Amino acid dipepetide frequency for Streptococcus satellite phage Javan602

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.438AlaCys: 0.438 ± 0.318
2.628AlaAsp: 2.628 ± 1.116
3.942AlaGlu: 3.942 ± 1.012
2.628AlaPhe: 2.628 ± 1.152
3.066AlaGly: 3.066 ± 0.921
0.0AlaHis: 0.0 ± 0.0
4.818AlaIle: 4.818 ± 0.915
4.818AlaLys: 4.818 ± 1.261
4.818AlaLeu: 4.818 ± 1.224
0.876AlaMet: 0.876 ± 0.63
5.256AlaAsn: 5.256 ± 2.085
1.314AlaPro: 1.314 ± 0.802
3.066AlaGln: 3.066 ± 1.442
2.19AlaArg: 2.19 ± 0.737
2.19AlaSer: 2.19 ± 0.907
3.066AlaThr: 3.066 ± 1.162
2.628AlaVal: 2.628 ± 0.794
0.876AlaTrp: 0.876 ± 0.61
3.066AlaTyr: 3.066 ± 0.927
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.876CysAsp: 0.876 ± 0.721
0.0CysGlu: 0.0 ± 0.0
0.438CysPhe: 0.438 ± 0.522
0.438CysGly: 0.438 ± 0.318
0.0CysHis: 0.0 ± 0.0
0.438CysIle: 0.438 ± 0.392
0.438CysLys: 0.438 ± 0.318
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.438CysAsn: 0.438 ± 0.318
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.438CysArg: 0.438 ± 0.346
0.438CysSer: 0.438 ± 0.476
0.0CysThr: 0.0 ± 0.0
0.438CysVal: 0.438 ± 0.392
0.0CysTrp: 0.0 ± 0.0
0.438CysTyr: 0.438 ± 0.473
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
0.438AspCys: 0.438 ± 0.473
3.504AspAsp: 3.504 ± 1.738
7.446AspGlu: 7.446 ± 1.61
4.38AspPhe: 4.38 ± 1.261
2.19AspGly: 2.19 ± 0.654
0.438AspHis: 0.438 ± 0.476
4.818AspIle: 4.818 ± 1.799
5.694AspLys: 5.694 ± 1.358
5.256AspLeu: 5.256 ± 1.482
2.628AspMet: 2.628 ± 0.971
6.132AspAsn: 6.132 ± 1.392
1.314AspPro: 1.314 ± 0.644
0.438AspGln: 0.438 ± 0.473
1.314AspArg: 1.314 ± 0.769
4.818AspSer: 4.818 ± 1.54
3.066AspThr: 3.066 ± 1.076
3.504AspVal: 3.504 ± 1.22
0.876AspTrp: 0.876 ± 0.635
3.942AspTyr: 3.942 ± 1.848
0.0AspXaa: 0.0 ± 0.0
Glu
5.256GluAla: 5.256 ± 1.308
0.438GluCys: 0.438 ± 0.497
3.066GluAsp: 3.066 ± 1.468
5.256GluGlu: 5.256 ± 1.608
4.38GluPhe: 4.38 ± 0.934
3.066GluGly: 3.066 ± 0.96
0.876GluHis: 0.876 ± 0.513
4.818GluIle: 4.818 ± 1.102
6.57GluLys: 6.57 ± 1.687
12.703GluLeu: 12.703 ± 2.036
1.314GluMet: 1.314 ± 0.562
4.38GluAsn: 4.38 ± 1.43
2.628GluPro: 2.628 ± 0.987
1.314GluGln: 1.314 ± 0.71
3.504GluArg: 3.504 ± 1.669
3.504GluSer: 3.504 ± 1.135
5.694GluThr: 5.694 ± 1.599
1.752GluVal: 1.752 ± 1.219
0.0GluTrp: 0.0 ± 0.0
