Amino acid dipepetide frequency for Bacteroides uniformis CAG:3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.295AlaAla: 6.295 ± 0.097	1.107AlaCys: 1.107 ± 0.031	4.477AlaAsp: 4.477 ± 0.074	4.944AlaGlu: 4.944 ± 0.08	3.326AlaPhe: 3.326 ± 0.046	5.417AlaGly: 5.417 ± 0.083	1.257AlaHis: 1.257 ± 0.03	4.656AlaIle: 4.656 ± 0.067	4.022AlaLys: 4.022 ± 0.065	6.99AlaLeu: 6.99 ± 0.079	2.002AlaMet: 2.002 ± 0.044	3.146AlaAsn: 3.146 ± 0.064	2.502AlaPro: 2.502 ± 0.049	2.751AlaGln: 2.751 ± 0.053	3.378AlaArg: 3.378 ± 0.051	4.397AlaSer: 4.397 ± 0.068	4.059AlaThr: 4.059 ± 0.063	5.138AlaVal: 5.138 ± 0.081	0.882AlaTrp: 0.882 ± 0.028	3.035AlaTyr: 3.035 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	0.798CysAla: 0.798 ± 0.027	0.249CysCys: 0.249 ± 0.015	0.624CysAsp: 0.624 ± 0.021	0.676CysGlu: 0.676 ± 0.022	0.673CysPhe: 0.673 ± 0.021	1.107CysGly: 1.107 ± 0.036	0.32CysHis: 0.32 ± 0.018	0.983CysIle: 0.983 ± 0.032	0.664CysLys: 0.664 ± 0.027	1.186CysLeu: 1.186 ± 0.033	0.359CysMet: 0.359 ± 0.017	0.589CysAsn: 0.589 ± 0.02	0.574CysPro: 0.574 ± 0.023	0.369CysGln: 0.369 ± 0.017	0.727CysArg: 0.727 ± 0.024	0.817CysSer: 0.817 ± 0.026	0.755CysThr: 0.755 ± 0.026	0.701CysVal: 0.701 ± 0.026	0.166CysTrp: 0.166 ± 0.012	0.561CysTyr: 0.561 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.102AspAla: 4.102 ± 0.056	0.621AspCys: 0.621 ± 0.023	2.609AspAsp: 2.609 ± 0.055	3.88AspGlu: 3.88 ± 0.06	3.0AspPhe: 3.0 ± 0.049	4.264AspGly: 4.264 ± 0.071	0.808AspHis: 0.808 ± 0.024	4.059AspIle: 4.059 ± 0.052	3.889AspLys: 3.889 ± 0.06	4.398AspLeu: 4.398 ± 0.057	1.707AspMet: 1.707 ± 0.039	2.743AspAsn: 2.743 ± 0.048	1.705AspPro: 1.705 ± 0.041	1.137AspGln: 1.137 ± 0.033	2.481AspArg: 2.481 ± 0.042	3.071AspSer: 3.071 ± 0.05	2.838AspThr: 2.838 ± 0.046	3.591AspVal: 3.591 ± 0.055	0.905AspTrp: 0.905 ± 0.027	2.891AspTyr: 2.891 ± 0.047	0.001AspXaa: 0.001 ± 0.001
Glu	5.148GluAla: 5.148 ± 0.074	0.637GluCys: 0.637 ± 0.024	3.309GluAsp: 3.309 ± 0.058	5.242GluGlu: 5.242 ± 0.087	2.522GluPhe: 2.522 ± 0.044	4.246GluGly: 4.246 ± 0.058	1.314GluHis: 1.314 ± 0.033	4.286GluIle: 4.286 ± 0.068	5.06GluLys: 5.06 ± 0.074	6.218GluLeu: 6.218 ± 0.079	2.082GluMet: 2.082 ± 0.043	3.397GluAsn: 3.397 ± 0.053	1.815GluPro: 1.815 ± 0.041	2.676GluGln: 2.676 ± 0.05	3.39GluArg: 3.39 ± 0.062	3.01GluSer: 3.01 ± 0.052	3.321GluThr: 3.321 ± 0.055	4.417GluVal: 4.417 ± 0.053	0.835GluTrp: 0.835 ± 0.028	2.853GluTyr: 2.853 