Amino acid dipepetide frequency for Frankia symbiont of Alnus alnobetula

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.317AlaAla: 24.317 ± 0.287	1.108AlaCys: 1.108 ± 0.034	9.316AlaAsp: 9.316 ± 0.1	8.227AlaGlu: 8.227 ± 0.103	3.401AlaPhe: 3.401 ± 0.064	15.6AlaGly: 15.6 ± 0.149	2.698AlaHis: 2.698 ± 0.05	4.257AlaIle: 4.257 ± 0.059	2.142AlaLys: 2.142 ± 0.058	13.878AlaLeu: 13.878 ± 0.126	2.498AlaMet: 2.498 ± 0.049	1.963AlaAsn: 1.963 ± 0.048	7.321AlaPro: 7.321 ± 0.106	3.74AlaGln: 3.74 ± 0.066	11.595AlaArg: 11.595 ± 0.115	6.381AlaSer: 6.381 ± 0.085	7.693AlaThr: 7.693 ± 0.091	12.636AlaVal: 12.636 ± 0.141	1.748AlaTrp: 1.748 ± 0.039	2.318AlaTyr: 2.318 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.079CysAla: 1.079 ± 0.033	0.144CysCys: 0.144 ± 0.013	0.466CysAsp: 0.466 ± 0.018	0.356CysGlu: 0.356 ± 0.018	0.218CysPhe: 0.218 ± 0.015	1.006CysGly: 1.006 ± 0.033	0.208CysHis: 0.208 ± 0.016	0.201CysIle: 0.201 ± 0.015	0.088CysLys: 0.088 ± 0.008	0.778CysLeu: 0.778 ± 0.029	0.094CysMet: 0.094 ± 0.009	0.121CysAsn: 0.121 ± 0.01	0.572CysPro: 0.572 ± 0.024	0.179CysGln: 0.179 ± 0.013	0.647CysArg: 0.647 ± 0.027	0.455CysSer: 0.455 ± 0.021	0.45CysThr: 0.45 ± 0.02	0.613CysVal: 0.613 ± 0.025	0.127CysTrp: 0.127 ± 0.011	0.167CysTyr: 0.167 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.248AspAla: 8.248 ± 0.097	0.427AspCys: 0.427 ± 0.018	3.978AspAsp: 3.978 ± 0.067	3.657AspGlu: 3.657 ± 0.069	1.384AspPhe: 1.384 ± 0.039	6.265AspGly: 6.265 ± 0.092	1.469AspHis: 1.469 ± 0.036	1.925AspIle: 1.925 ± 0.048	0.843AspLys: 0.843 ± 0.031	7.025AspLeu: 7.025 ± 0.091	0.706AspMet: 0.706 ± 0.025	0.861AspAsn: 0.861 ± 0.031	4.899AspPro: 4.899 ± 0.082	1.601AspGln: 1.601 ± 0.036	5.329AspArg: 5.329 ± 0.077	2.546AspSer: 2.546 ± 0.046	2.97AspThr: 2.97 ± 0.052	5.213AspVal: 5.213 ± 0.071	0.86AspTrp: 0.86 ± 0.031	1.089AspTyr: 1.089 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.078GluAla: 6.078 ± 0.077	0.293GluCys: 0.293 ± 0.018	2.244GluAsp: 2.244 ± 0.053	2.389GluGlu: 2.389 ± 0.05	1.367GluPhe: 1.367 ± 0.036	3.358GluGly: 3.358 ± 0.06	1.354GluHis: 1.354 ± 0.033	2.609GluIle: 2.609 ± 0.051	0.927GluLys: 0.927 ± 0.033	6.396GluLeu: 6.396 ± 0.088	0.825GluMet: 0.825 ± 0.029	0.802GluAsn: 0.802 ± 0.03	3.09GluPro: 3.09 ± 0.063	2.064GluGln: 2.064 ± 0.041	4.982GluArg: 4.982 ± 0.072	2.348GluSer: 2.348 ± 0.046	2.558GluThr: 2.558 ± 0.051	4.481GluVal: 4.481 ± 0.076	0.614GluTrp: 0.614 ± 0.022	0.912GluTyr: 0.912 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.776PheAla: 3.776 ± 0.07	0.269PheCys: 0.269 ± 0.018	2.038PheAsp: 2.038 ± 0.049	1.208PheGlu: 1.208 ± 0.037	0.779PhePhe: 0.779 ± 0.028	3.042PheGly: 3.042 ± 0.053	0.543PheHis: 0.543 ± 0.023	0.723PheIle: 0.723 ± 0.025	0.348PheLys: 0.348 ± 0.019	2.393PheLeu: 2.393 ± 0.049	0.326PheMet: 0.326 ± 0.021	0.486PheAsn: 0.486 ± 0.021	1.333PhePro: 1.333 ± 0.033	0.612PheGln: 0.612 ± 0.019	1.744PheArg: 1.744 ± 0.041	1.285PheSer: 1.285 ± 0.037	1.752PheThr: 1.752 ± 0.043	2.312PheVal: 2.312 ± 0.048	0.364PheTrp: 0.364 ± 0.02	0.547PheTyr: 0.547 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.489GlyAla: 11.489 ± 0.111	0.874GlyCys: 0.874 ± 0.032	5.219GlyAsp: 5.219 ± 0.075	4.678GlyGlu: 4.678 ± 0.073	2.731GlyPhe: 2.731 ± 0.048	9.534GlyGly: 9.534 ± 0.127	2.226GlyHis: 2.226 ± 0.05	3.628GlyIle: 3.628 ± 0.062	1.771GlyLys: 1.771 ± 0.046	9.865GlyLeu: 9.865 ± 0.099	1.867GlyMet: 1.867 ± 0.043	1.483GlyAsn: 1.483 ± 0.041	5.993GlyPro: 5.993 ± 0.087	2.878GlyGln: 2.878 ± 0.053	8.969GlyArg: 8.969 ± 0.094	5.578GlySer: 5.578 ± 0.078	5.724GlyThr: 5.724 ± 0.064	8.001GlyVal: 8.001 ± 0.094	1.766GlyTrp: 1.766 ± 0.046	2.179GlyTyr: 2.179 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.602HisAla: 2.602 ± 0.052	0.185HisCys: 0.185 ± 0.013	1.351HisAsp: 1.351 ± 0.041	0.956HisGlu: 0.956 ± 0.032	0.548HisPhe: 0.548 ± 0.023	2.229HisGly: 2.229 ± 0.053	0.64HisHis: 0.64 ± 0.028	0.617HisIle: 0.617 ± 0.025	0.218HisLys: 0.218 ± 0.012	2.464HisLeu: 2.464 ± 0.048	0.254HisMet: 0.254 ± 0.014	0.357HisAsn: 0.357 ± 0.02	1.944HisPro: 1.944 ± 0.046	0.648HisGln: 0.648 ± 0.026	2.177HisArg: 2.177 ± 0.05	1.005HisSer: 1.005 ± 0.031	1.158HisThr: 1.158 ± 0.033	1.676HisVal: 1.676 ± 0.043	0.308HisTrp: 0.308 ± 0.018	0.415HisTyr: 0.415 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.221IleAla: 5.221 ± 0.083	0.314IleCys: 0.314 ± 0.017	2.553IleAsp: 2.553 ± 0.052	2.024IleGlu: 2.024 ± 0.047	0.875IlePhe: 0.875 ± 0.03	3.786IleGly: 3.786 ± 0.06	0.704IleHis: 0.704 ± 0.025	1.279IleIle: 1.279 ± 0.04	0.618IleLys: 0.618 ± 0.026	2.844IleLeu: 2.844 ± 0.057	0.488IleMet: 0.488 ± 0.021	0.745IleAsn: 0.745 ± 0.026	2.011IlePro: 2.011 ± 0.042	0.693IleGln: 0.693 ± 0.024	2.734IleArg: 2.734 ± 0.044	1.94IleSer: 1.94 ± 0.045	2.339IleThr: 2.339 ± 0.047	3.397IleVal: 3.397 ± 0.065	0.336IleTrp: 0.336 ± 0.017	0.649IleTyr: 0.649 