.357CysAsn: 0.357 ± 0.017	0.395CysPro: 0.395 ± 0.019	0.378CysGln: 0.378 ± 0.018	0.385CysArg: 0.385 ± 0.018	0.666CysSer: 0.666 ± 0.021	0.411CysThr: 0.411 ± 0.017	0.643CysVal: 0.643 ± 0.026	0.1CysTrp: 0.1 ± 0.009	0.315CysTyr: 0.315 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.85AspAla: 4.85 ± 0.07	0.482AspCys: 0.482 ± 0.024	3.55AspAsp: 3.55 ± 0.063	4.045AspGlu: 4.045 ± 0.069	2.722AspPhe: 2.722 ± 0.051	3.797AspGly: 3.797 ± 0.07	0.951AspHis: 0.951 ± 0.033	4.533AspIle: 4.533 ± 0.063	3.469AspLys: 3.469 ± 0.056	5.301AspLeu: 5.301 ± 0.072	1.526AspMet: 1.526 ± 0.037	2.652AspAsn: 2.652 ± 0.045	2.038AspPro: 2.038 ± 0.045	1.762AspGln: 1.762 ± 0.04	2.137AspArg: 2.137 ± 0.047	3.585AspSer: 3.585 ± 0.062	2.943AspThr: 2.943 ± 0.054	4.154AspVal: 4.154 ± 0.061	0.822AspTrp: 0.822 ± 0.026	2.035AspTyr: 2.035 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.149GluAla: 5.149 ± 0.069	0.455GluCys: 0.455 ± 0.018	3.01GluAsp: 3.01 ± 0.057	3.627GluGlu: 3.627 ± 0.069	2.631GluPhe: 2.631 ± 0.047	3.429GluGly: 3.429 ± 0.059	1.475GluHis: 1.475 ± 0.037	4.073GluIle: 4.073 ± 0.063	3.959GluLys: 3.959 ± 0.072	6.748GluLeu: 6.748 ± 0.08	1.633GluMet: 1.633 ± 0.037	3.132GluAsn: 3.132 ± 0.053	1.848GluPro: 1.848 ± 0.041	3.679GluGln: 3.679 ± 0.066	3.117GluArg: 3.117 ± 0.061	4.076GluSer: 4.076 ± 0.056	3.121GluThr: 3.121 ± 0.056	4.061GluVal: 4.061 ± 0.066	0.689GluTrp: 0.689 ± 0.025	1.836GluTyr: 1.836 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.92PheAla: 3.92 ± 0.066	0.488PheCys: 0.488 ± 0.021	3.045PheAsp: 3.045 ± 0.051	2.817PheGlu: 2.817 ± 0.05	1.959PhePhe: 1.959 ± 0.046	3.204PheGly: 3.204 ± 0.056	0.795PheHis: 0.795 ± 0.026	3.073PheIle: 3.073 ± 0.058	2.213PheLys: 2.213 ± 0.048	3.642PheLeu: 3.642 ± 0.055	1.047PheMet: 1.047 ± 0.032	2.118PheAsn: 2.118 ± 0.041	1.396PhePro: 1.396 ± 0.04	1.231PheGln: 1.231 ± 0.036	1.478PheArg: 1.478 ± 0.04	3.706PheSer: 3.706 ± 0.061	2.573PheThr: 2.573 ± 0.046	3.072PheVal: 3.072 ± 0.052	0.511PheTrp: 0.511 ± 0.023	1.38PheTyr: 1.38 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.01GlyAla: 5.01 ± 0.086	0.779GlyCys: 0.779 ± 0.026	3.627GlyAsp: 3.627 ± 0.062	3.892GlyGlu: 3.892 ± 0.055	3.368GlyPhe: 3.368 ± 0.056	4.476GlyGly: 4.476 ± 0.085	1.408GlyHis: 1.408 ± 0.037	4.728GlyIle: 4.728 ± 0.065	4.033GlyLys: 4.033 ± 0.063	6.747GlyLeu: 6.747 ± 0.079	1.824GlyMet: 1.824 ± 0.04	2.785GlyAsn: 2.785 ± 0.062	1.632GlyPro: 1.632 ± 0.039	2.441GlyGln: 2.441 ± 0.046	2.706GlyArg: 2.706 ± 0.045	4.091GlySer: 4.091 ± 0.062	3.352GlyThr: 3.352 ± 0.062	4.803GlyVal: 4.803 ± 0.072	0.782GlyTrp: 0.782 ± 0.026	2.296GlyTyr: 2.296 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.64HisAla: 1.64 ± 0.035	0.289HisCys: 0.289 ± 0.018	1.058HisAsp: 1.058 ± 0.031	1.169HisGlu: 1.169 ± 0.03	