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.157PheAla: 3.157 ± 0.05	0.728PheCys: 0.728 ± 0.023	2.682PheAsp: 2.682 ± 0.047	2.437PheGlu: 2.437 ± 0.046	2.278PhePhe: 2.278 ± 0.052	3.324PheGly: 3.324 ± 0.054	0.964PheHis: 0.964 ± 0.026	3.101PheIle: 3.101 ± 0.056	2.295PheLys: 2.295 ± 0.04	4.155PheLeu: 4.155 ± 0.065	1.268PheMet: 1.268 ± 0.034	2.272PheAsn: 2.272 ± 0.045	1.796PhePro: 1.796 ± 0.039	1.311PheGln: 1.311 ± 0.031	2.274PheArg: 2.274 ± 0.044	3.344PheSer: 3.344 ± 0.049	2.802PheThr: 2.802 ± 0.052	2.939PheVal: 2.939 ± 0.049	0.58PheTrp: 0.58 ± 0.025	1.97PheTyr: 1.97 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.602GlyAla: 4.602 ± 0.074	0.983GlyCys: 0.983 ± 0.031	3.644GlyAsp: 3.644 ± 0.062	4.382GlyGlu: 4.382 ± 0.064	3.181GlyPhe: 3.181 ± 0.048	4.928GlyGly: 4.928 ± 0.082	1.338GlyHis: 1.338 ± 0.032	5.466GlyIle: 5.466 ± 0.076	5.384GlyLys: 5.384 ± 0.068	5.808GlyLeu: 5.808 ± 0.079	2.305GlyMet: 2.305 ± 0.047	3.625GlyAsn: 3.625 ± 0.065	1.299GlyPro: 1.299 ± 0.037	2.088GlyGln: 2.088 ± 0.042	3.07GlyArg: 3.07 ± 0.052	4.066GlySer: 4.066 ± 0.057	4.339GlyThr: 4.339 ± 0.064	4.851GlyVal: 4.851 ± 0.075	1.085GlyTrp: 1.085 ± 0.031	3.521GlyTyr: 3.521 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.301HisAla: 1.301 ± 0.037	0.321HisCys: 0.321 ± 0.016	0.993HisAsp: 0.993 ± 0.028	1.087HisGlu: 1.087 ± 0.03	1.045HisPhe: 1.045 ± 0.033	1.302HisGly: 1.302 ± 0.032	0.49HisHis: 0.49 ± 0.021	1.45HisIle: 1.45 ± 0.036	0.946HisLys: 0.946 ± 0.03	1.899HisLeu: 1.899 ± 0.045	0.386HisMet: 0.386 ± 0.017	0.933HisAsn: 0.933 ± 0.025	1.181HisPro: 1.181 ± 0.033	0.636HisGln: 0.636 ± 0.023	0.964HisArg: 0.964 ± 0.029	1.135HisSer: 1.135 ± 0.032	1.146HisThr: 1.146 ± 0.028	1.131HisVal: 1.131 ± 0.031	0.272HisTrp: 0.272 ± 0.015	0.942HisTyr: 0.942 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.167IleAla: 5.167 ± 0.072	0.968IleCys: 0.968 ± 0.029	4.03IleAsp: 4.03 ± 0.052	4.203IleGlu: 4.203 ± 0.055	2.732IlePhe: 2.732 ± 0.05	4.836IleGly: 4.836 ± 0.066	1.397IleHis: 1.397 ± 0.041	4.245IleIle: 4.245 ± 0.081	3.729IleLys: 3.729 ± 0.059	5.891IleLeu: 5.891 ± 0.083	1.432IleMet: 1.432 ± 0.033	3.17IleAsn: 3.17 ± 0.053	3.128IlePro: 3.128 ± 0.049	1.985IleGln: 1.985 ± 0.041	3.419IleArg: 3.419 ± 0.06	4.407IleSer: 4.407 ± 0.065	3.897IleThr: 3.897 ± 0.066	4.295IleVal: 4.295 ± 0.063	0.726IleTrp: 0.726 ± 0.024	2.73IleTyr: 2.73 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.918LysAla: 4.918 ± 0.086	0.529LysCys: 0.529 ± 0.021	3.84LysAsp: 3.84 ± 0.057	5.636LysGlu: 5.636 ± 0.065	2.081LysPhe: 2.081 ± 0.045	4.377LysGly: 4.377 ± 0.061	1.192LysHis: 1.192 ± 0.031	3.743LysIle: 3.743 ± 0.051	4.656LysLys: 4.656 ± 0.066	5.147LysLeu: 5.147 ± 0.071	1.935LysMet: 1.935 ± 0.037	3.348LysAsn: 3.348 ± 0.068	2.161LysPro: 2.161 ± 0.048	2.481LysGln: 2.481 ± 0.049	3.119LysArg: 3.119 ± 0.055	3.172LysSer: 3.172 ± 0.056	3.368LysThr: 3.368 ± 0.052	4.248LysVal: 4.248 ± 0.069	0.775LysTrp: 0.775 ± 0.028	2.895LysTyr: 2.895 ± 0.045	0.001LysXaa: 0.001 ± 0.001
Leu	6.668LeuAla: 6.668 ± 0.08	1.489LeuCys: 1.489 ± 0.036	4.626LeuAsp: 4.626 ± 0.062	5.089LeuGlu: 5.089 ± 0.068	4.431LeuPhe: 4.431 ± 0.07	5.817LeuGly: 5.817 ± 0.089	1.96LeuHis: 1.96 ± 0.044	5.247LeuIle: 5.247 ± 0.093	6.275LeuLys: 6.275 ± 0.084	9.233LeuLeu: 9.233 ± 0.128	2.618LeuMet: 2.618 ± 0.046	4.581LeuAsn: 4.581 ± 0.062	4.292LeuPro: 4.292 ± 0.066	3.533LeuGln: 3.533 ± 0.048	4.287LeuArg: 4.287 ± 0.066	6.328LeuSer: 6.328 ± 0.078	5.17LeuThr: 5.17 ± 0.058	5.425LeuVal: 5.425 ± 0.073	1.081LeuTrp: 1.081 ± 0.029	3.697LeuTyr: 3.697 ± 0.056	0.001LeuXaa: 0.001 ± 0.001
Met	2.118MetAla: 2.118 ± 0.041	0.264MetCys: 0.264 ± 0.014	1.549MetAsp: 1.549 ± 0.034	1.934MetGlu: 1.934 ± 0.044	1.063MetPhe: 1.063 ± 0.034	1.937MetGly: 1.937 ± 0.041	0.481MetHis: 0.481 ± 0.02	1.555MetIle: 1.555 ± 0.039	2.554MetLys: 2.554 ± 0.047	2.617MetLeu: 2.617 ± 0.046	0.874MetMet: 0.874 ± 0.03	1.595MetAsn: 1.595 ± 0.034	1.2MetPro: 1.2 ± 0.032	1.116MetGln: 1.116 ± 0.029	1.346MetArg: 1.346 ± 0.034	1.603MetSer: 1.603 ± 0.039	1.488MetThr: 1.488 ± 0.035	1.689MetVal: 1.689 ± 0.037	0.256MetTrp: 0.256 ± 0.016	0.861MetTyr: 0.861 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.602AsnAla: 3.602 ± 0.055	0.518AsnCys: 0.518 ± 0.024	2.471AsnAsp: 2.471 ± 0.042	2.99AsnGlu: 2.99 ± 0.062	2.198AsnPhe: 2.198 ± 0.048	3.778AsnGly: 3.778 ± 0.062	0.936AsnHis: 0.936 ± 0.026	3.596AsnIle: 3.596 ± 0.054	3.017AsnLys: 3.017 ± 0.054	4.357AsnLeu: 4.357 ± 0.062	1.304AsnMet: 1.304 ± 0.034	2.5AsnAsn: 2.5 ± 0.056	2.508AsnPro: 2.508 ± 0.047	1.5AsnGln: 1.5 ± 0.036	2.418AsnArg: 2.418 ± 0.049	2.793AsnSer: 2.793 ± 0.052	2.669AsnThr: 2.669 ± 0.05	3.074AsnVal: 3.074 ± 0.061	0.655AsnTrp: 0.655 ± 0.024	2.412AsnTyr: 2.412 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.98ProAla: 2.98 ± 0.059	0.397ProCys: 0.397 ± 0.02	2.622ProAsp: 2.622 ± 0.051	3.277ProGlu: 3.277 ± 0.05	1.942ProPhe: 1.942 ± 0.04	2.581ProGly: 2.581 ± 0.045	0.781ProHis: 0.781 ± 0.027	2.32ProIle: 2.32 ± 0.038	1.952ProLys: 1.952 ± 0.041	3.438ProLeu: 3.438 ± 0.05	1.028ProMet: 1.028 ± 0.028	1.648ProAsn: 1.648 ± 0.035	0.808ProPro: 0.808 ± 0.031	1.521ProGln: 1.521 ± 0.036	1.404ProArg: 1.404 ± 0.033	2.154ProSer: 2.154 ± 0.04	1.979ProThr: 1.979 ± 0.039	2.883ProVal: 2.883 ± 0.049	0.458ProTrp: 0.458 ± 0.02	1.78ProTyr: 1.78 ± 0.041	0.001ProXaa: 0.001 ± 0.001
Gln	2.605GlnAla: 2.605 ± 0.051	0.314GlnCys: 0.314 ± 0.016	1.564GlnAsp: 1.564 ± 0.038	2.459GlnGlu: 2.459 ± 0.049	1.314GlnPhe: 1.314 ± 0.031	2.115GlnGly: 2.115 ± 0.045	0.689GlnHis: 0.689 ± 0.024	2.271GlnIle: 2.271 ± 0.043	2.347GlnLys: 2.347 ± 0.043	3.367GlnLeu: 3.367 ± 0.059	1.064GlnMet: 1.064 ± 0.03	1.657GlnAsn: 1.657 ± 0.043	1.302GlnPro: 1.302 ± 0.033	1.576GlnGln: 1.576 ± 0.041	1.755GlnArg: 1.755 ± 0.038	1.942GlnSer: 1.942 ± 0.042	2.072GlnThr: 2.072 ± 0.044	2.201GlnVal: 2.201 ± 0.04	0.462GlnTrp: 0.462 ± 0.019	1.446GlnTyr: 1.446 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.006ArgAla: 3.006 ± 0.05	0.53ArgCys: 0.53 ± 0.022	2.185ArgAsp: 2.185 ± 0.036	3.205ArgGlu: 3.205 ± 0.064	2.323ArgPhe: 2.323 ± 0.039	2.539ArgGly: 2.539 ± 0.047	1.035ArgHis: 1.035 ± 0.032	3.779ArgIle: 3.779 ± 0.058	3.405ArgLys: 3.405 ± 0.056	4.727ArgLeu: 4.727 ± 0.059	1.607ArgMet: 1.607 ± 0.036	2.495ArgAsn: 2.495 ± 0.048	1.726ArgPro: 1.726 ± 0.046	1.926ArgGln: 1.926 ± 0.043	2.469ArgArg: 2.469 ± 0.043	2.447ArgSer: 2.447 ± 0.044	2.573ArgThr: 2.573 ± 0.048	2.674ArgVal: 2.674 ± 0.054	0.687ArgTrp: 0.687 ± 0.022	2.226ArgTyr: 2.226 ± 0.039	0.002ArgXaa: 0.002 ± 0.001
Ser	4.312SerAla: 4.312 ± 0.062	0.812SerCys: 0.812 ± 0.024	3.14SerAsp: 3.14 ± 0.049	3.332SerGlu: 3.332 ± 0.051	3.211SerPhe: 3.211 ± 0.055	4.582SerGly: 4.582 ± 0.073	1.199SerHis: 1.199 ± 0.03	4.259SerIle: 4.259 ± 0.065	3.099SerLys: 3.099 ± 0.057	5.903SerLeu: 5.903 ± 0.072	1.547SerMet: 1.547 ± 0.036	2.705SerAsn: 2.705 ± 0.049	2.249SerPro: 2.249 ± 0.046	1.845SerGln: 1.845 ± 0.042	2.672SerArg: 2.672 ± 0.051	3.87SerSer: 3.87 ± 0.068	3.189SerThr: 3.189 ± 0.044	4.188SerVal: 4.188 ± 0.061	0.836SerTrp: 0.836 ± 0.025	2.767SerTyr: 2.767 ± 0.058	0.001SerXaa: 0.001 ± 0.001
Thr	4.29ThrAla: 4.29 ± 0.063	0.614ThrCys: 0.614 ± 0.022	3.5ThrAsp: 3.5 ± 0.059	3.484ThrGlu: 3.484 ± 0.052	2.735ThrPhe: 2.735 ± 0.047	4.419ThrGly: 4.419 ± 0.062	1.041ThrHis: 1.041 ± 0.029	3.492ThrIle: 3.492 ± 0.052	2.652ThrLys: 2.652 ± 0.051	5.488ThrLeu: 5.488 ± 0.076	1.245ThrMet: 1.245 ± 0.032	2.412ThrAsn: 2.412 ± 0.046	2.853ThrPro: 2.853 ± 0.045	1.803ThrGln: 1.803 ± 0.036	2.295ThrArg: 2.295 ± 0.05	3.299ThrSer: 3.299 ± 0.049	3.023ThrThr: 3.023 ± 0.054	4.082ThrVal: 4.082 ± 0.072	0.698ThrTrp: 0.698 ± 0.026	2.489ThrTyr: 2.489 ± 0.053	0.001ThrXaa: 0.001 ± 0.001
Val	4.843ValAla: 4.843 ± 0.071	1.071ValCys: 1.071 ± 0.03	3.583ValAsp: 3.583 ± 0.05	4.172ValGlu: 4.172 ± 0.062	2.895ValPhe: 2.895 ± 0.055	4.212ValGly: 4.212 ± 0.071	1.144ValHis: 1.144 ± 0.035	4.295ValIle: 4.295 ± 0.063	4.08ValLys: 4.08 ± 0.062	5.948ValLeu: 5.948 ± 0.069	1.732ValMet: 1.732 ± 0.041	3.211ValAsn: 3.211 ± 0.054	2.593ValPro: 2.593 ± 0.048	2.108ValGln: 2.108 ± 0.044	3.082ValArg: 3.082 ± 0.052	4.477ValSer: 4.477 ± 0.073	3.816ValThr: 3.816 ± 0.061	4.558ValVal: 4.558 ± 0.071	0.743ValTrp: 0.743 ± 0.024	2.713ValTyr: 2.713 ± 0.055	0.001ValXaa: 0.001 ± 0.001
Trp	0.793TrpAla: 0.793 ± 0.024	0.166TrpCys: 0.166 ± 0.011	0.763TrpAsp: 0.763 ± 0.028	0.857TrpGlu: 0.857 ± 0.025	0.578TrpPhe: 0.578 ± 0.023	1.063TrpGly: 1.063 ± 0.035	0.287TrpHis: 0.287 ± 0.014	0.789TrpIle: 0.789 ± 0.026	0.93TrpLys: 0.93 ± 0.028	1.167TrpLeu: 1.167 ± 0.031	0.452TrpMet: 0.452 ± 0.021	0.825TrpAsn: 0.825 ± 0.03	0.283TrpPro: 0.283 ± 0.016	0.543TrpGln: 0.543 ± 0.02	0.591TrpArg: 0.591 ± 0.025	0.688TrpSer: 0.688 ± 0.027	0.706TrpThr: 0.706 ± 0.022	0.702TrpVal: 0.702 ± 0.025	0.229TrpTrp: 0.229 ± 0.014	0.542TrpTyr: 0.542 ± 0.021	0.001TrpXaa: 0.001 ± 0.001
Tyr	3.076TyrAla: 3.076 ± 0.055	0.58TyrCys: 0.58 ± 0.024	2.487TyrAsp: 2.487 ± 0.051	2.492TyrGlu: 2.492 ± 0.047	2.149TyrPhe: 2.149 ± 0.046	3.123TyrGly: 3.123 ± 0.053	0.928TyrHis: 0.928 ± 0.028	2.796TyrIle: 2.796 ± 0.053	2.666TyrLys: 2.666 ± 0.049	3.912TyrLeu: 3.912 ± 0.06	1.148TyrMet: 1.148 ± 0.03	2.441TyrAsn: 2.441 ± 0.048	1.975TyrPro: 1.975 ± 0.039	1.613TyrGln: 1.613 ± 0.039	2.426TyrArg: 2.426 ± 0.049	2.698TyrSer: 2.698 ± 0.049	2.702TyrThr: 2.702 ± 0.047	2.491TyrVal: 2.491 ± 0.053	0.626TyrTrp: 0.626 ± 0.025	2.123TyrTyr: 2.123 ± 0.044	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.002XaaAsn: 0.002 ± 0.001	0.003XaaPro: 0.003 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.021XaaXaa: 0.021 ± 0.006

Statistics based on 3570 proteins (1263016 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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