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	1.984LysAla: 1.984 ± 0.05	0.07LysCys: 0.07 ± 0.008	0.76LysAsp: 0.76 ± 0.031	0.673LysGlu: 0.673 ± 0.031	0.307LysPhe: 0.307 ± 0.016	1.245LysGly: 1.245 ± 0.039	0.311LysHis: 0.311 ± 0.016	0.862LysIle: 0.862 ± 0.033	0.474LysLys: 0.474 ± 0.025	1.482LysLeu: 1.482 ± 0.037	0.289LysMet: 0.289 ± 0.016	0.371LysAsn: 0.371 ± 0.023	0.905LysPro: 0.905 ± 0.033	0.522LysGln: 0.522 ± 0.024	1.088LysArg: 1.088 ± 0.035	0.842LysSer: 0.842 ± 0.036	0.954LysThr: 0.954 ± 0.03	1.504LysVal: 1.504 ± 0.043	0.173LysTrp: 0.173 ± 0.012	0.295LysTyr: 0.295 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	16.839LeuAla: 16.839 ± 0.16	0.824LeuCys: 0.824 ± 0.031	7.024LeuAsp: 7.024 ± 0.083	4.076LeuGlu: 4.076 ± 0.072	2.481LeuPhe: 2.481 ± 0.05	9.334LeuGly: 9.334 ± 0.096	2.145LeuHis: 2.145 ± 0.052	3.418LeuIle: 3.418 ± 0.06	1.2LeuLys: 1.2 ± 0.038	11.013LeuLeu: 11.013 ± 0.126	1.314LeuMet: 1.314 ± 0.036	1.414LeuAsn: 1.414 ± 0.04	6.361LeuPro: 6.361 ± 0.085	1.863LeuGln: 1.863 ± 0.036	9.386LeuArg: 9.386 ± 0.094	5.067LeuSer: 5.067 ± 0.071	6.606LeuThr: 6.606 ± 0.085	9.35LeuVal: 9.35 ± 0.087	1.164LeuTrp: 1.164 ± 0.037	1.654LeuTyr: 1.654 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.128MetAla: 2.128 ± 0.046	0.139MetCys: 0.139 ± 0.012	0.792MetAsp: 0.792 ± 0.025	0.605MetGlu: 0.605 ± 0.024	0.477MetPhe: 0.477 ± 0.022	1.109MetGly: 1.109 ± 0.037	0.313MetHis: 0.313 ± 0.018	0.793MetIle: 0.793 ± 0.028	0.281MetLys: 0.281 ± 0.014	1.64MetLeu: 1.64 ± 0.043	0.271MetMet: 0.271 ± 0.017	0.335MetAsn: 0.335 ± 0.017	1.099MetPro: 1.099 ± 0.034	0.353MetGln: 0.353 ± 0.018	1.419MetArg: 1.419 ± 0.036	1.28MetSer: 1.28 ± 0.037	1.472MetThr: 1.472 ± 0.039	1.26MetVal: 1.26 ± 0.032	0.155MetTrp: 0.155 ± 0.013	0.242MetTyr: 0.242 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	1.957AsnAla: 1.957 ± 0.045	0.12AsnCys: 0.12 ± 0.012	0.872AsnAsp: 0.872 ± 0.03	0.677AsnGlu: 0.677 ± 0.027	0.374AsnPhe: 0.374 ± 0.019	1.556AsnGly: 1.556 ± 0.041	0.346AsnHis: 0.346 ± 0.019	0.645AsnIle: 0.645 ± 0.029	0.282AsnLys: 0.282 ± 0.018	1.771AsnLeu: 1.771 ± 0.049	0.253AsnMet: 0.253 ± 0.015	0.358AsnAsn: 0.358 ± 0.018	1.34AsnPro: 1.34 ± 0.036	0.478AsnGln: 0.478 ± 0.021	1.338AsnArg: 1.338 ± 0.037	0.796AsnSer: 0.796 ± 0.028	0.952AsnThr: 0.952 ± 0.034	1.301AsnVal: 1.301 ± 0.036	0.22AsnTrp: 0.22 ± 0.016	0.366AsnTyr: 0.366 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	10.546ProAla: 10.546 ± 0.12	0.367ProCys: 0.367 ± 0.02	4.742ProAsp: 4.742 ± 0.071	3.339ProGlu: 3.339 ± 0.06	1.559ProPhe: 1.559 ± 0.035	7.194ProGly: 7.194 ± 0.092	1.246ProHis: 1.246 ± 0.034	1.783ProIle: 1.783 ± 0.039	0.854ProLys: 0.854 ± 0.026	5.07ProLeu: 5.07 ± 0.084	1.01ProMet: 1.01 ± 0.031	0.943ProAsn: 0.943 ± 0.029	4.622ProPro: 4.622 ± 0.1	1.533ProGln: 1.533 ± 0.037	4.54ProArg: 4.54 ± 0.072	3.481ProSer: 3.481 ± 0.052	3.943ProThr: 3.943 ± 0.069	5.578ProVal: 5.578 ± 0.077	0.898ProTrp: 0.898 ± 0.031	1.079ProTyr: 1.079 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.855GlnAla: 3.855 ± 0.058	0.169GlnCys: 0.169 ± 0.012	1.075GlnAsp: 1.075 ± 0.034	1.174GlnGlu: 1.174 ± 0.033	0.617GlnPhe: 0.617 ± 0.025	1.866GlnGly: 1.866 ± 0.047	0.595GlnHis: 0.595 ± 0.022	1.245GlnIle: 1.245 ± 0.038	0.437GlnLys: 0.437 ± 0.023	2.755GlnLeu: 2.755 ± 0.043	0.447GlnMet: 0.447 ± 0.023	0.454GlnAsn: 0.454 ± 0.02	1.851GlnPro: 1.851 ± 0.046	0.939GlnGln: 0.939 ± 0.035	2.357GlnArg: 2.357 ± 0.051	1.155GlnSer: 1.155 ± 0.029	1.405GlnThr: 1.405 ± 0.037	2.578GlnVal: 2.578 ± 0.049	0.43GlnTrp: 0.43 ± 0.021	0.506GlnTyr: 0.506 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	11.136ArgAla: 11.136 ± 0.12	0.722ArgCys: 0.722 ± 0.029	4.671ArgAsp: 4.671 ± 0.067	4.382ArgGlu: 4.382 ± 0.059	2.395ArgPhe: 2.395 ± 0.05	6.753ArgGly: 6.753 ± 0.086	2.207ArgHis: 2.207 ± 0.053	3.493ArgIle: 3.493 ± 0.055	1.175ArgLys: 1.175 ± 0.036	9.547ArgLeu: 9.547 ± 0.109	1.815ArgMet: 1.815 ± 0.041	1.317ArgAsn: 1.317 ± 0.039	6.007ArgPro: 6.007 ± 0.09	2.446ArgGln: 2.446 ± 0.047	9.868ArgArg: 9.868 ± 0.13	4.701ArgSer: 4.701 ± 0.071	5.093ArgThr: 5.093 ± 0.068	6.488ArgVal: 6.488 ± 0.092	1.456ArgTrp: 1.456 ± 0.037	1.81ArgTyr: 1.81 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.032SerAla: 7.032 ± 0.095	0.395SerCys: 0.395 ± 0.02	2.776SerAsp: 2.776 ± 0.051	2.102SerGlu: 2.102 ± 0.045	1.502SerPhe: 1.502 ± 0.042	5.799SerGly: 5.799 ± 0.078	0.94SerHis: 0.94 ± 0.03	1.676SerIle: 1.676 ± 0.042	0.825SerLys: 0.825 ± 0.032	4.665SerLeu: 4.665 ± 0.068	1.015SerMet: 1.015 ± 0.029	0.761SerAsn: 0.761 ± 0.026	3.619SerPro: 3.619 ± 0.059	1.202SerGln: 1.202 ± 0.029	4.344SerArg: 4.344 ± 0.067	3.102SerSer: 3.102 ± 0.064	3.3SerThr: 3.3 ± 0.06	4.29SerVal: 4.29 ± 0.067	0.892SerTrp: 0.892 ± 0.033	1.101SerTyr: 1.101 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	8.625ThrAla: 8.625 ± 0.082	0.445ThrCys: 0.445 ± 0.018	3.483ThrAsp: 3.483 ± 0.058	2.821ThrGlu: 2.821 ± 0.045	1.598ThrPhe: 1.598 ± 0.04	6.545ThrGly: 6.545 ± 0.079	1.081ThrHis: 1.081 ± 0.031	2.091ThrIle: 2.091 ± 0.045	0.893ThrLys: 0.893 ± 0.031	5.633ThrLeu: 5.633 ± 0.063	0.992ThrMet: 0.992 ± 0.027	0.969ThrAsn: 0.969 ± 0.03	3.981ThrPro: 3.981 ± 0.064	1.211ThrGln: 1.211 ± 0.037	4.479ThrArg: 4.479 ± 0.069	3.232ThrSer: 3.232 ± 0.054	3.818ThrThr: 3.818 ± 0.07	5.883ThrVal: 5.883 ± 0.078	0.808ThrTrp: 0.808 ± 0.026	1.069ThrTyr: 1.069 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	12.029ValAla: 12.029 ± 0.109	0.793ValCys: 0.793 ± 0.029	5.915ValAsp: 5.915 ± 0.078	4.77ValGlu: 4.77 ± 0.078	2.24ValPhe: 2.24 ± 0.048	7.558ValGly: 7.558 ± 0.096	1.926ValHis: 1.926 ± 0.043	3.28ValIle: 3.28 ± 0.056	1.19ValLys: 1.19 ± 0.039	9.389ValLeu: 9.389 ± 0.112	1.264ValMet: 1.264 ± 0.034	1.663ValAsn: 1.663 ± 0.049	5.373ValPro: 5.373 ± 0.07	1.887ValGln: 1.887 ± 0.042	7.303ValArg: 7.303 ± 0.084	4.342ValSer: 4.342 ± 0.065	5.592ValThr: 5.592 ± 0.076	8.69ValVal: 8.69 ± 0.117	1.046ValTrp: 1.046 ± 0.035	1.351ValTyr: 1.351 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.617TrpAla: 1.617 ± 0.044	0.154TrpCys: 0.154 ± 0.011	0.783TrpAsp: 0.783 ± 0.031	0.649TrpGlu: 0.649 ± 0.025	0.447TrpPhe: 0.447 ± 0.022	0.883TrpGly: 0.883 ± 0.031	0.381TrpHis: 0.381 ± 0.019	0.542TrpIle: 0.542 ± 0.022	0.266TrpLys: 0.266 ± 0.016	1.701TrpLeu: 1.701 ± 0.04	0.261TrpMet: 0.261 ± 0.017	0.269TrpAsn: 0.269 ± 0.017	0.901TrpPro: 0.901 ± 0.031	0.477TrpGln: 0.477 ± 0.023	1.38TrpArg: 1.38 ± 0.038	0.895TrpSer: 0.895 ± 0.025	0.835TrpThr: 0.835 ± 0.028	0.931TrpVal: 0.931 ± 0.029	0.326TrpTrp: 0.326 ± 0.018	0.291TrpTyr: 0.291 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.279TyrAla: 2.279 ± 0.046	0.156TyrCys: 0.156 ± 0.012	1.235TyrAsp: 1.235 ± 0.037	0.929TyrGlu: 0.929 ± 0.032	0.581TyrPhe: 0.581 ± 0.024	1.791TyrGly: 1.791 ± 0.04	0.417TyrHis: 0.417 ± 0.019	0.483TyrIle: 0.483 ± 0.022	0.279TyrLys: 0.279 ± 0.016	2.223TyrLeu: 2.223 ± 0.048	0.175TyrMet: 0.175 ± 0.013	0.331TyrAsn: 0.331 ± 0.019	1.106TyrPro: 1.106 ± 0.034	0.582TyrGln: 0.582 ± 0.024	1.806TyrArg: 1.806 ± 0.042	0.907TyrSer: 0.907 ± 0.03	1.043TyrThr: 1.043 ± 0.034	1.418TyrVal: 1.418 ± 0.035	0.299TyrTrp: 0.299 ± 0.017	0.419TyrTyr: 0.419 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3955 proteins (1112130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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