1.017HisPhe: 1.017 ± 0.026	1.364HisGly: 1.364 ± 0.031	0.571HisHis: 0.571 ± 0.025	1.407HisIle: 1.407 ± 0.037	1.118HisLys: 1.118 ± 0.028	2.016HisLeu: 2.016 ± 0.042	0.46HisMet: 0.46 ± 0.021	0.843HisAsn: 0.843 ± 0.027	1.01HisPro: 1.01 ± 0.03	0.98HisGln: 0.98 ± 0.028	0.888HisArg: 0.888 ± 0.026	1.362HisSer: 1.362 ± 0.036	0.988HisThr: 0.988 ± 0.03	1.291HisVal: 1.291 ± 0.033	0.325HisTrp: 0.325 ± 0.017	0.761HisTyr: 0.761 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.671IleAla: 6.671 ± 0.079	0.71IleCys: 0.71 ± 0.02	4.753IleAsp: 4.753 ± 0.069	4.982IleGlu: 4.982 ± 0.076	2.546IlePhe: 2.546 ± 0.05	4.723IleGly: 4.723 ± 0.07	1.188IleHis: 1.188 ± 0.032	4.113IleIle: 4.113 ± 0.063	3.794IleLys: 3.794 ± 0.064	5.607IleLeu: 5.607 ± 0.081	1.427IleMet: 1.427 ± 0.032	3.636IleAsn: 3.636 ± 0.064	2.604IlePro: 2.604 ± 0.044	2.481IleGln: 2.481 ± 0.044	2.716IleArg: 2.716 ± 0.046	5.069IleSer: 5.069 ± 0.066	3.852IleThr: 3.852 ± 0.055	4.621IleVal: 4.621 ± 0.06	0.619IleTrp: 0.619 ± 0.026	1.782IleTyr: 1.782 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	5.099LysAla: 5.099 ± 0.075	0.367LysCys: 0.367 ± 0.019	2.91LysAsp: 2.91 ± 0.053	3.414LysGlu: 3.414 ± 0.06	1.833LysPhe: 1.833 ± 0.035	3.284LysGly: 3.284 ± 0.053	1.354LysHis: 1.354 ± 0.039	3.466LysIle: 3.466 ± 0.05	3.485LysLys: 3.485 ± 0.066	5.813LysLeu: 5.813 ± 0.063	1.56LysMet: 1.56 ± 0.035	2.747LysAsn: 2.747 ± 0.05	2.371LysPro: 2.371 ± 0.044	3.29LysGln: 3.29 ± 0.059	2.861LysArg: 2.861 ± 0.048	3.705LysSer: 3.705 ± 0.05	3.393LysThr: 3.393 ± 0.06	3.973LysVal: 3.973 ± 0.055	0.631LysTrp: 0.631 ± 0.024	1.599LysTyr: 1.599 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	9.21LeuAla: 9.21 ± 0.089	1.025LeuCys: 1.025 ± 0.036	5.538LeuAsp: 5.538 ± 0.068	5.642LeuGlu: 5.642 ± 0.072	4.356LeuPhe: 4.356 ± 0.069	6.508LeuGly: 6.508 ± 0.078	2.019LeuHis: 2.019 ± 0.047	6.501LeuIle: 6.501 ± 0.089	5.384LeuLys: 5.384 ± 0.079	10.377LeuLeu: 10.377 ± 0.143	2.544LeuMet: 2.544 ± 0.041	4.883LeuAsn: 4.883 ± 0.053	4.465LeuPro: 4.465 ± 0.072	4.003LeuGln: 4.003 ± 0.065	4.236LeuArg: 4.236 ± 0.065	8.517LeuSer: 8.517 ± 0.088	5.683LeuThr: 5.683 ± 0.071	6.906LeuVal: 6.906 ± 0.075	0.892LeuTrp: 0.892 ± 0.03	2.616LeuTyr: 2.616 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.254MetAla: 2.254 ± 0.04	0.189MetCys: 0.189 ± 0.012	1.181MetAsp: 1.181 ± 0.031	1.094MetGlu: 1.094 ± 0.027	0.951MetPhe: 0.951 ± 0.03	1.657MetGly: 1.657 ± 0.04	0.602MetHis: 0.602 ± 0.021	1.48MetIle: 1.48 ± 0.032	1.477MetLys: 1.477 ± 0.032	2.912MetLeu: 2.912 ± 0.062	0.705MetMet: 0.705 ± 0.029	1.156MetAsn: 1.156 ± 0.035	1.256MetPro: 1.256 ± 0.03	1.401MetGln: 1.401 ± 0.035	1.189MetArg: 1.189 ± 0.03	1.972MetSer: 1.972 ± 0.043	1.626MetThr: 1.626 ± 0.036	1.529MetVal: 1.529 ± 0.033	0.217MetTrp: 0.217 ± 0.013	0.548MetTyr: 0.548 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	4.186AsnAla: 4.186 ± 0.066	0.43AsnCys: 0.43 ± 0.021	2.697AsnAsp: 2.697 ± 0.047	2.92AsnGlu: 2.92 ± 0.054	1.801AsnPhe: 1.801 ± 0.041	3.051AsnGly: 3.051 ± 0.06	0.838AsnHis: 0.838 ± 0.024	3.365AsnIle: 3.365 ± 0.058	2.941AsnLys: 2.941 ± 0.05	4.321AsnLeu: 4.321 ± 0.068	1.181AsnMet: 1.181 ± 0.03	2.428AsnAsn: 2.428 ± 0.054	2.053AsnPro: 2.053 ± 0.04	2.085AsnGln: 2.085 ± 0.043	2.044AsnArg: 2.044 ± 0.04	3.063AsnSer: 3.063 ± 0.059	2.637AsnThr: 2.637 ± 0.046	3.074AsnVal: 3.074 ± 0.057	0.607AsnTrp: 0.607 ± 0.023	1.446AsnTyr: 1.446 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.88ProAla: 2.88 ± 0.058	0.278ProCys: 0.278 ± 0.016	2.395ProAsp: 2.395 ± 0.052	2.88ProGlu: 2.88 ± 0.054	1.769ProPhe: 1.769 ± 0.038	2.133ProGly: 2.133 ± 0.046	0.768ProHis: 0.768 ± 0.024	2.696ProIle: 2.696 ± 0.045	2.041ProLys: 2.041 ± 0.041	3.699ProLeu: 3.699 ± 0.051	0.924ProMet: 0.924 ± 0.029	1.913ProAsn: 1.913 ± 0.045	1.08ProPro: 1.08 ± 0.033	1.439ProGln: 1.439 ± 0.037	1.274ProArg: 1.274 ± 0.032	2.637ProSer: 2.637 ± 0.043	2.007ProThr: 2.007 ± 0.041	2.707ProVal: 2.707 ± 0.052	0.444ProTrp: 0.444 ± 0.019	1.108ProTyr: 1.108 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.989GlnAla: 3.989 ± 0.059	0.315GlnCys: 0.315 ± 0.016	2.051GlnAsp: 2.051 ± 0.041	2.338GlnGlu: 2.338 ± 0.054	1.787GlnPhe: 1.787 ± 0.039	2.574GlnGly: 2.574 ± 0.042	1.147GlnHis: 1.147 ± 0.029	2.687GlnIle: 2.687 ± 0.04	2.473GlnLys: 2.473 ± 0.043	4.737GlnLeu: 4.737 ± 0.07	1.056GlnMet: 1.056 ± 0.034	1.903GlnAsn: 1.903 ± 0.043	1.499GlnPro: 1.499 ± 0.034	2.725GlnGln: 2.725 ± 0.054	2.183GlnArg: 2.183 ± 0.04	2.972GlnSer: 2.972 ± 0.049	2.343GlnThr: 2.343 ± 0.045	2.848GlnVal: 2.848 ± 0.048	0.549GlnTrp: 0.549 ± 0.024	1.333GlnTyr: 1.333 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.314ArgAla: 3.314 ± 0.058	0.344ArgCys: 0.344 ± 0.018	2.334ArgAsp: 2.334 ± 0.042	2.787ArgGlu: 2.787 ± 0.05	2.155ArgPhe: 2.155 ± 0.038	2.384ArgGly: 2.384 ± 0.052	0.88ArgHis: 0.88 ± 0.025	3.006ArgIle: 3.006 ± 0.047	2.427ArgLys: 2.427 ± 0.055	4.55ArgLeu: 4.55 ± 0.066	1.065ArgMet: 1.065 ± 0.026	1.964ArgAsn: 1.964 ± 0.041	1.44ArgPro: 1.44 ± 0.036	1.933ArgGln: 1.933 ± 0.042	2.04ArgArg: 2.04 ± 0.04	2.563ArgSer: 2.563 ± 0.047	2.049ArgThr: 2.049 ± 0.042	3.001ArgVal: 3.001 ± 0.054	0.535ArgTrp: 0.535 ± 0.024	1.492ArgTyr: 1.492 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.166SerAla: 6.166 ± 0.078	0.586SerCys: 0.586 ± 0.02	4.152SerAsp: 4.152 ± 0.063	4.327SerGlu: 4.327 ± 0.064	3.113SerPhe: 3.113 ± 0.054	5.009SerGly: 5.009 ± 0.082	1.363SerHis: 1.363 ± 0.032	5.069SerIle: 5.069 ± 0.07	3.932SerLys: 3.932 ± 0.059	7.26SerLeu: 7.26 ± 0.084	1.88SerMet: 1.88 ± 0.039	3.127SerAsn: 3.127 ± 0.057	2.559SerPro: 2.559 ± 0.042	2.918SerGln: 2.918 ± 0.049	2.749SerArg: 2.749 ± 0.05	5.007SerSer: 5.007 ± 0.072	3.756SerThr: 3.756 ± 0.053	4.893SerVal: 4.893 ± 0.068	0.74SerTrp: 0.74 ± 0.027	2.057SerTyr: 2.057 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.449ThrAla: 4.449 ± 0.072	0.493ThrCys: 0.493 ± 0.022	3.027ThrAsp: 3.027 ± 0.054	3.263ThrGlu: 3.263 ± 0.052	2.306ThrPhe: 2.306 ± 0.044	3.925ThrGly: 3.925 ± 0.066	1.135ThrHis: 1.135 ± 0.031	3.615ThrIle: 3.615 ± 0.057	2.74ThrLys: 2.74 ± 0.05	5.995ThrLeu: 5.995 ± 0.076	1.211ThrMet: 1.211 ± 0.031	2.343ThrAsn: 2.343 ± 0.049	2.459ThrPro: 2.459 ± 0.054	2.45ThrGln: 2.45 ± 0.044	2.097ThrArg: 2.097 ± 0.043	3.723ThrSer: 3.723 ± 0.061	2.944ThrThr: 2.944 ± 0.064	3.671ThrVal: 3.671 ± 0.062	0.593ThrTrp: 0.593 ± 0.022	1.512ThrTyr: 1.512 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	5.976ValAla: 5.976 ± 0.077	0.722ValCys: 0.722 ± 0.026	4.406ValAsp: 4.406 ± 0.062	4.318ValGlu: 4.318 ± 0.073	3.016ValPhe: 3.016 ± 0.058	4.309ValGly: 4.309 ± 0.057	1.267ValHis: 1.267 ± 0.033	4.902ValIle: 4.902 ± 0.061	3.785ValLys: 3.785 ± 0.056	6.666ValLeu: 6.666 ± 0.08	1.767ValMet: 1.767 ± 0.037	3.469ValAsn: 3.469 ± 0.056	2.552ValPro: 2.552 ± 0.047	2.228ValGln: 2.228 ± 0.044	2.661ValArg: 2.661 ± 0.05	5.226ValSer: 5.226 ± 0.07	3.935ValThr: 3.935 ± 0.066	5.112ValVal: 5.112 ± 0.072	0.695ValTrp: 0.695 ± 0.023	1.844ValTyr: 1.844 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.722TrpAla: 0.722 ± 0.027	0.128TrpCys: 0.128 ± 0.009	0.552TrpAsp: 0.552 ± 0.022	0.537TrpGlu: 0.537 ± 0.022	0.595TrpPhe: 0.595 ± 0.022	0.656TrpGly: 0.656 ± 0.025	0.312TrpHis: 0.312 ± 0.015	0.662TrpIle: 0.662 ± 0.027	0.483TrpLys: 0.483 ± 0.023	1.499TrpLeu: 1.499 ± 0.04	0.301TrpMet: 0.301 ± 0.018	0.416TrpAsn: 0.416 ± 0.022	0.404TrpPro: 0.404 ± 0.018	0.82TrpGln: 0.82 ± 0.03	0.61TrpArg: 0.61 ± 0.021	0.687TrpSer: 0.687 ± 0.026	0.529TrpThr: 0.529 ± 0.022	0.778TrpVal: 0.778 ± 0.022	0.169TrpTrp: 0.169 ± 0.012	0.348TrpTyr: 0.348 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.454TyrAla: 2.454 ± 0.047	0.343TyrCys: 0.343 ± 0.017	1.645TyrAsp: 1.645 ± 0.043	1.689TyrGlu: 1.689 ± 0.041	1.576TyrPhe: 1.576 ± 0.037	1.95TyrGly: 1.95 ± 0.04	0.66TyrHis: 0.66 ± 0.022	1.698TyrIle: 1.698 ± 0.039	1.511TyrLys: 1.511 ± 0.039	3.177TyrLeu: 3.177 ± 0.056	0.621TyrMet: 0.621 ± 0.025	1.177TyrAsn: 1.177 ± 0.035	1.209TyrPro: 1.209 ± 0.029	1.625TyrGln: 1.625 ± 0.035	1.52TyrArg: 1.52 ± 0.039	2.132TyrSer: 2.132 ± 0.045	1.391TyrThr: 1.391 ± 0.037	1.883TyrVal: 1.883 ± 0.04	0.439TyrTrp: 0.439 ± 0.018	0.997TyrTyr: 0.997 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3653 proteins (1214097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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