3.504GluTyr: 3.504 ± 1.123
0.0GluXaa: 0.0 ± 0.0
Phe
0.876PheAla: 0.876 ± 0.51
0.0PheCys: 0.0 ± 0.0
4.818PheAsp: 4.818 ± 1.072
4.818PheGlu: 4.818 ± 1.736
0.438PhePhe: 0.438 ± 0.473
2.19PheGly: 2.19 ± 1.038
0.438PheHis: 0.438 ± 0.346
3.066PheIle: 3.066 ± 1.138
3.066PheLys: 3.066 ± 0.943
5.694PheLeu: 5.694 ± 1.634
0.438PheMet: 0.438 ± 0.476
3.942PheAsn: 3.942 ± 1.779
0.438PhePro: 0.438 ± 0.392
0.876PheGln: 0.876 ± 0.498
1.752PheArg: 1.752 ± 0.95
1.752PheSer: 1.752 ± 0.67
2.19PheThr: 2.19 ± 0.993
0.876PheVal: 0.876 ± 0.609
0.876PheTrp: 0.876 ± 0.51
1.314PheTyr: 1.314 ± 0.579
0.0PheXaa: 0.0 ± 0.0
Gly
2.19GlyAla: 2.19 ± 0.872
0.876GlyCys: 0.876 ± 0.572
3.942GlyAsp: 3.942 ± 1.295
3.066GlyGlu: 3.066 ± 0.846
2.628GlyPhe: 2.628 ± 1.101
1.752GlyGly: 1.752 ± 0.743
0.438GlyHis: 0.438 ± 0.346
4.818GlyIle: 4.818 ± 0.945
3.942GlyLys: 3.942 ± 1.243
6.57GlyLeu: 6.57 ± 2.156
0.876GlyMet: 0.876 ± 0.54
4.38GlyAsn: 4.38 ± 1.644
0.0GlyPro: 0.0 ± 0.0
0.876GlyGln: 0.876 ± 0.525
1.752GlyArg: 1.752 ± 0.823
1.314GlySer: 1.314 ± 0.837
2.19GlyThr: 2.19 ± 0.732
5.256GlyVal: 5.256 ± 1.329
0.876GlyTrp: 0.876 ± 0.635
5.694GlyTyr: 5.694 ± 2.022
0.0GlyXaa: 0.0 ± 0.0
His
2.19HisAla: 2.19 ± 0.896
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.752HisGlu: 1.752 ± 0.718
1.314HisPhe: 1.314 ± 0.686
1.314HisGly: 1.314 ± 0.839
0.0HisHis: 0.0 ± 0.0
0.438HisIle: 0.438 ± 0.346
0.438HisLys: 0.438 ± 0.346
0.876HisLeu: 0.876 ± 0.517
0.0HisMet: 0.0 ± 0.0
0.876HisAsn: 0.876 ± 0.756
0.438HisPro: 0.438 ± 0.531
0.876HisGln: 0.876 ± 0.771
0.438HisArg: 0.438 ± 0.346
0.438HisSer: 0.438 ± 0.346
1.752HisThr: 1.752 ± 0.953
0.876HisVal: 0.876 ± 0.57
0.0HisTrp: 0.0 ± 0.0
1.314HisTyr: 1.314 ± 0.637
0.0HisXaa: 0.0 ± 0.0
Ile
5.694IleAla: 5.694 ± 1.741
0.438IleCys: 0.438 ± 0.522
5.256IleAsp: 5.256 ± 1.6
4.38IleGlu: 4.38 ± 1.35
1.314IlePhe: 1.314 ± 0.697
3.066IleGly: 3.066 ± 0.661
1.752IleHis: 1.752 ± 0.961
3.942IleIle: 3.942 ± 1.6
4.818IleLys: 4.818 ± 1.149
7.446IleLeu: 7.446 ± 2.13
0.876IleMet: 0.876 ± 0.519
3.066IleAsn: 3.066 ± 1.026
2.628IlePro: 2.628 ± 1.286
1.752IleGln: 1.752 ± 0.675
1.314IleArg: 1.314 ± 0.551
4.38IleSer: 4.38 ± 1.723
5.694IleThr: 5.694 ± 0.913
2.19IleVal: 2.19 ± 1.143
0.876IleTrp: 0.876 ± 1.045
5.256IleTyr: 5.256 ± 1.364
0.0IleXaa: 0.0 ± 0.0
Lys
4.818LysAla: 4.818 ± 1.732
0.438LysCys: 0.438 ± 0.392
4.818LysAsp: 4.818 ± 1.489
7.446LysGlu: 7.446 ± 1.669
3.504LysPhe: 3.504 ± 1.15
4.38LysGly: 4.38 ± 0.924
2.628LysHis: 2.628 ± 0.932
6.132LysIle: 6.132 ± 1.228
9.636LysLys: 9.636 ± 2.748
7.884LysLeu: 7.884 ± 1.786
1.314LysMet: 1.314 ± 0.55
6.132LysAsn: 6.132 ± 1.511
3.942LysPro: 3.942 ± 1.653
4.818LysGln: 4.818 ± 1.336
6.57LysArg: 6.57 ± 1.482
4.38LysSer: 4.38 ± 1.017
4.38LysThr: 4.38 ± 1.552
3.942LysVal: 3.942 ± 1.054
0.0LysTrp: 0.0 ± 0.0
2.19LysTyr: 2.19 ± 0.756
0.0LysXaa: 0.0 ± 0.0
Leu
7.884LeuAla: 7.884 ± 2.47
0.438LeuCys: 0.438 ± 0.318
7.884LeuAsp: 7.884 ± 1.515
8.76LeuGlu: 8.76 ± 3.125
3.066LeuPhe: 3.066 ± 0.85
7.884LeuGly: 7.884 ± 2.349
1.752LeuHis: 1.752 ± 0.905
4.38LeuIle: 4.38 ± 1.141
8.322LeuLys: 8.322 ± 2.019
7.884LeuLeu: 7.884 ± 1.607
2.19LeuMet: 2.19 ± 1.052
5.256LeuAsn: 5.256 ± 2.082
3.504LeuPro: 3.504 ± 1.296
3.942LeuGln: 3.942 ± 1.173
3.066LeuArg: 3.066 ± 1.696
7.446LeuSer: 7.446 ± 2.256
4.818LeuThr: 4.818 ± 1.122
4.38LeuVal: 4.38 ± 1.472
0.876LeuTrp: 0.876 ± 0.498
2.628LeuTyr: 2.628 ± 0.852
0.0LeuXaa: 0.0 ± 0.0
Met
0.876MetAla: 0.876 ± 0.8
0.0MetCys: 0.0 ± 0.0
2.19MetAsp: 2.19 ± 0.717
0.876MetGlu: 0.876 ± 0.635
0.0MetPhe: 0.0 ± 0.0
1.314MetGly: 1.314 ± 0.654
0.0MetHis: 0.0 ± 0.0
1.314MetIle: 1.314 ± 0.702
1.752MetLys: 1.752 ± 1.113
1.314MetLeu: 1.314 ± 0.807
0.876MetMet: 0.876 ± 0.407
1.314MetAsn: 1.314 ± 0.501
0.438MetPro: 0.438 ± 0.392
0.438MetGln: 0.438 ± 0.544
0.876MetArg: 0.876 ± 0.717
2.19MetSer: 2.19 ± 1.205
2.19MetThr: 2.19 ± 0.829
2.628MetVal: 2.628 ± 1.225
0.438MetTrp: 0.438 ± 0.473
0.876MetTyr: 0.876 ± 0.539
0.0MetXaa: 0.0 ± 0.0
Asn
3.942AsnAla: 3.942 ± 1.364
0.0AsnCys: 0.0 ± 0.0
3.504AsnAsp: 3.504 ± 1.182
4.38AsnGlu: 4.38 ± 0.963
1.314AsnPhe: 1.314 ± 0.933
6.132AsnGly: 6.132 ± 1.213
0.438AsnHis: 0.438 ± 0.346
3.504AsnIle: 3.504 ± 1.427
6.132AsnLys: 6.132 ± 1.507
4.818AsnLeu: 4.818 ± 1.57
2.19AsnMet: 2.19 ± 1.235
4.38AsnAsn: 4.38 ± 1.463
4.38AsnPro: 4.38 ± 1.311
0.876AsnGln: 0.876 ± 0.575
2.19AsnArg: 2.19 ± 0.99
5.694AsnSer: 5.694 ± 2.049
7.008AsnThr: 7.008 ± 1.428
3.942AsnVal: 3.942 ± 0.939
0.438AsnTrp: 0.438 ± 0.473
4.818AsnTyr: 4.818 ± 1.021
0.0AsnXaa: 0.0 ± 0.0
Pro
2.19ProAla: 2.19 ± 0.838
0.0ProCys: 0.0 ± 0.0
1.314ProAsp: 1.314 ± 0.912
0.876ProGlu: 0.876 ± 0.629
2.628ProPhe: 2.628 ± 1.184
0.0ProGly: 0.0 ± 0.0
0.438ProHis: 0.438 ± 0.392
3.066ProIle: 3.066 ± 1.375
3.066ProLys: 3.066 ± 1.525
2.628ProLeu: 2.628 ± 0.763
0.0ProMet: 0.0 ± 0.0
3.942ProAsn: 3.942 ± 2.137
2.19ProPro: 2.19 ± 1.094
0.876ProGln: 0.876 ± 0.525
1.752ProArg: 1.752 ± 0.823
1.314ProSer: 1.314 ± 0.802
1.314ProThr: 1.314 ± 0.681
3.066ProVal: 3.066 ± 1.278
0.438ProTrp: 0.438 ± 0.318
1.752ProTyr: 1.752 ± 0.526
0.0ProXaa: 0.0 ± 0.0
Gln
1.314GlnAla: 1.314 ± 0.622
0.0GlnCys: 0.0 ± 0.0
2.19GlnAsp: 2.19 ± 1.423
5.256GlnGlu: 5.256 ± 1.286
1.752GlnPhe: 1.752 ± 0.771
1.314GlnGly: 1.314 ± 0.818
1.314GlnHis: 1.314 ± 0.837
2.19GlnIle: 2.19 ± 1.049
2.628GlnLys: 2.628 ± 1.059
1.314GlnLeu: 1.314 ± 0.818
0.438GlnMet: 0.438 ± 0.522
0.876GlnAsn: 0.876 ± 0.586
1.314GlnPro: 1.314 ± 0.727
0.876GlnGln: 0.876 ± 0.613
0.876GlnArg: 0.876 ± 0.635
3.504GlnSer: 3.504 ± 1.128
3.066GlnThr: 3.066 ± 1.04
1.752GlnVal: 1.752 ± 0.881
0.0GlnTrp: 0.0 ± 0.0
0.438GlnTyr: 0.438 ± 0.346
0.0GlnXaa: 0.0 ± 0.0
Arg
3.066ArgAla: 3.066 ± 1.133
0.0ArgCys: 0.0 ± 0.0
1.314ArgAsp: 1.314 ± 0.644
1.752ArgGlu: 1.752 ± 0.892
0.0ArgPhe: 0.0 ± 0.0
2.19ArgGly: 2.19 ± 0.991
0.876ArgHis: 0.876 ± 0.572
3.942ArgIle: 3.942 ± 1.312
2.628ArgLys: 2.628 ± 0.896
3.066ArgLeu: 3.066 ± 1.103
0.438ArgMet: 0.438 ± 0.467
5.694ArgAsn: 5.694 ± 0.934
1.314ArgPro: 1.314 ± 0.697
0.876ArgGln: 0.876 ± 0.594
0.876ArgArg: 0.876 ± 0.601
2.19ArgSer: 2.19 ± 0.766
2.628ArgThr: 2.628 ± 1.023
3.504ArgVal: 3.504 ± 1.542
0.438ArgTrp: 0.438 ± 0.544
3.504ArgTyr: 3.504 ± 1.136
0.0ArgXaa: 0.0 ± 0.0
Ser
2.628SerAla: 2.628 ± 0.953
0.0SerCys: 0.0 ± 0.0
4.818SerAsp: 4.818 ± 0.879
3.504SerGlu: 3.504 ± 1.598
1.752SerPhe: 1.752 ± 0.709
3.066SerGly: 3.066 ± 0.948
0.438SerHis: 0.438 ± 0.346
3.942SerIle: 3.942 ± 1.158
7.884SerLys: 7.884 ± 1.964
5.256SerLeu: 5.256 ± 1.361
0.876SerMet: 0.876 ± 0.407
4.38SerAsn: 4.38 ± 1.474
1.314SerPro: 1.314 ± 0.929
3.066SerGln: 3.066 ± 1.46
2.19SerArg: 2.19 ± 0.927
3.066SerSer: 3.066 ± 2.021
3.066SerThr: 3.066 ± 1.408
3.504SerVal: 3.504 ± 1.283
2.19SerTrp: 2.19 ± 1.19
3.504SerTyr: 3.504 ± 1.54
0.0SerXaa: 0.0 ± 0.0
Thr
2.628ThrAla: 2.628 ± 0.748
0.0ThrCys: 0.0 ± 0.0
3.504ThrAsp: 3.504 ± 1.675
1.752ThrGlu: 1.752 ± 0.651
3.942ThrPhe: 3.942 ± 1.812
3.504ThrGly: 3.504 ± 1.672
1.752ThrHis: 1.752 ± 0.771
3.942ThrIle: 3.942 ± 1.704
6.57ThrLys: 6.57 ± 1.244
7.008ThrLeu: 7.008 ± 1.798
3.066ThrMet: 3.066 ± 1.035
3.504ThrAsn: 3.504 ± 1.105
1.752ThrPro: 1.752 ± 0.692
1.752ThrGln: 1.752 ± 1.219
5.256ThrArg: 5.256 ± 2.029
3.066ThrSer: 3.066 ± 1.238
3.942ThrThr: 3.942 ± 1.615
7.884ThrVal: 7.884 ± 1.73
0.438ThrTrp: 0.438 ± 0.392
2.19ThrTyr: 2.19 ± 1.004
0.0ThrXaa: 0.0 ± 0.0
Val
4.38ValAla: 4.38 ± 1.403
0.876ValCys: 0.876 ± 0.533
1.752ValAsp: 1.752 ± 1.018
2.628ValGlu: 2.628 ± 1.467
3.066ValPhe: 3.066 ± 1.149
3.066ValGly: 3.066 ± 0.743
0.438ValHis: 0.438 ± 0.346
3.504ValIle: 3.504 ± 0.842
5.694ValLys: 5.694 ± 1.374
7.008ValLeu: 7.008 ± 1.837
0.438ValMet: 0.438 ± 0.505
2.628ValAsn: 2.628 ± 1.302
2.19ValPro: 2.19 ± 0.964
2.19ValGln: 2.19 ± 0.91
0.876ValArg: 0.876 ± 0.635
3.504ValSer: 3.504 ± 1.334
8.76ValThr: 8.76 ± 1.683
4.38ValVal: 4.38 ± 1.321
0.0ValTrp: 0.0 ± 0.0
1.752ValTyr: 1.752 ± 1.101
0.0ValXaa: 0.0 ± 0.0
Trp
0.438TrpAla: 0.438 ± 0.473
0.0TrpCys: 0.0 ± 0.0
0.876TrpAsp: 0.876 ± 0.517
0.438TrpGlu: 0.438 ± 0.544
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.438TrpHis: 0.438 ± 0.318
0.438TrpIle: 0.438 ± 0.318
1.314TrpLys: 1.314 ± 0.529
2.19TrpLeu: 2.19 ± 1.315
0.438TrpMet: 0.438 ± 0.473
0.438TrpAsn: 0.438 ± 0.522
0.0TrpPro: 0.0 ± 0.0
0.438TrpGln: 0.438 ± 0.318
0.438TrpArg: 0.438 ± 0.318
1.314TrpSer: 1.314 ± 0.575
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.438TrpTrp: 0.438 ± 0.346
0.876TrpTyr: 0.876 ± 0.51
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.314TyrAla: 1.314 ± 0.617
0.438TyrCys: 0.438 ± 0.392
3.942TyrAsp: 3.942 ± 1.296
5.694TyrGlu: 5.694 ± 1.635
1.314TyrPhe: 1.314 ± 0.896
3.504TyrGly: 3.504 ± 0.998
0.876TyrHis: 0.876 ± 0.55
3.066TyrIle: 3.066 ± 0.874
3.942TyrLys: 3.942 ± 1.779
2.628TyrLeu: 2.628 ± 1.104
2.19TyrMet: 2.19 ± 1.127
3.066TyrAsn: 3.066 ± 1.726
1.752TyrPro: 1.752 ± 0.915
3.066TyrGln: 3.066 ± 1.243
2.628TyrArg: 2.628 ± 0.963
3.942TyrSer: 3.942 ± 1.748
2.628TyrThr: 2.628 ± 1.033
2.628TyrVal: 2.628 ± 1.217
0.438TyrTrp: 0.438 ± 0.473
2.628TyrTyr: 2.628 ± 1.269
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2284 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski