Amino acid dipepetide frequency for Bacillus coagulans 36D1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.066AlaAla: 8.066 ± 0.121
0.822AlaCys: 0.822 ± 0.036
4.009AlaAsp: 4.009 ± 0.065
5.689AlaGlu: 5.689 ± 0.089
3.976AlaPhe: 3.976 ± 0.065
7.167AlaGly: 7.167 ± 0.103
1.536AlaHis: 1.536 ± 0.041
5.774AlaIle: 5.774 ± 0.084
5.424AlaLys: 5.424 ± 0.072
8.212AlaLeu: 8.212 ± 0.1
2.294AlaMet: 2.294 ± 0.051
2.845AlaAsn: 2.845 ± 0.064
2.397AlaPro: 2.397 ± 0.061
2.461AlaGln: 2.461 ± 0.058
3.655AlaArg: 3.655 ± 0.072
4.434AlaSer: 4.434 ± 0.073
3.322AlaThr: 3.322 ± 0.058
6.854AlaVal: 6.854 ± 0.096
0.743AlaTrp: 0.743 ± 0.028
2.725AlaTyr: 2.725 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.615CysAla: 0.615 ± 0.03
0.131CysCys: 0.131 ± 0.012
0.38CysAsp: 0.38 ± 0.02
0.472CysGlu: 0.472 ± 0.025
0.404CysPhe: 0.404 ± 0.022
0.837CysGly: 0.837 ± 0.032
0.199CysHis: 0.199 ± 0.014
0.626CysIle: 0.626 ± 0.027
0.386CysLys: 0.386 ± 0.021
0.869CysLeu: 0.869 ± 0.028
0.211CysMet: 0.211 ± 0.015
0.278CysAsn: 0.278 ± 0.019
0.43CysPro: 0.43 ± 0.025
0.235CysGln: 0.235 ± 0.017
0.448CysArg: 0.448 ± 0.024
0.493CysSer: 0.493 ± 0.024
0.45CysThr: 0.45 ± 0.023
0.475CysVal: 0.475 ± 0.023
0.06CysTrp: 0.06 ± 0.008
0.298CysTyr: 0.298 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.897AspAla: 3.897 ± 0.066
0.451AspCys: 0.451 ± 0.019
2.157AspAsp: 2.157 ± 0.06
4.159AspGlu: 4.159 ± 0.08
2.403AspPhe: 2.403 ± 0.051
3.513AspGly: 3.513 ± 0.068
1.156AspHis: 1.156 ± 0.036
3.684AspIle: 3.684 ± 0.065
2.81AspLys: 2.81 ± 0.059
4.79AspLeu: 4.79 ± 0.077
1.275AspMet: 1.275 ± 0.041
1.368AspAsn: 1.368 ± 0.038
2.33AspPro: 2.33 ± 0.059
1.642AspGln: 1.642 ± 0.044
2.54AspArg: 2.54 ± 0.056
2.075AspSer: 2.075 ± 0.051
2.557AspThr: 2.557 ± 0.054
3.337AspVal: 3.337 ± 0.068
0.629AspTrp: 0.629 ± 0.03
1.926AspTyr: 1.926 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
6.327GluAla: 6.327 ± 0.099
0.381GluCys: 0.381 ± 0.02
3.502GluAsp: 3.502 ± 0.067
6.318GluGlu: 6.318 ± 0.105
2.067GluPhe: 2.067 ± 0.049
4.236GluGly: 4.236 ± 0.072
1.381GluHis: 1.381 ± 0.035
5.205GluIle: 5.205 ± 0.081
7.697GluLys: 7.697 ± 0.1
6.164GluLeu: 6.164 ± 0.096
2.389GluMet: 2.389 ± 0.049
3.504GluAsn: 3.504 ± 0.063
2.104GluPro: 2.104 ± 0.048
3.104GluGln: 3.104 ± 0.071
3.49GluArg: 3.49 ± 0.065
3.011GluSer: 3.011 ± 0.064
4.334GluThr: 4.334 ± 0.069
4.311GluVal: 4.311 ± 0.07
0.77GluTrp: 0.77 ± 0.028
1.808GluTyr: 1.808 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.489PheAla: 3.489 ± 0.064
0.407PheCys: 0.407 ± 0.02
2.25PheAsp: 2.25 ± 0.046
2.675PheGlu: 2.675 ± 0.052
2.466PhePhe: 2.466 ± 0.065
3.646PheGly: 3.646 ± 0.063
1.147PheHis: 1.147 ± 0.036
3.344PheIle: 3.344 ± 0.067
2.378PheLys: 2.378 ± 0.049
4.757PheLeu: 4.757 ± 0.089
1.154PheMet: 1.154 ± 0.032
1.505PheAsn: 1.505 ± 0.038
1.846PhePro: 1.846 ± 0.052
1.557PheGln: 1.557 ± 0.039
1.92PheArg: 1.92 ± 0.041
3.225PheSer: 3.225 ± 0.058
2.48PheThr: 2.48 ± 0.053
2.913PheVal: 2.913 ± 0.066
0.51PheTrp: 0.51 ± 0.027
1.704PheTyr: 1.704 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.519GlyAla: 5.519 ± 0.086
0.746GlyCys: 0.746 ± 0.028
3.157GlyAsp: 3.157 ± 0.066
4.611GlyGlu: 4.611 ± 0.073
3.445GlyPhe: 3.445 ± 0.067
5.155GlyGly: 5.155 ± 0.092
1.582GlyHis: 1.582 ± 0.048
6.105GlyIle: 6.105 ± 0.099
5.915GlyLys: 5.915 ± 0.088
6.83GlyLeu: 6.83 ± 0.105
2.379GlyMet: 2.379 ± 0.05
2.778GlyAsn: 2.778 ± 0.058
1.896GlyPro: 1.896 ± 0.048
2.255GlyGln: 2.255 ± 0.051
3.445GlyArg: 3.445 ± 0.065
4.088GlySer: 4.088 ± 0.071
4.455GlyThr: 4.455 ± 0.088
5.061GlyVal: 5.061 ± 0.076
0.845GlyTrp: 0.845 ± 0.037
2.799GlyTyr: 2.799 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.727HisAla: 1.727 ± 0.041
0.254HisCys: 0.254 ± 0.017
1.034HisAsp: 1.034 ± 0.032
1.431HisGlu: 1.431 ± 0.038
1.229HisPhe: 1.229 ± 0.038
1.53HisGly: 1.53 ± 0.041
0.75HisHis: 0.75 ± 0.031
1.487HisIle: 1.487 ± 0.04
0.985HisLys: 0.985 ± 0.035
2.263HisLeu: 2.263 ± 0.053
0.531HisMet: 0.531 ± 0.026
0.63HisAsn: 0.63 ± 0.028
1.372HisPro: 1.372 ± 0.038
0.773HisGln: 0.773 ± 0.029
1.005HisArg: 1.005 ± 0.031
1.075HisSer: 1.075 ± 0.041
1.068HisThr: 1.068 ± 0.031
1.527HisVal: 1.527 ± 0.045
0.247HisTrp: 0.247 ± 0.016
0.909HisTyr: 0.909 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.223IleAla: 6.223 ± 0.082
0.717IleCys: 0.717 ± 0.027
3.572IleAsp: 3.572 ± 0.063
4.946IleGlu: 4.946 ± 0.073
3.169IlePhe: 3.169 ± 0.065
5.688IleGly: 5.688 ± 0.092
1.684IleHis: 1.684 ± 0.044
4.463IleIle: 4.463 ± 0.08
3.94IleLys: 3.94 ± 0.073
6.865IleLeu: 6.865 ± 0.088
1.565IleMet: 1.565 ± 0.046
2.307IleAsn: 2.307 ± 0.052
3.338IlePro: 3.338 ± 0.056
2.559IleGln: 2.559 ± 0.06
3.962IleArg: 3.962 ± 0.063
4.396IleSer: 4.396 ± 0.068
3.763IleThr: 3.763 ± 0.065
4.993IleVal: 4.993 ± 0.078
0.682IleTrp: 0.682 ± 0.03
2.166IleTyr: 2.166 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
5.721LysAla: 5.721 ± 0.089
0.384LysCys: 0.384 ± 0.019
3.445LysAsp: 3.445 ± 0.062
6.233LysGlu: 6.233 ± 0.1
1.973LysPhe: 1.973 ± 0.051
4.63LysGly: 4.63 ± 0.071
1.263LysHis: 1.263 ± 0.035
4.882LysIle: 4.882 ± 0.08
6.579LysLys: 6.579 ± 0.088
5.802LysLeu: 5.802 ± 0.082
2.458LysMet: 2.458 ± 0.048
3.366LysAsn: 3.366 ± 0.063
2.4LysPro: 2.4 ± 0.048
3.218LysGln: 3.218 ± 0.058
3.66LysArg: 3.66 ± 0.065
3.429LysSer: 3.429 ± 0.073
4.237LysThr: 4.237 ± 0.064
4.478LysVal: 4.478 ± 0.081
0.884LysTrp: 0.884 ± 0.03
2.23LysTyr: 2.23 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
8.412LeuAla: 8.412 ± 0.106
0.797LeuCys: 0.797 ± 0.028
4.941LeuAsp: 4.941 ± 0.075
6.64LeuGlu: 6.64 ± 0.093
4.847LeuPhe: 4.847 ± 0.087
6.434LeuGly: 6.434 ± 0.094
2.033LeuHis: 2.033 ± 0.053
6.563LeuIle: 6.563 ± 0.088
7.027LeuLys: 7.027 ± 0.099
9.974LeuLeu: 9.974 ± 0.131
2.381LeuMet: 2.381 ± 0.045
3.843LeuAsn: 3.843 ± 0.066
4.188LeuPro: 4.188 ± 0.059
3.466LeuGln: 3.466 ± 0.061
3.929LeuArg: 3.929 ± 0.069
6.678LeuSer: 6.678 ± 0.091
4.914LeuThr: 4.914 ± 0.069
6.217LeuVal: 6.217 ± 0.096
0.853LeuTrp: 0.853 ± 0.031
3.286LeuTyr: 3.286 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.587MetAla: 2.587 ± 0.057
0.159MetCys: 0.159 ± 0.012
1.535MetAsp: 1.535 ± 0.04
2.308MetGlu: 2.308 ± 0.054
1.01MetPhe: 1.01 ± 0.036
1.762MetGly: 1.762 ± 0.048
0.56MetHis: 0.56 ± 0.023
2.068MetIle: 2.068 ± 0.05
2.38MetLys: 2.38 ± 0.047
2.624MetLeu: 2.624 ± 0.052
0.909MetMet: 0.909 ± 0.036
1.294MetAsn: 1.294 ± 0.036
1.225MetPro: 1.225 ± 0.041
0.972MetGln: 0.972 ± 0.033
1.185MetArg: 1.185 ± 0.036
1.387MetSer: 1.387 ± 0.035
1.353MetThr: 1.353 ± 0.037
1.84MetVal: 1.84 ± 0.045
0.162MetTrp: 0.162 ± 0.012
0.657MetTyr: 0.657 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.874AsnAla: 2.874 ± 0.053
0.306AsnCys: 0.306 ± 0.019
1.745AsnAsp: 1.745 ± 0.045
2.841AsnGlu: 2.841 ± 0.057
1.382AsnPhe: 1.382 ± 0.037
3.557AsnGly: 3.557 ± 0.073
0.938AsnHis: 0.938 ± 0.035
2.886AsnIle: 2.886 ± 0.055
2.211AsnLys: 2.211 ± 0.055
3.504AsnLeu: 3.504 ± 0.058
1.061AsnMet: 1.061 ± 0.035
1.248AsnAsn: 1.248 ± 0.049
2.062AsnPro: 2.062 ± 0.051
1.505AsnGln: 1.505 ± 0.04
2.212AsnArg: 2.212 ± 0.054
1.732AsnSer: 1.732 ± 0.049
1.913AsnThr: 1.913 ± 0.043
2.677AsnVal: 2.677 ± 0.052
0.517AsnTrp: 0.517 ± 0.023
1.146AsnTyr: 1.146 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
3.33ProAla: 3.33 ± 0.068
0.249ProCys: 0.249 ± 0.016
2.561ProAsp: 2.561 ± 0.048
3.47ProGlu: 3.47 ± 0.076
2.147ProPhe: 2.147 ± 0.044
2.931ProGly: 2.931 ± 0.058
0.906ProHis: 0.906 ± 0.034
2.075ProIle: 2.075 ± 0.045
2.277ProLys: 2.277 ± 0.056
3.736ProLeu: 3.736 ± 0.065
0.799ProMet: 0.799 ± 0.031
1.482ProAsn: 1.482 ± 0.047
1.161ProPro: 1.161 ± 0.04
1.177ProGln: 1.177 ± 0.041
1.294ProArg: 1.294 ± 0.036
2.094ProSer: 2.094 ± 0.051
1.455ProThr: 1.455 ± 0.038
3.91ProVal: 3.91 ± 0.066
0.373ProTrp: 0.373 ± 0.022
1.49ProTyr: 1.49 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
3.008GlnAla: 3.008 ± 0.058
0.177GlnCys: 0.177 ± 0.013
1.5GlnAsp: 1.5 ± 0.042
2.517GlnGlu: 2.517 ± 0.063
1.509GlnPhe: 1.509 ± 0.04
1.822GlnGly: 1.822 ± 0.041
0.795GlnHis: 0.795 ± 0.029
2.483GlnIle: 2.483 ± 0.05
2.983GlnLys: 2.983 ± 0.062
3.724GlnLeu: 3.724 ± 0.063
1.208GlnMet: 1.208 ± 0.037
1.593GlnAsn: 1.593 ± 0.038
1.288GlnPro: 1.288 ± 0.035
1.653GlnGln: 1.653 ± 0.045
1.393GlnArg: 1.393 ± 0.039
1.942GlnSer: 1.942 ± 0.052
1.998GlnThr: 1.998 ± 0.048
2.146GlnVal: 2.146 ± 0.05
0.366GlnTrp: 0.366 ± 0.021
1.405GlnTyr: 1.405 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
3.228ArgAla: 3.228 ± 0.068
0.308ArgCys: 0.308 ± 0.018
2.24ArgAsp: 2.24 ± 0.049
3.693ArgGlu: 3.693 ± 0.064
2.356ArgPhe: 2.356 ± 0.048
2.717ArgGly: 2.717 ± 0.061
1.154ArgHis: 1.154 ± 0.034
3.313ArgIle: 3.313 ± 0.064
3.906ArgLys: 3.906 ± 0.069
4.819ArgLeu: 4.819 ± 0.092
1.487ArgMet: 1.487 ± 0.038
1.932ArgAsn: 1.932 ± 0.043
1.695ArgPro: 1.695 ± 0.041
1.869ArgGln: 1.869 ± 0.041
2.261ArgArg: 2.261 ± 0.058
2.268ArgSer: 2.268 ± 0.048
2.356ArgThr: 2.356 ± 0.054
2.771ArgVal: 2.771 ± 0.055
0.448ArgTrp: 0.448 ± 0.02
1.789ArgTyr: 1.789 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.224SerAla: 4.224 ± 0.083
0.467SerCys: 0.467 ± 0.023
2.451SerAsp: 2.451 ± 0.053
3.245SerGlu: 3.245 ± 0.065
2.926SerPhe: 2.926 ± 0.059
5.054SerGly: 5.054 ± 0.09
1.149SerHis: 1.149 ± 0.034
3.979SerIle: 3.979 ± 0.06
3.455SerLys: 3.455 ± 0.071
5.555SerLeu: 5.555 ± 0.085
1.545SerMet: 1.545 ± 0.043
1.979SerAsn: 1.979 ± 0.049
2.1SerPro: 2.1 ± 0.05
1.731SerGln: 1.731 ± 0.042
2.644SerArg: 2.644 ± 0.057
3.323SerSer: 3.323 ± 0.08
2.643SerThr: 2.643 ± 0.061
3.976SerVal: 3.976 ± 0.066
0.55SerTrp: 0.55 ± 0.026
1.944SerTyr: 1.944 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.663ThrAla: 4.663 ± 0.082
0.432ThrCys: 0.432 ± 0.024
2.678ThrAsp: 2.678 ± 0.057
3.289ThrGlu: 3.289 ± 0.068
2.445ThrPhe: 2.445 ± 0.054
5.029ThrGly: 5.029 ± 0.087
1.028ThrHis: 1.028 ± 0.031
3.881ThrIle: 3.881 ± 0.069
3.147ThrLys: 3.147 ± 0.059
4.859ThrLeu: 4.859 ± 0.073
1.245ThrMet: 1.245 ± 0.04
2.0ThrAsn: 2.0 ± 0.053
2.258ThrPro: 2.258 ± 0.053
1.234ThrGln: 1.234 ± 0.035
1.963ThrArg: 1.963 ± 0.043
2.667ThrSer: 2.667 ± 0.06
2.532ThrThr: 2.532 ± 0.072
4.574ThrVal: 4.574 ± 0.08
0.466ThrTrp: 0.466 ± 0.023
1.857ThrTyr: 1.857 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
5.315ValAla: 5.315 ± 0.091
0.703ValCys: 0.703 ± 0.028
3.253ValAsp: 3.253 ± 0.062
4.417ValGlu: 4.417 ± 0.074
3.306ValPhe: 3.306 ± 0.061
4.02ValGly: 4.02 ± 0.074
1.405ValHis: 1.405 ± 0.036
5.107ValIle: 5.107 ± 0.072
5.026ValLys: 5.026 ± 0.087
7.542ValLeu: 7.542 ± 0.093
1.928ValMet: 1.928 ± 0.052
2.66ValAsn: 2.66 ± 0.05
3.081ValPro: 3.081 ± 0.054
2.375ValGln: 2.375 ± 0.054
3.237ValArg: 3.237 ± 0.061
4.418ValSer: 4.418 ± 0.067
4.047ValThr: 4.047 ± 0.073
4.758ValVal: 4.758 ± 0.089
0.653ValTrp: 0.653 ± 0.026
2.37ValTyr: 2.37 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
0.69TrpAla: 0.69 ± 0.025
0.073TrpCys: 0.073 ± 0.01
0.522TrpAsp: 0.522 ± 0.02
0.66TrpGlu: 0.66 ± 0.025
0.536TrpPhe: 0.536 ± 0.023
0.673TrpGly: 0.673 ± 0.027
0.257TrpHis: 0.257 ± 0.017
0.807TrpIle: 0.807 ± 0.033
0.779TrpLys: 0.779 ± 0.027
1.172TrpLeu: 1.172 ± 0.037
0.347TrpMet: 0.347 ± 0.02
0.485TrpAsn: 0.485 ± 0.02
0.292TrpPro: 0.292 ± 0.02
0.388TrpGln: 0.388 ± 0.018
0.445TrpArg: 0.445 ± 0.023
0.509TrpSer: 0.509 ± 0.025
0.477TrpThr: 0.477 ± 0.022
0.693TrpVal: 0.693 ± 0.027
0.134TrpTrp: 0.134 ± 0.015
0.331TrpTyr: 0.331 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.491TyrAla: 2.491 ± 0.058
0.329TyrCys: 0.329 ± 0.02
1.768TyrAsp: 1.768 ± 0.048
2.489TyrGlu: 2.489 ± 0.059
1.774TyrPhe: 1.774 ± 0.043
2.667TyrGly: 2.667 ± 0.054
0.906TyrHis: 0.906 ± 0.034
2.265TyrIle: 2.265 ± 0.05
1.966TyrLys: 1.966 ± 0.057
3.365TyrLeu: 3.365 ± 0.066
0.811TyrMet: 0.811 ± 0.028
1.22TyrAsn: 1.22 ± 0.039
1.457TyrPro: 1.457 ± 0.039
1.336TyrGln: 1.336 ± 0.042
1.919TyrArg: 1.919 ± 0.046
1.697TyrSer: 1.697 ± 0.048
1.893TyrThr: 1.893 ± 0.044
2.11TyrVal: 2.11 ± 0.052
0.377TyrTrp: 0.377 ± 0.021
1.287TyrTyr: 1.287 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3275 proteins (954149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski